NO20083598L - Karbosykliske og heterosykliske arylsulfoner som inhibitorer av gamma-sekretase - Google Patents
Karbosykliske og heterosykliske arylsulfoner som inhibitorer av gamma-sekretaseInfo
- Publication number
- NO20083598L NO20083598L NO20083598A NO20083598A NO20083598L NO 20083598 L NO20083598 L NO 20083598L NO 20083598 A NO20083598 A NO 20083598A NO 20083598 A NO20083598 A NO 20083598A NO 20083598 L NO20083598 L NO 20083598L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- arylsulfones
- carbocyclic
- heterocyclic
- gamma secretase
- Prior art date
Links
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title 1
- 125000002837 carbocyclic group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000003540 gamma secretase inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/14—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/20—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76084206P | 2006-01-20 | 2006-01-20 | |
| US81487106P | 2006-06-19 | 2006-06-19 | |
| PCT/US2007/001302 WO2007084595A2 (en) | 2006-01-20 | 2007-01-18 | Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20083598L true NO20083598L (no) | 2008-10-20 |
Family
ID=38171604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083598A NO20083598L (no) | 2006-01-20 | 2008-08-19 | Karbosykliske og heterosykliske arylsulfoner som inhibitorer av gamma-sekretase |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8067621B2 (pt) |
| EP (1) | EP1976843B1 (pt) |
| JP (1) | JP5047992B2 (pt) |
| KR (1) | KR20080095885A (pt) |
| CN (1) | CN102702044A (pt) |
| AR (1) | AR059075A1 (pt) |
| AU (1) | AU2007207481B2 (pt) |
| BR (1) | BRPI0706685A2 (pt) |
| CA (1) | CA2637897A1 (pt) |
| EC (1) | ECSP088638A (pt) |
| IL (1) | IL192906A0 (pt) |
| MX (1) | MX2008009414A (pt) |
| NO (1) | NO20083598L (pt) |
| PE (1) | PE20071321A1 (pt) |
| RU (1) | RU2448964C2 (pt) |
| TW (1) | TW200738666A (pt) |
| WO (1) | WO2007084595A2 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005097768A2 (en) * | 2004-04-05 | 2005-10-20 | Schering Corporation | Novel gamma secretase inhibitors |
| PE20060481A1 (es) * | 2004-06-30 | 2006-06-19 | Schering Corp | N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas |
| CN102702044A (zh) | 2006-01-20 | 2012-10-03 | 先灵公司 | 作为γ分泌酶抑制剂的碳环和杂环芳基砜化合物 |
| WO2009008980A2 (en) * | 2007-07-05 | 2009-01-15 | Schering Corporation | Tetrahydropyranochromene gamma secretase inhibitors |
| EP2178882B1 (en) * | 2007-07-17 | 2013-04-17 | Merck Sharp & Dohme Corp. | Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| CA2830027C (en) * | 2011-03-31 | 2016-04-26 | Pfizer Inc. | Novel bicyclic pyridinones |
| WO2012138678A1 (en) * | 2011-04-04 | 2012-10-11 | Merck Sharp & Dohme Corp. | Gamma secretase inhibitors |
| US9226927B2 (en) | 2011-09-09 | 2016-01-05 | Merck Sharp & Dohme Corp. | Gamma secretase inhibitors |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| EP2925313A4 (en) * | 2012-11-29 | 2016-05-11 | Merck Sharp & Dohme | SPIROCYCLIC SULPHONES AS GAMMA SECRETASE INHIBITORS |
| JP6387360B2 (ja) | 2013-03-14 | 2018-09-05 | ノバルティス アーゲー | 変異ｉｄｈの阻害薬としての３−ピリミジン−４−イル−オキサゾリジン−２−オン |
| US9643947B2 (en) | 2013-08-28 | 2017-05-09 | Northwestern University | 7-membered fused heterocycles and methods of their synthesis |
| MX368391B (es) | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
| AR104555A1 (es) * | 2015-05-07 | 2017-07-26 | Bristol Myers Squibb Co | SULFONAS TRICÍCLICAS COMO MODULARES DE RORg |
| SG11201805286RA (en) * | 2015-12-24 | 2018-07-30 | Kyowa Hakko Kirin Co Ltd | α,β-UNSATURATED AMIDE COMPOUND |
| EP3523279A1 (en) * | 2016-10-10 | 2019-08-14 | Bristol-Myers Squibb Company | Tricyclic sulfones as ror gamma modulators |
| KR102506326B1 (ko) * | 2016-10-13 | 2023-03-03 | 브리스톨-마이어스 스큅 컴퍼니 | Ror 감마 조정제로서의 헤테로시클릭 술폰 |
| AR110152A1 (es) * | 2016-11-09 | 2019-02-27 | Bristol Myers Squibb Co | SULFONAS TRICÍCLICAS COMO MODULADORES DE RORg |
| EP3634978A1 (en) | 2017-06-07 | 2020-04-15 | Adrx, Inc. | Tau aggregation inhibitors |
| US11447471B2 (en) | 2017-06-23 | 2022-09-20 | Kyowa Kirin Co., Ltd. | α,β-unsaturated amide compound |
| EP3668886A2 (en) | 2017-08-18 | 2020-06-24 | Adrx, Inc. | Tau aggregation peptide inhibitors |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| CN112119060A (zh) * | 2018-05-17 | 2020-12-22 | 百时美施贵宝公司 | 作为RORγ调节剂的三环砜化合物 |
| CN120923391B (zh) * | 2025-08-01 | 2026-04-17 | 西北大学 | 一种钴催化砜基联烯与有机硼酸反应合成α-取代烯丙基砜的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4826967A (en) * | 1987-06-16 | 1989-05-02 | Naxcor | Psoralen-nucleoside adducts and method for their preparation |
| FR2639349B1 (fr) * | 1988-11-23 | 1991-02-22 | Sanofi Sa | Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant |
| CA2009664A1 (en) * | 1989-02-27 | 1990-08-27 | Philip Thiam Shin Lau | Tetrahydroquinolines and method of preparation |
| US5416087A (en) * | 1990-10-10 | 1995-05-16 | Wong; Jesse K. | Bis-benzo, cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use |
| WO1995020587A1 (en) * | 1994-01-31 | 1995-08-03 | Pfizer Inc. | Neuroprotective chroman compounds |
| DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| JP3810838B2 (ja) * | 1994-12-12 | 2006-08-16 | 三共アグロ株式会社 | 除草性イソオキサゾリン誘導体 |
| KR20020009383A (ko) * | 1998-04-01 | 2002-02-01 | 우에노 도시오 | 축합 티오펜 유도체 및 이의 유도체를 유효 성분으로 하는약제 |
| NZ514453A (en) | 1999-02-26 | 2003-04-29 | Merck & Co Inc | Novel sulfonamide compounds and uses thereof |
| AR034390A1 (es) | 2001-08-03 | 2004-02-25 | Schering Corp | Derivados de 1-sulfonil-tetrahidro quinolinas sustituidas, composiciones farmaceuticas y el uso de las mismas para la elaboracion de medicamentos como inhibidores de la gama secretasa |
| GB0223039D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| MXPA05012323A (es) * | 2003-05-16 | 2006-01-30 | Merck Sharp & Dohme | Sulfonamidas ciclicas para la inhibicion de gama-secretasa. |
| EP1586561A1 (en) | 2004-04-13 | 2005-10-19 | Cephalon, Inc. | Bicyclic aromatic sulfinyl derivatives |
| PE20060481A1 (es) | 2004-06-30 | 2006-06-19 | Schering Corp | N-arilsulfonilaminas heterociclicas sustituidas como inhibidores de gamma-secretasas |
| CN102702044A (zh) | 2006-01-20 | 2012-10-03 | 先灵公司 | 作为γ分泌酶抑制剂的碳环和杂环芳基砜化合物 |
| TW200813054A (en) | 2006-06-02 | 2008-03-16 | Elan Pharm Inc | Fused, tricyclic sulfonamide inhibitors of gamma secretase |
| WO2009008980A2 (en) | 2007-07-05 | 2009-01-15 | Schering Corporation | Tetrahydropyranochromene gamma secretase inhibitors |
-
2007
- 2007-01-18 CN CN2012101778321A patent/CN102702044A/zh active Pending
- 2007-01-18 BR BRPI0706685-6A patent/BRPI0706685A2/pt not_active IP Right Cessation
- 2007-01-18 WO PCT/US2007/001302 patent/WO2007084595A2/en not_active Ceased
- 2007-01-18 KR KR1020087020378A patent/KR20080095885A/ko not_active Withdrawn
- 2007-01-18 JP JP2008551381A patent/JP5047992B2/ja not_active Expired - Fee Related
- 2007-01-18 US US11/654,821 patent/US8067621B2/en active Active
- 2007-01-18 AR ARP070100225A patent/AR059075A1/es not_active Application Discontinuation
- 2007-01-18 PE PE2007000055A patent/PE20071321A1/es not_active Application Discontinuation
- 2007-01-18 RU RU2008133856/04A patent/RU2448964C2/ru not_active IP Right Cessation
- 2007-01-18 EP EP07716750.0A patent/EP1976843B1/en active Active
- 2007-01-18 AU AU2007207481A patent/AU2007207481B2/en not_active Ceased
- 2007-01-18 CA CA002637897A patent/CA2637897A1/en not_active Abandoned
- 2007-01-18 MX MX2008009414A patent/MX2008009414A/es active IP Right Grant
- 2007-01-19 TW TW096102137A patent/TW200738666A/zh unknown
-
2008
- 2008-07-17 IL IL192906A patent/IL192906A0/en unknown
- 2008-07-18 EC EC2008008638A patent/ECSP088638A/es unknown
- 2008-08-19 NO NO20083598A patent/NO20083598L/no not_active Application Discontinuation
-
2011
- 2011-10-06 US US13/267,324 patent/US8569521B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007207481B2 (en) | 2012-08-23 |
| TW200738666A (en) | 2007-10-16 |
| IL192906A0 (en) | 2009-02-11 |
| PE20071321A1 (es) | 2007-12-29 |
| CA2637897A1 (en) | 2007-07-26 |
| US20070197581A1 (en) | 2007-08-23 |
| EP1976843A2 (en) | 2008-10-08 |
| RU2448964C2 (ru) | 2012-04-27 |
| CN102702044A (zh) | 2012-10-03 |
| KR20080095885A (ko) | 2008-10-29 |
| US8569521B2 (en) | 2013-10-29 |
| JP5047992B2 (ja) | 2012-10-10 |
| WO2007084595A2 (en) | 2007-07-26 |
| US20120264736A1 (en) | 2012-10-18 |
| US8067621B2 (en) | 2011-11-29 |
| MX2008009414A (es) | 2008-10-01 |
| BRPI0706685A2 (pt) | 2011-04-05 |
| RU2008133856A (ru) | 2010-02-27 |
| WO2007084595A3 (en) | 2007-09-07 |
| ECSP088638A (es) | 2008-08-29 |
| JP2009528980A (ja) | 2009-08-13 |
| EP1976843B1 (en) | 2013-09-04 |
| AR059075A1 (es) | 2008-03-12 |
| AU2007207481A1 (en) | 2007-07-26 |
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