NO20092574L - Piperidinylamino-pyridaziner og deres anvendelse som raskt dissosierende dopamin-2-reseptor-antagonister - Google Patents

Piperidinylamino-pyridaziner og deres anvendelse som raskt dissosierende dopamin-2-reseptor-antagonister

Info

Publication number
NO20092574L
NO20092574L NO20092574A NO20092574A NO20092574L NO 20092574 L NO20092574 L NO 20092574L NO 20092574 A NO20092574 A NO 20092574A NO 20092574 A NO20092574 A NO 20092574A NO 20092574 L NO20092574 L NO 20092574L
Authority
NO
Norway
Prior art keywords
receptor antagonists
piperidinylamino
pyridazines
compounds
dissociating dopamine
Prior art date
Application number
NO20092574A
Other languages
English (en)
Norwegian (no)
Inventor
Jose Ignacio Andres-Gil
Gregor James Macdonald
Frans Alfons Maria Van Den Keybus
Jose Manuel Bartolome-Nebreda
Michiel Luc Maria Van Gool
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37964744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20092574(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20092574L publication Critical patent/NO20092574L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20092574A 2006-12-08 2009-07-07 Piperidinylamino-pyridaziner og deres anvendelse som raskt dissosierende dopamin-2-reseptor-antagonister NO20092574L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125685 2006-12-08
PCT/EP2007/063338 WO2008068277A1 (en) 2006-12-08 2007-12-05 Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists

Publications (1)

Publication Number Publication Date
NO20092574L true NO20092574L (no) 2009-09-08

Family

ID=37964744

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092574A NO20092574L (no) 2006-12-08 2009-07-07 Piperidinylamino-pyridaziner og deres anvendelse som raskt dissosierende dopamin-2-reseptor-antagonister

Country Status (28)

Country Link
US (1) US8466153B2 (de)
EP (1) EP2091938B1 (de)
JP (1) JP5255568B2 (de)
KR (1) KR101468384B1 (de)
CN (1) CN101547915B (de)
AR (1) AR064198A1 (de)
AT (1) ATE486070T1 (de)
AU (1) AU2007328897B2 (de)
BR (1) BRPI0720247A2 (de)
CA (1) CA2665924C (de)
CL (1) CL2007003556A1 (de)
CY (1) CY1112227T1 (de)
DE (1) DE602007010179D1 (de)
DK (1) DK2091938T3 (de)
EA (1) EA016654B1 (de)
ES (1) ES2354756T3 (de)
IL (1) IL199076A (de)
JO (1) JO2642B1 (de)
MX (1) MX2009005983A (de)
MY (1) MY148772A (de)
NO (1) NO20092574L (de)
NZ (1) NZ576484A (de)
PL (1) PL2091938T3 (de)
PT (1) PT2091938E (de)
SI (1) SI2091938T1 (de)
TW (1) TWI433676B (de)
UA (1) UA98940C2 (de)
WO (1) WO2008068277A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JP2010525013A (ja) * 2007-04-23 2010-07-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 高速解離性ドパミン２受容体アンタゴニストとしてのピリジン誘導体
CA2683111A1 (en) * 2007-04-23 2008-10-30 Janssen Pharmaceutica N.V. 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
MX2009011416A (es) * 2007-04-23 2009-11-05 Janssen Pharmaceutica Nv Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
JP5417439B2 (ja) * 2008-07-03 2014-02-12 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ５−ｈｔ６受容体アンタゴニストとしての置換された６−（１−ピペラジニル）−ピリダジン類
CN102171189B (zh) * 2008-07-31 2013-11-20 詹森药业有限公司 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶
EP4574152A1 (de) * 2023-12-22 2025-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Kaliumkanalaktivatoren zur behandlung von epileptischen erkrankungen

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2341965C3 (de) 1973-08-20 1979-01-25 C.H. Boehringer Sohn, 6507 Ingelheim 4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen
NO147672C (no) 1975-09-23 1983-05-25 Janssen Pharmaceutica Nv Analogifremgangsmaate for fremstilling av n-aryl-n-(1-l1-4-piperidinyl)-arylacetamider
US4197304A (en) 1975-09-23 1980-04-08 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
EG12406A (en) 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
DE3218482A1 (de) 1982-05-15 1983-11-17 Bayer Ag, 5090 Leverkusen Substituierte 5-trifluormethyl-1,3,4-thiadiazol-2-yloxyessigsaeureamide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
MX173362B (es) 1987-03-02 1994-02-23 Pfizer Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
GB9216298D0 (en) 1991-08-15 1992-09-16 Ici Plc Piperidine derivatives
TW406075B (en) 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
US5753679A (en) 1995-05-10 1998-05-19 Hoffmann-La Roche Inc. Benzyl-piperidine derivatives
MY116093A (en) 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
CN1265660A (zh) * 1997-08-15 2000-09-06 辉瑞产品公司 2－(4－芳基或杂芳基－哌嗪－1－基甲基)－1h－吲哚衍生物
KR100261139B1 (ko) 1998-01-16 2000-08-01 황준수 신규한 알릴티오피리다진 유도체 및 그의 제조방법
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
EA005974B1 (ru) 2001-02-23 2005-08-25 Мерк Энд Ко., Инк. N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
PT1443046E (pt) 2001-10-09 2009-02-26 Nisshin Pharma Inc Novas 4-(2-furoil)aminopiperidinas, produtos intermédios para a sua síntese, processos para a sua produção e utilização das mesmas em medicina
AU2002360561A1 (en) 2001-12-11 2003-06-23 Sepracor, Inc. 4-substituted piperidines, and methods of use thereof
CA2474322A1 (en) 2002-01-25 2003-07-31 Kylix Pharmaceuticals B.V. 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2
CN1628109A (zh) 2002-02-05 2005-06-15 诺沃挪第克公司 新颖的芳基－与杂芳基－哌嗪
EP1486490A1 (de) 2002-02-28 2004-12-15 Takeda Chemical Industries, Ltd. Azolverbindungen
SE0201544D0 (sv) 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
AU2003272892A1 (en) 2002-09-26 2004-04-19 Mandom Corporation Antiseptic bactericides and cosmetics, drugs and foods containing the antiseptic bactericides
CA2524498C (en) 2003-05-08 2012-01-24 Kyorin Pharmaceutical Co., Ltd. 4-(2-furoyl)aminopiperidine compound useful as therapeutic agent for itching
WO2005005779A2 (en) 2003-07-14 2005-01-20 Genesis Mining Technologies (Pty) Ltd Dual retention cutting arrangement
AU2004259263B2 (en) 2003-07-29 2010-12-16 High Point Pharmaceuticals, Llc Pyridazinyl- piperazines and their use as histamine H3 receptor ligands
EP1653969A4 (de) 2003-08-07 2006-12-20 Japan Tobacco Inc Pyrrolo 1,2-b pyridazin-derivate
CA2563963A1 (en) 2004-04-28 2005-11-10 Pfizer Inc. 3-heterocyclyl-4-phenyl-triazole derivatives as inhibitors of the vasopressin v1a receptor
CN101005842A (zh) 2004-05-28 2007-07-25 弗特克斯药品有限公司 蕈毒碱性受体调节剂
CA2580855A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
HUE039584T2 (hu) 2004-10-29 2019-01-28 Kalypsys Inc PPAR-modulátor szulfonil-szubsztituált biciklusos vegyületek
EP1902046B1 (de) 2005-06-20 2009-12-02 Schering Corporation Als antagonisten von histamin h3 geeignete piperidinderivate
JO2769B1 (en) 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
WO2007130383A2 (en) 2006-04-28 2007-11-15 Northwestern University Compositions and treatments using pyridazine compounds and secretases
MX2009001498A (es) 2006-08-15 2009-02-18 Hoffmann La Roche Derivados de fenilo, piridina y quinolina.
CA2606658A1 (en) 2006-10-13 2008-04-13 Mike Tyers Compositions and methods for treating neurological disorders or damage
JO2849B1 (en) 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
CN102171189B (zh) 2008-07-31 2013-11-20 詹森药业有限公司 作为快速解离多巴胺2受体拮抗剂的哌嗪-1-基-三氟甲基取代的吡啶

Also Published As

Publication number Publication date
IL199076A (en) 2012-12-31
CN101547915B (zh) 2013-08-21
EP2091938B1 (de) 2010-10-27
AU2007328897A1 (en) 2008-06-12
US8466153B2 (en) 2013-06-18
KR101468384B1 (ko) 2014-12-03
EA016654B1 (ru) 2012-06-29
DK2091938T3 (da) 2011-02-07
CA2665924A1 (en) 2008-06-12
CA2665924C (en) 2014-08-12
KR20090089858A (ko) 2009-08-24
CY1112227T1 (el) 2015-12-09
AU2007328897B2 (en) 2013-01-10
JP2010511673A (ja) 2010-04-15
SI2091938T1 (sl) 2011-02-28
PL2091938T3 (pl) 2011-04-29
WO2008068277A1 (en) 2008-06-12
PT2091938E (pt) 2011-01-20
ATE486070T1 (de) 2010-11-15
HK1137434A1 (en) 2010-07-30
JO2642B1 (en) 2012-06-17
CN101547915A (zh) 2009-09-30
NZ576484A (en) 2010-10-29
TWI433676B (zh) 2014-04-11
BRPI0720247A2 (pt) 2013-12-31
MX2009005983A (es) 2009-06-16
JP5255568B2 (ja) 2013-08-07
EA200970553A1 (ru) 2009-10-30
UA98940C2 (ru) 2012-07-10
DE602007010179D1 (de) 2010-12-09
US20100076187A1 (en) 2010-03-25
AR064198A1 (es) 2009-03-18
CL2007003556A1 (es) 2008-06-13
ES2354756T3 (es) 2011-03-17
TW200831098A (en) 2008-08-01
EP2091938A1 (de) 2009-08-26
MY148772A (en) 2013-05-31

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