MA28220A1 - Methode de production de derives de (3-oxo-2,3-dihydro-1h-isoindol-1-yl)acetylguanidine - Google Patents
Methode de production de derives de (3-oxo-2,3-dihydro-1h-isoindol-1-yl)acetylguanidineInfo
- Publication number
- MA28220A1 MA28220A1 MA29077A MA29077A MA28220A1 MA 28220 A1 MA28220 A1 MA 28220A1 MA 29077 A MA29077 A MA 29077A MA 29077 A MA29077 A MA 29077A MA 28220 A1 MA28220 A1 MA 28220A1
- Authority
- MA
- Morocco
- Prior art keywords
- isoindol
- dihydro
- oxo
- derivatives
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HLFLSXJZAJUCFK-UHFFFAOYSA-N n-carbamimidoyl-n-(3-oxo-1,2-dihydroisoindol-1-yl)acetamide Chemical class C1=CC=C2C(N(C(=O)C)C(N)=N)NC(=O)C2=C1 HLFLSXJZAJUCFK-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 4
- -1 2-carbamoylphenyl Chemical group 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- KAUMDYDNLPQESC-UHFFFAOYSA-N 3-hydroxy-2,3-dihydroisoindol-1-one Chemical class C1=CC=C2C(O)NC(=O)C2=C1 KAUMDYDNLPQESC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004252 isoindol-1-yl group Chemical group [H]N1C([H])=C2C([H])=C([H])C([H])=C([H])C2=C1* 0.000 abstract 1
- NGGXACLSAZXJGM-UHFFFAOYSA-N n-(diaminomethylidene)acetamide Chemical compound CC(=O)N=C(N)N NGGXACLSAZXJGM-UHFFFAOYSA-N 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Méthode de production de dérivés de (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acétylguanidine La présente invention concerne des procédés de préparation de dérivés de (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acétylguanidine de formule I par l'intermédiaire de dérivés de 3-hydroxy-2,3-dihydro-1H-isoindol-1-one ou de dérivés d'ester 3-(2-carbamoylphényl)acrylique en tant qu'intermédiaires, un procédé de dédoublement optique, ainsi que des intermédiaires du procédé selon l'invention.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10356717A DE10356717A1 (de) | 2003-12-02 | 2003-12-02 | Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA28220A1 true MA28220A1 (fr) | 2006-10-02 |
Family
ID=34638338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA29077A MA28220A1 (fr) | 2003-12-02 | 2006-06-02 | Methode de production de derives de (3-oxo-2,3-dihydro-1h-isoindol-1-yl)acetylguanidine |
Country Status (37)
| Country | Link |
|---|---|
| EP (1) | EP1692105B1 (fr) |
| JP (1) | JP4809774B2 (fr) |
| KR (1) | KR101202604B1 (fr) |
| CN (1) | CN100526297C (fr) |
| AR (1) | AR046733A1 (fr) |
| AT (1) | ATE395334T1 (fr) |
| AU (1) | AU2004295056B2 (fr) |
| BR (1) | BRPI0417147A (fr) |
| CA (1) | CA2548020C (fr) |
| CR (1) | CR8376A (fr) |
| CY (1) | CY1108187T1 (fr) |
| DE (2) | DE10356717A1 (fr) |
| DK (1) | DK1692105T3 (fr) |
| EC (1) | ECSP066597A (fr) |
| EG (1) | EG25498A (fr) |
| ES (1) | ES2304634T3 (fr) |
| HR (1) | HRP20080253T3 (fr) |
| IL (1) | IL175834A (fr) |
| JO (1) | JO2498B1 (fr) |
| MA (1) | MA28220A1 (fr) |
| MY (1) | MY136467A (fr) |
| NO (1) | NO20063058L (fr) |
| NZ (1) | NZ547625A (fr) |
| OA (1) | OA13293A (fr) |
| PA (1) | PA8618701A1 (fr) |
| PE (1) | PE20051037A1 (fr) |
| PL (1) | PL1692105T3 (fr) |
| PT (1) | PT1692105E (fr) |
| RS (1) | RS50571B (fr) |
| RU (1) | RU2397159C2 (fr) |
| SI (1) | SI1692105T1 (fr) |
| TN (1) | TNSN06167A1 (fr) |
| TW (1) | TWI334348B (fr) |
| UA (1) | UA83883C2 (fr) |
| UY (1) | UY28648A1 (fr) |
| WO (1) | WO2005054195A1 (fr) |
| ZA (1) | ZA200603338B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200812962A (en) * | 2006-07-12 | 2008-03-16 | Astrazeneca Ab | New compounds I/418 |
| US8354382B2 (en) * | 2008-04-16 | 2013-01-15 | Kissei Pharmaceutical Co., Ltd. | Hemifumarate of a pyrazole derivative |
| RU2518740C1 (ru) * | 2013-03-22 | 2014-06-10 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" | СРЕДСТВО, ИНГИБИРУЮЩЕЕ Na+/H+-ОБМЕН, И ДИГИДРОХЛОРИД 2-(3,4-МЕТИЛЕНДИОКСИФЕНИЛ)-9-МОРФОЛИНОЭТИЛИМИДАЗО[1,2-a]БЕНЗИМИДАЗОЛА |
| CN107778238B (zh) * | 2016-08-29 | 2022-07-22 | 中山大学 | 一种3，4-二氢异喹啉-1-酮的合成新方法 |
| CN107286074B (zh) * | 2017-08-16 | 2019-08-20 | 厦门华厦学院 | 3-羟基异吲哚-1-酮衍生物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU581324B2 (en) * | 1985-07-05 | 1989-02-16 | Smith Kline & French Laboratories Limited | Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones |
| DE19737224A1 (de) * | 1997-08-27 | 1999-03-18 | Hoechst Marion Roussel De Gmbh | Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen |
| DE19832429A1 (de) * | 1998-07-18 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| RU2186057C1 (ru) * | 2001-03-22 | 2002-07-27 | Аляутдин Ренад Николаевич | 4-нитро-3-трифторметил-перфторнонаноиланилид (флустат), способ его получения и фармацевтическая композиция на его основе |
| PT1385823E (pt) | 2001-04-09 | 2007-01-31 | Novartis Vaccines & Diagnostic | Compostos de guanidino como agonistas do receptor de melanocortina-4 (r-mc4) |
| FR2840302B1 (fr) * | 2002-06-03 | 2004-07-16 | Aventis Pharma Sa | Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
-
2003
- 2003-12-02 DE DE10356717A patent/DE10356717A1/de not_active Withdrawn
-
2004
- 2004-11-04 JO JO2004155A patent/JO2498B1/en active
- 2004-11-19 PL PL04803188T patent/PL1692105T3/pl unknown
- 2004-11-19 HR HR20080253T patent/HRP20080253T3/xx unknown
- 2004-11-19 CA CA2548020A patent/CA2548020C/fr not_active Expired - Fee Related
- 2004-11-19 RU RU2006123410/04A patent/RU2397159C2/ru not_active IP Right Cessation
- 2004-11-19 DE DE502004007177T patent/DE502004007177D1/de not_active Expired - Lifetime
- 2004-11-19 CN CNB2004800348122A patent/CN100526297C/zh not_active Expired - Fee Related
- 2004-11-19 OA OA1200600177A patent/OA13293A/en unknown
- 2004-11-19 NZ NZ547625A patent/NZ547625A/en not_active IP Right Cessation
- 2004-11-19 AT AT04803188T patent/ATE395334T1/de active
- 2004-11-19 DK DK04803188T patent/DK1692105T3/da active
- 2004-11-19 WO PCT/EP2004/013153 patent/WO2005054195A1/fr not_active Ceased
- 2004-11-19 BR BRPI0417147-0A patent/BRPI0417147A/pt not_active IP Right Cessation
- 2004-11-19 ES ES04803188T patent/ES2304634T3/es not_active Expired - Lifetime
- 2004-11-19 UA UAA200607292A patent/UA83883C2/ru unknown
- 2004-11-19 AU AU2004295056A patent/AU2004295056B2/en not_active Ceased
- 2004-11-19 SI SI200430747T patent/SI1692105T1/sl unknown
- 2004-11-19 JP JP2006541829A patent/JP4809774B2/ja not_active Expired - Fee Related
- 2004-11-19 RS RSP-2008/0311A patent/RS50571B/sr unknown
- 2004-11-19 EP EP04803188A patent/EP1692105B1/fr not_active Expired - Lifetime
- 2004-11-19 PT PT04803188T patent/PT1692105E/pt unknown
- 2004-11-19 KR KR1020067010920A patent/KR101202604B1/ko not_active Expired - Fee Related
- 2004-11-29 PE PE2004001175A patent/PE20051037A1/es not_active Application Discontinuation
- 2004-11-30 AR ARP040104450A patent/AR046733A1/es not_active Application Discontinuation
- 2004-11-30 TW TW093136804A patent/TWI334348B/zh not_active IP Right Cessation
- 2004-12-01 PA PA20048618701A patent/PA8618701A1/es unknown
- 2004-12-01 MY MYPI20044973A patent/MY136467A/en unknown
- 2004-12-02 UY UY28648A patent/UY28648A1/es not_active Application Discontinuation
-
2006
- 2006-04-26 ZA ZA200603338A patent/ZA200603338B/en unknown
- 2006-04-28 CR CR8376A patent/CR8376A/es unknown
- 2006-05-22 IL IL175834A patent/IL175834A/en not_active IP Right Cessation
- 2006-06-01 EC EC2006006597A patent/ECSP066597A/es unknown
- 2006-06-01 EG EGNA2006000508 patent/EG25498A/xx active
- 2006-06-01 TN TNP2006000167A patent/TNSN06167A1/en unknown
- 2006-06-02 MA MA29077A patent/MA28220A1/fr unknown
- 2006-06-30 NO NO20063058A patent/NO20063058L/no unknown
-
2008
- 2008-07-11 CY CY20081100727T patent/CY1108187T1/el unknown
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