NO20091782L - Fremgangsmate for syntese av derivater av 3-amino-tetrahydrofuran-3-karboxylsyre og deres anvendelse som medikamenter - Google Patents

Fremgangsmate for syntese av derivater av 3-amino-tetrahydrofuran-3-karboxylsyre og deres anvendelse som medikamenter

Info

Publication number
NO20091782L
NO20091782L NO20091782A NO20091782A NO20091782L NO 20091782 L NO20091782 L NO 20091782L NO 20091782 A NO20091782 A NO 20091782A NO 20091782 A NO20091782 A NO 20091782A NO 20091782 L NO20091782 L NO 20091782L
Authority
NO
Norway
Prior art keywords
tetrahydrofuran
amino
carboxylic acid
synthesis
drugs
Prior art date
Application number
NO20091782A
Other languages
English (en)
Inventor
Wolfgang Wienen
Henning Priepke
Peter Sieger
Roland Pfau
Annette Maria Schuler-Metz
Herbert Nar
Wenjun Tang
Dhileepkumar Krishnamurthy
Chris H Senanayake
Zhengxu Han
Kai Gerlach
Burkhard Matthes
Yibo Xu
Nathan K Yee
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO20091782L publication Critical patent/NO20091782L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Foreliggende oppfinnelse angår en fremgangsmåte for fremstilling av substituerte 3-amino-tetrahydrofuran-3-karboksylsyreamider med den generelle formel (I) og deres forløpere med høy optisk renhet (I), forløperne for syntese av substituerte 3-amino-tetrahydrofuran-3-karboksylsyreamider med den generelle formel (I) med høy optisk renhet og tautomerene, enantiomerene, diastereomerene, blandinger og salter av substituerte 3-amino-tetrahydrofuran-3-karboksylsyreamider med den generelle formel (I) med høy optisk renhet, spesielt de fysiologisk akseptable salter derav med uorganiske eller organiske syrer eller baser, som har verdifulle egenskaper.
NO20091782A 2006-12-31 2009-05-06 Fremgangsmate for syntese av derivater av 3-amino-tetrahydrofuran-3-karboxylsyre og deres anvendelse som medikamenter NO20091782L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88293706P 2006-12-31 2006-12-31
PCT/EP2007/064406 WO2008080891A2 (en) 2006-12-31 2007-12-21 Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments

Publications (1)

Publication Number Publication Date
NO20091782L true NO20091782L (no) 2009-06-10

Family

ID=39253961

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091782A NO20091782L (no) 2006-12-31 2009-05-06 Fremgangsmate for syntese av derivater av 3-amino-tetrahydrofuran-3-karboxylsyre og deres anvendelse som medikamenter

Country Status (23)

Country Link
US (2) US20100317848A1 (no)
EP (1) EP2114909A2 (no)
JP (1) JP2010514729A (no)
KR (1) KR20090097208A (no)
CN (1) CN101573346B (no)
AR (1) AR064708A1 (no)
AU (1) AU2007341335A1 (no)
BR (1) BRPI0720748A2 (no)
CA (1) CA2674168A1 (no)
CL (1) CL2007003875A1 (no)
EA (1) EA200900797A1 (no)
EC (1) ECSP099406A (no)
MA (1) MA31116B1 (no)
MY (1) MY148769A (no)
NO (1) NO20091782L (no)
NZ (1) NZ578715A (no)
PE (1) PE20081834A1 (no)
TN (1) TN2009000276A1 (no)
TW (1) TW200846345A (no)
UA (1) UA96973C2 (no)
UY (1) UY30851A1 (no)
WO (1) WO2008080891A2 (no)
ZA (1) ZA200902451B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070171A1 (es) 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa
WO2009063028A2 (en) 2007-11-15 2009-05-22 Boehringer Ingelheim International Gmbh Substituted amides, manufacturing and use thereof as medicaments
CN103415301A (zh) * 2011-03-09 2013-11-27 德国杰特贝林生物制品有限公司 用于与包括与人造表面接触的医疗操作一起施用的fxii抑制剂
EP2497489A1 (en) 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
US9096579B2 (en) 2012-04-20 2015-08-04 Boehringer Ingelheim International Gmbh Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
WO2014060575A2 (en) * 2012-10-19 2014-04-24 Medichem S.A. Process for the enantioselective synthesis of a tetrahydrobenzazepine compound
RU2520134C1 (ru) * 2013-02-27 2014-06-20 Общество с ограниченной ответственностью "Авионко" (ООО "Авионко") Замещенные (r)-3-(4-метилкарбамоил-3-фторфениламино)-тетрагидро-фуран-3-енкарбоновые кислоты и их эфиры, способ их получения и применения
WO2014135694A1 (en) 2013-03-08 2014-09-12 Csl Behring Ag Treatment and prevention of remote ischemia-reperfusion injury
WO2014187768A1 (en) * 2013-05-20 2014-11-27 Lek Pharmaceuticals D.D. Novel synthetic processes to 8-chloro-3-benzo[d]azepine via friedel-crafts alkylation of olefin
CN104530029B (zh) * 2014-12-09 2017-04-12 广东东阳光药业有限公司 作为Xa因子抑制剂的杂环化合物及其使用方法和用途
WO2026154081A1 (en) 2025-01-17 2026-07-23 Astrazeneca Ab 7-fluoro-5-methoxy-2,3-dihydro-[1,3]oxazino[4,5,6-de]quinazoline derivatives as ras g12d inhibitors for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005111014A1 (de) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituierte thiophencarbonsäureamide, deren herstellung und deren verwendung als arzneimittel
WO2005111013A1 (de) * 2004-05-13 2005-11-24 Boehringer Ingelheim International Gmbh Substituierte thiophen-2-carbonsäureamide, deren herstellung und deren verwendung als arzneimittel
KR20070012552A (ko) * 2004-05-13 2007-01-25 베링거 인겔하임 인터내셔날 게엠베하 신규한 치환된 티오펜카복스아미드, 이의 제조방법 및약제로서의 이의 용도
DE102004047840A1 (de) * 2004-09-29 2006-03-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel
PE20070171A1 (es) * 2005-06-30 2007-03-08 Boehringer Ingelheim Int GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa

Also Published As

Publication number Publication date
WO2008080891A2 (en) 2008-07-10
KR20090097208A (ko) 2009-09-15
MY148769A (en) 2013-05-31
NZ578715A (en) 2012-06-29
UA96973C2 (ru) 2011-12-26
AU2007341335A1 (en) 2008-07-10
ECSP099406A (es) 2009-07-31
BRPI0720748A2 (pt) 2015-05-19
EA200900797A1 (ru) 2009-12-30
JP2010514729A (ja) 2010-05-06
CA2674168A1 (en) 2008-07-10
US20100317848A1 (en) 2010-12-16
AR064708A1 (es) 2009-04-22
CN101573346A (zh) 2009-11-04
TW200846345A (en) 2008-12-01
CL2007003875A1 (es) 2008-04-18
US20130005962A1 (en) 2013-01-03
CN101573346B (zh) 2013-01-09
EP2114909A2 (en) 2009-11-11
UY30851A1 (es) 2008-07-31
WO2008080891A3 (en) 2008-10-02
ZA200902451B (en) 2010-05-26
TN2009000276A1 (fr) 2010-10-18
PE20081834A1 (es) 2009-01-16
MA31116B1 (fr) 2010-01-04

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