NO20063841L - Krystallinske polymorfer av en CXC-kjemokinreseptorligand - Google Patents
Krystallinske polymorfer av en CXC-kjemokinreseptorligandInfo
- Publication number
- NO20063841L NO20063841L NO20063841A NO20063841A NO20063841L NO 20063841 L NO20063841 L NO 20063841L NO 20063841 A NO20063841 A NO 20063841A NO 20063841 A NO20063841 A NO 20063841A NO 20063841 L NO20063841 L NO 20063841L
- Authority
- NO
- Norway
- Prior art keywords
- chemokine receptor
- cxc chemokine
- crystalline polymorphs
- receptor ligand
- methods
- Prior art date
Links
- 108091008928 CXC chemokine receptors Proteins 0.000 title abstract 2
- 102000054900 CXCR Receptors Human genes 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title abstract 2
- 229940126062 Compound A Drugs 0.000 abstract 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
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- Medicinal Chemistry (AREA)
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- Diabetes (AREA)
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- Communicable Diseases (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
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Abstract
Den foreliggende oppfinnelse vedrører fire forskjellige krystallinske polymorfer av monohydrat av forbindelse A som har den følgende kjemiske stnikturformel (A). Disse fire polymorfe formene, her henvist til som formene I, II, III og IV, er aktive som CXC-kjemokinreseptorligander. Oppfinnelsen er videre rettet mot preparater, fremgangsmåter for behandling og fremgangsmåter for syntese av disse polymorfe formene.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54048704P | 2004-01-30 | 2004-01-30 | |
| PCT/US2005/003414 WO2005075447A1 (en) | 2004-01-30 | 2005-01-28 | Crystalline polymorphs of a cxc-chemokine receptor ligand |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20063841L true NO20063841L (no) | 2006-10-27 |
Family
ID=34837390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20063841A NO20063841L (no) | 2004-01-30 | 2006-08-29 | Krystallinske polymorfer av en CXC-kjemokinreseptorligand |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20050192345A1 (no) |
| EP (1) | EP1723131B1 (no) |
| JP (2) | JP2007519751A (no) |
| KR (1) | KR100883476B1 (no) |
| CN (1) | CN1914187B (no) |
| AR (1) | AR047739A1 (no) |
| AT (1) | ATE478061T1 (no) |
| AU (1) | AU2005210504B2 (no) |
| BR (1) | BRPI0507329A (no) |
| CA (1) | CA2554709C (no) |
| CO (1) | CO5700731A2 (no) |
| DE (1) | DE602005022986D1 (no) |
| EC (1) | ECSP066733A (no) |
| ES (1) | ES2349788T3 (no) |
| IL (1) | IL177033A0 (no) |
| MX (1) | MXPA06008599A (no) |
| MY (1) | MY144657A (no) |
| NO (1) | NO20063841L (no) |
| NZ (1) | NZ548499A (no) |
| PE (1) | PE20051093A1 (no) |
| PL (1) | PL380997A1 (no) |
| RU (1) | RU2388756C2 (no) |
| TW (1) | TW200536848A (no) |
| WO (1) | WO2005075447A1 (no) |
| ZA (1) | ZA200606295B (no) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040106794A1 (en) | 2001-04-16 | 2004-06-03 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| WO2006051340A1 (en) * | 2004-07-22 | 2006-05-18 | Pliva - Istrazivanje I Razvoj D.O.O. | Novel form of celecoxib |
| GB2418427A (en) | 2004-09-02 | 2006-03-29 | Univ Cambridge Tech | Ligands for G-protein coupled receptors |
| AU2007258325B2 (en) | 2006-06-12 | 2013-02-21 | Merck Sharp & Dohme Corp. | Pharmaceutical formulations and compositions of a selective antagonist of either CXCR2 or both CXCR1 and CXCR2 and methods of using the same for treating inflammatory disorders |
| WO2009005801A1 (en) * | 2007-07-03 | 2009-01-08 | Schering Corporation | Process and intermediates for the synthesis of 1,2-substituted 3,4-dioxo-1-cyclobutene compounds |
| CN101778836A (zh) * | 2007-07-05 | 2010-07-14 | 先灵公司 | 在1,2-取代的3,4-二氧-1-环丁烯化合物中控制的晶体大小的方法 |
| CA2706883A1 (en) * | 2007-12-04 | 2009-06-11 | Schering Corporation | Methods of treating copd |
| GB2455539B (en) * | 2007-12-12 | 2012-01-18 | Cambridge Entpr Ltd | Anti-inflammatory compositions and combinations |
| UA103198C2 (en) | 2008-08-04 | 2013-09-25 | Новартис Аг | Squaramide derivatives as cxcr2 antagonists |
| WO2010063802A1 (en) * | 2008-12-05 | 2010-06-10 | Novartis Ag | 3, 4-di-substituted cyclobutene- 1, 2 -diones as cxcr2 receptor antagonists |
| EP2509596B1 (en) | 2009-12-08 | 2019-08-28 | Case Western Reserve University | Gamma aminoacids for treating ocular disorders |
| SI2760821T1 (en) | 2011-09-02 | 2018-02-28 | Novartis Ag | A salt salt of an anti-inflammatory substituted cyclobutenedione compound |
| US8865723B2 (en) | 2012-10-25 | 2014-10-21 | Tetra Discovery Partners Llc | Selective PDE4 B inhibition and improvement in cognition in subjects with brain injury |
| US9763992B2 (en) | 2014-02-13 | 2017-09-19 | Father Flanagan's Boys' Home | Treatment of noise induced hearing loss |
| TWI724056B (zh) | 2015-11-19 | 2021-04-11 | 美商卡默森屈有限公司 | Cxcr2抑制劑 |
| TWI734715B (zh) | 2015-11-19 | 2021-08-01 | 美商卡默森屈有限公司 | 趨化因子受體調節劑 |
| EP3426253A4 (en) | 2016-03-11 | 2019-11-06 | Ardea Biosciences, Inc. | CXCR-2 INHIBITORS FOR THE TREATMENT OF CRYSTALARTHROPATHIES |
| WO2019055509A1 (en) * | 2017-09-12 | 2019-03-21 | Ardea Biosciences, Inc. | INHIBITORS OF CXCR-2 FOR THE TREATMENT OF DISORDERS |
| MA50424A (fr) | 2018-01-08 | 2020-08-26 | Chemocentryx Inc | Méthodes de traitement du psoriasis pustuleux généralisé avec un antagoniste de ccr6 ou cxcr2 |
| EP4686469A1 (en) * | 2024-07-31 | 2026-02-04 | Dompé farmaceutici SpA | Cxcl8 inhibitors for use in the treatment of diabetes-associated comorbidities |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5125894A (en) * | 1990-03-30 | 1992-06-30 | Alza Corporation | Method and apparatus for controlled environment electrotransport |
| EE9600184A (et) * | 1994-06-27 | 1997-06-16 | Cytomed, Inc. | Kardiovaskulaar-, inflammatoor- ja immuunhaiguste raviühendid ja -meetodid |
| US7027859B1 (en) * | 1994-09-26 | 2006-04-11 | Alza Corporation | Electrotransport delivery device having improved safety and reduced abuse potential |
| RU2220721C2 (ru) * | 1997-12-24 | 2004-01-10 | Санкио Компани, Лимитед | Активный агент для ингибирования роста опухолей у млекопитающих, лечения и/или профилактики связанных с опухолями нарушений и метастаз опухолей у млекопитающих |
| ES2287284T3 (es) * | 2001-04-16 | 2007-12-16 | Schering Corporation | Ciclobuteno-1,2-dionas disustituidas en las posiciones 3,4 como ligandos de receptores de quimiocinas cxc. |
| US7132445B2 (en) * | 2001-04-16 | 2006-11-07 | Schering Corporation | 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands |
| US20040053953A1 (en) * | 2002-03-18 | 2004-03-18 | Schering Corporation | Treatment of chemokine mediated diseases |
| ATE457307T1 (de) * | 2003-04-18 | 2010-02-15 | Schering Corp | Synthese von 2-hydroxy-n,n-dimethyl-3-[[2-[1(r)- (5-methyl-2-furanyl)propyl amino -3,4-dioxo-1- cyclobuten-1-yl amino benzamid |
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2005
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