NO20063329L - Tricykliske steroidhormone nukleaer reseptormodulatorer - Google Patents

Tricykliske steroidhormone nukleaer reseptormodulatorer

Info

Publication number: NO20063329L
Authority: NO; Norway
Prior art keywords: receptor modulators; nuclear receptor; steroid hormone; compound; formula
Prior art date: 2003-12-19

Application number

NO20063329A

Other languages

English (en)

Norwegian (no)

Inventor

Donald Paul Matthews

Jonathan Edward Green

Prabhakar Kondaji Jadhav

Konstantinos Gavardinas

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-19

Filing date

2006-07-18

Publication date

2006-09-14

2006-07-18 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2006-09-14 Publication of NO20063329L publication Critical patent/NO20063329L/no

Links

108020005497 Nuclear hormone receptor Proteins 0.000 title 1
102000006255 nuclear receptors Human genes 0.000 title 1
108020004017 nuclear receptors Proteins 0.000 title 1
239000003270 steroid hormone Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
206010019280 Heart failures Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Nutrition Science (AREA)
Otolaryngology (AREA)
Child & Adolescent Psychology (AREA)

NO20063329A 2003-12-19 2006-07-18 Tricykliske steroidhormone nukleaer reseptormodulatorer NO20063329L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53128303P	2003-12-19	2003-12-19
PCT/US2004/038233 WO2005066161A1 (en)	2003-12-19	2004-12-08	Tricyclic steroid hormone nuclear receptor modulators

Publications (1)

Publication Number	Publication Date
NO20063329L true NO20063329L (no)	2006-09-14

Family

ID=34748755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20063329A NO20063329L (no)	2003-12-19	2006-07-18	Tricykliske steroidhormone nukleaer reseptormodulatorer

Country Status (21)

Country	Link
US (1)	US7803814B2 (de)
EP (1)	EP1697350B1 (de)
JP (1)	JP4846596B2 (de)
CN (1)	CN1918151A (de)
AR (1)	AR046951A1 (de)
AT (1)	ATE399163T1 (de)
AU (1)	AU2004312293A1 (de)
BR (1)	BRPI0416882A (de)
CA (1)	CA2549053C (de)
CY (1)	CY1108309T1 (de)
DE (1)	DE602004014640D1 (de)
DK (1)	DK1697350T3 (de)
ES (1)	ES2308296T3 (de)
IL (1)	IL175996A0 (de)
MX (1)	MXPA06007055A (de)
NO (1)	NO20063329L (de)
PL (1)	PL1697350T3 (de)
PT (1)	PT1697350E (de)
SI (1)	SI1697350T1 (de)
WO (1)	WO2005066161A1 (de)
ZA (1)	ZA200604889B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200400816A (en) *	2002-06-26	2004-01-16	Lilly Co Eli	Tricyclic steroid hormone nuclear receptor modulators
EP1838672B1 (de) *	2004-12-23	2015-02-18	Athersys, Inc.	Tertiäre 4-piperidinolamine als inhibitoren des histamin-3-rezeptors zur behandlung von obesitas und anderen zns-erkrankungen
DE102005022020A1 (de) *	2005-05-12	2006-11-23	Merckle Gmbh	Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten
TWI385161B (zh)	2006-02-02	2013-02-11	Mitsubishi Tanabe Pharma Corp	含氮雜雙環化合物
US8034940B2 (en)	2006-08-09	2011-10-11	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
ES2375877T3 (es)	2006-10-31	2012-03-07	Pfizer Products Inc.	Compuestos de pirazolina como antagonistas de receptores de mineralocorticoides.
TWI431010B (zh)	2007-12-19	2014-03-21	Lilly Co Eli	礦皮質素受體拮抗劑及使用方法
ES2370148T3 (es) *	2008-01-11	2011-12-13	Eli Lilly & Company	(e)-n-{3-[fluoro-11h-10-oxa-1-aza-dibenzo-[a,d]-ciclohepten-5-iliden)-propil]-fenil}-metilsulfonamida como modulador del receptor de glucocorticoides para el tratamiento de artritis reumatoide.
JPWO2010001990A1 (ja) *	2008-07-03	2011-12-22	協和発酵キリン株式会社	四環系化合物
WO2010104721A1 (en)	2009-03-12	2010-09-16	Eli Lilly And Company	Mineralocorticoid receptor antagonist and methods of use
WO2011081173A1 (ja) *	2009-12-29	2011-07-07	協和発酵キリン株式会社	四環系化合物
EP2568986B1 (de)	2010-05-10	2016-01-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Verfahren und Zusammensetzungen zur Behandlung von Flüssigkeitsansammlung in und/oder unter der Netzhaut
EP2582365B1 (de)	2010-06-16	2019-03-20	INSERM (Institut National de la Santé et de la Recherche Médicale)	Zusammensetzungen zur stimulierung der reepithelialisation während der wundheilung
EP2638012A1 (de)	2010-11-10	2013-09-18	Boehringer Ingelheim International GmbH	Pyridylharnstoffe als mineralocorticoid- rezeptorantagonisten
KR20140051998A (ko) *	2011-08-03	2014-05-02	교와 핫꼬 기린 가부시키가이샤	디벤조옥세핀 유도체
CN116783181B (zh) *	2021-04-12	2026-01-30	上海瑛派药业有限公司	取代的稠合双环类化合物作为parp抑制剂及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2603713B1 (fr) *	1986-09-10	1992-07-24	Canon Kk	Derive nouveau de 5h-dibenzo(a,d)cycloheptane-(ene)ylidene, son procede de production et support electrophotographique photosensible le contenant
JPH01161245A (ja)	1987-12-18	1989-06-23	Canon Inc	電子写真感光体
US4999363A (en) *	1988-06-09	1991-03-12	Kyowa Hakko Kogyo Co., Ltd.	Tricyclic compounds
US5093210A (en) *	1989-06-30	1992-03-03	Ricoh Company, Ltd.	Electroluminescent device
JPH0446352A (ja)	1990-06-14	1992-02-17	Minolta Camera Co Ltd	感光体
US6372779B1 (en) *	1997-12-29	2002-04-16	Ortho Pharmaceutical Corporation	Anti-inflammatory compounds
EP1154997A4 (de)	1999-01-26	2002-11-04	Dana Farber Cancer Inst Inc	Pharmazeutisch aktive verbindungen und ein verfahren zu ihrer herstellung
US7087636B2 (en) *	2001-12-19	2006-08-08	Bristol-Myers Squibb Company	Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
JP2006508893A (ja)	2002-03-15	2006-03-16	イーライ・リリー・アンド・カンパニー	ステロイドホルモン核内レセプターモジュレーターとしてのジヒドロインドール−２−オン誘導体
TW200400816A (en) *	2002-06-26	2004-01-16	Lilly Co Eli	Tricyclic steroid hormone nuclear receptor modulators

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- 2004-12-08 DE DE602004014640T patent/DE602004014640D1/de not_active Expired - Lifetime
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- 2004-12-08 SI SI200430840T patent/SI1697350T1/sl unknown
- 2004-12-08 WO PCT/US2004/038233 patent/WO2005066161A1/en not_active Ceased
- 2004-12-08 CN CNA2004800418534A patent/CN1918151A/zh active Pending
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JP2007515431A (ja)	2007-06-14
JP4846596B2 (ja)	2011-12-28
IL175996A0 (en)	2006-10-05
ZA200604889B (en)	2007-11-28
DK1697350T3 (da)	2008-10-13
PL1697350T3 (pl)	2008-11-28
CA2549053A1 (en)	2005-07-21
CA2549053C (en)	2012-08-28
SI1697350T1 (sl)	2008-12-31
PT1697350E (pt)	2008-09-18
US20070037788A1 (en)	2007-02-15
ATE399163T1 (de)	2008-07-15
EP1697350B1 (de)	2008-06-25
AR046951A1 (es)	2006-01-04
EP1697350A1 (de)	2006-09-06
AU2004312293A1 (en)	2005-07-21
WO2005066161A1 (en)	2005-07-21
ES2308296T3 (es)	2008-12-01
CY1108309T1 (el)	2014-02-12
BRPI0416882A (pt)	2007-02-27
US7803814B2 (en)	2010-09-28
DE602004014640D1 (de)	2008-08-07
MXPA06007055A (es)	2007-01-30
CN1918151A (zh)	2007-02-21

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Publication	Publication Date	Title
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