NO20082748L - Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater - Google Patents

Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater

Info

Publication number
NO20082748L
NO20082748L NO20082748A NO20082748A NO20082748L NO 20082748 L NO20082748 L NO 20082748L NO 20082748 A NO20082748 A NO 20082748A NO 20082748 A NO20082748 A NO 20082748A NO 20082748 L NO20082748 L NO 20082748L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
aryl
isoxazol
imidazo
Prior art date
Application number
NO20082748A
Other languages
English (en)
Norwegian (no)
Inventor
Bernd Buettelmann
Bo Han
Henner Knust
Andrew Thomas
Jiaqiang Dong
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20082748L publication Critical patent/NO20082748L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20082748A 2005-12-27 2008-06-13 Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater NO20082748L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05112988 2005-12-27
PCT/EP2006/069792 WO2007074089A1 (en) 2005-12-27 2006-12-18 Aryl-isoxazol-4-yl-imidazo[1, 5-a]pyridine derivatives

Publications (1)

Publication Number Publication Date
NO20082748L true NO20082748L (no) 2008-09-24

Family

ID=37909303

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082748A NO20082748L (no) 2005-12-27 2008-06-13 Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater

Country Status (17)

Country Link
US (1) US7399769B2 (de)
EP (1) EP1968977B1 (de)
JP (1) JP4864982B2 (de)
KR (1) KR101033719B1 (de)
CN (1) CN101346377B (de)
AR (1) AR058728A1 (de)
AT (1) ATE537171T1 (de)
AU (1) AU2006331363B2 (de)
BR (1) BRPI0620760A2 (de)
CA (1) CA2633536A1 (de)
ES (1) ES2376357T3 (de)
IL (1) IL192236A0 (de)
NO (1) NO20082748L (de)
RU (1) RU2420527C2 (de)
TW (1) TWI324156B (de)
WO (1) WO2007074089A1 (de)
ZA (1) ZA200805354B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101121372B1 (ko) * 2005-12-27 2012-04-12 에프. 호프만-라 로슈 아게 아릴-이속사졸-4-일-이미다졸 유도체
CA2690975A1 (en) * 2007-06-22 2008-12-31 F. Hoffmann-La Roche Ag Isoxazole-imidazole derivatives
CN101889010B (zh) 2007-12-04 2012-12-05 弗·哈夫曼-拉罗切有限公司 异*唑-吡啶衍生物
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
CN104411703A (zh) 2012-06-26 2015-03-11 萨尼奥纳有限责任公司 苯基三唑衍生物及其调节gabaa受体复合体的用途
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
CN104411699B (zh) 2012-06-26 2017-06-13 萨尼奥纳有限责任公司 苯基三唑衍生物及其用于调节gabaa 受体复合体的用途
CN106164066B (zh) 2014-02-13 2020-01-17 因赛特公司 作为lsd1抑制剂的环丙胺
BR112016018555B1 (pt) 2014-02-13 2024-01-23 Incyte Holdings Corporation Ciclopropilaminas como inibidores de lsd1, seu uso, composição farmacêutica que os compreende e método de inibição de lsd1
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
TWI687419B (zh) * 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
ES2757948T3 (es) 2015-04-03 2020-04-30 Incyte Corp Compuestos heterocíclicos como inhibidores LSD1
CN110402244B (zh) 2015-08-12 2023-02-03 因赛特公司 Lsd1抑制剂的盐
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2213611T3 (es) * 1999-10-08 2004-09-01 Grunenthal Gmbh Derivados biciclicos de imidazo-3-il-amina.
CA2388593A1 (en) * 1999-11-12 2001-05-17 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds
DE60225174T2 (de) 2001-11-20 2009-02-12 Eli Lilly And Co., Indianapolis Beta-3 adrenergische agonisten

Also Published As

Publication number Publication date
ZA200805354B (en) 2009-10-28
EP1968977B1 (de) 2011-12-14
US7399769B2 (en) 2008-07-15
CN101346377B (zh) 2011-05-11
AU2006331363B2 (en) 2012-07-05
BRPI0620760A2 (pt) 2011-11-22
CN101346377A (zh) 2009-01-14
IL192236A0 (en) 2008-12-29
RU2420527C2 (ru) 2011-06-10
WO2007074089A1 (en) 2007-07-05
ES2376357T3 (es) 2012-03-13
AR058728A1 (es) 2008-02-20
ATE537171T1 (de) 2011-12-15
CA2633536A1 (en) 2007-07-05
JP4864982B2 (ja) 2012-02-01
TW200734328A (en) 2007-09-16
JP2009521517A (ja) 2009-06-04
AU2006331363A1 (en) 2007-07-05
US20070191421A1 (en) 2007-08-16
RU2008125040A (ru) 2010-02-10
TWI324156B (en) 2010-05-01
KR20080072072A (ko) 2008-08-05
KR101033719B1 (ko) 2011-05-09
EP1968977A1 (de) 2008-09-17

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