NO20082748L - Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater - Google Patents

Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater

Info

Publication number
NO20082748L
NO20082748L NO20082748A NO20082748A NO20082748L NO 20082748 L NO20082748 L NO 20082748L NO 20082748 A NO20082748 A NO 20082748A NO 20082748 A NO20082748 A NO 20082748A NO 20082748 L NO20082748 L NO 20082748L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
aryl
isoxazol
imidazo
Prior art date
Application number
NO20082748A
Other languages
English (en)
Norwegian (no)
Inventor
Bernd Buettelmann
Bo Han
Henner Knust
Andrew Thomas
Jiaqiang Dong
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20082748L publication Critical patent/NO20082748L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20082748A 2005-12-27 2008-06-13 Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater NO20082748L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05112988 2005-12-27
PCT/EP2006/069792 WO2007074089A1 (en) 2005-12-27 2006-12-18 Aryl-isoxazol-4-yl-imidazo[1, 5-a]pyridine derivatives

Publications (1)

Publication Number Publication Date
NO20082748L true NO20082748L (no) 2008-09-24

Family

ID=37909303

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082748A NO20082748L (no) 2005-12-27 2008-06-13 Aryl-isoksazol-4-yl-imidazo[1, 5-a]pyridinderivater

Country Status (17)

Country Link
US (1) US7399769B2 (de)
EP (1) EP1968977B1 (de)
JP (1) JP4864982B2 (de)
KR (1) KR101033719B1 (de)
CN (1) CN101346377B (de)
AR (1) AR058728A1 (de)
AT (1) ATE537171T1 (de)
AU (1) AU2006331363B2 (de)
BR (1) BRPI0620760A2 (de)
CA (1) CA2633536A1 (de)
ES (1) ES2376357T3 (de)
IL (1) IL192236A0 (de)
NO (1) NO20082748L (de)
RU (1) RU2420527C2 (de)
TW (1) TWI324156B (de)
WO (1) WO2007074089A1 (de)
ZA (1) ZA200805354B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101121372B1 (ko) * 2005-12-27 2012-04-12 에프. 호프만-라 로슈 아게 아릴-이속사졸-4-일-이미다졸 유도체
BRPI0814718A2 (pt) * 2007-06-22 2015-02-24 Hoffmann La Roche Derivados de isoxazol-imidazol
EP2227467B1 (de) 2007-12-04 2014-12-31 F. Hoffmann-La Roche AG Isoxazolo-pyridin-derivate
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
WO2014001279A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
KR20150033679A (ko) 2012-06-26 2015-04-01 사니오나 에이피에스 페닐 트리아졸 유도체 및 이의 gabaa 수용체 복합체 조절용 용도
WO2014001278A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
WO2014001280A1 (en) 2012-06-26 2014-01-03 Aniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
CA2876778A1 (en) 2012-06-26 2014-01-03 Saniona Aps A phenyl triazole derivative and its use for modulating the gabaa receptor complex
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
NZ723203A (en) 2014-02-13 2020-08-28 Incyte Corp Cyclopropylamines as lsd1 inhibitors
KR102421235B1 (ko) 2014-02-13 2022-07-15 인사이트 코포레이션 Lsd1 저해제로서 사이클로프로필아민
WO2016007731A1 (en) * 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
UA122688C2 (uk) 2015-04-03 2020-12-28 Інсайт Корпорейшн Гетероциклічні сполуки як інгібітори lsd1
JP7427363B2 (ja) 2015-08-12 2024-02-05 インサイト・ホールディングス・コーポレイション Ｌｓｄ１阻害剤の塩
BR102019014802A2 (pt) 2018-07-20 2020-02-04 Boehringer Ingelheim Int difluorometil-fenil triazóis
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1218382E (pt) * 1999-10-08 2004-06-30 Gruenenthal Gmbh Derivados de imidazo-3-il-amina biciclica
MXPA02004735A (es) * 1999-11-12 2003-01-28 Orive Javier Uhthoff Compuestos heteroaromaticos, biciclicos y triciclicos.
AU2002353844A1 (en) * 2001-11-20 2003-06-10 Eli Lilly And Company Beta 3 adrenergic agonists

Also Published As

Publication number Publication date
CN101346377B (zh) 2011-05-11
RU2420527C2 (ru) 2011-06-10
RU2008125040A (ru) 2010-02-10
KR101033719B1 (ko) 2011-05-09
TWI324156B (en) 2010-05-01
IL192236A0 (en) 2008-12-29
AR058728A1 (es) 2008-02-20
ATE537171T1 (de) 2011-12-15
JP2009521517A (ja) 2009-06-04
AU2006331363B2 (en) 2012-07-05
US20070191421A1 (en) 2007-08-16
CN101346377A (zh) 2009-01-14
BRPI0620760A2 (pt) 2011-11-22
EP1968977A1 (de) 2008-09-17
ZA200805354B (en) 2009-10-28
ES2376357T3 (es) 2012-03-13
TW200734328A (en) 2007-09-16
AU2006331363A1 (en) 2007-07-05
JP4864982B2 (ja) 2012-02-01
EP1968977B1 (de) 2011-12-14
US7399769B2 (en) 2008-07-15
KR20080072072A (ko) 2008-08-05
CA2633536A1 (en) 2007-07-05
WO2007074089A1 (en) 2007-07-05

Similar Documents

Publication Publication Date Title
NO20082956L (no) Aryl-isoksazol-4-yl-imidazo[1,2-A]pyridin anvendbar for behandling av Alzheimers sykdom via GABA-reseptorer
WO2023185864A1 (en) Compounds for Targeted Degradation of KRAS
CN111741769B (zh) 一种多功能化合物、其制备方法及其在医药上的应用
EP3209656B1 (de) Indol-carboxamide als kinaseinhibitoren geeignete verbindungen
JP5933746B2 (ja) イミダゾリジンジオン系化合物およびその用途
NO20082719L (no) Aryl-isoksazol-4-yl-oksadiazolderivater
JP7130873B2 (ja) バニン阻害剤としてのヘテロ芳香族化合物
CN106795165B (zh) 咪唑并哒嗪化合物
WO2016014522A1 (en) Inhibitors of deubiquitinating proteases
WO2009134617A1 (en) Aminodihydrothiazine derivatives as bace inhibitors for the treatment of alzheimer's disease
BR112017018832B1 (pt) Profármacos de riluzol e seu uso e composição
NO20082747L (no) Arylisoksazol-4-yl-imidazolderivater
NO20075365L (no) 3,4-substituerte pyrrolidinderivater for behandling av hypertensjon
Sadashiva et al. Synthesis and efficacy of 1-[bis (4-fluorophenyl)-methyl] piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer’s disease
EP3172210A1 (de) Olopyrimidine compounds
TW200734328A (en) Aryl-isoxazolo-4-yl-imidazo [1,5-a] pyridine derivatives
HUT71353A (en) 4-[4'-piperidinyl or 3'pirrolidinyl] substituted imidazoles as h3-receptor antagonists and therapeutic uses thereof
JP2012520288A (ja) ピラゾロ［１，５−ａ］−１，３，５−トリアジン誘導体、その調製、及びその治療的使用方法
US20210130348A1 (en) Positive allosteric modulators of the muscarinic acetylcholine receptor m1
JP2017531680A (ja) 三環式アトロプ異性体の化合物
UA123071C2 (uk) ІНГІБІТОРИ ДОФАМІН-<font face="Symbol">b</font>-ГІДРОКСИЛАЗИ
EP2261224A3 (de) 6-(Pyridinyl)-4-Pyrimidonderivate als Tau-Proteinkinase-1-Hemmer
CN114127050A (zh) 适用于稳定化致淀粉样变免疫球蛋白轻链的苯并吡喃和咪唑衍生物
Hashem et al. Synthesis and reactions of some 2 (3h) and 2 (5h) furanone derivatives: a comparative study
CN1314674C (zh) 2－氨基－二氢噻唑衍生物及其作为诱导型no－合酶抑制剂的用途

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application