NO20071311L - Fremgangsmate ved fremstilling av citalopram - Google Patents

Fremgangsmate ved fremstilling av citalopram

Info

Publication number
NO20071311L
NO20071311L NO20071311A NO20071311A NO20071311L NO 20071311 L NO20071311 L NO 20071311L NO 20071311 A NO20071311 A NO 20071311A NO 20071311 A NO20071311 A NO 20071311A NO 20071311 L NO20071311 L NO 20071311L
Authority
NO
Norway
Prior art keywords
citalopram
preparation
arylsulfonyl
alkylsulfonyl
dimethylamino
Prior art date
Application number
NO20071311A
Other languages
English (en)
Inventor
Hans Petersen
Michael Harold Rock
Peter Ellegaard
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK1999/000581 external-priority patent/WO2000012044A2/en
Publication of NO20071311L publication Critical patent/NO20071311L/no
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

Fremgangsmåte ved fremstillingen av citalopram omfattende reaksjon av en forbindelse med formel (VI), hvori R er C_-alkyl, acyl, C.-alkylsulfonyl eller arylsulfonyl, med 3-(N,N-dimetylamino)-propylmagnesiumhalid, for å fremstille citalopram.
NO20071311A 1999-10-25 2007-03-09 Fremgangsmate ved fremstilling av citalopram NO20071311L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000581 WO2000012044A2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
NO20071311L true NO20071311L (no) 2001-08-24

Family

ID=8157164

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071311A NO20071311L (no) 1999-10-25 2007-03-09 Fremgangsmate ved fremstilling av citalopram

Country Status (25)

Country Link
US (1) US6566540B2 (no)
EP (1) EP1298124B1 (no)
KR (1) KR100505820B1 (no)
AR (1) AR024518A1 (no)
AT (2) ATE277032T1 (no)
CA (1) CA2291133C (no)
CY (1) CY1107635T1 (no)
CZ (1) CZ292894B6 (no)
DE (3) DE69935355T2 (no)
DK (2) DK1298124T3 (no)
EA (1) EA002801B1 (no)
ES (1) ES2282365T3 (no)
HK (1) HK1043129B (no)
HR (1) HRP20020344B1 (no)
HU (1) HUP0200169A3 (no)
IL (3) IL143875A0 (no)
IS (1) IS2260B (no)
NO (1) NO20071311L (no)
NZ (1) NZ512406A (no)
PL (1) PL201056B1 (no)
PT (2) PT1228056E (no)
SI (2) SI1228056T1 (no)
SK (1) SK287140B6 (no)
TR (1) TR200401456T1 (no)
UA (1) UA72238C2 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR040970A1 (es) * 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
UA80170C2 (en) * 2002-12-23 2007-08-27 Lundbeck & Co As H Escitalopram hydrobromide
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
AU2006304889A1 (en) * 2005-10-14 2007-04-26 H. Lundbeck A/S Stable pharmaceutical formulations containing escitalopram and bupropion
EP1954257A4 (en) * 2005-10-14 2009-05-20 Lundbeck & Co As H METHOD FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM WITH A LOW-DOSED COMBINATION OF ESCITALOPRAM AND BUPROPION
CN101815519B (zh) * 2007-08-03 2013-08-21 吉瑞工厂 包含多巴胺受体配体的药物组合物和使用多巴胺受体配体的治疗方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (no) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
WO1998019513A2 (en) 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EP1042310B1 (en) 1997-11-11 2002-07-31 H. Lundbeck A/S Method for the preparation of citalopram
CA2291134C (en) 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
TR200101796T2 (tr) 1998-12-23 2001-11-21 H. Lundbeck A/S 5-Siyanofitalitin preparasyonuna yönelik metot
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
AU759716B2 (en) 1999-04-14 2003-04-17 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
ATE222899T1 (de) 2000-12-28 2002-09-15 Lundbeck & Co As H Verfahren zur herstellung von reinem citalopram

Also Published As

Publication number Publication date
CZ292894B6 (cs) 2003-12-17
EP1298124B1 (en) 2007-02-28
HK1043129B (zh) 2004-10-21
US6566540B2 (en) 2003-05-20
US20020177722A1 (en) 2002-11-28
UA72238C2 (en) 2005-02-15
SI1228056T1 (en) 2005-02-28
DE69920526D1 (de) 2004-10-28
PT1298124E (pt) 2007-05-31
EP1298124A1 (en) 2003-04-02
HUP0200169A2 (en) 2002-06-29
IL143875A0 (en) 2002-04-21
SK287140B6 (sk) 2010-01-07
DE69920526T2 (de) 2006-02-23
DE19983836C1 (de) 2003-10-23
IS5970A (is) 2001-06-15
NZ512406A (en) 2004-01-30
ES2282365T3 (es) 2007-10-16
PT1228056E (pt) 2005-02-28
DK1298124T3 (da) 2007-07-09
EA002801B1 (ru) 2002-10-31
DE69935355T2 (de) 2007-11-08
CA2291133C (en) 2003-06-17
PL349440A1 (en) 2002-07-29
TR200401456T1 (tr) 2005-04-21
KR20010092799A (ko) 2001-10-27
EA200100593A1 (ru) 2001-10-22
DK1228056T3 (da) 2005-01-24
ATE355268T1 (de) 2006-03-15
HRP20020344A2 (en) 2004-02-29
ATE277032T1 (de) 2004-10-15
HK1043129A1 (en) 2002-09-06
HUP0200169A3 (en) 2002-11-28
CA2291133A1 (en) 2001-04-25
DE69935355D1 (de) 2007-04-12
IL176943A0 (en) 2006-12-10
CY1107635T1 (el) 2013-04-18
AR024518A1 (es) 2002-10-16
PL201056B1 (pl) 2009-03-31
SI1298124T1 (sl) 2007-08-31
HRP20020344B1 (hr) 2010-10-31
IL143875A (en) 2008-03-20
KR100505820B1 (ko) 2005-08-03
IS2260B (is) 2007-06-15

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