NO20073926L - Pyrazolforbindelser som modulerer aktivitet av CDK-, GSK- og aurorakinaser - Google Patents
Pyrazolforbindelser som modulerer aktivitet av CDK-, GSK- og aurorakinaserInfo
- Publication number
- NO20073926L NO20073926L NO20073926A NO20073926A NO20073926L NO 20073926 L NO20073926 L NO 20073926L NO 20073926 A NO20073926 A NO 20073926A NO 20073926 A NO20073926 A NO 20073926A NO 20073926 L NO20073926 L NO 20073926L
- Authority
- NO
- Norway
- Prior art keywords
- gsk
- cdk
- aurorakinases
- compounds
- pyrazole compounds
- Prior art date
Links
- 102000003989 Aurora kinases Human genes 0.000 title abstract 2
- 108090000433 Aurora kinases Proteins 0.000 title abstract 2
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64059704P | 2004-12-30 | 2004-12-30 | |
| US64047504P | 2004-12-30 | 2004-12-30 | |
| GB0428552A GB0428552D0 (en) | 2004-12-30 | 2004-12-30 | Pharmaceutical compounds |
| GB0428554A GB0428554D0 (en) | 2004-12-30 | 2004-12-30 | Pharmaceutical compounds |
| PCT/GB2005/005097 WO2006070195A1 (en) | 2004-12-30 | 2005-12-30 | Pyrazole compounds that modulate the activity of cdk, gsk and aurora kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20073926L true NO20073926L (no) | 2007-10-01 |
Family
ID=39495737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073926A NO20073926L (no) | 2004-12-30 | 2007-07-26 | Pyrazolforbindelser som modulerer aktivitet av CDK-, GSK- og aurorakinaser |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8110573B2 (pt) |
| EP (2) | EP1833819A1 (pt) |
| JP (1) | JP5507049B2 (pt) |
| KR (1) | KR101334511B1 (pt) |
| AU (1) | AU2005321091B2 (pt) |
| BR (1) | BRPI0519759A2 (pt) |
| CA (1) | CA2593993C (pt) |
| IL (1) | IL183751A0 (pt) |
| MX (1) | MX2007008008A (pt) |
| NO (1) | NO20073926L (pt) |
| NZ (1) | NZ555982A (pt) |
| RU (1) | RU2416610C2 (pt) |
| TW (1) | TWI427077B (pt) |
| WO (1) | WO2006070195A1 (pt) |
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| TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
| JP2008526721A (ja) * | 2004-12-30 | 2008-07-24 | アステックス、セラピューティックス、リミテッド | Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するチアゾールおよびイソチアゾール誘導体 |
| MX2007008008A (es) | 2004-12-30 | 2007-11-12 | Astex Therapeutics Ltd | Compuestos de pirazol que modulan la actividad de las cinasas cdk, gsk y aurora. |
| JP5154406B2 (ja) | 2005-04-13 | 2013-02-27 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| US8624027B2 (en) * | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US8399442B2 (en) * | 2005-12-30 | 2013-03-19 | Astex Therapeutics Limited | Pharmaceutical compounds |
| SA07280004B1 (ar) | 2006-02-02 | 2011-10-29 | استرازينيكا ايه بي | ملح سترات من مركب 2- هيدروكسي –3- [5- (مورفولين –4- يل ميثيل) بيريدين –2- يل] 1h- إندول –5- كربونيتريل سترات |
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| SG158147A1 (en) | 2006-10-09 | 2010-01-29 | Takeda Pharmaceutical | Kinase inhibitors |
| GB0620259D0 (en) | 2006-10-12 | 2006-11-22 | Astex Therapeutics Ltd | Pharmaceutical compounds |
| JP5518478B2 (ja) | 2006-10-12 | 2014-06-11 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
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| RU2535032C2 (ru) | 2008-12-22 | 2014-12-10 | Милленниум Фармасьютикалз, Инк. | Сочетание ингибиторов аврора киназы и анти-cd 20 антител |
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2005
- 2005-12-30 MX MX2007008008A patent/MX2007008008A/es active IP Right Grant
- 2005-12-30 WO PCT/GB2005/005097 patent/WO2006070195A1/en not_active Ceased
- 2005-12-30 JP JP2007548898A patent/JP5507049B2/ja not_active Expired - Fee Related
- 2005-12-30 EP EP05823721A patent/EP1833819A1/en not_active Withdrawn
- 2005-12-30 EP EP11180160A patent/EP2395000A1/en not_active Withdrawn
- 2005-12-30 US US11/813,031 patent/US8110573B2/en not_active Expired - Fee Related
- 2005-12-30 CA CA2593993A patent/CA2593993C/en not_active Expired - Fee Related
- 2005-12-30 TW TW094147642A patent/TWI427077B/zh not_active IP Right Cessation
- 2005-12-30 RU RU2007128959/04A patent/RU2416610C2/ru not_active IP Right Cessation
- 2005-12-30 AU AU2005321091A patent/AU2005321091B2/en not_active Ceased
- 2005-12-30 KR KR1020077017527A patent/KR101334511B1/ko not_active Expired - Fee Related
- 2005-12-30 NZ NZ555982A patent/NZ555982A/en not_active IP Right Cessation
- 2005-12-30 BR BRPI0519759-7A patent/BRPI0519759A2/pt not_active IP Right Cessation
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2007
- 2007-06-07 IL IL183751A patent/IL183751A0/en unknown
- 2007-07-26 NO NO20073926A patent/NO20073926L/no not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2005321091A1 (en) | 2006-07-06 |
| MX2007008008A (es) | 2007-11-12 |
| KR101334511B1 (ko) | 2013-11-29 |
| AU2005321091B2 (en) | 2012-04-12 |
| TWI427077B (zh) | 2014-02-21 |
| JP5507049B2 (ja) | 2014-05-28 |
| US8110573B2 (en) | 2012-02-07 |
| RU2416610C2 (ru) | 2011-04-20 |
| US20120190673A1 (en) | 2012-07-26 |
| NZ555982A (en) | 2011-01-28 |
| US8778936B2 (en) | 2014-07-15 |
| CA2593993C (en) | 2014-07-29 |
| RU2007128959A (ru) | 2009-02-10 |
| KR20070094639A (ko) | 2007-09-20 |
| JP2008526722A (ja) | 2008-07-24 |
| BRPI0519759A2 (pt) | 2009-03-10 |
| TW200635918A (en) | 2006-10-16 |
| WO2006070195A1 (en) | 2006-07-06 |
| WO2006070195A8 (en) | 2006-08-24 |
| US20080132495A1 (en) | 2008-06-05 |
| CA2593993A1 (en) | 2006-07-06 |
| EP1833819A1 (en) | 2007-09-19 |
| EP2395000A1 (en) | 2011-12-14 |
| IL183751A0 (en) | 2007-09-20 |
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