NO20076072L - Tigecyklin og metoder for fremstilling av 9-nitrominocyklin - Google Patents

Tigecyklin og metoder for fremstilling av 9-nitrominocyklin

Info

Publication number
NO20076072L
NO20076072L NO20076072A NO20076072A NO20076072L NO 20076072 L NO20076072 L NO 20076072L NO 20076072 A NO20076072 A NO 20076072A NO 20076072 A NO20076072 A NO 20076072A NO 20076072 L NO20076072 L NO 20076072L
Authority
NO
Norway
Prior art keywords
methods
tigecycline
preparation
nitrominocycline
preparations
Prior art date
Application number
NO20076072A
Other languages
English (en)
Inventor
Phaik-Eng Sum
Sylvain Daigneault
Michel Bernatchez
Anthony Scott Pilcher
Lalitha Krishnan
Jeffrey Marshall Horne
Adam Joseph Tuper
Iii Joseph James Mccauley
Adam P Michaud
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20076072L publication Critical patent/NO20076072L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Det er beskrevet metoder for fremstilling og rensing av tetrasykliner, så som tigesyklin. Det er også beskrevet tetrasyklin-preparater, så som tigesyklin-preparater, som er fremstilt ved disse metodene. Fig. 1
NO20076072A 2005-05-27 2007-11-26 Tigecyklin og metoder for fremstilling av 9-nitrominocyklin NO20076072L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68529105P 2005-05-27 2005-05-27
PCT/US2006/020540 WO2006130501A2 (en) 2005-05-27 2006-05-25 Tigecycline and methods of preparing 9-nitrominocycline

Publications (1)

Publication Number Publication Date
NO20076072L true NO20076072L (no) 2008-02-19

Family

ID=36933528

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076072A NO20076072L (no) 2005-05-27 2007-11-26 Tigecyklin og metoder for fremstilling av 9-nitrominocyklin

Country Status (20)

Country Link
US (1) US20070049560A1 (no)
EP (1) EP1885687A2 (no)
JP (1) JP2008545708A (no)
KR (1) KR20080016893A (no)
CN (1) CN101228111A (no)
AR (1) AR057033A1 (no)
AU (1) AU2006252687A1 (no)
BR (1) BRPI0610268A2 (no)
CA (1) CA2609264A1 (no)
CR (1) CR9543A (no)
EC (1) ECSP078042A (no)
GT (1) GT200600223A (no)
IL (1) IL187539A0 (no)
MX (1) MX2007014718A (no)
NO (1) NO20076072L (no)
PE (1) PE20061422A1 (no)
RU (1) RU2007143164A (no)
TW (1) TW200716514A (no)
WO (1) WO2006130501A2 (no)
ZA (1) ZA200710173B (no)

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AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
US20070244335A1 (en) * 2006-04-17 2007-10-18 Teva Pharmaceutical Industries Ltd. Isolation of tetracycline derivatives
US8198470B2 (en) 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
ES2622356T3 (es) * 2006-04-24 2017-07-06 Teva Pharmaceutical Industries, Ltd. Formas cristalinas de tigeciclina y procesos para su preparación
MX2008009520A (es) * 2006-11-29 2009-02-26 Teva Pharma Formas cristalinas de tigeciclina y procesos de preparacion de ellas.
MX2008009727A (es) * 2006-11-30 2009-01-09 Teva Pharma Procesos para la preparacion de 9-haloacetamidominociclinas.
US20080214869A1 (en) * 2007-03-01 2008-09-04 Sergei Fine Processes for purification of tigecycline
WO2009052152A2 (en) * 2007-10-16 2009-04-23 Wyeth Tigecycline and methods of preparing intermediates
EP2220033B1 (en) * 2007-11-14 2014-12-17 Sandoz AG Crystalline forms of tigecycline hydrochloride
US8513224B2 (en) 2008-12-18 2013-08-20 Sandoz Ag Crystalline form C of tigecycline dihydrochloride and methods for its preparation
CA2751238A1 (en) 2009-03-12 2010-10-07 Wyeth Llc Nitration of tetracyclines
ES2469829T3 (es) * 2009-11-26 2014-06-20 Sandoz Ag Reacción de compuestos orgánicos con bajas cantidades de hidrógeno
PT2568987T (pt) 2010-05-12 2017-02-03 Rempex Pharmaceuticals Inc Composições de tetraciclina
CN102391148B (zh) * 2011-10-24 2014-01-08 江苏奥赛康药业股份有限公司 一种高纯度替加环素的合成方法
CN103044281A (zh) * 2013-01-02 2013-04-17 湖南赛隆药业有限公司 高纯度替加环素的制法
CN104418766B (zh) * 2013-08-26 2018-09-07 江苏豪森药业集团有限公司 替加环素的纯化方法
US20160143925A1 (en) 2013-11-12 2016-05-26 Galenicum Health S.L. Stable pharmaceutical compositions
CN104211617A (zh) * 2014-08-29 2014-12-17 重庆康乐制药有限公司 一种替加环素的制备方法
CN111362829B (zh) * 2018-12-26 2021-11-30 浙江昌海制药有限公司 一种米诺环素二对氯苯磺酸盐晶型及其制备方法和应用
CN111060641B (zh) * 2019-12-27 2020-10-23 瀚晖制药有限公司 一种注射用替加环素中9-硝基米诺环素的检测方法
WO2022029796A1 (en) * 2020-08-04 2022-02-10 Sumar Biotech Llp An improved process for the preparation of Tigecycline intermediate and process for the preparation of Tigecycline therefrom
CN114957031B (zh) * 2022-05-17 2024-05-31 河北圣雪大成制药有限责任公司 一种合成9-氨基米诺环素硫酸盐的新方法

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Also Published As

Publication number Publication date
GT200600223A (es) 2007-05-08
ECSP078042A (es) 2008-01-23
PE20061422A1 (es) 2007-01-29
BRPI0610268A2 (pt) 2010-06-08
MX2007014718A (es) 2008-02-15
WO2006130501A3 (en) 2007-03-29
RU2007143164A (ru) 2009-07-10
CA2609264A1 (en) 2006-12-07
AU2006252687A1 (en) 2006-12-07
TW200716514A (en) 2007-05-01
KR20080016893A (ko) 2008-02-22
ZA200710173B (en) 2009-09-30
US20070049560A1 (en) 2007-03-01
WO2006130501A2 (en) 2006-12-07
JP2008545708A (ja) 2008-12-18
IL187539A0 (en) 2008-03-20
AR057033A1 (es) 2007-11-14
EP1885687A2 (en) 2008-02-13
CN101228111A (zh) 2008-07-23
CR9543A (es) 2008-02-20

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