NO20084375L - Imidazo[1,2-B]pyridaziner, deres fremstilling og deres anvendelse som GABA reseptorligander - Google Patents

Imidazo[1,2-B]pyridaziner, deres fremstilling og deres anvendelse som GABA reseptorligander

Info

Publication number
NO20084375L
NO20084375L NO20084375A NO20084375A NO20084375L NO 20084375 L NO20084375 L NO 20084375L NO 20084375 A NO20084375 A NO 20084375A NO 20084375 A NO20084375 A NO 20084375A NO 20084375 L NO20084375 L NO 20084375L
Authority
NO
Norway
Prior art keywords
pyridazines
preparation
imidazo
receptor ligands
compounds
Prior art date
Application number
NO20084375A
Other languages
English (en)
Inventor
Antonio Guglietta
Jose Luis Falco
Albert Palomer
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of NO20084375L publication Critical patent/NO20084375L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives nye imidazo[1,2-b]pyridaziner med formel (I) og farmasøytisk akseptable salter, polymorfer, hydrater, tautomerer, solvater og stereoisomerer derav. Forbindelser med formel (I) er nyttige for terapi eller prevensjon av sykdommer assosiert med GABAA reseptormodulering, angst, epilepsi, søvnforstyrrelser, inkludert insomnia, og for indusering av sedering-hypnose, anestesi, søvn- og muskelrelaksasjon. Oppfinnelsen tilveiebringer også syntetiske prosedyrer for fremstilling av disse forbindelser og visse mellomprodukter, så vel som mellomproduktene per se.
NO20084375A 2006-03-29 2008-10-17 Imidazo[1,2-B]pyridaziner, deres fremstilling og deres anvendelse som GABA reseptorligander NO20084375L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06111899A EP1845098A1 (en) 2006-03-29 2006-03-29 Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands
PCT/EP2007/052988 WO2007110437A1 (en) 2006-03-29 2007-03-28 Imidazo [1, 2-b] pyridazines, their processes of preparation and their use as gaba receptor ligands

Publications (1)

Publication Number Publication Date
NO20084375L true NO20084375L (no) 2008-10-17

Family

ID=36323447

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084375A NO20084375L (no) 2006-03-29 2008-10-17 Imidazo[1,2-B]pyridaziner, deres fremstilling og deres anvendelse som GABA reseptorligander

Country Status (22)

Country Link
US (2) US8153789B2 (no)
EP (2) EP1845098A1 (no)
JP (1) JP5091944B2 (no)
KR (1) KR20090008275A (no)
CN (1) CN101448831B (no)
AR (1) AR060212A1 (no)
AT (1) ATE471325T1 (no)
AU (1) AU2007231362B2 (no)
BR (1) BRPI0709207A2 (no)
CA (1) CA2647116C (no)
CY (1) CY1111211T1 (no)
DE (1) DE602007007203D1 (no)
DK (1) DK2010536T3 (no)
ES (1) ES2347182T3 (no)
MX (1) MX2008012274A (no)
NO (1) NO20084375L (no)
PL (1) PL2010536T3 (no)
PT (1) PT2010536E (no)
RU (1) RU2486188C9 (no)
SI (1) SI2010536T1 (no)
TW (1) TWI403512B (no)
WO (2) WO2007110437A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2555263A1 (en) * 2004-02-12 2005-09-01 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
PE20121506A1 (es) 2006-07-14 2012-11-26 Amgen Inc Compuestos triazolopiridinas como inhibidores de c-met
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
FR2918061B1 (fr) 2007-06-28 2010-10-22 Sanofi Aventis Derives de 6-cycloamino-3-(pyridin-4-yl)imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique.
JPWO2009057577A1 (ja) * 2007-10-30 2011-03-10 日本メジフィジックス株式会社 新規アミロイド親和性化合物の使用及び製造方法
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
CA2710016A1 (en) * 2007-12-21 2009-07-02 The University Of Sydney Translocator protein ligands
EP2103614A1 (en) * 2008-03-18 2009-09-23 Santhera Pharmaceuticals (Schweiz) AG Substituted imidazopyrimidine, imidazopyrazine and imidazopyridazine derivatives as melanocortin-4 receptor modulators
AU2009249186B2 (en) * 2008-05-19 2014-05-22 Sunovion Pharmaceuticals Inc. Imidazo [1, 2-a] pyridine compounds as GABA-A receptor modulators
CN102131801B (zh) 2008-06-25 2015-04-08 福拉姆医药股份有限公司 1,2-二取代的杂环化合物
US20100267730A1 (en) * 2008-10-09 2010-10-21 Giuseppe Alvaro Novel compounds
SI2617420T1 (sl) 2009-05-07 2016-02-29 Forum Pharmaceuticals Inc. Fenoksimetil heterociklične spojine
TWI617559B (zh) * 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物
UA112028C2 (uk) * 2012-12-14 2016-07-11 Пфайзер Лімітед Похідні імідазопіридазину як модулятори гамка-рецептора
GB201321734D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents

Family Cites Families (18)

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FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
DE3542661A1 (de) * 1985-12-03 1987-06-04 Bayer Ag Imidazopyridazinalkensaeureamide, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung
DE8808030U1 (de) * 1987-07-04 1988-11-03 Krones Ag Hermann Kronseder Maschinenfabrik, 8402 Neutraubling Etikettiervorrichtung für Behälter
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
AU7079998A (en) * 1997-04-25 1998-11-24 Takeda Chemical Industries Ltd. Condensed pyridazine derivatives, their production and use
AU746866B2 (en) * 1998-01-14 2002-05-02 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
ATE256128T1 (de) * 1998-10-21 2003-12-15 Takeda Chemical Industries Ltd Kondensierte pyridazinderivate, verfahren zu ihrer herstellung und ihre anwendung
KR100756592B1 (ko) * 1999-10-08 2007-09-10 그뤼넨탈 게엠베하 비사이클릭 이미다조-3-일-아민 유도체, 이의 제조방법 및 이를 포함하는 진통제
CN1413112A (zh) * 1999-11-11 2003-04-23 武田药品工业株式会社 含有稠合哒嗪衍生物的滴鼻剂
JP2002371042A (ja) * 2001-06-12 2002-12-26 Takeda Chem Ind Ltd ジアミン化合物、その製造法および用途
ES2276048T3 (es) * 2002-03-05 2007-06-16 Eli Lilly And Company Derivados de purina como inhibidores de cinasa.
GB0210124D0 (en) * 2002-05-02 2002-06-12 Merck Sharp & Dohme Therapeutic agents
WO2004058758A1 (en) * 2002-12-18 2004-07-15 Mallinckrodt Inc. Synthesis of heteroaryl acetamides
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
MX2007005611A (es) * 2004-11-11 2007-07-11 Ferrer Int Compuestos de imidazo[1,2-a]piridina, composiciones, usos y metodos relacionados.
EP1848420A4 (en) * 2005-01-28 2008-01-23 Merck & Co Inc POLYMORPH SHAPES OF A GABAA AGONIST
EP1803722A1 (en) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
US20090318410A1 (en) * 2006-10-30 2009-12-24 Novartis Ag Imidazopyridazines as lipid kinase inhibitors

Also Published As

Publication number Publication date
RU2008142841A (ru) 2010-05-10
WO2007110438A1 (en) 2007-10-04
DK2010536T3 (da) 2010-10-04
RU2486188C2 (ru) 2013-06-27
PT2010536E (pt) 2010-09-03
TW200813062A (en) 2008-03-16
EP1845098A1 (en) 2007-10-17
EP2010536B1 (en) 2010-06-16
RU2486188C9 (ru) 2013-08-10
US8993562B2 (en) 2015-03-31
US20090176788A1 (en) 2009-07-09
HK1127917A1 (en) 2009-10-09
AR060212A1 (es) 2008-06-04
TWI403512B (zh) 2013-08-01
JP2009531384A (ja) 2009-09-03
ES2347182T3 (es) 2010-10-26
US8153789B2 (en) 2012-04-10
ATE471325T1 (de) 2010-07-15
EP2010536A1 (en) 2009-01-07
JP5091944B2 (ja) 2012-12-05
US20120040979A1 (en) 2012-02-16
CY1111211T1 (el) 2015-06-11
CA2647116C (en) 2013-12-31
CN101448831A (zh) 2009-06-03
DE602007007203D1 (de) 2010-07-29
PL2010536T3 (pl) 2010-11-30
WO2007110437A1 (en) 2007-10-04
CN101448831B (zh) 2013-05-01
AU2007231362B2 (en) 2012-07-19
AU2007231362A1 (en) 2007-10-04
MX2008012274A (es) 2008-11-12
SI2010536T1 (sl) 2010-10-29
CA2647116A1 (en) 2007-10-04
KR20090008275A (ko) 2009-01-21
BRPI0709207A2 (pt) 2011-06-28

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