NO20092050L - Nye sulfonamidderivater som bradykininantagonister - Google Patents

Nye sulfonamidderivater som bradykininantagonister

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Publication number
NO20092050L
NO20092050L NO20092050A NO20092050A NO20092050L NO 20092050 L NO20092050 L NO 20092050L NO 20092050 A NO20092050 A NO 20092050A NO 20092050 A NO20092050 A NO 20092050A NO 20092050 L NO20092050 L NO 20092050L
Authority
NO
Norway
Prior art keywords
sulfonamide derivatives
novel sulfonamide
bradykinin antagonists
bradykinin
novel
Prior art date
Application number
NO20092050A
Other languages
English (en)
Inventor
Sandor Farkas
Eva Schmidt
Istvan Vago
Gyorgy Keseru
Eva Bozo
Gyula Beke
Janos Eles
Katalin Hornok
Eva Szentirmay
Monika Vastag
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of NO20092050L publication Critical patent/NO20092050L/no

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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
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Abstract

Foreliggende oppfinnelse gjelder nye sulfonamidderivater med formel (I) hvori R1-R5 og Z er som definert i kravene, og optiske antipoder eller racemater, salter, hydrater og/eller solvater derav, som er selektive antagonister av bradykinin Bl, fremgangsmåter for fremstilling av disse forbindelsene, farmakologiske preparater som inneholder dem og anvendelse av dem for behandling eller forebyggelse av smertefulle tilstander og betennelsestilstander.
NO20092050A 2006-10-27 2009-05-26 Nye sulfonamidderivater som bradykininantagonister NO20092050L (no)

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HU0600810A HUP0600810A3 (en) 2006-10-27 2006-10-27 New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
PCT/HU2007/000104 WO2008050168A1 (en) 2006-10-27 2007-10-27 New sulfonamide derivatives as bradykinin antagonists

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