NO20075557L - Krystaller av morfinanderivat og fremgangsmate for fremstilling derav - Google Patents

Krystaller av morfinanderivat og fremgangsmate for fremstilling derav

Info

Publication number
NO20075557L
NO20075557L NO20075557A NO20075557A NO20075557L NO 20075557 L NO20075557 L NO 20075557L NO 20075557 A NO20075557 A NO 20075557A NO 20075557 A NO20075557 A NO 20075557A NO 20075557 L NO20075557 L NO 20075557L
Authority
NO
Norway
Prior art keywords
preparation
crystals
derivative crystals
morphine derivative
cyclopropylmethyl
Prior art date
Application number
NO20075557A
Other languages
English (en)
Other versions
NO339927B1 (no
Inventor
Hisanori Wakita
Masahiro Akimoto
Takahiro Takeda
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Publication of NO20075557L publication Critical patent/NO20075557L/no
Publication of NO339927B1 publication Critical patent/NO339927B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Det er beskrevet 17-syklopropylmetyl-3,14P-dihydroksy-4,5a-epoksy-6P-[N-metyl-trans-3-(3- fiiiyl)akiylamido]morfiiian hydroklorid. Den har en høy renhet og beholder konstant kvalitet etter fremstilling. 17-syklopropylmetyl-3,14P-dihydroksy-4,5a-epoksy-6P-[N-metyl-trans-3-(3- fiiryl)akrylamido]morfinan, hydrokloridet er i form av krystaller, spesielt A-form, B-form og C-form krystaller.
NO20075557A 2005-04-06 2007-11-02 Krystaller av morfinanderivat og fremgangsmåte for fremstilling derav NO339927B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005110096 2005-04-06
PCT/JP2006/307331 WO2006109671A1 (ja) 2005-04-06 2006-04-06 モルヒナン誘導体の結晶及びその製造法

Publications (2)

Publication Number Publication Date
NO20075557L true NO20075557L (no) 2007-11-02
NO339927B1 NO339927B1 (no) 2017-02-13

Family

ID=37086947

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20075557A NO339927B1 (no) 2005-04-06 2007-11-02 Krystaller av morfinanderivat og fremgangsmåte for fremstilling derav

Country Status (16)

Country Link
US (1) US7803942B2 (no)
EP (1) EP1873158B1 (no)
JP (1) JP5076498B2 (no)
KR (1) KR101333620B1 (no)
CN (1) CN101155814B (no)
AU (1) AU2006234257B2 (no)
BR (1) BRPI0608671B1 (no)
CA (1) CA2602968C (no)
DK (1) DK1873158T3 (no)
ES (1) ES2568475T3 (no)
HU (1) HUE029202T2 (no)
NO (1) NO339927B1 (no)
NZ (1) NZ563133A (no)
PL (1) PL1873158T3 (no)
RU (1) RU2397173C2 (no)
WO (1) WO2006109671A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
WO2010096790A1 (en) * 2009-02-23 2010-08-26 Mallinckrodt Inc. (+)-morphinananium n-oxides and processes for their production
JP2012518652A (ja) * 2009-02-23 2012-08-16 マリンクロッド インコーポレイテッド （＋）−６−ヒドロキシ−モルフィナンまたは（＋）−６−アミノ−モルフィナン誘導体
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8420819B2 (en) * 2009-06-03 2013-04-16 Boehringer Ingelheim International Gmbh Process for optimizing the particle size of an active pharmaceutical ingredient by crystallization
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
TWI449704B (zh) * 2013-04-26 2014-08-21 Everlight Chem Ind Corp 嗎啡喃衍生物之結晶、其製造方法、及使用其之醫藥組成物
CN106866688B (zh) * 2015-12-10 2019-05-03 山东诚创医药技术开发有限公司 一种纳呋拉啡的精制方法
HUE069820T2 (hu) 2018-03-08 2025-04-28 Victoria Link Ltd Nalfurafin alkalmazása demielinizációs betegségek kezelésére
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN115960108B (zh) * 2021-10-09 2026-02-03 山东新时代药业有限公司 一种无定型盐酸纳呋拉啡及其制备方法
CN114736210A (zh) * 2022-03-29 2022-07-12 伊诺药物研究(南京)有限公司 吗啡喃衍生物的一种晶型的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4110116C2 (de) * 1991-03-27 1996-06-13 Thermodach Dachtechnik Gmbh Energiespeichernde Wärmedämmplatte
US6323212B1 (en) * 1992-01-23 2001-11-27 Toray Industries, Inc. Morphinan derivative and its pharmaceutical applications
EP0657163B1 (en) * 1993-06-30 1998-10-14 Toray Industries, Inc. Antitussive
EP0661283B1 (en) 1993-07-19 1998-10-21 Toray Industries, Inc. Brain cell protective
EP0663401B1 (en) 1993-07-23 2000-06-07 Toray Industries, Inc. Morphinan derivative and medicinal use
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ATE359076T1 (de) 1996-11-25 2007-05-15 Toray Industries Mittel gegen juckreiz

Also Published As

Publication number Publication date
BRPI0608671A2 (pt) 2010-01-19
DK1873158T3 (en) 2016-06-27
EP1873158A4 (en) 2010-06-02
EP1873158A1 (en) 2008-01-02
HUE029202T2 (en) 2017-02-28
BRPI0608671B1 (pt) 2022-07-19
US7803942B2 (en) 2010-09-28
NZ563133A (en) 2010-07-30
KR20080004500A (ko) 2008-01-09
AU2006234257B2 (en) 2011-03-10
US20090062544A1 (en) 2009-03-05
JPWO2006109671A1 (ja) 2008-11-13
CN101155814B (zh) 2010-06-16
RU2007140890A (ru) 2009-05-20
CA2602968C (en) 2014-09-23
WO2006109671A1 (ja) 2006-10-19
CA2602968A1 (en) 2006-10-19
ES2568475T3 (es) 2016-04-29
NO339927B1 (no) 2017-02-13
KR101333620B1 (ko) 2013-11-27
RU2397173C2 (ru) 2010-08-20
AU2006234257A1 (en) 2006-10-19
CN101155814A (zh) 2008-04-02
JP5076498B2 (ja) 2012-11-21
EP1873158B1 (en) 2016-04-06
PL1873158T3 (pl) 2016-09-30

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