NO20076437L - Anti-GM-CSF antistoffer og anvendelser for disse - Google Patents

Anti-GM-CSF antistoffer og anvendelser for disse

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Publication number
NO20076437L
NO20076437L NO20076437A NO20076437A NO20076437L NO 20076437 L NO20076437 L NO 20076437L NO 20076437 A NO20076437 A NO 20076437A NO 20076437 A NO20076437 A NO 20076437A NO 20076437 L NO20076437 L NO 20076437L
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Norway
Prior art keywords
antibodies
csf
various disorders
applications
role
Prior art date
Application number
NO20076437A
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English (en)
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NO344992B1 (no
Inventor
Stefan Steidl
Elisabeth Thomassen-Wolf
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Morphosys Ag
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Publication date
Application filed by Morphosys Ag filed Critical Morphosys Ag
Publication of NO20076437L publication Critical patent/NO20076437L/no
Publication of NO344992B1 publication Critical patent/NO344992B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Sammendrag Foreliggende oppfinnelse skaffer til veie rekombinant antigen-bindende regioner, antistoffer og funksjonelle fragmenter av disse som er spesifikke for GM-CSF, som spiller en integrert rolle i forskjellige forstyrrelser og forhold. Disse antistoffene kan således bli anvendt for å behandle, for eksempel inflammatoriske sykdommer slik som reumatoid artritt. Antistoffer fra oppfinnelsen kan også bli anvendt innen det diagnostiske feltet, så vel som for videre undersøkelser av rollen til GM-CSF i utvikling av for skjellige forstyrrelser. Oppfinnelsen skaffer også til veie nukleinsyre sekvenser som koder for foregående antistoffer, vektorer som inneholder det samme, farmasøytiske sammensetninger og kits (sett) med instruksjoner for bruk.
NO20076437A 2005-05-18 2007-12-13 Anti-GM-CSF antistoffer og anvendelser for disse NO344992B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68200905P 2005-05-18 2005-05-18
PCT/EP2006/004696 WO2006122797A2 (en) 2005-05-18 2006-05-17 Anti-gm-csf antibodies and uses therefor

Publications (2)

Publication Number Publication Date
NO20076437L true NO20076437L (no) 2007-12-13
NO344992B1 NO344992B1 (no) 2020-08-17

Family

ID=37114333

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076437A NO344992B1 (no) 2005-05-18 2007-12-13 Anti-GM-CSF antistoffer og anvendelser for disse

Country Status (26)

Country Link
US (5) US7867495B2 (no)
EP (4) EP2468773A3 (no)
JP (2) JP5295759B2 (no)
KR (1) KR101308087B1 (no)
CN (2) CN103087190B (no)
AR (1) AR053608A1 (no)
AU (1) AU2006249062B2 (no)
BR (1) BRPI0610796B8 (no)
CA (1) CA2608498C (no)
CY (2) CY1115920T1 (no)
DK (2) DK3620171T3 (no)
ES (2) ES2918209T3 (no)
HR (2) HRP20150023T1 (no)
HU (1) HUE058876T2 (no)
IL (1) IL187375A (no)
LT (1) LT3620171T (no)
ME (1) ME02059B (no)
NO (1) NO344992B1 (no)
NZ (1) NZ564027A (no)
PL (2) PL1888643T3 (no)
PT (2) PT3620171T (no)
RS (2) RS63382B1 (no)
RU (1) RU2447085C2 (no)
SI (2) SI1888643T1 (no)
TW (1) TWI477512B (no)
WO (1) WO2006122797A2 (no)

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Also Published As

Publication number Publication date
JP5295759B2 (ja) 2013-09-18
US7867495B2 (en) 2011-01-11
PT3620171T (pt) 2022-06-30
IL187375A (en) 2012-06-28
US20200024340A1 (en) 2020-01-23
EP1888643A2 (en) 2008-02-20
DK3620171T3 (da) 2022-06-07
CN103087190B (zh) 2016-08-03
CA2608498C (en) 2017-04-04
EP3620171A1 (en) 2020-03-11
JP2013116912A (ja) 2013-06-13
RU2007147870A (ru) 2009-06-27
EP2468773A3 (en) 2012-09-19
SI1888643T1 (sl) 2015-03-31
AU2006249062B2 (en) 2012-12-20
AR053608A1 (es) 2007-05-09
US10377820B2 (en) 2019-08-13
ES2918209T3 (es) 2022-07-14
CN101218255B (zh) 2013-01-09
ME02059B (me) 2015-05-20
EP3150221A1 (en) 2017-04-05
US11028165B2 (en) 2021-06-08
HUE058876T2 (hu) 2022-09-28
IL187375A0 (en) 2008-02-09
DK1888643T3 (en) 2015-01-05
ES2527428T3 (es) 2015-01-23
BRPI0610796B8 (pt) 2021-05-25
HK1114620A1 (en) 2008-11-07
EP3620171B1 (en) 2022-04-20
NO344992B1 (no) 2020-08-17
PL1888643T3 (pl) 2015-04-30
US20170218061A1 (en) 2017-08-03
US20210347879A1 (en) 2021-11-11
HRP20220755T3 (hr) 2022-09-02
EP2468773A2 (en) 2012-06-27
US9751939B2 (en) 2017-09-05
KR20080015008A (ko) 2008-02-15
WO2006122797A2 (en) 2006-11-23
AU2006249062A1 (en) 2006-11-23
CA2608498A1 (en) 2006-11-23
US20110045000A1 (en) 2011-02-24
KR101308087B1 (ko) 2013-10-16
PL3620171T3 (pl) 2022-08-08
EP1888643B1 (en) 2014-10-29
WO2006122797A3 (en) 2007-02-15
RS53743B1 (sr) 2015-06-30
SI3620171T1 (sl) 2022-09-30
RS63382B1 (sr) 2022-08-31
PT1888643E (pt) 2015-01-14
JP5769744B2 (ja) 2015-08-26
BRPI0610796B1 (pt) 2020-01-21
BRPI0610796A2 (pt) 2010-11-09
CN101218255A (zh) 2008-07-09
CY1125427T1 (el) 2025-05-09
NZ564027A (en) 2011-06-30
CN103087190A (zh) 2013-05-08
WO2006122797B1 (en) 2007-04-19
JP2008545632A (ja) 2008-12-18
TWI477512B (zh) 2015-03-21
US20090053213A1 (en) 2009-02-26
LT3620171T (lt) 2022-06-10
TW200716674A (en) 2007-05-01
CY1115920T1 (el) 2017-01-25
HRP20150023T1 (hr) 2015-02-27
RU2447085C2 (ru) 2012-04-10

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