NO994049L - Metode for aa fremstille farmasöytiske forbindelser - Google Patents

Metode for aa fremstille farmasöytiske forbindelser

Info

Publication number
NO994049L
NO994049L NO994049A NO994049A NO994049L NO 994049 L NO994049 L NO 994049L NO 994049 A NO994049 A NO 994049A NO 994049 A NO994049 A NO 994049A NO 994049 L NO994049 L NO 994049L
Authority
NO
Norway
Prior art keywords
pharmaceutical compounds
preparing pharmaceutical
early
epoxidation
compounds
Prior art date
Application number
NO994049A
Other languages
English (en)
Other versions
NO994049D0 (no
Inventor
David W Hoard
Eric D Moher
Vinod Francis Patel
Original Assignee
Lilly Co Eli
Univ Hawaii
Univ Wayne State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Univ Hawaii, Univ Wayne State filed Critical Lilly Co Eli
Publication of NO994049L publication Critical patent/NO994049L/no
Publication of NO994049D0 publication Critical patent/NO994049D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/46—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by amide or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Kryptofycinforbindelser kan bli fremstilt ved å utnytte en epkosideringstrinn tidlig i den syntetiske prosessen under betingelser som er framsatt heri. Denne oppfinnelsen vedrø- rer også nye intermediater dannet ved denne tidlige epoksideringsprosessen.
NO994049A 1997-02-26 1999-08-23 Metode for å fremstille farmasöytiske forbindelser NO994049D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3911697P 1997-02-26 1997-02-26
US3911497P 1997-02-26 1997-02-26
PCT/US1998/003655 WO1998038158A1 (en) 1997-02-26 1998-02-25 Process for preparing pharmaceutical compounds

Publications (2)

Publication Number Publication Date
NO994049L true NO994049L (no) 1999-08-23
NO994049D0 NO994049D0 (no) 1999-08-23

Family

ID=26715826

Family Applications (2)

Application Number Title Priority Date Filing Date
NO994049A NO994049D0 (no) 1997-02-26 1999-08-23 Metode for å fremstille farmasöytiske forbindelser
NO994083A NO994083L (no) 1997-02-26 1999-08-24 Selektiv epoksideringsmetode for fremstilling av farmasöytiske forbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO994083A NO994083L (no) 1997-02-26 1999-08-24 Selektiv epoksideringsmetode for fremstilling av farmasöytiske forbindelser

Country Status (17)

Country Link
US (1) US6143909A (no)
EP (2) EP0861838A3 (no)
JP (2) JP2002512603A (no)
KR (2) KR20000075623A (no)
CN (2) CN1255121A (no)
AU (2) AU738999B2 (no)
BR (2) BR9811252A (no)
CA (2) CA2281104A1 (no)
CZ (1) CZ9902998A3 (no)
EA (2) EA002547B1 (no)
ID (2) ID24527A (no)
IL (2) IL131162A0 (no)
NO (2) NO994049D0 (no)
NZ (1) NZ336918A (no)
PL (2) PL335347A1 (no)
TR (2) TR199902065T2 (no)
WO (2) WO1998038158A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977387A (en) * 1996-08-30 1999-11-02 Eli Lilly And Company Process for preparing pharmaceutical compounds
CA2264557A1 (en) * 1996-09-06 1998-03-12 Eli Lilly And Company Process and novel intermediates
AU1123200A (en) * 1998-10-16 2000-05-08 Eli Lilly And Company Stereoselective process for producing antineoplastic agents
AU1930200A (en) * 1998-12-07 2000-06-26 Eli Lilly And Company Crotylboration process to produce antineoplastic and antifungal agents
AU1930100A (en) * 1998-12-07 2000-06-26 Eli Lilly And Company Crotylboration process to produce cryptophycin compounds
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
WO2005116200A2 (en) 2004-05-05 2005-12-08 Regents Of The University Of Minnesota Nucleic acids and polypeptides involved in the production of cryptophycin
CN101962323B (zh) * 2010-07-16 2013-06-05 中国人民解放军第二军医大学 2-丙烯酰x基-3-取代苯基丙酸类化合物及其用途
CN111333560B (zh) * 2020-04-13 2024-01-23 合肥工业大学 一种制备螺环β-内酰胺的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946835A (en) * 1988-07-15 1990-08-07 Merck & Co., Inc. Antifungal fermentation product and method
US4868208A (en) * 1988-07-15 1989-09-19 Merck & Co., Inc. Antifungal agent and method
US4845086A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
US4845085A (en) * 1988-08-09 1989-07-04 Merck & Co., Inc. Antifungal agent
ATE123780T1 (de) * 1989-02-17 1995-06-15 Chiron Mimotopes Pty Ltd Verfahren zur verwendung und herstellung von peptiden.
US5256802A (en) * 1990-04-03 1993-10-26 Miles Inc. Process for the production of oxiranes
AU680450B2 (en) * 1992-11-06 1997-07-31 Mimotopes Pty Ltd Support for the synthesis of modular polymers
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
US5952298A (en) * 1993-12-21 1999-09-14 The University Of Hawaii Cryptophycins
JPH09510436A (ja) * 1993-12-21 1997-10-21 ユニバーシティー オブ ハワイ 新規なクリプトフィシン類
DE69516415T2 (de) * 1994-10-14 2000-09-14 Stratagene, La Jolla Porphyrin-markierung von polynukleotiden
AP737A (en) * 1995-03-07 1999-03-15 Univ Hawaii New cryptophycins from synthesis.
EP0826681B1 (en) * 1995-03-31 2002-10-09 Nippon Chemiphar Co., Ltd. Epoxysuccinic acid derivatives
US5700826A (en) * 1995-06-07 1997-12-23 Ontogen Corporation 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance
BR9610214A (pt) * 1995-08-30 1999-06-15 Lilly Co Eli Compostos farmacéuticos
EP0869786B1 (en) * 1995-12-22 2003-03-05 Eli Lilly And Company Pharmaceutical compounds
AU724312B2 (en) * 1996-02-07 2000-09-14 Buckman Laboratories International, Inc. Synergistic antimicrobial compositions containing an ionene polymer and a salt of dodecylamine and methods of using the same
ATE201018T1 (de) * 1996-02-27 2001-05-15 Lilly Co Eli Cryptophycinderivate und ihre verwendung als antimikrotubuli mittel
AU722492B2 (en) * 1996-08-30 2000-08-03 University Of Hawaii Pharmaceutical compounds
AU4169897A (en) * 1996-08-30 1998-03-19 Eli Lilly And Company Pharmaceutical compounds
EP0957912A1 (en) * 1996-08-30 1999-11-24 Eli Lilly And Company Pharmaceutical compounds
US6025506A (en) * 1997-02-21 2000-02-15 Dsm N.V. Process for preparing an optically active phenylglycidyl acid derivative
IL123352A0 (en) * 1997-02-27 1998-09-24 Tanabe Seiyaku Co Process for preparing an optically active trans-3-substituted glycidic acid ester

Also Published As

Publication number Publication date
CN1252788A (zh) 2000-05-10
AU6667298A (en) 1998-09-18
EA002547B1 (ru) 2002-06-27
IL131162A0 (en) 2001-01-28
AU738999B2 (en) 2001-10-04
EP0861839A1 (en) 1998-09-02
ID22984A (id) 1999-12-23
PL335347A1 (en) 2000-04-25
NO994083L (no) 1999-10-25
TR199902064T2 (xx) 2001-10-22
CA2281108A1 (en) 1998-09-03
BR9807265A (pt) 2000-05-23
AU6667198A (en) 1998-09-18
US6143909A (en) 2000-11-07
CN1255121A (zh) 2000-05-31
KR20000075623A (ko) 2000-12-26
BR9811252A (pt) 2000-09-26
EA199900772A1 (ru) 2000-04-24
ID24527A (id) 2000-07-20
NO994083D0 (no) 1999-08-24
NZ336918A (en) 2001-11-30
EA199900770A1 (ru) 2000-04-24
CA2281104A1 (en) 1998-09-03
PL335478A1 (en) 2000-04-25
JP2002512603A (ja) 2002-04-23
JP2002513403A (ja) 2002-05-08
NO994049D0 (no) 1999-08-23
EP0861838A2 (en) 1998-09-02
KR20000075671A (ko) 2000-12-26
WO1998038158A1 (en) 1998-09-03
TR199902065T2 (xx) 2000-02-21
CZ9902998A3 (cs) 2002-10-16
IL131205A0 (en) 2001-01-28
WO1998038164A1 (en) 1998-09-03
EP0861838A3 (en) 1998-12-09

Similar Documents

Publication Publication Date Title
EA200000358A1 (ru) Способ получения диарилпиридинов, полезных в качестве ингибиторов cox-2
ATE211732T1 (de) N-benzylpiperidin- und tetrahydropyridin-derivate
EA199800290A1 (ru) (метилсульфонил) фенил-2-(5н)-фураноны в качестве ингибиторов циклооксигеназы-2
EA200100971A1 (ru) Новые соединения и композиции в качестве ингибиторов протеазы
EA199700124A1 (ru) Производные гуанина
YU49003A (sh) Novi postupak za sintezu fenilamida 5-(4-fluorofenil) -1-(2-((2r,4r)-4-hidroksi-6-okso-tetrahidro-piran-2-il)- etil)-2-izopropil-4-fenil-1h-pirol-3-karboksilne kiseline
RU94042903A (ru) 3,4,4-трехзамещенные пиперидинил-n-алкилкарбоксилаты и промежуточные соединения, способ их получения, фармкомпозиция
DE69630214D1 (de) Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien
BR0013885A (pt) Comprimidos aperfeiçoados
FI20030370A7 (fi) Uusia yhdisteitä
CA2405486A1 (fr) Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
EA200600621A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
NO20006645D0 (no) Ny form av irbesartan, fremgangsmåte for å oppnå den nevnte form og farmasöytiske preparater inneholdende den samme
NO994049L (no) Metode for aa fremstille farmasöytiske forbindelser
EA199900948A1 (ru) Способ получения 2-арил-3-арил-5-галогенпиридинов, используемых в качестве ингибиторов cox-2
CA2429133A1 (en) Novel imidazole derivatives, production method thereof and use thereof
NO20016151L (no) Fremstilling av substituerte piperidin-4-oner
DE60015508T2 (de) C-16 ungesätigte fp-selektive prostaglandin analoge
EA200100040A1 (ru) Химический синтез морфолиновых производных
EA200000322A1 (ru) Способ синтеза производных хинолина
ATE281434T1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
EA199900235A1 (ru) Аморфные бензотиофены, способы получения и способы применения
ATE244706T1 (de) Enantiomere von mercaptolactonen und verfahren zu ihrer herstellung
EA200300400A1 (ru) 17α-ФТОРАЛКИЛСТЕРОИДЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ЭТИ СОЕДИНЕНИЯ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
HRP20020021B1 (en) Method for preparing 2-(2-arylmorpholin-2-yl)ethanol derivatives and intermediates

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application