NO20080461L - Solvat av kabergolin og preparater av kobergolin form I - Google Patents
Solvat av kabergolin og preparater av kobergolin form IInfo
- Publication number
- NO20080461L NO20080461L NO20080461A NO20080461A NO20080461L NO 20080461 L NO20080461 L NO 20080461L NO 20080461 A NO20080461 A NO 20080461A NO 20080461 A NO20080461 A NO 20080461A NO 20080461 L NO20080461 L NO 20080461L
- Authority
- NO
- Norway
- Prior art keywords
- cabergoline
- cobergoline
- preparations
- solvent
- solvate
- Prior art date
Links
- KORNTPPJEAJQIU-KJXAQDMKSA-N Cabaser Chemical compound C1=CC([C@H]2C[C@H](CN(CC=C)[C@@H]2C2)C(=O)N(CCCN(C)C)C(=O)NCC)=C3C2=CNC3=C1 KORNTPPJEAJQIU-KJXAQDMKSA-N 0.000 title abstract 7
- 229960004596 cabergoline Drugs 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000002904 solvent Substances 0.000 title 1
- 239000012453 solvate Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- -1 p-disubstituted benzene Chemical class 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Fremgangsmåte for fremstilling av kabergolin Form I, som omfatter å danne et solvat inkluderende kabergolin og et p-disubstituert benzen med formel (A) og å oppnå kabergolin Form I fra solvatet. Et annet aspekt av den foreliggende oppfinnelse tilveiebringer en fremgangsmåte for fremstilling av kabergolin Form I som omfatter å oppløse kabergolin i p-disubstituert benzen og å utvinne kabergolin Form I poly-lomorfen, passende ved direkte krystallisering av Form I eller ved utvinning av et solvat som kan omdannes til Form I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0515430.7A GB0515430D0 (en) | 2005-07-27 | 2005-07-27 | Preparation of cabergoline |
| PCT/GB2006/002784 WO2007012846A1 (en) | 2005-07-27 | 2006-07-27 | Solvate of cabergoline and preparations of cabergoline form i |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20080461L true NO20080461L (no) | 2008-04-18 |
Family
ID=34976701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20080461A NO20080461L (no) | 2005-07-27 | 2008-01-24 | Solvat av kabergolin og preparater av kobergolin form I |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1912984A1 (no) |
| JP (1) | JP2009502895A (no) |
| CN (1) | CN101228159A (no) |
| AU (1) | AU2006273831A1 (no) |
| CA (1) | CA2616738A1 (no) |
| GB (1) | GB0515430D0 (no) |
| IL (1) | IL188598A0 (no) |
| NO (1) | NO20080461L (no) |
| WO (1) | WO2007012846A1 (no) |
| ZA (1) | ZA200801151B (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1925616A1 (en) * | 2006-10-26 | 2008-05-28 | LEK Pharmaceuticals D.D. | Process for the preparation of crystal forms of cabergoline via stable solvates of cabergoline |
| CN104147041B (zh) * | 2014-08-17 | 2017-02-22 | 山西振东安特生物制药有限公司 | 一种含胶体果胶铋的分散制剂及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0007308D0 (en) * | 2000-03-24 | 2000-05-17 | Pharmacia & Upjohn Spa | Process for preparing crystalline form | of cabergoline |
| KR100605794B1 (ko) * | 2002-03-15 | 2006-08-01 | 파마시아 코포레이션 | 카베르골린의 제1형 결정을 제조하는 방법 |
| MXPA04008915A (es) * | 2002-03-15 | 2005-06-20 | Pharmacia Corp | Proceso para la preparacion de la forma cristalina 1 de la cabergolina. |
| EP1620101A4 (en) * | 2003-05-08 | 2008-07-09 | Ivax Pharmaceuticals Sro | POLYMORPHS OF CABERGOLIN |
-
2005
- 2005-07-27 GB GBGB0515430.7A patent/GB0515430D0/en not_active Ceased
-
2006
- 2006-07-27 JP JP2008523446A patent/JP2009502895A/ja not_active Withdrawn
- 2006-07-27 AU AU2006273831A patent/AU2006273831A1/en not_active Abandoned
- 2006-07-27 ZA ZA200801151A patent/ZA200801151B/xx unknown
- 2006-07-27 CN CNA200680027137XA patent/CN101228159A/zh active Pending
- 2006-07-27 WO PCT/GB2006/002784 patent/WO2007012846A1/en not_active Ceased
- 2006-07-27 CA CA002616738A patent/CA2616738A1/en not_active Abandoned
- 2006-07-27 EP EP06765107A patent/EP1912984A1/en not_active Withdrawn
-
2008
- 2008-01-06 IL IL188598A patent/IL188598A0/en unknown
- 2008-01-24 NO NO20080461A patent/NO20080461L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2616738A1 (en) | 2007-02-01 |
| CN101228159A (zh) | 2008-07-23 |
| ZA200801151B (en) | 2009-04-29 |
| AU2006273831A1 (en) | 2007-02-01 |
| GB0515430D0 (en) | 2005-08-31 |
| EP1912984A1 (en) | 2008-04-23 |
| JP2009502895A (ja) | 2009-01-29 |
| IL188598A0 (en) | 2008-04-13 |
| WO2007012846A1 (en) | 2007-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |