NO20082805L - Bicykliske cinnamidforbindelser - Google Patents

Bicykliske cinnamidforbindelser

Info

Publication number
NO20082805L
NO20082805L NO20082805A NO20082805A NO20082805L NO 20082805 L NO20082805 L NO 20082805L NO 20082805 A NO20082805 A NO 20082805A NO 20082805 A NO20082805 A NO 20082805A NO 20082805 L NO20082805 L NO 20082805L
Authority
NO
Norway
Prior art keywords
group
optionally substituted
alkyl
bicyclic
bicyclic cinnamide
Prior art date
Application number
NO20082805A
Other languages
English (en)
Inventor
Koichi Ito
Teiji Kimura
Koki Kawano
Eriko Doi
Noritaka Kitazawa
Takehiko Miyagawa
Toshihiko Kaneko
Mamoru Takaishi
Takeo Sasaki
Hiroaki Hagiwara
Yu Yoshida
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of NO20082805L publication Critical patent/NO20082805L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En bisyklisk cinnamidforbindelse representerert ved den generelle forniel (l): hvori ---- representerer en enkeltbinding eller en dobbeltbinding; Ar1 representerer en fenylgruppe eller pyridinylgruppe eventuelt substituert med en til tre substituenter; R1 og R2 representerer hver en C1-6 alkylgruppe, en hydroksylgruppe, etc.; Z1 representerer en eventuelt substituert metylengruppe eller vinylengruppe, et oksygenatom, eller en iminigruppe eventuelt substituert ved en C1-6 alkylgruppe eller en C1-6 acylgruppe; og p, q og r er hver et helt tall fra 0 til 2. Den fungerer med å redusere produksjon av Aß40 og Aß42. Den er således særlig anvendelig som et preventivt eller botende middel for neurodegenerative sykdommer hvor Aß er årsaken, slik som Alzheimer's sykdom og Down's syndrom.
NO20082805A 2005-11-24 2008-06-19 Bicykliske cinnamidforbindelser NO20082805L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005337963 2005-11-24
JP2006205538 2006-07-28
PCT/JP2006/321877 WO2007060821A1 (ja) 2005-11-24 2006-11-01 ２環式シンナミド化合物

Publications (1)

Publication Number Publication Date
NO20082805L true NO20082805L (no) 2008-08-20

Family

ID=38067057

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082805A NO20082805L (no) 2005-11-24 2008-06-19 Bicykliske cinnamidforbindelser

Country Status (25)

Country Link
US (1) US8048878B2 (no)
EP (1) EP1953158B1 (no)
JP (1) JP5178203B2 (no)
KR (1) KR101296239B1 (no)
AR (1) AR057915A1 (no)
AU (1) AU2006317468B2 (no)
BR (1) BRPI0618890A2 (no)
CA (1) CA2629512C (no)
CR (1) CR9983A (no)
EA (1) EA014427B1 (no)
EC (1) ECSP088466A (no)
ES (1) ES2394364T3 (no)
GE (1) GEP20115172B (no)
HN (1) HN2008000792A (no)
MA (1) MA29968B1 (no)
ME (1) ME00040B (no)
MY (1) MY144596A (no)
NO (1) NO20082805L (no)
NZ (1) NZ568422A (no)
PE (1) PE20071029A1 (no)
PL (1) PL1953158T3 (no)
RS (1) RS20080242A (no)
SA (1) SA06270432B1 (no)
TW (1) TWI370130B (no)
WO (1) WO2007060821A1 (no)

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Also Published As

Publication number Publication date
PL1953158T3 (pl) 2013-02-28
CA2629512A1 (en) 2007-05-31
TWI370130B (en) 2012-08-11
JP5178203B2 (ja) 2013-04-10
WO2007060821A1 (ja) 2007-05-31
KR20080072057A (ko) 2008-08-05
EA014427B1 (ru) 2010-12-30
BRPI0618890A2 (pt) 2013-01-08
JPWO2007060821A1 (ja) 2009-05-07
ECSP088466A (es) 2008-08-29
AU2006317468A1 (en) 2007-05-31
KR101296239B1 (ko) 2013-08-13
EA200801417A1 (ru) 2009-02-27
PE20071029A1 (es) 2007-11-17
US8048878B2 (en) 2011-11-01
AR057915A1 (es) 2007-12-26
EP1953158A4 (en) 2010-09-01
EP1953158A1 (en) 2008-08-06
EP1953158B1 (en) 2012-09-12
AU2006317468B2 (en) 2011-10-13
MY144596A (en) 2011-10-14
HN2008000792A (es) 2010-09-17
RS20080242A (sr) 2009-09-08
CA2629512C (en) 2014-04-22
MA29968B1 (fr) 2008-11-03
NZ568422A (en) 2010-09-30
CR9983A (es) 2008-08-21
GEP20115172B (en) 2011-03-10
US20090181945A1 (en) 2009-07-16
ES2394364T3 (es) 2013-01-31
TW200804372A (en) 2008-01-16
SA06270432B1 (ar) 2011-06-22
ME00040B (me) 2010-06-10
HK1122806A1 (en) 2009-05-29

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