NO20084375L - Imidazo[1,2-B]pyridaziner, deres fremstilling og deres anvendelse som GABA reseptorligander - Google Patents

Imidazo[1,2-B]pyridaziner, deres fremstilling og deres anvendelse som GABA reseptorligander

Info

Publication number
NO20084375L
NO20084375L NO20084375A NO20084375A NO20084375L NO 20084375 L NO20084375 L NO 20084375L NO 20084375 A NO20084375 A NO 20084375A NO 20084375 A NO20084375 A NO 20084375A NO 20084375 L NO20084375 L NO 20084375L
Authority
NO
Norway
Prior art keywords
pyridazines
preparation
imidazo
receptor ligands
compounds
Prior art date
Application number
NO20084375A
Other languages
English (en)
Inventor
Antonio Guglietta
Jose Luis Falco
Albert Palomer
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of NO20084375L publication Critical patent/NO20084375L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det beskrives nye imidazo[1,2-b]pyridaziner med formel (I) og farmasøytisk akseptable salter, polymorfer, hydrater, tautomerer, solvater og stereoisomerer derav. Forbindelser med formel (I) er nyttige for terapi eller prevensjon av sykdommer assosiert med GABAA reseptormodulering, angst, epilepsi, søvnforstyrrelser, inkludert insomnia, og for indusering av sedering-hypnose, anestesi, søvn- og muskelrelaksasjon. Oppfinnelsen tilveiebringer også syntetiske prosedyrer for fremstilling av disse forbindelser og visse mellomprodukter, så vel som mellomproduktene per se.
NO20084375A 2006-03-29 2008-10-17 Imidazo[1,2-B]pyridaziner, deres fremstilling og deres anvendelse som GABA reseptorligander NO20084375L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06111899A EP1845098A1 (en) 2006-03-29 2006-03-29 Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
PCT/EP2007/052988 WO2007110437A1 (en) 2006-03-29 2007-03-28 Imidazo [1, 2-b] pyridazines, their processes of preparation and their use as gaba receptor ligands

Publications (1)

Publication Number Publication Date
NO20084375L true NO20084375L (no) 2008-10-17

Family

ID=36323447

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084375A NO20084375L (no) 2006-03-29 2008-10-17 Imidazo[1,2-B]pyridaziner, deres fremstilling og deres anvendelse som GABA reseptorligander

Country Status (22)

Country Link
US (2) US8153789B2 (no)
EP (2) EP1845098A1 (no)
JP (1) JP5091944B2 (no)
KR (1) KR20090008275A (no)
CN (1) CN101448831B (no)
AR (1) AR060212A1 (no)
AT (1) ATE471325T1 (no)
AU (1) AU2007231362B2 (no)
BR (1) BRPI0709207A2 (no)
CA (1) CA2647116C (no)
CY (1) CY1111211T1 (no)
DE (1) DE602007007203D1 (no)
DK (1) DK2010536T3 (no)
ES (1) ES2347182T3 (no)
MX (1) MX2008012274A (no)
NO (1) NO20084375L (no)
PL (1) PL2010536T3 (no)
PT (1) PT2010536E (no)
RU (1) RU2486188C9 (no)
SI (1) SI2010536T1 (no)
TW (1) TWI403512B (no)
WO (2) WO2007110438A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090023737A1 (en) * 2004-02-12 2009-01-22 Neurogen Corporation Imidazo-Pyridazines, Triazolo-Pyridazines and Related Benzodiazepine Receptor Ligands
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
FR2918061B1 (fr) * 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
CN101909658A (zh) * 2007-10-30 2010-12-08 日本医事物理股份有限公司 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
AU2008340182A1 (en) 2007-12-21 2009-07-02 The University Of Sydney Translocator protein ligands
EP2103614A1 (en) * 2008-03-18 2009-09-23 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyrimidine, imidazopyrazine and imidazopyridazine derivatives as melanocortin-4 receptor modulators
CA2724842A1 (en) * 2008-05-19 2009-11-26 Sunovion Pharmaceuticals Inc. Imidazo[1,2-a]pyridine compounds
CN102131801B (zh) 2008-06-25 2015-04-08 福拉姆医药股份有限公司 1,2-二取代的杂环化合物
US20100267730A1 (en) * 2008-10-09 2010-10-21 Giuseppe Alvaro Novel compounds
KR101662699B1 (ko) 2009-05-07 2016-10-05 포럼 파마슈티칼즈 인크. 페녹시메틸 헤테로고리 화합물
TWI617559B (zh) * 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物
UA112028C2 (uk) * 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
GB201321734D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (18)

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FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
DE3542661A1 (de) * 1985-12-03 1987-06-04 Bayer Ag Imidazopyridazinalkensaeureamide, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung
DE8808030U1 (de) * 1987-07-04 1988-11-03 Krones Ag Hermann Kronseder Maschinenfabrik, 8402 Neutraubling Etikettiervorrichtung für Behälter
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
CA2285264A1 (en) * 1997-04-25 1998-11-05 Michiyo Gyoten Condensed pyridazine derivatives, their production and use
EP1047697A1 (en) * 1998-01-14 2000-11-02 MERCK SHARP & DOHME LTD. Triazolo-pyridazine derivatives as ligands for gaba receptors
KR20010087738A (ko) * 1998-10-21 2001-09-21 다케다 야쿠힌 고교 가부시키가이샤 축합 피리다진 유도체, 이의 제조 방법 및 용도
HUP0203052A3 (en) * 1999-10-08 2004-06-28 Gruenenthal Gmbh Bicyclic imidazo-3-yl-amine derivatives, process for their preparation, pharmaceutical compositions containing them and their use
CA2390919A1 (en) * 1999-11-11 2001-05-17 Takeda Chemical Industries, Ltd. Nose drop containing condensed pyridazine
JP2002371042A (ja) * 2001-06-12 2002-12-26 Takeda Chem Ind Ltd ジアミン化合物、その製造法および用途
DK1483265T3 (da) * 2002-03-05 2007-03-19 Lilly Co Eli Purinderivater som kinaseinhibitorer
GB0210124D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
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DK1814880T3 (da) * 2004-11-11 2009-05-18 Ferrer Int Imidazo[1,2-a]pyridinforbindelser, og sammensætninger, anvendelser og fremgangsmåder, der er forbundet dermed
WO2006083682A2 (en) * 2005-01-28 2006-08-10 H.Lundbeck A/S Polymorphic forms of a gabaa agonist
EP1803722A1 (en) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
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Also Published As

Publication number Publication date
US20120040979A1 (en) 2012-02-16
JP2009531384A (ja) 2009-09-03
EP2010536A1 (en) 2009-01-07
SI2010536T1 (sl) 2010-10-29
CN101448831A (zh) 2009-06-03
CY1111211T1 (el) 2015-06-11
WO2007110437A1 (en) 2007-10-04
MX2008012274A (es) 2008-11-12
PT2010536E (pt) 2010-09-03
TW200813062A (en) 2008-03-16
RU2486188C2 (ru) 2013-06-27
BRPI0709207A2 (pt) 2011-06-28
AU2007231362A1 (en) 2007-10-04
US20090176788A1 (en) 2009-07-09
JP5091944B2 (ja) 2012-12-05
EP2010536B1 (en) 2010-06-16
DE602007007203D1 (de) 2010-07-29
PL2010536T3 (pl) 2010-11-30
TWI403512B (zh) 2013-08-01
AU2007231362B2 (en) 2012-07-19
ES2347182T3 (es) 2010-10-26
WO2007110438A1 (en) 2007-10-04
HK1127917A1 (en) 2009-10-09
ATE471325T1 (de) 2010-07-15
US8153789B2 (en) 2012-04-10
CN101448831B (zh) 2013-05-01
DK2010536T3 (da) 2010-10-04
AR060212A1 (es) 2008-06-04
US8993562B2 (en) 2015-03-31
CA2647116C (en) 2013-12-31
RU2486188C9 (ru) 2013-08-10
RU2008142841A (ru) 2010-05-10
CA2647116A1 (en) 2007-10-04
EP1845098A1 (en) 2007-10-17
KR20090008275A (ko) 2009-01-21

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