NO20092373L - Substituerte heteroarylpyridopyrimidonderivater - Google Patents

Substituerte heteroarylpyridopyrimidonderivater

Info

Publication number: NO20092373L
Authority: NO; Norway
Prior art keywords: group; atom; alkyl group; hydrogen atom; optionally substituted
Prior art date: 2006-12-20

Application number

NO20092373A

Other languages

English (en)

Norwegian (no)

Inventor

Aude Fayol

Thierry Gallet

Alistair Lochead

Mourad Saady

Corinne Veronique

Philippe Yaiche

Original Assignee

Mitsubishi Tanabe Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-20

Filing date

2009-06-22

Publication date

2009-08-28

2009-06-22 Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp

2009-08-28 Publication of NO20092373L publication Critical patent/NO20092373L/no

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
125000005843 halogen group Chemical group 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004430 oxygen atom Chemical group O* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000004434 sulfur atom Chemical group 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
102000001267 GSK3 Human genes 0.000 abstract 1
108060006662 GSK3 Proteins 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Dermatology (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Obesity (AREA)
Physical Education & Sports Medicine (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Zoology (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Cardiology (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Endocrinology (AREA)
Environmental Sciences (AREA)
Orthopedic Medicine & Surgery (AREA)

NO20092373A 2006-12-20 2009-06-22 Substituerte heteroarylpyridopyrimidonderivater NO20092373L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06291995A EP1939187A1 (en)	2006-12-20	2006-12-20	Substituted heteroaryl pyridopyrimidone derivatives
PCT/IB2007/004409 WO2008078196A2 (en)	2006-12-20	2007-12-20	Substituted heteroaryl pyridopyrimidone derivatives

Publications (1)

Publication Number	Publication Date
NO20092373L true NO20092373L (no)	2009-08-28

Family

ID=38002236

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20092373A NO20092373L (no)	2006-12-20	2009-06-22	Substituerte heteroarylpyridopyrimidonderivater

Country Status (16)

Country	Link
US (1)	US8198287B2 (pt)
EP (2)	EP1939187A1 (pt)
JP (1)	JP2010513463A (pt)
KR (1)	KR20090102756A (pt)
CN (1)	CN101563328B (pt)
AU (1)	AU2007337826A1 (pt)
BR (1)	BRPI0721058A2 (pt)
CA (1)	CA2672564A1 (pt)
EA (1)	EA200970598A1 (pt)
IL (1)	IL198524A (pt)
MX (1)	MX2009006024A (pt)
NO (1)	NO20092373L (pt)
NZ (1)	NZ576894A (pt)
TW (1)	TW200831099A (pt)
WO (1)	WO2008078196A2 (pt)
ZA (1)	ZA200903237B (pt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2138494A1 (en) *	2008-06-26	2009-12-30	Sanofi-Aventis	Substituted alkyl pyrimidin-4-one derivatives
EP2138492A1 (en) *	2008-06-26	2009-12-30	Sanofi-Aventis	Substituted pyrimidin-4-one derivatives
DE102008038220A1 (de)	2008-08-18	2010-02-25	Merck Patent Gmbh	Oxadiazolderivate
DE102008038221A1 (de)	2008-08-18	2010-02-25	Merck Patent Gmbh	7-Azaindolderivate
WO2011107494A1 (de)	2010-03-03	2011-09-09	Sanofi	Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
AU2011261164A1 (en) *	2010-06-01	2012-12-13	The University Of Queensland	Haematopoietic-prostaglandin D2 synthase inhibitors
EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en)	2010-06-21	2013-09-10	Sanofi	Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en)	2010-07-05	2012-04-16	Sanofi Aventis	Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en)	2010-07-05	2012-04-16	Sanofi Sa	(2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en)	2010-07-05	2012-06-01	Sanofi Sa	Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en)	2011-09-12	2013-03-21	Sanofi	6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en)	2011-09-27	2013-04-04	Sanofi	6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
FR2992316A1 (fr) *	2012-06-22	2013-12-27	Sanofi Sa	Derives de pyrimidinones, leur preparation et leur application en therapeutique
JP7071917B2 (ja)	2015-12-09	2022-05-19	カデントセラピューティクス，インコーポレーテッド	ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用
IL287136B2 (en)	2016-02-05	2023-09-01	Denali Therapeutics Inc	Receptor inhibitors - interacting with protein kinase 1
MX2019001918A (es)	2016-08-15	2019-09-06	Bayer Cropscience Ag	Derivados del heterociclo biciclico condensado como agentes de control de plagas.
JP7208137B2 (ja)	2016-12-09	2023-01-18	デナリセラピューティクスインコーポレイテッド	化合物、組成物および方法
US11274107B2 (en)	2016-12-22	2022-03-15	Cadent Therapeutics, Inc.	NMDA receptor modulators and uses thereof
MA49014A (fr) *	2017-03-21	2020-02-05	Arbutus Biopharma Corp	Dihydroindène-4-carboxamides substitués, leurs analogues et procédés d'utilisation correspondant
AR115905A1 (es)	2018-08-03	2021-03-10	Cadent Therapeutics Inc	5-(3-cloro-4-fluorofenil)-7-ciclopropil-3-(2-(3-fluoro-3-metilazetidin-1-il)-2-oxoetil)-3,7-dihidro-4h-pirrolo[2,3-d]pirimidin-4-ona como modulador de los receptores de nmda
CN109748914B (zh) *	2018-12-29	2021-05-25	上海珂臻医药科技有限公司	吡啶并嘧啶类化合物及其应用
TW202334164A (zh)	2022-01-12	2023-09-01	美商戴納立製藥公司	（Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EG13192A (en)	1976-02-10	1982-12-31	Rhone Poulenc Ind	Nouveaux derives du dithiole-1,2 leur preparation et les compositions qui les contiennent
US5629322A (en)	1994-11-15	1997-05-13	Merck & Co., Inc.	Cyclic amidine analogs as inhibitors of nitric oxide synthase
EA007165B1 (ru) *	2001-09-21	2006-08-25	Санофи-Авентис	Производные замещенного 2-пиримидинил-6, 7, 8, 9-тетрагидропиримидо [1,2-а]пиримидин-4-она и 7-пиримидинил-2,3-дигидроимидазо[1, 2-а]пиримидин-5( 1н )она для нейродегенеративных нарушений
EP1460075A1 (en) *	2003-03-21	2004-09-22	Sanofi-Synthelabo	Substituted 8-Pyridinyl-6,7,8,9-Tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 8-Phenyl-6-7,8,9-Tetrahydropyrimido[1,2-a]Pyrimidin-4-one derivatives
EP1460076A1 (en) *	2003-03-21	2004-09-22	Sanofi-Synthelabo	Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one derivatives

2006
- 2006-12-20 EP EP06291995A patent/EP1939187A1/en not_active Withdrawn
2007
- 2007-12-18 TW TW096148482A patent/TW200831099A/zh unknown
- 2007-12-20 WO PCT/IB2007/004409 patent/WO2008078196A2/en not_active Ceased
- 2007-12-20 BR BRPI0721058-2A patent/BRPI0721058A2/pt not_active IP Right Cessation
- 2007-12-20 JP JP2009542272A patent/JP2010513463A/ja not_active Withdrawn
- 2007-12-20 EP EP07870445A patent/EP2121635A2/en not_active Withdrawn
- 2007-12-20 NZ NZ576894A patent/NZ576894A/en not_active IP Right Cessation
- 2007-12-20 EA EA200970598A patent/EA200970598A1/ru unknown
- 2007-12-20 CN CN2007800468908A patent/CN101563328B/zh not_active Expired - Fee Related
- 2007-12-20 ZA ZA200903237A patent/ZA200903237B/xx unknown
- 2007-12-20 CA CA002672564A patent/CA2672564A1/en not_active Abandoned
- 2007-12-20 KR KR1020097012761A patent/KR20090102756A/ko not_active Withdrawn
- 2007-12-20 AU AU2007337826A patent/AU2007337826A1/en not_active Abandoned
- 2007-12-20 MX MX2009006024A patent/MX2009006024A/es active IP Right Grant
2009
- 2009-05-03 IL IL198524A patent/IL198524A/en not_active IP Right Cessation
- 2009-06-18 US US12/487,270 patent/US8198287B2/en active Active
- 2009-06-22 NO NO20092373A patent/NO20092373L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2007337826A1 (en)	2008-07-03
IL198524A (en)	2013-03-24
KR20090102756A (ko)	2009-09-30
NZ576894A (en)	2011-09-30
MX2009006024A (es)	2009-06-30
CN101563328B (zh)	2012-03-14
EP1939187A1 (en)	2008-07-02
JP2010513463A (ja)	2010-04-30
CA2672564A1 (en)	2008-07-03
EP2121635A2 (en)	2009-11-25
ZA200903237B (en)	2010-08-25
US20090306088A1 (en)	2009-12-10
BRPI0721058A2 (pt)	2014-02-25
WO2008078196A2 (en)	2008-07-03
IL198524A0 (en)	2010-02-17
EA200970598A1 (ru)	2009-12-30
CN101563328A (zh)	2009-10-21
US8198287B2 (en)	2012-06-12
WO2008078196A3 (en)	2008-11-06
TW200831099A (en)	2008-08-01

Legal Events

Date	Code	Title	Description
2013-07-29	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20092373L (no)	2009-08-28	Substituerte heteroarylpyridopyrimidonderivater
NO20054330L (no)	2005-12-21	8-substituerte-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on-derivater
CY1112642T1 (el)	2016-02-10	Παραγωγα 4-(πυριδιν-4-υλο)-1η-[1,3,5]τριαζιν-2-ονης ως αναστολεις της gsκ3-βετα για τη θεραπεια των νευροεκφυλιστικων ασθενειων
AR053082A1 (es)	2007-04-25	DERIVADOS 8-PERFLUOROALQUIL-6,7,8,9-TETRAHIDROPIRIMIDO[1,2-A]PIRIMIDIN-4-ONA SUBSTITUIDOS NHIBIDORES DE GSK3BETA Y SU EMPLEO EN LA FABRICACIoN DE MEDICAMENTOS PARA EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS.
EA201070896A1 (ru)	2011-02-28	ЗАМЕЩЕННЫЕ АРИЛАМИДДИАЗЕПИНОПИРИМИДОНОВЫЕ ПРОИЗВОДНЫЕ ДЛЯ ЛЕЧЕНИЯ НЕЙРОДЕГЕНЕРАТИВНЫХ ЗАБОЛЕВАНИЙ, ВЫЗВАННЫХ АНОМАЛЬНОЙ АКТИВНОСТЬЮ GSK3β
NO20064456L (no)	2006-10-02	Thiadiazolidinoner som GSK-3 inhibitorer
NO20054140L (no)	2005-12-02	Dihydrospiro-[cykloalkyl]-pyrimidonderivat, anvendelser derav for fremstilling av et medikament, medikament omfattende en slik forbindelse, og mellomproduktforbindelse
NO20091596L (no)	2009-06-30	Benzoylamino-heterocykliske forbindelser som Glucokinase-(GLK)-activatorer
BR112012033770A2 (pt)	2016-11-22	novo derivado de nicotinamida ou sal do mesmo
EA201170094A1 (ru)	2011-08-30	Производные замещенного пиримидо[2,1-а]изохинолин-4-она
NO20090952L (no)	2009-04-23	N-(aminoheteroaryl) - lh - indol-2-karboksamidderivater og fremstilling og terapeutisk anvendelse derav
BRPI0417208A (pt)	2007-02-06	derivados de 8'-piri(mi)dinil-diidroespiro-[cicloalquilamina]-pirimid o[1,2-ona]pirimidin-6-ona
MX2010008360A (es)	2010-08-30	Derivados de oxazepinopirimidona heteroarilamida sustituidos.
AR063577A1 (es)	2009-02-04	Derivados 8- piperidinil - pirimido [1 2 a] pirimidin -6-ona y 8- piperidinil-2- pirimidinil- pirimido [1,2-a] pirimidin -6- ona sustituidos
WO2007057790A3 (en)	2007-10-11	Substituted bicyclic pyrimidone derivatives
AR072226A1 (es)	2010-08-11	Derivados triciclicos sustituidos, proceso e intermediario para su sintesis y su uso en medicamentos para el tratamiento de enfermedades mediadas por la actividad de gsk3beta.
EA200300150A1 (ru)	2003-08-28	ПРОИЗВОДНЫЕ 1-[АЛКИЛ], 1-[(ГЕТЕРОАРИЛ)АЛКИЛ] И 1-[(АРИЛ)АЛКИЛ]-7-ПИРИДИНИЛ-ИМИДАЗО[1, 2-a]ПИРИМИДИН-5(1H)ОНА
AU2012342226A1 (en)	2014-06-19	1,4- dihydropyridine derivatives with Hsp modulating activity
CY1110622T1 (el)	2015-04-29	Νεα παραγωγα 3-φαινυλοπροπιονικου οξεος για την αντιμετωπιση του διαβητη
NO20081195L (no)	2008-04-28	Imidazopyridinderivater som kannabinoidreceptorligander
CY1113801T1 (el)	2016-07-27	Παραγωγο κιναζολινης και φαρμακευτικο ειδος
NO20091419L (no)	2009-05-20	Fenyleddiksyrederivat
NO20054141L (no)	2005-12-07	2-(diazabicykloalkyl)pyrimidonderivat, anvendelser derav for fremstilling av et medikament, medikament omfattende en slik forbindelse og mellomproduktforbindelse
ATE412416T1 (de)	2008-11-15	Indolin-2-one-pyridin-derivate, herstellung und therapeutische verwendung dafür
DK1813610T3 (da)	2010-12-06	Nye pyridoncarboxylsyrederivater eller salte deraf