NO20080162L - Tienopyrimidin og tienopyrimidinderivater som FLT-3 kinaseinhibitorer - Google Patents

Tienopyrimidin og tienopyrimidinderivater som FLT-3 kinaseinhibitorer

Info

Publication number: NO20080162L
Authority: NO; Norway
Prior art keywords: compounds; flt3; tienopyrimidine; flt; kinase inhibitors
Prior art date: 2005-06-10

Application number

NO20080162A

Other languages

English (en)

Norwegian (no)

Inventor

Michael David Gaul

Kevin Douglas Kreutter

Christian Andrew Baumann

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-10

Filing date

2008-01-09

Publication date

2008-03-07

2008-01-09 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2008-03-07 Publication of NO20080162L publication Critical patent/NO20080162L/no

Links

102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 title abstract 4
FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 title 1
101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical class C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
230000002062 proliferating effect Effects 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
108091000080 Phosphotransferase Proteins 0.000 abstract 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
102000020233 phosphotransferase Human genes 0.000 abstract 1
229940125670 thienopyridine Drugs 0.000 abstract 1
239000002175 thienopyridine Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Materials For Medical Uses (AREA)

NO20080162A 2005-06-10 2008-01-09 Tienopyrimidin og tienopyrimidinderivater som FLT-3 kinaseinhibitorer NO20080162L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68971005P	2005-06-10	2005-06-10
US74694106P	2006-05-10	2006-05-10
PCT/US2006/022151 WO2006135639A1 (en)	2005-06-10	2006-06-07	Thiξnopyrimidine and thienopyridine derivatives as flt-3 kinase inhibitors

Publications (1)

Publication Number	Publication Date
NO20080162L true NO20080162L (no)	2008-03-07

Family

ID=37074647

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20080162A NO20080162L (no)	2005-06-10	2008-01-09	Tienopyrimidin og tienopyrimidinderivater som FLT-3 kinaseinhibitorer

Country Status (19)

Country	Link
US (3)	US20060281768A1 (pt)
EP (1)	EP1899355A1 (pt)
JP (1)	JP2008543759A (pt)
KR (1)	KR20080021126A (pt)
AR (1)	AR057063A1 (pt)
AU (1)	AU2006258049A1 (pt)
BR (1)	BRPI0613644A2 (pt)
CA (1)	CA2611587A1 (pt)
CR (1)	CR9650A (pt)
EA (1)	EA200800011A1 (pt)
EC (1)	ECSP077992A (pt)
IL (1)	IL187689A0 (pt)
MX (1)	MX2007015741A (pt)
NI (1)	NI200700311A (pt)
NO (1)	NO20080162L (pt)
PE (1)	PE20070070A1 (pt)
TW (1)	TW200716651A (pt)
UY (1)	UY29590A1 (pt)
WO (1)	WO2006135639A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY179032A (en)	2004-10-25	2020-10-26	Cancer Research Tech Ltd	Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
JP2009534454A (ja) *	2006-04-25	2009-09-24	アステックス、セラピューティックス、リミテッド	医薬化合物
DK3421471T3 (da)	2006-04-25	2021-06-14	Astex Therapeutics Ltd	Purin- og deazapurinderivater som farmaceutiske forbindelser
US20080076770A1 (en) *	2006-09-25	2008-03-27	Arete Therapeutics, Inc.	Soluble epoxide hydrolase inhibitors
CA2705719C (en)	2007-09-14	2016-10-11	Janssen Pharmaceutica N.V.	Thieno-and furo-pyrimidine modulators of the histamine h4 receptor
PL2201012T3 (pl)	2007-10-11	2014-11-28	Astrazeneca Ab	Pochodne pirolo[2,3-d]pirymidyny jako inhibitory kinazy białkowej b
EA027506B1 (ru)	2011-04-01	2017-08-31	Астразенека Аб	Способ лечения рака молочной железы
CA2835835C (en)	2011-05-13	2019-04-02	Array Biopharma Inc.	Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors
AR090037A1 (es) *	2011-11-15	2014-10-15	Xention Ltd	Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
HRP20191982T4 (hr)	2011-11-30	2023-01-06	Astrazeneca Ab	Kombinacijsko liječenje raka
AU2013204533B2 (en)	2012-04-17	2017-02-02	Astrazeneca Ab	Crystalline forms
MA40434B1 (fr)	2014-05-15	2019-09-30	Array Biopharma Inc	1-((3s,4r)-4-(3-fluorophényl)-1-(2-méthoxyéthyl)pyrrolidin-3-yl)-3-(4-méthyl-3-(2-méthylpyrimidin-5-yl)-1-phényl-1h-pyrazol-5-yl)urée comme inhibiteur de la kinase trka
US10806737B2 (en)	2016-12-23	2020-10-20	Arvinas Operations, Inc.	Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
KR101954370B1 (ko)	2018-07-25	2019-03-05	한미약품 주식회사	피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물
WO2020132384A1 (en)	2018-12-21	2020-06-25	Celgene Corporation	Thienopyridine inhibitors of ripk2
BR112021016522A2 (pt)	2019-02-22	2021-10-26	Hanmi Pharm. Co., Ltd.	Composição farmacêutica para o tratamento da leucemia mieloide aguda
EA202290154A1 (ru)	2019-06-27	2022-03-29	Ханми Фарм. Ко., Лтд.	Фармацевтическая композиция для лечения острого миелоидного лейкоза, содержащая ингибитор flt3 и химиотерапевтические агенты
CN121586574A (zh) *	2023-05-31	2026-02-27	韩美药品株式会社	髓样激酶组抑制剂的固体分散体和包含所述固体分散体的药物组合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT627940E (pt) *	1992-03-05	2003-07-31	Univ Texas	Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados
US5474765A (en) *	1992-03-23	1995-12-12	Ut Sw Medical Ctr At Dallas	Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5932765A (en) *	1997-05-23	1999-08-03	Merck Patent Gesellschaft Mit	Nitromethyl ketones, process for preparing them and compositions containing them
EP1028964A1 (en) *	1997-11-11	2000-08-23	Pfizer Products Inc.	Thienopyrimidine and thienopyridine derivatives useful as anticancer agents
TR200002182T2 (tr) *	1998-01-27	2000-12-21	Aventis Pharmaceuticals Products Inc.	İkame edilmiş aksozaherosayklil faktör xa inhibitörleri
US6342219B1 (en) *	1999-04-28	2002-01-29	Board Of Regents, The University Of Texas System	Antibody compositions for selectively inhibiting VEGF
US6776796B2 (en) *	2000-05-12	2004-08-17	Cordis Corportation	Antiinflammatory drug and delivery device
DE10110750A1 (de) *	2001-03-07	2002-09-12	Bayer Ag	Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
TWI238824B (en) *	2001-05-14	2005-09-01	Novartis Ag	4-amino-5-phenyl-7-cyclobutyl-pyrrolo[2,3-d]pyrimidine derivatives
US7105505B2 (en) *	2002-04-18	2006-09-12	Schering Corporation	Benzimidazole derivatives useful as histamine H3 antagonists
MY141867A (en) *	2002-06-20	2010-07-16	Vertex Pharma	Substituted pyrimidines useful as protein kinase inhibitors
PL375042A1 (en) *	2002-08-12	2005-11-14	Takeda Pharmaceutical Company Limited	Fused benzene derivative and use
EP1566379A4 (en) *	2002-10-29	2005-11-09	Kirin Brewery	CHINOLINE DERIVATIVES AND CHINAZOLINE DERIVATIVES AS INHIBITORS OF FLT3 AUTOPHOSPHORYLATION AND THE MEDICAL COMPOSITIONS CONTAINING THEREOF
US20050026944A1 (en) *	2003-07-24	2005-02-03	Patrick Betschmann	Thienopyridine and furopyridine kinase inhibitors
US20060281769A1 (en) *	2005-06-10	2006-12-14	Baumann Christian A	Synergistic modulation of flt3 kinase using thienopyrimidine and thienopyridine kinase modulators

2006
- 2006-06-06 US US11/422,359 patent/US20060281768A1/en not_active Abandoned
- 2006-06-07 EP EP06772445A patent/EP1899355A1/en not_active Withdrawn
- 2006-06-07 WO PCT/US2006/022151 patent/WO2006135639A1/en not_active Ceased
- 2006-06-07 JP JP2008515879A patent/JP2008543759A/ja not_active Withdrawn
- 2006-06-07 BR BRPI0613644-3A patent/BRPI0613644A2/pt not_active Application Discontinuation
- 2006-06-07 CA CA002611587A patent/CA2611587A1/en not_active Abandoned
- 2006-06-07 NI NI200700311A patent/NI200700311A/es unknown
- 2006-06-07 AU AU2006258049A patent/AU2006258049A1/en not_active Abandoned
- 2006-06-07 MX MX2007015741A patent/MX2007015741A/es unknown
- 2006-06-07 EA EA200800011A patent/EA200800011A1/ru unknown
- 2006-06-07 KR KR1020087000618A patent/KR20080021126A/ko not_active Withdrawn
- 2006-06-08 UY UY29590A patent/UY29590A1/es unknown
- 2006-06-08 PE PE2006000640A patent/PE20070070A1/es not_active Application Discontinuation
- 2006-06-09 TW TW095120482A patent/TW200716651A/zh unknown
- 2006-06-09 AR ARP060102425A patent/AR057063A1/es not_active Application Discontinuation
2007
- 2007-11-27 IL IL187689A patent/IL187689A0/en unknown
- 2007-12-10 EC EC2007007992A patent/ECSP077992A/es unknown
2008
- 2008-01-09 NO NO20080162A patent/NO20080162L/no not_active Application Discontinuation
- 2008-01-09 CR CR9650A patent/CR9650A/es not_active Application Discontinuation
2009
- 2009-01-30 US US12/362,933 patent/US20090143378A1/en not_active Abandoned
- 2009-01-30 US US12/363,043 patent/US20090163710A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1899355A1 (en)	2008-03-19
AU2006258049A1 (en)	2006-12-21
IL187689A0 (en)	2008-08-07
BRPI0613644A2 (pt)	2011-01-25
NI200700311A (es)	2009-03-03
PE20070070A1 (es)	2007-03-08
AR057063A1 (es)	2007-11-14
ECSP077992A (es)	2008-01-23
US20090143378A1 (en)	2009-06-04
TW200716651A (en)	2007-05-01
WO2006135639A1 (en)	2006-12-21
EA200800011A1 (ru)	2008-06-30
CR9650A (es)	2008-09-09
US20060281768A1 (en)	2006-12-14
MX2007015741A (es)	2008-04-29
AU2006258049A8 (en)	2006-12-21
KR20080021126A (ko)	2008-03-06
JP2008543759A (ja)	2008-12-04
CA2611587A1 (en)	2006-12-21
UY29590A1 (es)	2006-10-02
US20090163710A1 (en)	2009-06-25

Legal Events

Date	Code	Title	Description
2011-01-31	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20080162L (no)	2008-03-07	Tienopyrimidin og tienopyrimidinderivater som FLT-3 kinaseinhibitorer
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NO20080161L (no)	2008-01-28	Aminopyrimidiner som kinasemodulatorer
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EA200970486A1 (ru)	2009-10-30	Соединения для ингибирования митоза
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NO20080417L (no)	2008-03-18	Benzosykloheptapyridiner som inhibitorer av reseptortyrosinkinasen MET
MX2010007927A (es)	2010-08-09	Derivados de 4-(pirrolo[2,3-c]piridin-3-il)pirimidin-2-ilamina.
ATE502935T1 (de)	2011-04-15	C-met-proteinkinasehemmer
UA106082C2 (uk)	2014-07-25	АМІНОПІРАЗОЛ ТРИАЗОЛОТІАДІАЗОЛЬНІ ІНГІБІТОРИ ПРОТЕЇНКІНАЗИ c-МЕТ
NZ630353A (en)	2016-06-24	Pyrazolopyrimidines and related heterocycles as ck2 inhibitors
UA109764C2 (uk)	2015-10-12	Похідні ізохінолінону, композиція на їх основі та застосування як інгібіторів рі3k