|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
|
FR2413974A1
(fr)
|
1978-01-06 |
1979-08-03 |
David Bernard |
Sechoir pour feuilles imprimees par serigraphie
|
|
US4935341A
(en)
|
1986-06-04 |
1990-06-19 |
Whitehead Institute For Biomedical Research |
Detection of point mutations in neu genes
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
ATE97498T1
(de)
|
1984-01-30 |
1993-12-15 |
Imp Cancer Res Tech |
Verbesserungen an wachstumsfaktoren.
|
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US7838216B1
(en)
*
|
1986-03-05 |
2010-11-23 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Human gene related to but distinct from EGF receptor gene
|
|
US5401638A
(en)
|
1986-06-04 |
1995-03-28 |
Oncogene Science, Inc. |
Detection and quantification of neu related proteins in the biological fluids of humans
|
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
|
US4968603A
(en)
|
1986-12-31 |
1990-11-06 |
The Regents Of The University Of California |
Determination of status in neoplastic disease
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US5283187A
(en)
|
1987-11-17 |
1994-02-01 |
Brown University Research Foundation |
Cell culture-containing tubular capsule produced by co-extrusion
|
|
US4892538A
(en)
|
1987-11-17 |
1990-01-09 |
Brown University Research Foundation |
In vivo delivery of neurotransmitters by implanted, encapsulated cells
|
|
US5824311A
(en)
|
1987-11-30 |
1998-10-20 |
Trustees Of The University Of Pennsylvania |
Treatment of tumors with monoclonal antibodies against oncogene antigens
|
|
US5720937A
(en)
*
|
1988-01-12 |
1998-02-24 |
Genentech, Inc. |
In vivo tumor detection assay
|
|
WO1989006692A1
(en)
*
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
|
JPH03505964A
(ja)
|
1988-04-18 |
1991-12-26 |
アプライド・バイオテクノロジー・インコーポレーテッド |
ｎｅｕ遺伝子の発現及び遺伝子産物の検出
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
|
DE69031120T2
(de)
*
|
1989-05-19 |
1998-01-15 |
Genentech, Inc., South San Francisco, Calif. |
Her2 extrazellulare domäne
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
ES2096590T3
(es)
|
1989-06-29 |
1997-03-16 |
Medarex Inc |
Reactivos biespecificos para la terapia del sida.
|
|
US5705157A
(en)
|
1989-07-27 |
1998-01-06 |
The Trustees Of The University Of Pennsylvania |
Methods of treating cancerous cells with anti-receptor antibodies
|
|
CA2042064C
(en)
|
1989-08-04 |
2008-10-21 |
Susan G. Stuart |
C-erbb-2 external domain:gp75
|
|
US6884418B1
(en)
|
1989-08-04 |
2005-04-26 |
Berlex Laboratories, Inc. |
Use of ligand-mimicking agents and anti-neoplastic drugs in cancer therapy
|
|
EP0491007B1
(en)
|
1989-09-08 |
1996-03-13 |
The Johns Hopkins University |
Structural alterations of the egf receptor gene in human gliomas
|
|
DE68926248T2
(de)
|
1989-09-29 |
1996-12-19 |
Oncogene Science Inc |
p100 "neu" menschlisches Protein and Verwendung dieses Proteins zum Nachweis von preneoplasmatischen- oder neoplasmatischen beim Menschen
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5183884A
(en)
|
1989-12-01 |
1993-02-02 |
United States Of America |
Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5571894A
(en)
*
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
AU662311B2
(en)
|
1991-02-05 |
1995-08-31 |
Novartis Ag |
Recombinant antibodies specific for a growth factor receptor
|
|
EP0586505A1
(en)
|
1991-05-14 |
1994-03-16 |
Repligen Corporation |
Heteroconjugate antibodies for treatment of hiv infection
|
|
IL101943A0
(en)
|
1991-05-24 |
1992-12-30 |
Genentech Inc |
Structure,production and use of heregulin
|
|
US6800738B1
(en)
|
1991-06-14 |
2004-10-05 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US5939531A
(en)
|
1991-07-15 |
1999-08-17 |
Novartis Corp. |
Recombinant antibodies specific for a growth factor receptor
|
|
US5264586A
(en)
|
1991-07-17 |
1993-11-23 |
The Scripps Research Institute |
Analogs of calicheamicin gamma1I, method of making and using the same
|
|
DE69228300T2
(de)
|
1991-08-22 |
1999-09-23 |
Becton Dickinson And Co., Franklin Lakes |
Methoden und zusammensetzungen zur krebstherapie und zur vorhersagbarkeit der reaktionen auf diese behandlung
|
|
WO1993006217A1
(en)
|
1991-09-19 |
1993-04-01 |
Genentech, Inc. |
EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
US5288477A
(en)
|
1991-09-27 |
1994-02-22 |
Becton, Dickinson And Company |
Method for prognosticating response to cancer therapy
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
AU3236793A
(en)
|
1991-12-12 |
1993-07-19 |
Berlex Laboratories, Inc. |
Recombinant and chimeric antibodies to c-erbB-2
|
|
AU675929B2
(en)
*
|
1992-02-06 |
1997-02-27 |
Curis, Inc. |
Biosynthetic binding protein for cancer marker
|
|
ATE244763T1
(de)
|
1992-02-11 |
2003-07-15 |
Cell Genesys Inc |
Erzielen von homozygotem durch zielgerichtete genetische ereignisse
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
WO1993021319A1
(en)
|
1992-04-08 |
1993-10-28 |
Cetus Oncology Corporation |
HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
EP0646178A1
(en)
|
1992-06-04 |
1995-04-05 |
The Regents Of The University Of California |
expression cassette with regularoty regions functional in the mammmlian host
|
|
EP0655924A4
(en)
|
1992-06-30 |
1996-09-11 |
Oncologix Inc |
A COMBINATION OF MONOCLONAL ANTIBODIES AGAINST erbB-2 AND METHOD FOR THEIR USE.
|
|
EP0656064B1
(en)
|
1992-08-17 |
1997-03-05 |
Genentech, Inc. |
Bispecific immunoadhesins
|
|
AU5355594A
(en)
*
|
1992-10-09 |
1994-05-09 |
Oncor, Inc. |
Methods for the detection of chromosome structural abnormalities by (in situ) hybridization to fixed tissue
|
|
RU2170589C2
(ru)
*
|
1992-10-28 |
2001-07-20 |
Генентек Инк. |
Композиция для ингибирования ангиогенеза, моноклональное антитело, полипептид, способ ингибирования роста опухоли (варианты)
|
|
MD1367C2
(ro)
|
1992-11-13 |
2000-11-30 |
Idec Pharmaceuticals Corporation |
Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom.
|
|
CA2103323A1
(en)
|
1992-11-24 |
1994-05-25 |
Gregory D. Plowman |
Her4 human receptor tyrosine kinase
|
|
PT616812E
(pt)
|
1993-03-24 |
2000-04-28 |
Berlex Biosciences |
Combinacao de compostos anti-hormonais e moleculas de ligacao no tratamento do cancro
|
|
WO1994022478A1
(en)
|
1993-03-30 |
1994-10-13 |
The Trustees Of The University Of Pennsylvania |
PREVENTION OF TUMORS WITH MONOCLONAL ANTIBODIES AGAINST $i(NEU)
|
|
AU697142B2
(en)
|
1993-11-23 |
1998-10-01 |
Genentech Inc. |
Protein tyrosine kinases named Rse
|
|
WO1995014930A1
(en)
|
1993-11-23 |
1995-06-01 |
Genentech, Inc. |
Kinase receptor activation assay
|
|
US6287784B1
(en)
|
1993-11-23 |
2001-09-11 |
Genentech, Inc. |
Kinase receptor activation assay
|
|
EP0659439B1
(en)
|
1993-12-24 |
2001-10-24 |
MERCK PATENT GmbH |
Immunoconjugates
|
|
US20030108545A1
(en)
|
1994-02-10 |
2003-06-12 |
Patricia Rockwell |
Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist
|
|
US6811779B2
(en)
*
|
1994-02-10 |
2004-11-02 |
Imclone Systems Incorporated |
Methods for reducing tumor growth with VEGF receptor antibody combined with radiation and chemotherapy
|
|
US5773001A
(en)
|
1994-06-03 |
1998-06-30 |
American Cyanamid Company |
Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
|
|
PL179659B1
(pl)
|
1994-07-21 |
2000-10-31 |
Akzo Nobel Nv |
Kompozycja cyklicznych nadtlenków ketonów sluzaca do modyfikowania (ko)polimerów zwlaszcza do degradacji polipropylenu PL PL PL PL PL PL PL
|
|
US5910486A
(en)
|
1994-09-06 |
1999-06-08 |
Uab Research Foundation |
Methods for modulating protein function in cells using, intracellular antibody homologues
|
|
US5804396A
(en)
|
1994-10-12 |
1998-09-08 |
Sugen, Inc. |
Assay for agents active in proliferative disorders
|
|
US5846749A
(en)
|
1994-10-12 |
1998-12-08 |
The Regents Of The University Of California |
Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination
|
|
US6214388B1
(en)
|
1994-11-09 |
2001-04-10 |
The Regents Of The University Of California |
Immunoliposomes that optimize internalization into target cells
|
|
DE69504278T2
(de)
|
1994-11-10 |
1999-05-06 |
Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum, 72076 Tuebingen |
Verfahren zur Wachstumshemmung von Leukämischen Zellen durch HER-2-Protein-Zeilen
|
|
JPH10511085A
(ja)
|
1994-12-02 |
1998-10-27 |
カイロン コーポレイション |
二重特異性抗体を用いる免疫応答を促進する方法
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
MX9707453A
(es)
|
1995-03-30 |
1997-12-31 |
Pfizer |
Derivados de quinazolina.
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5783404A
(en)
*
|
1995-04-13 |
1998-07-21 |
Amgen Inc. |
Methods and compositions for determining HER-2/neu expression using monoclonal antibodies
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
CA2219361C
(en)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
GB9508565D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quiazoline derivative
|
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
US6410690B1
(en)
|
1995-06-07 |
2002-06-25 |
Medarex, Inc. |
Therapeutic compounds comprised of anti-Fc receptor antibodies
|
|
AU6267896A
(en)
|
1995-06-07 |
1996-12-30 |
Imclone Systems Incorporated |
Antibody and antibody fragments for inhibiting the growth oftumors
|
|
US5837234A
(en)
|
1995-06-07 |
1998-11-17 |
Cytotherapeutics, Inc. |
Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
|
|
US5714586A
(en)
|
1995-06-07 |
1998-02-03 |
American Cyanamid Company |
Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
|
|
US5712374A
(en)
|
1995-06-07 |
1998-01-27 |
American Cyanamid Company |
Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
|
|
CA2245835A1
(en)
|
1995-06-14 |
1997-01-03 |
The Regents Of The University Of California |
Novel high affinity human antibodies to tumor antigens
|
|
US6685940B2
(en)
*
|
1995-07-27 |
2004-02-03 |
Genentech, Inc. |
Protein formulation
|
|
CA2226575C
(en)
|
1995-07-27 |
2011-10-18 |
Genentech, Inc. |
Stabile isotonic lyophilized protein formulation
|
|
US6267958B1
(en)
|
1995-07-27 |
2001-07-31 |
Genentech, Inc. |
Protein formulation
|
|
DE19544393A1
(de)
|
1995-11-15 |
1997-05-22 |
Hoechst Schering Agrevo Gmbh |
Synergistische herbizide Mischungen
|
|
UY24367A1
(es)
*
|
1995-11-23 |
2000-10-31 |
Boehringer Ingelheim Int |
Vacunas contra tumores y procedimiento para su produccion
|
|
US5783186A
(en)
|
1995-12-05 |
1998-07-21 |
Amgen Inc. |
Antibody-induced apoptosis
|
|
GB9603256D0
(en)
|
1996-02-16 |
1996-04-17 |
Wellcome Found |
Antibodies
|
|
HU228446B1
(en)
|
1996-04-12 |
2013-03-28 |
Warner Lambert Co |
Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof
|
|
US5925519A
(en)
*
|
1996-06-03 |
1999-07-20 |
The Regents Of The University Of California |
Genetic alterations associated with prostate cancer
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
US7371376B1
(en)
|
1996-10-18 |
2008-05-13 |
Genentech, Inc. |
Anti-ErbB2 antibodies
|
|
CN101412758A
(zh)
|
1996-10-18 |
2009-04-22 |
基因技术股份有限公司 |
抗ErbB2抗体
|
|
WO1998018489A1
(en)
|
1996-10-30 |
1998-05-07 |
The Uab Research Foundation |
Enhancement of tumor cell chemosensitivity and radiosensitivity using single chain intracellular antibodies
|
|
US6468547B1
(en)
|
1996-10-30 |
2002-10-22 |
Uab Research Foundation |
Enhancement of tumor cell chemosensitivity and radiosensitivity using single chain secretory antibodies
|
|
EP0852951A1
(de)
|
1996-11-19 |
1998-07-15 |
Roche Diagnostics GmbH |
Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern
|
|
EP0950067B1
(en)
|
1996-11-27 |
2007-08-29 |
Genentech, Inc. |
Affinity purification of polypeptide on protein a matrix
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US20030171551A1
(en)
|
1997-01-31 |
2003-09-11 |
Joseph D. Rosenblatt |
Chimeric antibody fusion proteins for the recruitment and stimulation of an antitumor immune response
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
US20020076695A1
(en)
*
|
1997-04-04 |
2002-06-20 |
Jeffrey S. Ross |
Methods for treating prostate cancer
|
|
US5994071A
(en)
|
1997-04-04 |
1999-11-30 |
Albany Medical College |
Assessment of prostate cancer
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
ATE296315T1
(de)
|
1997-06-24 |
2005-06-15 |
Genentech Inc |
Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung
|
|
ZA986732B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitiors of tyrosine kinases
|
|
ZA986729B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitors of tyrosine kinases
|
|
TW436485B
(en)
|
1997-08-01 |
2001-05-28 |
American Cyanamid Co |
Substituted quinazoline derivatives
|
|
AU9805398A
(en)
|
1997-10-15 |
1999-05-03 |
Children's Medical Center Corporation |
Novel human egf receptors and use thereof
|
|
WO1999022764A1
(en)
|
1997-10-31 |
1999-05-14 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
ZA9811162B
(en)
|
1997-12-12 |
2000-06-07 |
Genentech Inc |
Treatment with anti-ERBB2 antibodies.
|
|
US6358682B1
(en)
|
1998-01-26 |
2002-03-19 |
Ventana Medical Systems, Inc. |
Method and kit for the prognostication of breast cancer
|
|
US6417168B1
(en)
|
1998-03-04 |
2002-07-09 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods of treating tumors
|
|
US20020192211A1
(en)
|
1998-03-17 |
2002-12-19 |
Hudziak Robert M. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
|
JP2002507404A
(ja)
*
|
1998-03-27 |
2002-03-12 |
ジェネンテク・インコーポレイテッド |
Ａｐｏ−２リガンド−抗ＨＥＲ−２抗体相乗作用
|
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
ES2292236T3
(es)
|
1998-04-02 |
2008-03-01 |
Genentech, Inc. |
Variantes de anticuerpos y sus fragmentos.
|
|
ES2434961T5
(es)
|
1998-04-20 |
2018-01-18 |
Roche Glycart Ag |
Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
|
|
US7244826B1
(en)
|
1998-04-24 |
2007-07-17 |
The Regents Of The University Of California |
Internalizing ERB2 antibodies
|
|
PT1308456E
(pt)
|
1998-05-06 |
2007-12-03 |
Genentech Inc |
Purificação de anticorpos por cromatografia de permuta iónica
|
|
US6573043B1
(en)
|
1998-10-07 |
2003-06-03 |
Genentech, Inc. |
Tissue analysis and kits therefor
|
|
HU230769B1
(hu)
|
1999-01-15 |
2018-03-28 |
Genentech Inc. |
Módosított effektor-funkciójú polipeptid-változatok
|
|
ATE425749T1
(de)
|
1999-01-27 |
2009-04-15 |
Cornell Res Foundation Inc |
Behandlung von mit her-2/neu-uberexprimierung einhergehendem krebs
|
|
US6322980B1
(en)
|
1999-04-30 |
2001-11-27 |
Aclara Biosciences, Inc. |
Single nucleotide detection using degradation of a fluorescent sequence
|
|
US6316462B1
(en)
|
1999-04-09 |
2001-11-13 |
Schering Corporation |
Methods of inducing cancer cell death and tumor regression
|
|
US6333348B1
(en)
|
1999-04-09 |
2001-12-25 |
Aventis Pharma S.A. |
Use of docetaxel for treating cancers
|
|
JP5623681B2
(ja)
|
1999-05-14 |
2014-11-12 |
ジェネンテック， インコーポレイテッド |
抗−ＥｒｂＢ２抗体による治療
|
|
JP3485252B2
(ja)
|
1999-06-16 |
2004-01-13 |
インターナショナル・ビジネス・マシーンズ・コーポレーション |
情報処理方法、情報端末支援サーバ、コラボレーション・システム、情報処理プログラムを格納する記憶媒体
|
|
AUPQ105799A0
(en)
|
1999-06-18 |
1999-07-08 |
Victor Chang Cardiac Research Institute, The |
Cell growth inhibition
|
|
US20030086924A1
(en)
|
1999-06-25 |
2003-05-08 |
Genentech, Inc. |
Treatment with anti-ErbB2 antibodies
|
|
IL147017A0
(en)
*
|
1999-06-25 |
2002-08-14 |
Genentech Inc |
TREATING PROSTATE CANCER WITH ANTI-ErbB2 ANTIBODIES
|
|
CA2376596C
(en)
|
1999-06-25 |
2009-10-06 |
Genentech, Inc. |
Humanized anti-erbb2 antibodies and treatment with anti-erbb2 antibodies
|
|
US20040013667A1
(en)
|
1999-06-25 |
2004-01-22 |
Genentech, Inc. |
Treatment with anti-ErbB2 antibodies
|
|
US7041292B1
(en)
*
|
1999-06-25 |
2006-05-09 |
Genentech, Inc. |
Treating prostate cancer with anti-ErbB2 antibodies
|
|
EP1191944A2
(en)
|
1999-06-25 |
2002-04-03 |
Genentech, Inc. |
METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES
|
|
US6949245B1
(en)
*
|
1999-06-25 |
2005-09-27 |
Genentech, Inc. |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
|
|
GB9917012D0
(en)
|
1999-07-20 |
1999-09-22 |
Pharmacia & Upjohn Spa |
Combined preparations comprising antitumor agents
|
|
DE60037896D1
(de)
|
1999-07-29 |
2008-03-13 |
Medarex Inc |
Menschliche antikörper gegen her2/neu
|
|
TR200200472T2
(tr)
|
1999-08-27 |
2002-06-21 |
Genentech, Inc. |
Anti-Erb B2 antikorları ile tedavi için dozajlar
|
|
CA2383615A1
(en)
|
1999-09-22 |
2001-03-29 |
Corixa Corporation |
Methods for diagnosis and therapy of hematological and virus-associated malignancies
|
|
GB9925958D0
(en)
|
1999-11-02 |
1999-12-29 |
Bundred Nigel J |
Therapeutic use
|
|
AU2001227966A1
(en)
|
2000-01-20 |
2001-07-31 |
Chiron Corporation |
Methods for treating tumors
|
|
AU2001254672A1
(en)
|
2000-02-29 |
2001-09-12 |
Janssen Pharmaceutica N.V. |
Farnesyl protein transferase inhibitor combinations with an her2 antibody
|
|
US6632979B2
(en)
*
|
2000-03-16 |
2003-10-14 |
Genentech, Inc. |
Rodent HER2 tumor model
|
|
US7097840B2
(en)
|
2000-03-16 |
2006-08-29 |
Genentech, Inc. |
Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
|
|
US6767541B2
(en)
|
2000-03-20 |
2004-07-27 |
The Regents Of The University Of California |
HER-2/neu overexpression abrogates growth inhibitory pathways
|
|
GB0008368D0
(en)
|
2000-04-06 |
2000-05-24 |
Astrazeneca Ab |
Combination product
|
|
EP1275398A4
(en)
|
2000-04-06 |
2004-09-01 |
Kyowa Hakko Kogyo Kk |
DIAGNOSTIC AND MEDICINAL PRODUCTS FOR TREATING RHEUMATOID ARTHRITES
|
|
CN101289511A
(zh)
|
2000-04-11 |
2008-10-22 |
杰南技术公司 |
多价抗体及其应用
|
|
KR20030014223A
(ko)
|
2000-05-15 |
2003-02-15 |
파마시아 이탈리아 에스.피.에이. |
항종양제로서의 아로마타제 억제제 및 모노클로날항-ｈｅｒ2 항체
|
|
US7306801B2
(en)
|
2000-05-15 |
2007-12-11 |
Health Research, Inc. |
Methods of therapy for cancers characterized by overexpression of the HER2 receptor protein
|
|
KR20130056201A
(ko)
*
|
2000-05-19 |
2013-05-29 |
제넨테크, 인크. |
ＥｒｂＢ 길항제에 의한 암 치료요법에 대한 효과적인 반응의 가능성을 개선시키기 위한 유전자 검출 분석
|
|
GB0017635D0
(en)
|
2000-07-18 |
2000-09-06 |
Pharmacia & Upjohn Spa |
Antitumor combined therapy
|
|
TWI317285B
(en)
*
|
2000-07-28 |
2009-11-21 |
Dainippon Sumitomo Pharma Co |
New use and kit for remedies for cancer
|
|
AU9500201A
(en)
|
2000-08-09 |
2002-02-18 |
Imclone Systems Inc |
Treatment of hyperproliferative diseases with epidermal growth factor receptor antagonists
|
|
US6984494B2
(en)
|
2000-08-15 |
2006-01-10 |
Genentech, Inc. |
Analytical method
|
|
KR100395902B1
(ko)
*
|
2000-11-01 |
2003-08-25 |
학교법인 서강대학교 |
제올라이트 또는 유사분자체의 패턴화된 단층 또는 다층복합체의 제조 방법 및 이에 의해 제조된 복합체
|
|
US7005278B2
(en)
*
|
2001-03-02 |
2006-02-28 |
Danenberg Kathleen D |
Method of determining dihydropyrimidine dehydrogenase gene expression
|
|
US6602670B2
(en)
|
2000-12-01 |
2003-08-05 |
Response Genetics, Inc. |
Method of determining a chemotherapeutic regimen based on ERCC1 expression
|
|
CA2436910C
(en)
|
2000-12-01 |
2014-06-17 |
Response Genetics, Inc. |
Method of determining epidermal growth factor receptor and her2-neu gene expression and correlation of levels thereof with survival rates
|
|
US6582919B2
(en)
|
2001-06-11 |
2003-06-24 |
Response Genetics, Inc. |
Method of determining epidermal growth factor receptor and HER2-neu gene expression and correlation of levels thereof with survival rates
|
|
US20020142328A1
(en)
*
|
2000-12-01 |
2002-10-03 |
Danenberg Kathleen D. |
Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors
|
|
WO2002045653A2
(en)
|
2000-12-08 |
2002-06-13 |
Uab Research Foundation |
Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody
|
|
NZ526720A
(en)
|
2000-12-28 |
2007-11-30 |
Altus Pharmaceuticals Inc |
Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies
|
|
WO2002055106A2
(en)
|
2001-01-09 |
2002-07-18 |
Merck Patent Gmbh |
Combination therapy using receptor tyrosine kinase inhibitors and angiogenesis inhibitors
|
|
US20040138160A1
(en)
*
|
2001-04-27 |
2004-07-15 |
Kenichiro Naito |
Preventive/therapeutic method for cancer
|
|
JP2004528368A
(ja)
|
2001-05-08 |
2004-09-16 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
抗ｅｇｆｒ抗体と抗ホルモン剤を用いた組合せ療法
|
|
ITRM20010408A1
(it)
|
2001-07-10 |
2003-01-10 |
Univ Napoli Federico Ii |
Mini-anticorpo umano citotossico per cellule tumorali che esprimono il recettore erbb2.
|
|
AU2002326531A1
(en)
|
2001-08-03 |
2003-02-17 |
The Trustees Of The University Of Pennsylvania |
Monoclonal antibodies to activated erbb family members and methods of use thereof
|
|
EP2180044A1
(en)
|
2001-08-03 |
2010-04-28 |
GlycArt Biotechnology AG |
Antibody glycosylation variants having increased anti-body-dependent cellular cytotoxicity
|
|
US20030068318A1
(en)
*
|
2001-09-28 |
2003-04-10 |
O'brien Timothy |
Treatment of uterine serous papillary cancer
|
|
HUP0600342A3
(en)
|
2001-10-25 |
2011-03-28 |
Genentech Inc |
Glycoprotein compositions
|
|
US20030096823A1
(en)
|
2001-11-16 |
2003-05-22 |
Beryl Asp |
Method for the treatment of cardiotoxicity induced by antitumor compounds
|
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
|
US20030175845A1
(en)
|
2002-03-13 |
2003-09-18 |
Kalbag Suresh M. |
Use of sulfitolysis in high performance peptide mapping
|
|
US20030190689A1
(en)
|
2002-04-05 |
2003-10-09 |
Cell Signaling Technology,Inc. |
Molecular profiling of disease and therapeutic response using phospho-specific antibodies
|
|
AU2003221684A1
(en)
|
2002-04-08 |
2003-10-27 |
Smithkline Beecham Corporation |
Cancer treatment method comprising administering an erb-family inhibitor and a raf and/or ras inhibitor
|
|
US7435797B2
(en)
|
2002-04-10 |
2008-10-14 |
Genentech, Inc. |
Anti-HER2 antibody variants
|
|
ITTO20020340A1
(it)
|
2002-04-19 |
2003-10-20 |
Biother Di Contardi Gabriella |
Localizzazione del recettore her2 mediante anticorpo umanizzato biotinilato.
|
|
US20030202973A1
(en)
*
|
2002-04-29 |
2003-10-30 |
Dr. George Pieczenik |
Treatment of refractory human tumors with epidermal growth factor receptor and HER1 mitogenic ligand (EGFRML) antagonists
|
|
AU2003235470A1
(en)
|
2002-06-19 |
2004-01-06 |
Smithkline Beecham Corporation |
Predictive markers in cancer therapy
|
|
ES2392525T3
(es)
|
2002-07-15 |
2012-12-11 |
F. Hoffmann-La Roche Ag |
Tratamiento del cáncer con el anticuerpo dirigido contra ErbB2 rhuMAb 2C4
|
|
US20040013297A1
(en)
|
2002-07-18 |
2004-01-22 |
Roger Lo |
Method for performing color gamut compression
|
|
SI1543038T2
(sl)
|
2002-09-11 |
2020-12-31 |
Genentech, Inc. |
Čiščenje proteinov
|
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
JP2006516117A
(ja)
*
|
2002-11-21 |
2006-06-22 |
ジェネンテック・インコーポレーテッド |
抗ＥｒｂＢ２抗体を用いた非悪性疾病または疾患の治療
|
|
ES2246191T1
(es)
|
2002-12-11 |
2006-02-16 |
Ventana Medical Systems, Inc. |
Metodo para predecir la respuesta a la terapia dirigida a her2.
|
|
JP2007520995A
(ja)
|
2003-01-08 |
2007-08-02 |
ブリストル−マイヤーズ スクイブ カンパニー |
上皮増殖因子受容体モデュレーターに対する感受性を決定するためのバイオマーカーおよび方法
|
|
US20040231909A1
(en)
|
2003-01-15 |
2004-11-25 |
Tai-Yang Luh |
Motorized vehicle having forward and backward differential structure
|
|
WO2004087207A2
(en)
|
2003-03-27 |
2004-10-14 |
Georgetown University |
Method for inducing apoptosis and aneuploidy regression in cancer cells
|
|
EP1648940B1
(en)
|
2003-07-28 |
2016-04-27 |
Genentech, Inc. |
Reducing protein a leaching during protein a affinity chromatography
|
|
US7163287B2
(en)
*
|
2004-01-21 |
2007-01-16 |
Silverbrook Research Pty Ltd |
Combined cutter and slitter module for a printer
|
|
JP4969440B2
(ja)
|
2004-04-08 |
2012-07-04 |
デビッド， ビー． エイガス， |
疼痛治療のためのＥｒｂＢアンタゴニスト
|
|
KR20120064120A
(ko)
|
2004-06-01 |
2012-06-18 |
제넨테크, 인크. |
항체 약물 접합체 및 방법
|
|
SV2006002143A
(es)
*
|
2004-06-16 |
2006-01-26 |
Genentech Inc |
Uso de un anticuerpo para el tratamiento del cancer resistente al platino
|
|
KR20140032004A
(ko)
|
2004-07-22 |
2014-03-13 |
제넨테크, 인크. |
Ｈｅｒ２ 항체 조성물
|
|
KR20070057839A
(ko)
|
2004-08-19 |
2007-06-07 |
제넨테크, 인크. |
변경된 이펙터 기능을 갖는 폴리펩티드 변이체
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
JP2008523073A
(ja)
*
|
2004-12-07 |
2008-07-03 |
ジェネンテック・インコーポレーテッド |
Ｈｅｒ阻害剤を用いた治療のための患者の選択
|
|
CA2592177A1
(en)
*
|
2005-01-21 |
2006-07-27 |
Genentech, Inc. |
Fixed dosing of her antibodies
|
|
TW200640443A
(en)
|
2005-02-23 |
2006-12-01 |
Alcon Inc |
Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors
|
|
EP1850874B1
(en)
|
2005-02-23 |
2013-10-16 |
Genentech, Inc. |
Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
|
|
WO2006096861A2
(en)
*
|
2005-03-08 |
2006-09-14 |
Genentech, Inc. |
METHODS FOR IDENTIFYING TUMORS RESPONSIVE TO TREATMENT WITH HER DIMERIZATION INHIBITORS (HDIs)
|
|
US20060212956A1
(en)
|
2005-03-14 |
2006-09-21 |
Genentech, Inc. |
Animal model of ligand activated HER2 expressing tumors
|
|
JP2006316040A
(ja)
|
2005-05-13 |
2006-11-24 |
Genentech Inc |
Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法
|
|
MY157955A
(en)
|
2005-07-06 |
2016-08-30 |
Hoffmann La Roche |
Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody
|
|
PE20070207A1
(es)
|
2005-07-22 |
2007-03-09 |
Genentech Inc |
Tratamiento combinado de los tumores que expresan el her
|
|
US7700299B2
(en)
|
2005-08-12 |
2010-04-20 |
Hoffmann-La Roche Inc. |
Method for predicting the response to a treatment
|
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
|
JP2009539836A
(ja)
|
2006-06-05 |
2009-11-19 |
ジェネンテック・インコーポレーテッド |
ＥＧＦまたはＴＧＦ−αのレベルの上昇が生じている癌患者の生存の延長
|
|
DK2056874T3
(da)
|
2006-08-21 |
2012-10-15 |
Hoffmann La Roche |
Tumorterapi med et anti-vegf-antistof
|
|
WO2008031531A1
(en)
|
2006-09-15 |
2008-03-20 |
F. Hoffmann-La Roche Ag |
Tumor therapy with a combination of anti-her2 antibodies
|
|
MX2009008981A
(es)
|
2007-03-02 |
2009-09-02 |
Genentech Inc |
Prediccion de respuesta a un inhibidor her.
|
|
MX2009012838A
(es)
|
2007-06-06 |
2009-12-11 |
Hoffmann La Roche |
Composicion de un primer anticuerpo monoclonal no marcado que se aglutina a un antigeno tumoral y a un segundo anticuerpo monoclonal de reaccion no cruzada marcado con un marcador fluorescsente del infrarrojo proximo.
|
|
US9551033B2
(en)
|
2007-06-08 |
2017-01-24 |
Genentech, Inc. |
Gene expression markers of tumor resistance to HER2 inhibitor treatment
|
|
EP2171090B1
(en)
|
2007-06-08 |
2013-04-03 |
Genentech, Inc. |
Gene expression markers of tumor resistance to her2 inhibitor treatment
|
|
AU2008298948B2
(en)
|
2007-09-12 |
2014-09-04 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
CN101889025B
(zh)
|
2007-10-30 |
2013-11-13 |
健泰科生物技术公司 |
通过阳离子交换层析进行的抗体纯化
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
|
|
EP2260056A1
(en)
|
2008-03-06 |
2010-12-15 |
Genentech, Inc. |
Combination therapy with c-met and her antagonists
|
|
NZ602675A
(en)
|
2008-03-18 |
2014-03-28 |
Genentech Inc |
Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
|
|
BRPI0812682A2
(pt)
|
2008-06-16 |
2010-06-22 |
Genentech Inc |
tratamento de cáncer de mama metastático
|
|
EP2435071A1
(en)
|
2009-05-29 |
2012-04-04 |
F. Hoffmann-La Roche AG |
Modulators for her2 signaling in her2 expressing patients with gastric cancer
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
|
WO2013055874A2
(en)
|
2011-10-14 |
2013-04-18 |
Genentech, Inc. |
Uses for and article of manufacture including her2 dimerization inhibitor pertuzumab
|
|
US9376715B2
(en)
|
2011-12-09 |
2016-06-28 |
Roche Molecular Systems, Inc |
Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
|
|
US20130195851A1
(en)
|
2011-12-23 |
2013-08-01 |
Genentech, Inc. |
Articles of manufacture and methods for co-administration of antibodies
|
|
JP6138018B2
(ja)
*
|
2013-10-03 |
2017-05-31 |
三菱電機株式会社 |
赤外線固体撮像素子
|