NO20076675L - Aminopiperidinquinoliner og deres azaisosteriske analoger med antibakteriell aktivitet - Google Patents

Aminopiperidinquinoliner og deres azaisosteriske analoger med antibakteriell aktivitet

Info

Publication number
NO20076675L
NO20076675L NO20076675A NO20076675A NO20076675L NO 20076675 L NO20076675 L NO 20076675L NO 20076675 A NO20076675 A NO 20076675A NO 20076675 A NO20076675 A NO 20076675A NO 20076675 L NO20076675 L NO 20076675L
Authority
NO
Norway
Prior art keywords
antibacterial activity
medicaments
humans
warm
bacterial infections
Prior art date
Application number
NO20076675A
Other languages
English (en)
Inventor
Folkert Reck
Marshall Morningstar
Hajnalka Hartl
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20076675L publication Critical patent/NO20076675L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser som demonstrerer antibakteriell aktivitet, fremgangsmåter for deres fremstilling, farmasøytiske sammensetninger som inneholder dem som aktiv ingrediens, deres anvendelse som medikamenter og deres anvendelse ved fremstilling av medikamenter for anvendelse ved behandling av bakterielle infeksjoner hos varmblodige dyr slik som mennesker. Spesielt angår foreliggende oppfinnelse forbindelser anvendelige for behandling av bakterielle infeksjoner hos varmblodige dyr slik som mennesker, mer spesielt anvendelse av disse forbindelsene ved fremstilling av medikamenter for anvendelse ved behandling av bakterielle infeksjoner hos varmblodige dyr slik som mennesker.
NO20076675A 2005-05-24 2007-12-27 Aminopiperidinquinoliner og deres azaisosteriske analoger med antibakteriell aktivitet NO20076675L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68403005P 2005-05-24 2005-05-24
PCT/GB2006/001889 WO2006125974A1 (en) 2005-05-24 2006-05-23 Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity

Publications (1)

Publication Number Publication Date
NO20076675L true NO20076675L (no) 2007-12-27

Family

ID=36685663

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076675A NO20076675L (no) 2005-05-24 2007-12-27 Aminopiperidinquinoliner og deres azaisosteriske analoger med antibakteriell aktivitet

Country Status (14)

Country Link
US (1) US20090131444A1 (no)
EP (1) EP1891078A1 (no)
JP (1) JP2008542249A (no)
KR (1) KR20080016577A (no)
CN (1) CN101258157A (no)
AU (1) AU2006250987A1 (no)
BR (1) BRPI0609887A2 (no)
CA (1) CA2608072A1 (no)
IL (1) IL187134A0 (no)
MX (1) MX2007014507A (no)
NO (1) NO20076675L (no)
RU (1) RU2007147413A (no)
WO (1) WO2006125974A1 (no)
ZA (1) ZA200709870B (no)

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MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
CA2643962A1 (en) * 2006-03-10 2007-09-20 Actelion Pharmaceuticals Ltd Antibiotic compounds
EP2001887B1 (en) 2006-04-06 2010-09-15 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
AU2007268749B2 (en) 2006-05-26 2012-07-26 Taisho Pharmaceutical Co., Ltd. Novel heterocyclic compound or salt thereof and intermediate thereof
TW200815425A (en) * 2006-06-08 2008-04-01 Speedel Experimenta Ag 2,5-disubstituted piperidines
AU2008240764C1 (en) * 2007-04-20 2011-10-20 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
ATE520687T1 (de) * 2007-06-15 2011-09-15 Actelion Pharmaceuticals Ltd 3-amino-6-(1-amino-ethyl)-tetrahydropyranderiva e
ES2411930T3 (es) 2008-02-20 2013-07-09 Actelion Pharmaceuticals Ltd. Compuestos antibióticos azatricíclicos
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
EP2352734A1 (en) 2008-10-17 2011-08-10 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
AU2009325902B2 (en) 2008-12-12 2015-01-29 Idorsia Pharmaceuticals Ltd 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives
US20120053350A1 (en) * 2009-04-30 2012-03-01 Ian Mangion Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
RU2605549C2 (ru) * 2010-04-02 2016-12-20 Синомикс, Инк. Производные 3-карбокси-4-аминохинолина, полезные как модификаторы сладкого вкуса
SG193002A1 (en) 2011-03-10 2013-09-30 Daiichi Sankyo Co Ltd Dispiropyrrolidine derivative
KR102143660B1 (ko) * 2011-06-17 2020-08-11 화이자 안티-인펙티브스 에이비 트랜스-7-옥소-6-(술포옥시)-1,6-디아자비시클로[3,2,1]옥탄-2-카르복스아미드 및 그의 염을 포함하는 헤테로시클릭 화합물의 제조 방법
AU2012295255B2 (en) 2011-08-12 2016-04-21 Senomyx, Inc. Sweet flavor modifier
TW201343645A (zh) 2012-03-30 2013-11-01 Cubist Pharm Inc １，３，４－□二唑及１，３，４－噻二唑β－內醯胺酶抑制劑
AR090844A1 (es) * 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
US9120795B2 (en) 2013-03-14 2015-09-01 Cubist Pharmaceuticals, Inc. Crystalline form of a β-lactamase inhibitor
US9120796B2 (en) 2013-10-02 2015-09-01 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
CN103613530B (zh) * 2013-12-02 2015-08-19 江苏弘和药物研发有限公司 一种芴甲氧羰基-3-哌啶醇的合成方法
JP6687238B2 (ja) 2013-12-27 2020-04-22 株式会社エーピーアイ コーポレーション ５−ヒドロキシピペリジン−２−カルボン酸の製造方法
US10702521B2 (en) 2014-08-22 2020-07-07 Glaxosmithkline Intellectual Property Development Limited Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones
WO2016073251A1 (en) 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
TW201722965A (zh) * 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
ME03738B (me) * 2016-06-08 2021-01-20 Acraf Novi antibakterijski spojevi
AU2017295863B2 (en) 2016-07-13 2022-07-07 Medic Life Sciences, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
US11485733B2 (en) 2017-06-30 2022-11-01 Bayer Animal Health Gmbh Azaquinoline derivatives
CN118239937A (zh) 2017-08-09 2024-06-25 戴纳立制药公司 化合物、组合物及方法
DK3676297T3 (da) * 2017-09-01 2023-08-14 Denali Therapeutics Inc Forbindelser, sammensætninger og fremgangsmåder
MY202326A (en) 2017-09-14 2024-04-24 Daiichi Sankyo Co Ltd Compound having cyclic structure
CR20210287A (es) 2018-11-01 2022-02-15 Syros Pharmaceuticals Inc Inhibidores de cinasa 7 dependiente de ciclina (cdk7)
MA54953A (fr) 2019-02-13 2021-12-22 Denali Therapeutics Inc Composés, compositions et procédés
US12091392B2 (en) 2019-02-13 2024-09-17 Denali Therapeutics Inc. Compounds, compositions and methods

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GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
EP1305308B1 (en) * 2000-07-26 2006-12-20 Smithkline Beecham Plc Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2002024684A1 (en) * 2000-09-21 2002-03-28 Smithkline Beecham P.L.C. Quinoline derivatives as antibacterials
JP4887297B2 (ja) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質

Also Published As

Publication number Publication date
WO2006125974A1 (en) 2006-11-30
CN101258157A (zh) 2008-09-03
RU2007147413A (ru) 2009-06-27
AU2006250987A1 (en) 2006-11-30
BRPI0609887A2 (pt) 2011-10-11
IL187134A0 (en) 2008-02-09
JP2008542249A (ja) 2008-11-27
KR20080016577A (ko) 2008-02-21
EP1891078A1 (en) 2008-02-27
US20090131444A1 (en) 2009-05-21
ZA200709870B (en) 2008-11-26
CA2608072A1 (en) 2006-11-30
MX2007014507A (es) 2008-02-07

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