NO20080359L - Krystallinsk base av escitalopram og orodispergerbare tabletter omfattende escitalopram base - Google Patents

Krystallinsk base av escitalopram og orodispergerbare tabletter omfattende escitalopram base

Info

Publication number: NO20080359L
Authority: NO; Norway
Prior art keywords: escitalopram; base; salts; crystalline; oxalate
Prior art date: 2005-06-22

Application number

NO20080359A

Other languages

English (en)

Norwegian (no)

Inventor

Hans Petersen

Ole Nielsen

Michael Harold Rock

Robert Dancer

Helle Eliasen

Ken Lijegren

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-22

Filing date

2008-01-18

Publication date

2008-01-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37546630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20080359(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-01-18 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

2008-01-18 Publication of NO20080359L publication Critical patent/NO20080359L/no

Links

229960004341 escitalopram Drugs 0.000 title abstract 6
WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title abstract 6
150000003839 salts Chemical class 0.000 abstract 6
239000002585 base Substances 0.000 abstract 3
238000009472 formulation Methods 0.000 abstract 3
238000004519 manufacturing process Methods 0.000 abstract 3
239000000203 mixture Substances 0.000 abstract 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 2
239000008186 active pharmaceutical agent Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
239000000945 filler Substances 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
238000002844 melting Methods 0.000 abstract 1
230000008018 melting Effects 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO20080359A 2005-06-22 2008-01-18 Krystallinsk base av escitalopram og orodispergerbare tabletter omfattende escitalopram base NO20080359L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200500912		2005-06-22
PCT/DK2006/000366 WO2006136169A2 (en)	2005-06-22	2006-06-22	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

Publications (1)

Publication Number	Publication Date
NO20080359L true NO20080359L (no)	2008-01-18

Family

ID=37546630

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20080359A NO20080359L (no)	2005-06-22	2008-01-18	Krystallinsk base av escitalopram og orodispergerbare tabletter omfattende escitalopram base
NO20101777A NO20101777L (no)	2005-06-22	2010-12-20	Orodispergerbare tabletter

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20101777A NO20101777L (no)	2005-06-22	2010-12-20	Orodispergerbare tabletter

Country Status (39)

Country	Link
EP (3)	EP2385044A1 (de)
JP (5)	JP4906852B2 (de)
KR (5)	KR20080018191A (de)
CN (2)	CN101928269A (de)
AR (2)	AR055062A1 (de)
AT (3)	AT10983U1 (de)
AU (2)	AU2006261452B2 (de)
BG (1)	BG66086B1 (de)
BR (1)	BRPI0612295A2 (de)
CA (2)	CA2646780A1 (de)
CY (1)	CY1112392T1 (de)
CZ (3)	CZ301286B6 (de)
DE (2)	DE602006019961D1 (de)
DK (3)	DK1896439T4 (de)
EA (2)	EA201001108A1 (de)
EE (1)	EE00773U1 (de)
ES (2)	ES2319073B1 (de)
FI (2)	FI20080548L (de)
GB (2)	GB2442160B (de)
HR (1)	HRP20110093T4 (de)
HU (1)	HUP0800135A3 (de)
IL (1)	IL187454A0 (de)
IS (1)	IS8705A (de)
LT (1)	LT5550B (de)
LV (1)	LV13677B (de)
MX (1)	MX2007015328A (de)
MY (2)	MY143239A (de)
NO (2)	NO20080359L (de)
PL (2)	PL384185A1 (de)
PT (1)	PT1896439E (de)
RS (1)	RS51575B2 (de)
SG (1)	SG169358A1 (de)
SI (1)	SI1896439T2 (de)
SK (1)	SK500402007A3 (de)
TR (2)	TR200708792T1 (de)
TW (2)	TWI347942B (de)
UA (1)	UA86536C2 (de)
WO (1)	WO2006136169A2 (de)
ZA (2)	ZA200711066B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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GB0123400D0 (en)	2001-09-28	2001-11-21	Novartis Ag	Organic compounds
WO2008059514A2 (en) *	2006-07-31	2008-05-22	Cadila Healthcare Limited	Process for preparing escitalopram
EP2134325A2 (de) *	2007-03-01	2009-12-23	Aurobindo Pharma Limited	Stabile solide dosierformen eines antidepressivums
DK2595979T3 (en)	2010-07-23	2016-05-17	Lundbeck & Co As H	A process for the purification of pharmaceutically acceptable salts of escitalopram
CN103360353A (zh) *	2013-08-07	2013-10-23	中国药科大学	草酸艾司西酞普兰杂质的制备方法
JP2018016569A (ja) *	2016-07-26	2018-02-01	株式会社トクヤマ	（１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法
WO2018190294A1 (ja) *	2017-04-10	2018-10-18	東和薬品株式会社	エスシタロプラム医薬組成物
CN110711198B (zh) *	2018-07-12	2022-03-15	山东大学	D-甘露糖在制备抗抑郁药物中的应用
KR102331187B1 (ko)	2019-04-09	2021-11-26	주식회사 라이트팜텍	에스시탈로프람을 함유하는 안정성이 우수한 경구용 액제 조성물 및 그의 제조방법
WO2022153262A1 (en) *	2021-01-18	2022-07-21	Anton Frenkel	Pharmaceutical dosage form

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GB8814057D0 (en)	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
JPH05222041A (ja) *	1992-02-13	1993-08-31	Mitsubishi Gas Chem Co Inc	アデニン誘導体の精製法
FI962989A0 (fi) *	1994-01-27	1996-07-26	Univ Oklahoma	Nopeasti liukeneva oraalinen annosmuoto
US5607697A (en) *	1995-06-07	1997-03-04	Cima Labs, Incorporated	Taste masking microparticles for oral dosage forms
EP0993524B1 (de)	1997-06-30	2002-11-20	Beloit Technologies, Inc.	Verfahren und vorrichtung zum auftragen einer beschichtung auf eine bei hoher geschwindigkeit laufende papierbahn
TR200000066T2 (tr)	1997-07-08	2000-11-21	H. Lundbeck A/S	Sitalopram hazırlanması için yöntem.
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AR034759A1 (es)	2001-07-13	2004-03-17	Lundbeck & Co As H	Metodo para la preparacion de escitalopram
HRP20031073A2 (en) *	2001-07-31	2004-04-30	Lundbeck & Co As H	Crystalline composition containing escitalopram
IS7239A (is)	2001-12-14	2004-04-29	H. Lundbeck A/S	Aðferð til framleiðslu á essítalóprami
WO2003057132A2 (en) *	2002-01-07	2003-07-17	Sun Pharmaceutical Industries Limited	Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
FR2834889B1 (fr) *	2002-01-18	2004-04-02	Roquette Freres	Forme pharmaceutique solide orodispersible
GB0204607D0 (en) *	2002-02-27	2002-04-10	Matrix Lab Ltd	Process
EP1517676A1 (de) *	2002-05-03	2005-03-30	Skyepharma Canada Inc.	Orale darreichungsformen mit fenofibrat
CN100349885C (zh)	2002-12-23	2007-11-21	H·隆德贝克有限公司	依他普仑氢溴酸盐及其制备方法
CN1510024A (zh) *	2002-12-24	2004-07-07	北京德众万全药物技术开发有限公司	可用于制备西酞普兰(s)-对映异构体的新的化合物及其制备方法
DE10305984A1 (de) *	2003-02-13	2004-09-02	Helm Ag	Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
CN1819819B (zh) *	2003-05-07	2011-03-09	株式会社三养社	用于制备速熔片的高度可塑性颗粒
KR101159617B1 (ko) *	2003-10-15	2012-06-27	후지카가쿠고교가부시키가이샤	구강내 속붕해성 정제
AU2003282383A1 (en) *	2003-11-20	2005-06-08	Natco Pharma Limited	A process for the preparation of high purity escitalopram
HU227491B1 (en) *	2003-11-25	2011-07-28	Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag	Tablet containing citalopram hydrogen bromide
BRPI0508266A (pt) *	2004-03-05	2007-07-31	Lundbeck & Co As H	partìculas cristalinas de oxalato de escitalopram, forma de dosagem única sólida, e, métodos para a fabricação de partìculas cristalinas de oxalato de escitalopram e para reduzir a quantidade de hidroxila que contém impurezas no citalopram, escitalopram ou uma mistura não racêmica de r- e s-citalopram
EP1877394A1 (de) *	2005-04-04	2008-01-16	Jubilant Organosys Limited	Verfahren zur herstellung von escitalopram oder seinen säureadditionssalzen

2006
- 2006-06-15 TW TW095121358A patent/TWI347942B/zh not_active IP Right Cessation
- 2006-06-15 TW TW100102601A patent/TWI358407B/zh not_active IP Right Cessation
- 2006-06-21 MY MYPI2010000618A patent/MY143239A/en unknown
- 2006-06-21 MY MYPI20062933A patent/MY143252A/en unknown
- 2006-06-21 AR ARP060102654A patent/AR055062A1/es not_active Application Discontinuation
- 2006-06-22 HU HU0800135A patent/HUP0800135A3/hu unknown
- 2006-06-22 WO PCT/DK2006/000366 patent/WO2006136169A2/en not_active Ceased
- 2006-06-22 DK DK06742481.2T patent/DK1896439T4/en active
- 2006-06-22 TR TR2007/08792T patent/TR200708792T1/xx unknown
- 2006-06-22 CN CN201010286088XA patent/CN101928269A/zh active Pending
- 2006-06-22 PL PL384185A patent/PL384185A1/pl unknown
- 2006-06-22 KR KR1020077028918A patent/KR20080018191A/ko not_active Ceased
- 2006-06-22 CA CA002646780A patent/CA2646780A1/en not_active Abandoned
- 2006-06-22 BR BRPI0612295-7A patent/BRPI0612295A2/pt not_active IP Right Cessation
- 2006-06-22 EP EP10179318A patent/EP2385044A1/de not_active Withdrawn
- 2006-06-22 CA CA2612827A patent/CA2612827C/en not_active Expired - Fee Related
- 2006-06-22 GB GB0724557A patent/GB2442160B/en not_active Expired - Fee Related
- 2006-06-22 PT PT06742481T patent/PT1896439E/pt unknown
- 2006-06-22 CZ CZ20080429A patent/CZ301286B6/cs not_active IP Right Cessation
- 2006-06-22 CZ CZ20070898A patent/CZ299906B6/cs not_active IP Right Cessation
- 2006-06-22 AT AT0900506U patent/AT10983U1/de not_active IP Right Cessation
- 2006-06-22 DE DE602006019961T patent/DE602006019961D1/de active Active
- 2006-06-22 GB GB0811164A patent/GB2448834B/en not_active Expired - Fee Related
- 2006-06-22 KR KR1020117015711A patent/KR20110084341A/ko not_active Ceased
- 2006-06-22 ES ES200750085A patent/ES2319073B1/es not_active Expired - Fee Related
- 2006-06-22 RS RS20110057A patent/RS51575B2/sr unknown
- 2006-06-22 KR KR1020107026804A patent/KR20100133023A/ko not_active Ceased
- 2006-06-22 FI FI20080548A patent/FI20080548L/fi unknown
- 2006-06-22 AT AT06742481T patent/ATE497500T1/de active
- 2006-06-22 HR HRP20110093TT patent/HRP20110093T4/hr unknown
- 2006-06-22 EA EA201001108A patent/EA201001108A1/ru unknown
- 2006-06-22 SI SI200630923T patent/SI1896439T2/sl unknown
- 2006-06-22 CZ CZ20080430A patent/CZ300686B6/cs not_active IP Right Cessation
- 2006-06-22 EP EP10179395A patent/EP2325177A1/de not_active Withdrawn
- 2006-06-22 UA UAA200800362A patent/UA86536C2/ru unknown
- 2006-06-22 FI FI20077133A patent/FI20077133A7/fi unknown
- 2006-06-22 EA EA200800102A patent/EA019239B1/ru not_active IP Right Cessation
- 2006-06-22 PL PL06742481T patent/PL1896439T5/pl unknown
- 2006-06-22 CN CNA2006800200393A patent/CN101189220A/zh active Pending
- 2006-06-22 KR KR1020127014205A patent/KR20120064140A/ko not_active Ceased
- 2006-06-22 MX MX2007015328A patent/MX2007015328A/es active IP Right Grant
- 2006-06-22 ES ES06742481.2T patent/ES2356838T5/es active Active
- 2006-06-22 TR TR2010/00625T patent/TR201000625T1/xx unknown
- 2006-06-22 SG SG201100648-3A patent/SG169358A1/en unknown
- 2006-06-22 EE EEU200800003U patent/EE00773U1/xx not_active IP Right Cessation
- 2006-06-22 KR KR1020117005777A patent/KR101340815B1/ko active Active
- 2006-06-22 AU AU2006261452A patent/AU2006261452B2/en not_active Withdrawn - After Issue
- 2006-06-22 JP JP2008517323A patent/JP4906852B2/ja active Active
- 2006-06-22 EP EP06742481.2A patent/EP1896439B2/de active Active
- 2006-06-22 ZA ZA200711066A patent/ZA200711066B/xx unknown
- 2006-06-22 DE DE112006001619T patent/DE112006001619T5/de not_active Withdrawn
- 2006-06-22 SK SK50040-2007A patent/SK500402007A3/sk unknown
2007
- 2007-11-18 IL IL187454A patent/IL187454A0/en unknown
- 2007-12-19 BG BG10110024A patent/BG66086B1/bg unknown
- 2007-12-21 LV LVP-07-157A patent/LV13677B/lv unknown
2008
- 2008-01-14 IS IS8705A patent/IS8705A/is unknown
- 2008-01-18 NO NO20080359A patent/NO20080359L/no unknown
- 2008-01-21 DK DK200800075A patent/DK200800075A/da not_active Application Discontinuation
- 2008-01-21 LT LT2008005A patent/LT5550B/lt not_active IP Right Cessation
- 2008-10-07 JP JP2008260742A patent/JP4415056B2/ja active Active
2009
- 2009-02-27 DK DKPA200900284A patent/DK200900284A/da not_active Application Discontinuation
- 2009-03-10 ZA ZA200901698A patent/ZA200901698B/en unknown
- 2009-05-12 JP JP2009115279A patent/JP2009179634A/ja active Pending
- 2009-05-12 JP JP2009115280A patent/JP2009179635A/ja active Pending
- 2009-07-07 AT AT0041709U patent/AT11883U1/de not_active IP Right Cessation
2010
- 2010-03-05 AU AU2010200844A patent/AU2010200844A1/en not_active Withdrawn
- 2010-12-20 NO NO20101777A patent/NO20101777L/no not_active Application Discontinuation
- 2010-12-27 AR ARP100104958A patent/AR079750A2/es not_active Application Discontinuation
2011
- 2011-02-03 CY CY20111100116T patent/CY1112392T1/el unknown
- 2011-11-24 JP JP2011255804A patent/JP5731957B2/ja active Active

Also Published As

Publication number	Publication date
EA019239B1 (ru)	2014-02-28
AT11883U1 (de)	2011-06-15
EP1896439A2 (de)	2008-03-12
GB2442160A (en)	2008-03-26
PT1896439E (pt)	2011-02-15
TW200740785A (en)	2007-11-01
JP4906852B2 (ja)	2012-03-28
CA2612827A1 (en)	2006-12-28
BG66086B1 (bg)	2011-03-31
JP2009046506A (ja)	2009-03-05
KR20120064140A (ko)	2012-06-18
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