NO20091936L - 4-imidazoliner som TAAR ligander - Google Patents

4-imidazoliner som TAAR ligander

Info

Publication number
NO20091936L
NO20091936L NO20091936A NO20091936A NO20091936L NO 20091936 L NO20091936 L NO 20091936L NO 20091936 A NO20091936 A NO 20091936A NO 20091936 A NO20091936 A NO 20091936A NO 20091936 L NO20091936 L NO 20091936L
Authority
NO
Norway
Prior art keywords
disorders
lower alkyl
phenyl
lower alkoxy
halogen
Prior art date
Application number
NO20091936A
Other languages
English (en)
Inventor
Guido Galley
Katrin Groebke-Zbinden
Roger Norcross
Henri Stalder
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20091936L publication Critical patent/NO20091936L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Oppfinnelsen angår forbindelser med formel I hvor R er hydrogen, lavere alkyl eller amino; X-R1 er -CH2-, -CH(lavere alkoksy)- eller -CH(OH)- og Y-R2 er -CH2, -CH(lavere alkyl)-, -CH(lavere alkoksy)- -O-, -S-, -S(O)-, -S(O)2-, -CH(fenyl)- eller -C(lavere alkyl)2-; eller X-R1 er -NH- og Y-R2 er -CH2, -CH(lavere alkyl)-, -CH(lavere alkoksy)-, -CH(fenyl)- eller -C(lavere alkyl)2-; Ar er fenyl, napthyl eller benzofuranyl, hvor ringene er usubstituerte eller substituerte med én eller flere substituenter, valgt fra gruppen bestående av lavere alkyl, lavere alkyl substituert med halogen, halogen, lavere alkoksy, lavere alkoksy substituert med halogen, hydroksy, amino, di-alkylamino, morfolinyl, fenyl, benzyl eller med O-benzyl; eller farmasøytisk egnede syreaddisjonssalter. Det er funnet at forbindelsene med formel I har en god affinitet til å spore amin assosierte reseptorer (TAARs), spesielt for TAAR1. Forbindelsene kan anvendes for behandling av depresjon, angst lidelser, bipolar lidelse, oppmerksomhetssvikt hyperaktivitets lidelse (ADHD), stress-relaterte lidelser, psykotiske lidelser så som schizofreni, nevrologiske sykdommer så som Parkinson's sykdom, neurodegenerative lidelser så som Alzheimer's sykdom, epilepsi, migrene, hypertensjon, stoffmisbruk og metabolske lidelser så som spiseforstyrrelser, diabetes, diabetiske komplikasjoner, fedme, dyslipidemi, lidelser ved energikonsum og assimilasjon, lidelser og feilfunksjon av kroppstemperatur homeostase, lidelser innen søvn og cirkadisk rytme og kardiovaskulære lidelser.
NO20091936A 2006-12-18 2009-05-19 4-imidazoliner som TAAR ligander NO20091936L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126307 2006-12-18
PCT/EP2007/063585 WO2008074679A2 (en) 2006-12-18 2007-12-10 4-imidazolines as taar's ligands

Publications (1)

Publication Number Publication Date
NO20091936L true NO20091936L (no) 2009-07-14

Family

ID=39153757

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091936A NO20091936L (no) 2006-12-18 2009-05-19 4-imidazoliner som TAAR ligander

Country Status (18)

Country Link
US (3) US20080146523A1 (no)
EP (1) EP2094668A2 (no)
JP (1) JP5175297B2 (no)
KR (1) KR101188992B1 (no)
CN (1) CN101578271B (no)
AR (1) AR064376A1 (no)
AU (1) AU2007336351A1 (no)
BR (1) BRPI0721291A2 (no)
CA (1) CA2671838A1 (no)
CL (1) CL2007003653A1 (no)
IL (1) IL198878A0 (no)
MX (1) MX2009006215A (no)
NO (1) NO20091936L (no)
PE (1) PE20081386A1 (no)
RU (1) RU2465269C2 (no)
TW (1) TWI345467B (no)
WO (1) WO2008074679A2 (no)
ZA (1) ZA200903841B (no)

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KR101222412B1 (ko) 2007-02-15 2013-01-15 에프. 호프만-라 로슈 아게 Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
WO2009097995A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012078817A1 (en) 2010-12-08 2012-06-14 Vanderbilt University Bicyclic pyrazole compounds as allosteric modulators of mglur5 receptors
WO2012125732A1 (en) * 2011-03-15 2012-09-20 Vanderbilt University Substituted imadazapyrinidin-5(6h)-ones as allosteric modulators of mglur5 receptors
US8865725B2 (en) 2011-03-15 2014-10-21 Vanderbilt University Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103910658B (zh) * 2013-12-23 2016-08-17 宁夏大学 一种硫醚氧化成砜的方法
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Also Published As

Publication number Publication date
CL2007003653A1 (es) 2008-07-11
CN101578271A (zh) 2009-11-11
AU2007336351A1 (en) 2008-06-26
PE20081386A1 (es) 2008-09-18
TW200833327A (en) 2008-08-16
TWI345467B (en) 2011-07-21
US20100204233A1 (en) 2010-08-12
RU2009122665A (ru) 2011-01-27
AR064376A1 (es) 2009-04-01
RU2465269C2 (ru) 2012-10-27
EP2094668A2 (en) 2009-09-02
BRPI0721291A2 (pt) 2014-03-25
KR20090081431A (ko) 2009-07-28
JP2010513373A (ja) 2010-04-30
ZA200903841B (en) 2010-03-31
CN101578271B (zh) 2013-06-19
US8399463B2 (en) 2013-03-19
MX2009006215A (es) 2009-06-22
IL198878A0 (en) 2010-02-17
WO2008074679A2 (en) 2008-06-26
KR101188992B1 (ko) 2012-10-08
WO2008074679A3 (en) 2008-10-09
US20080146523A1 (en) 2008-06-19
US20120004230A1 (en) 2012-01-05
JP5175297B2 (ja) 2013-04-03
CA2671838A1 (en) 2008-06-26

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