NO20090075L - Nye CXCR2 inhibitorer - Google Patents

Nye CXCR2 inhibitorer

Info

Publication number
NO20090075L
NO20090075L NO20090075A NO20090075A NO20090075L NO 20090075 L NO20090075 L NO 20090075L NO 20090075 A NO20090075 A NO 20090075A NO 20090075 A NO20090075 A NO 20090075A NO 20090075 L NO20090075 L NO 20090075L
Authority
NO
Norway
Prior art keywords
new
inhibitors
cxcr2 inhibitors
compounds
formula
Prior art date
Application number
NO20090075A
Other languages
English (en)
Inventor
Elisabeth Defossa
Stephanie Hachtel
Juergen Dedio
Sven Grueneberg
Holger Heitsch
William Bock
Charlie Chen
Raymond KOSLEY
Chung-Yi Kung
Marcel Patek
Rosy Sher
Stephen Shimshock
Aleksandra Weichsel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20090075L publication Critical patent/NO20090075L/no

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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/24—Oxygen atoms attached in position 8
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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Abstract

Foreliggende oppfinnelse angår forbindelser med formel I hvori RI, R2, X, A, B, Z og Yl til Y4 har betydningene indikert i kravene, og/eller et farmasøytisk akseptabelt salt og/eller et prodrug derav. På grunn av deres egenskaper som inhibitorer av kjemokine reseptorer, særlig som CXCR2-inhibitorer, er forbindelsene med formel I og de farmasøytisk akseptable saltene og prodrugene derav egnet for hindring og behandling av kjemokinmedierte sykdommer.
NO20090075A 2006-06-28 2009-01-06 Nye CXCR2 inhibitorer NO20090075L (no)

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IL196067A0 (en) 2009-09-01
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