NO2015015I2 - Bazedoksifen, eventuelt på form av et farmasøytisk akseptabelt salt slik som acetatsaltet, og konjugerte østrogener. - Google Patents

Bazedoksifen, eventuelt på form av et farmasøytisk akseptabelt salt slik som acetatsaltet, og konjugerte østrogener.

Info

Publication number
NO2015015I2
NO2015015I2 NO2015015C NO2015015C NO2015015I2 NO 2015015 I2 NO2015015 I2 NO 2015015I2 NO 2015015 C NO2015015 C NO 2015015C NO 2015015 C NO2015015 C NO 2015015C NO 2015015 I2 NO2015015 I2 NO 2015015I2
Authority
NO
Norway
Prior art keywords
bazedoxifene
optionally
pharmaceutically acceptable
salt
conjugated estrogens
Prior art date
Application number
NO2015015C
Other languages
English (en)
Other versions
NO2015015I1 (no
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2015015(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of NO2015015I2 publication Critical patent/NO2015015I2/no
Publication of NO2015015I1 publication Critical patent/NO2015015I1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO2015015C 1998-05-15 2015-06-02 Bazedoksifen, eventuelt på form av et farmasøytisk akseptabelt salt slik som acetatsaltet, og konjugerte østrogener. NO2015015I1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15
PCT/US1999/010217 WO1999059581A1 (en) 1998-05-15 1999-05-11 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens

Publications (2)

Publication Number Publication Date
NO2015015I2 true NO2015015I2 (no) 2015-06-02
NO2015015I1 NO2015015I1 (no) 2015-06-02

Family

ID=22151320

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20005770A NO328129B1 (no) 1998-05-15 2000-11-14 Farmasoytisk sammensetning samt anvendelse
NO2015015C NO2015015I1 (no) 1998-05-15 2015-06-02 Bazedoksifen, eventuelt på form av et farmasøytisk akseptabelt salt slik som acetatsaltet, og konjugerte østrogener.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20005770A NO328129B1 (no) 1998-05-15 2000-11-14 Farmasoytisk sammensetning samt anvendelse

Country Status (41)

Country Link
EP (1) EP1076558B1 (no)
JP (3) JP2002515431A (no)
KR (1) KR100620772B1 (no)
CN (1) CN1230163C (no)
AP (1) AP1424A (no)
AR (1) AR020074A1 (no)
AT (1) ATE245026T1 (no)
AU (1) AU760378B2 (no)
BE (1) BE2015C026I2 (no)
BG (1) BG64783B1 (no)
BR (1) BR9911040A (no)
CA (1) CA2329530A1 (no)
CU (1) CU23241B7 (no)
CY (1) CY2015020I1 (no)
CZ (1) CZ299334B6 (no)
DE (1) DE69909616T2 (no)
DK (1) DK1076558T3 (no)
EA (1) EA005932B1 (no)
EE (1) EE04262B1 (no)
ES (1) ES2203131T3 (no)
FR (1) FR15C0035I2 (no)
GE (1) GEP20033079B (no)
HR (1) HRP20000778B1 (no)
HU (2) HU226587B1 (no)
ID (1) ID26890A (no)
IL (1) IL139130A (no)
IN (1) IN192220B (no)
LT (1) LTC1076558I2 (no)
LU (1) LU92699I2 (no)
NO (2) NO328129B1 (no)
NZ (1) NZ508200A (no)
OA (1) OA11552A (no)
PL (1) PL194750B1 (no)
PT (1) PT1076558E (no)
SI (1) SI1076558T1 (no)
SK (1) SK284666B6 (no)
TR (1) TR200003377T2 (no)
TW (1) TW565554B (no)
UA (1) UA66861C2 (no)
WO (1) WO1999059581A1 (no)
ZA (1) ZA200006959B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20000778B1 (en) * 1998-05-15 2004-10-31 Wyeth Corp 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
DE60043305D1 (de) 1999-07-06 2009-12-24 Endorech Inc Pharmazeutische zubereitungen zur behandlung von insulinresitenz
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
WO2002003976A2 (en) * 2000-07-06 2002-01-17 Wyeth Combinations of bisphosphonates, estrogenic agents and optionally estrogens
BR0112365A (pt) * 2000-07-06 2003-05-13 Wyeth Corp Combinações de estatinas, agentes estrogênicos e opcionalmente estrogênios
WO2002003992A2 (en) * 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
CA2448235A1 (en) 2001-07-31 2003-02-13 Pfizer Products Inc. Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
US8367665B2 (en) 2008-04-16 2013-02-05 Karo Bio Ab Estrogen receptor ligands
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
AU2018386201A1 (en) 2017-12-15 2020-07-30 Bristol-Myers Squibb Company Substituted indole ether compounds
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
WO2021185291A1 (zh) * 2020-03-17 2021-09-23 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
US5496844A (en) * 1992-05-08 1996-03-05 Otsuka Pharmaceutical Factory, Inc. Indole derivatives
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
ES2162198T3 (es) * 1996-04-19 2001-12-16 American Home Prod Agentes estrogenos.
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
AU3620597A (en) * 1996-07-09 1998-02-02 Smithkline Beecham Laboratoires Pharmaceutiques Indole derivatives for the treatment of osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
JP2001519410A (ja) * 1997-10-15 2001-10-23 アメリカン・ホーム・プロダクツ・コーポレイション 新規なアリールオキシ−アルキル−ジアルキルアミン
CA2308069A1 (en) * 1997-10-28 1999-05-06 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
UA68365C2 (en) * 1997-11-06 2004-08-16 Wyeth Corp Peroral contraception by combination of anti-estrogen and progestin
HRP20000778B1 (en) * 1998-05-15 2004-10-31 Wyeth Corp 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens

Also Published As

Publication number Publication date
EE200000652A (et) 2002-04-15
ATE245026T1 (de) 2003-08-15
CA2329530A1 (en) 1999-11-25
TR200003377T2 (tr) 2001-03-21
HRP20000778B1 (en) 2004-10-31
BG64783B1 (bg) 2006-04-28
EP1076558A1 (en) 2001-02-21
IL139130A (en) 2005-11-20
CU23241B7 (es) 2007-10-17
BR9911040A (pt) 2001-02-13
LU92699I2 (fr) 2015-06-24
HK1031691A1 (en) 2001-06-22
JP2014159472A (ja) 2014-09-04
PL345268A1 (en) 2001-12-03
JP2009019042A (ja) 2009-01-29
EA200001193A1 (ru) 2001-12-24
NO2015015I1 (no) 2015-06-02
NO20005770D0 (no) 2000-11-14
DE69909616D1 (de) 2003-08-21
JP5872624B2 (ja) 2016-03-01
FR15C0035I2 (fr) 2015-08-28
CN1326347A (zh) 2001-12-12
AU3894499A (en) 1999-12-06
AR020074A1 (es) 2002-04-10
LTC1076558I2 (lt) 2016-11-10
PL194750B1 (pl) 2007-06-29
CN1230163C (zh) 2005-12-07
ZA200006959B (en) 2001-11-27
BE2015C026I2 (en) 2018-08-24
CZ20004254A3 (cs) 2001-12-12
NO20005770L (no) 2001-01-12
AP1424A (en) 2005-06-06
KR20010043641A (ko) 2001-05-25
AU760378B2 (en) 2003-05-15
KR100620772B1 (ko) 2006-09-13
JP5607871B2 (ja) 2014-10-15
CY2015020I1 (el) 2020-05-29
FR15C0035I1 (no) 2015-06-26
HRP20000778A2 (en) 2001-06-30
AP2000001970A0 (en) 2000-12-31
EE04262B1 (et) 2004-04-15
BG104930A (en) 2001-07-31
IN192220B (no) 2004-03-20
ES2203131T3 (es) 2004-04-01
JP2002515431A (ja) 2002-05-28
HU226587B1 (en) 2009-04-28
HUS1500023I1 (hu) 2017-03-28
OA11552A (en) 2004-06-07
PT1076558E (pt) 2003-11-28
HUP0103096A2 (hu) 2002-05-29
TW565554B (en) 2003-12-11
EA005932B1 (ru) 2005-08-25
ID26890A (id) 2001-02-15
SK17202000A3 (sk) 2001-07-10
SK284666B6 (sk) 2005-08-04
GEP20033079B (en) 2003-10-27
IL139130A0 (en) 2001-11-25
WO1999059581A1 (en) 1999-11-25
HUP0103096A3 (en) 2002-11-28
DE69909616T2 (de) 2004-06-17
NZ508200A (en) 2003-09-26
NO328129B1 (no) 2009-12-14
EP1076558B1 (en) 2003-07-16
CZ299334B6 (cs) 2008-06-25
SI1076558T1 (en) 2003-10-31
DK1076558T3 (da) 2003-11-03
UA66861C2 (uk) 2004-06-15

Similar Documents

Publication Publication Date Title
NO2015015I1 (no) Bazedoksifen, eventuelt på form av et farmasøytisk akseptabelt salt slik som acetatsaltet, og konjugerte østrogener.
MXPA01011070A (es) Derivados de esteroides.
NO20021719D0 (no) 6-posisjon substituerte indoliner, fremstilling og anvendelse derav som medikament
ZA200203316B (en) New use and novel n-azabicyclo-amide derivatives.
MXPA02008801A (es) Derivados de indol, proceso para la preparacion de los mismos y su uso.
NO20012567D0 (no) Azepinoindolderivater, fremstilling og anvendelse derav
NO2014012I1 (no) Oklacitinib, evt. i form av et farmasøytisk akseptabelt salt så som maleat
ZA200201509B (en) Pharmaceutically active sulfonamide derivatives.
NO20021379D0 (no) Benzodiazepin-derivater, fremstilling og anvendelse derav
MXPA02005101A (es) Derivados de indol canabimimeticos.
HUP0105414A3 (en) Pyrrolo-isoquinoline, azepino- and diazepino-indole derivatives, their use and pharmaceutical compisitions containing them
DK1119557T3 (da) Indeno-, naphto- og benzocyclohepta-dihydrothiazolderivater, fremstilling deraf og anvendelse deraf som anorektiske medikamenter
MXPA03000753A (es) Derivados de benzimidazola, su preparacion y su aplicacion terapeutica.
AU2922600A (en) Pyridopyranoazepine derivatives, preparation and therapeutic use
HUP9902449A3 (en) Androstene derivatives, medicaments containing the same and their use
ZA991590B (en) Indole derivatives and pharmaceutical compositions comprising the same.
ZA200001746B (en) 3-amino-3-arylpropan-1-ol derivatives, and their preparation and use.
TR200002099A3 (tr) Siklobüten türevleri, bunlarin hazirlanmasi ve terapötik kullanimlari
AU2001264044A1 (en) 1,4-diazabicyclo(3.2.2)nonabenzoxazole, -benzothiazole and benzimidazole derivatives, preparation and therapeutic use thereof
AU2001264042A1 (en) 1,4-diazabicyclo(3.2.2)nonane-phenylisoxazole derivatives, preparation and therapeutic use thereof
NO2010004I1 (no) 0,02 mg etinylostradiol (som betadexclathrat) og 3mg drospirenon
NO20016247D0 (no) Streptograminderivater, deres fremstilling og preparater inneholdende derivatene
MXPA03000644A (es) Nuevos derivados de indol y uso como medicamentos.
AU3971500A (en) Indazole derivatives, preparation and therapeutic application thereof
DE60144456D1 (de) DibenzoÄb,fÜazepin-Derivate und ihre Herstellung

Legal Events

Date Code Title Description
MK1K Patent expired
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: WYETH LLC, US