AR020074A1 - COMPOSICIoN FARMACÉUTICA DE 2-FENIL-1-[4-(2-AMINOETOXI)BENCIL]-INDOL Y ESTRoGENO, Y,SU USO PARA LA MANUFACTURA DE UN MEDICAMENTO - Google Patents
COMPOSICIoN FARMACÉUTICA DE 2-FENIL-1-[4-(2-AMINOETOXI)BENCIL]-INDOL Y ESTRoGENO, Y,SU USO PARA LA MANUFACTURA DE UN MEDICAMENTOInfo
- Publication number
- AR020074A1 AR020074A1 ARP990102310A ARP990102310A AR020074A1 AR 020074 A1 AR020074 A1 AR 020074A1 AR P990102310 A ARP990102310 A AR P990102310A AR P990102310 A ARP990102310 A AR P990102310A AR 020074 A1 AR020074 A1 AR 020074A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- straight
- branched chain
- optionally substituted
- group
- Prior art date
Links
- 229940011871 estrogen Drugs 0.000 title abstract 2
- 239000000262 estrogen Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- -1 C1- alkylthio 4 Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 150000002170 ethers Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- SMYMDRJWEFCCCI-UHFFFAOYSA-N trichloro(trichloromethoxy)methane Chemical compound ClC(Cl)(Cl)OC(Cl)(Cl)Cl SMYMDRJWEFCCCI-UHFFFAOYSA-N 0.000 abstract 2
- WZEOZJQLTRFNCU-UHFFFAOYSA-N trifluoro(trifluoromethoxy)methane Chemical compound FC(F)(F)OC(F)(F)F WZEOZJQLTRFNCU-UHFFFAOYSA-N 0.000 abstract 2
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 abstract 1
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- KQXRJVROLOXPNS-UHFFFAOYSA-N 2-[4-[(2-phenylindol-1-yl)methyl]phenoxy]ethanamine Chemical compound C1=CC(OCCN)=CC=C1CN1C2=CC=CC=C2C=C1C1=CC=CC=C1 KQXRJVROLOXPNS-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000004951 trihalomethoxy group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composicion farmacéutica que contiene uno o más estrogenos y compuestos de 2-fenil-1-[4-(2-aminoetoxi)-bencil]-indol que son utiles comoa gentesestrogénicos, que tienen las siguientes estructuras generales 1 y 2 donde R1 se selecciona de H, OH,oéste res de C1-2 (cadena recta o ramificada) o sus alquiléteres de C1-12 (cadena recta o ramificada o cíclicos) o, halogenos; o éteres halogenados de C1-4 incluyendo al trifluorometil éter y triclorometil éter; R2,R3R4,R5 y R6 se seleccionanindependiente mente de H, OH o ésteres de C1-12(cadena recta o ramificada)o sus alquil éteres de C1-12(cadena recta o ramificada ocíclicos), o éteres halogenados de C1-4 incluyendo al trifluorometil éter y triclorometil éter, ciano alquiloC1-6(cadena recta o rami ficada), o trifluorometilo, con la condicion de que cuando R1 es H, R2 no es OH; X se selecciona de H,alquilo C1-6, ciano, nitro, trifluorometilo, halogeno; n es 2 o 3; Y seselecciona de: a) la porcion (3), donde R7 y R8 seseleccionan independientem ente del grupo formado por H, alquilo C1-6 o fenilo opcionalmente sustituido porCN, alquilo C1-6 (cadena recta o ramificada), alcoxi C1-6(cadena recta o ramificada), halogeno, -OH, -CF3 o -OCF3; b) un heterociclo de 5miembros saturado, nosaturado o parcialmente no saturado que contiene hasta 2 heteroátomos seleccionados del grupo formado por -O-, -NH-, -N(alquilo C1-4)-, -N=, y -S(O)m-; donde mes un entero entre 0-2, opcionalmente sustituido por 1-3sustituyentes independientemente seleccionado s del grupo formado por hidrogeno, hidroxilo, halo,alquilo C1-4, trihalometilo, alcoxi C1-4, trihalometoxi, aciloxi C1-4, alquiltio C1-4, alquilsulfinilo C1-4, alquilsulfonilo C1-4, hidroxi alquiloC1-4,-CO2H-, -CN-, -CONHR1-, -NH2-, alquilamino C1-4 , dialquilamino C1-4, -NHSO2R1-, -NO2, y fenilo opcionalmente sustituido con 1-3alquilo C1-4, c) unheterociclo de 6 miembros saturados, no saturados o parcialmente no saturados que contiene hastados heteroátomos seleccionados del grupo formado por - O-,-NH-, -N(alquilo C1-4)-, -N=, y -S(O)m-, donde m es un entero entre 0-1, opcionalmente sustituido con 1-3 sustituyentes independientemente seleccionados
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7956198A | 1998-05-15 | 1998-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020074A1 true AR020074A1 (es) | 2002-04-10 |
Family
ID=22151320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102310A AR020074A1 (es) | 1998-05-15 | 1999-05-14 | COMPOSICIoN FARMACÉUTICA DE 2-FENIL-1-[4-(2-AMINOETOXI)BENCIL]-INDOL Y ESTRoGENO, Y,SU USO PARA LA MANUFACTURA DE UN MEDICAMENTO |
Country Status (41)
| Country | Link |
|---|---|
| EP (1) | EP1076558B1 (es) |
| JP (3) | JP2002515431A (es) |
| KR (1) | KR100620772B1 (es) |
| CN (1) | CN1230163C (es) |
| AP (1) | AP1424A (es) |
| AR (1) | AR020074A1 (es) |
| AT (1) | ATE245026T1 (es) |
| AU (1) | AU760378B2 (es) |
| BE (1) | BE2015C026I2 (es) |
| BG (1) | BG64783B1 (es) |
| BR (1) | BR9911040A (es) |
| CA (1) | CA2329530A1 (es) |
| CU (1) | CU23241B7 (es) |
| CY (1) | CY2015020I1 (es) |
| CZ (1) | CZ299334B6 (es) |
| DE (1) | DE69909616T2 (es) |
| DK (1) | DK1076558T3 (es) |
| EA (1) | EA005932B1 (es) |
| EE (1) | EE04262B1 (es) |
| ES (1) | ES2203131T3 (es) |
| FR (1) | FR15C0035I2 (es) |
| GE (1) | GEP20033079B (es) |
| HR (1) | HRP20000778B1 (es) |
| HU (2) | HU226587B1 (es) |
| ID (1) | ID26890A (es) |
| IL (1) | IL139130A (es) |
| IN (1) | IN192220B (es) |
| LT (1) | LTC1076558I2 (es) |
| LU (1) | LU92699I2 (es) |
| NO (2) | NO328129B1 (es) |
| NZ (1) | NZ508200A (es) |
| OA (1) | OA11552A (es) |
| PL (1) | PL194750B1 (es) |
| PT (1) | PT1076558E (es) |
| SI (1) | SI1076558T1 (es) |
| SK (1) | SK284666B6 (es) |
| TR (1) | TR200003377T2 (es) |
| TW (1) | TW565554B (es) |
| UA (1) | UA66861C2 (es) |
| WO (1) | WO1999059581A1 (es) |
| ZA (1) | ZA200006959B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20000778B1 (en) * | 1998-05-15 | 2004-10-31 | Wyeth Corp | 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens |
| US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US6465445B1 (en) | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| DE60043305D1 (de) | 1999-07-06 | 2009-12-24 | Endorech Inc | Pharmazeutische zubereitungen zur behandlung von insulinresitenz |
| US20020013327A1 (en) * | 2000-04-18 | 2002-01-31 | Lee Andrew G. | Compositions and methods for treating female sexual dysfunction |
| US6455568B2 (en) | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
| WO2002003976A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Combinations of bisphosphonates, estrogenic agents and optionally estrogens |
| BR0112365A (pt) * | 2000-07-06 | 2003-05-13 | Wyeth Corp | Combinações de estatinas, agentes estrogênicos e opcionalmente estrogênios |
| WO2002003992A2 (en) * | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating prosthesis-related bone degeneration |
| AU2001271781A1 (en) * | 2000-07-06 | 2002-01-21 | Wyeth | Use of substituted indole compounds for treating sphincter incontinence |
| US6376486B1 (en) | 2000-07-06 | 2002-04-23 | American Home Products Corporation | Methods of inhibiting sphincter incontinence |
| DE10117441A1 (de) * | 2001-04-03 | 2002-10-10 | Schering Ag | 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate |
| CA2448235A1 (en) | 2001-07-31 | 2003-02-13 | Pfizer Products Inc. | Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins |
| KR100470274B1 (ko) | 2002-11-08 | 2005-02-05 | 진 장 | 덮개층을 이용한 비정질 물질의 상 변화 방법 |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| FR2880625B1 (fr) * | 2005-01-07 | 2007-03-09 | Sanofi Aventis Sa | Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique |
| US8367665B2 (en) | 2008-04-16 | 2013-02-05 | Karo Bio Ab | Estrogen receptor ligands |
| AR072297A1 (es) * | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| GB201113538D0 (en) | 2011-08-04 | 2011-09-21 | Karobio Ab | Novel estrogen receptor ligands |
| CN102690225B (zh) * | 2012-04-11 | 2014-12-24 | 南京友杰医药科技有限公司 | 巴多昔芬的合成方法 |
| CN103709090A (zh) * | 2014-01-16 | 2014-04-09 | 江苏万特制药有限公司 | 醋酸巴多昔芬的制备方法及其关键中间体 |
| CN103739540B (zh) * | 2014-01-20 | 2016-05-04 | 华润赛科药业有限责任公司 | 一种醋酸巴多昔芬中间体的制备方法 |
| CN105669518B (zh) * | 2014-12-04 | 2019-06-04 | 上海医药集团股份有限公司 | 醋酸巴多昔芬及其a晶型的制备方法 |
| AU2018386201A1 (en) | 2017-12-15 | 2020-07-30 | Bristol-Myers Squibb Company | Substituted indole ether compounds |
| IT201800006562A1 (it) * | 2018-06-21 | 2019-12-21 | Procedimento e intermedi utili per la preparazione di indoli | |
| WO2021185291A1 (zh) * | 2020-03-17 | 2021-09-23 | 南京明德新药研发有限公司 | 蛋白降解调节剂与其使用方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4729999A (en) * | 1984-10-12 | 1988-03-08 | Bcm Technologies | Antiestrogen therapy for symptoms of estrogen deficiency |
| US5496844A (en) * | 1992-05-08 | 1996-03-05 | Otsuka Pharmaceutical Factory, Inc. | Indole derivatives |
| TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| GB9326332D0 (en) * | 1993-12-23 | 1994-02-23 | Karo Bio | Indole derivatives |
| DE4426625A1 (de) * | 1994-07-27 | 1996-03-14 | Schering Ag | 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln |
| ES2162198T3 (es) * | 1996-04-19 | 2001-12-16 | American Home Prod | Agentes estrogenos. |
| TW397821B (en) * | 1996-04-19 | 2000-07-11 | American Home Produits Corp | 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof |
| AU3620597A (en) * | 1996-07-09 | 1998-02-02 | Smithkline Beecham Laboratoires Pharmaceutiques | Indole derivatives for the treatment of osteoporosis |
| US5672609A (en) * | 1996-07-18 | 1997-09-30 | Eli Lilly And Company | Pyridine compounds, intermediates compositions and methods of use |
| JP2001519410A (ja) * | 1997-10-15 | 2001-10-23 | アメリカン・ホーム・プロダクツ・コーポレイション | 新規なアリールオキシ−アルキル−ジアルキルアミン |
| CA2308069A1 (en) * | 1997-10-28 | 1999-05-06 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
| UA68365C2 (en) * | 1997-11-06 | 2004-08-16 | Wyeth Corp | Peroral contraception by combination of anti-estrogen and progestin |
| HRP20000778B1 (en) * | 1998-05-15 | 2004-10-31 | Wyeth Corp | 2-phenyl-1-/4-(2-aminoethoxy)-benzyl/-indole in combination with estrogens |
-
1999
- 1999-05-11 HR HR20000778A patent/HRP20000778B1/xx not_active IP Right Cessation
- 1999-05-11 ID IDW20002312A patent/ID26890A/id unknown
- 1999-05-11 GE GEAP19995675A patent/GEP20033079B/en unknown
- 1999-05-11 AU AU38944/99A patent/AU760378B2/en not_active Expired
- 1999-05-11 EE EEP200000652A patent/EE04262B1/xx active Protection Beyond IP Right Term
- 1999-05-11 CA CA002329530A patent/CA2329530A1/en not_active Abandoned
- 1999-05-11 HU HU0103096A patent/HU226587B1/hu active Protection Beyond IP Right Term
- 1999-05-11 CN CNB99808655XA patent/CN1230163C/zh not_active Expired - Lifetime
- 1999-05-11 PL PL99345268A patent/PL194750B1/pl unknown
- 1999-05-11 JP JP2000549246A patent/JP2002515431A/ja not_active Withdrawn
- 1999-05-11 EA EA200001193A patent/EA005932B1/ru not_active IP Right Cessation
- 1999-05-11 NZ NZ508200A patent/NZ508200A/en not_active IP Right Cessation
- 1999-05-11 PT PT99921834T patent/PT1076558E/pt unknown
- 1999-05-11 BR BR9911040-7A patent/BR9911040A/pt not_active Application Discontinuation
- 1999-05-11 ES ES99921834T patent/ES2203131T3/es not_active Expired - Lifetime
- 1999-05-11 DE DE69909616T patent/DE69909616T2/de not_active Expired - Lifetime
- 1999-05-11 IL IL13913099A patent/IL139130A/xx not_active IP Right Cessation
- 1999-05-11 OA OA1200000311A patent/OA11552A/en unknown
- 1999-05-11 SI SI9930339T patent/SI1076558T1/xx unknown
- 1999-05-11 TR TR2000/03377T patent/TR200003377T2/xx unknown
- 1999-05-11 WO PCT/US1999/010217 patent/WO1999059581A1/en not_active Ceased
- 1999-05-11 AP APAP/P/2000/001970A patent/AP1424A/en active
- 1999-05-11 AT AT99921834T patent/ATE245026T1/de active
- 1999-05-11 SK SK1720-2000A patent/SK284666B6/sk not_active IP Right Cessation
- 1999-05-11 CZ CZ20004254A patent/CZ299334B6/cs not_active IP Right Cessation
- 1999-05-11 UA UA2000127184A patent/UA66861C2/uk unknown
- 1999-05-11 EP EP99921834A patent/EP1076558B1/en not_active Expired - Lifetime
- 1999-05-11 KR KR1020007012821A patent/KR100620772B1/ko not_active Expired - Lifetime
- 1999-05-11 DK DK99921834T patent/DK1076558T3/da active
- 1999-05-13 TW TW088107747A patent/TW565554B/zh not_active IP Right Cessation
- 1999-05-14 AR ARP990102310A patent/AR020074A1/es not_active Application Discontinuation
-
2000
- 2000-11-08 BG BG104930A patent/BG64783B1/bg unknown
- 2000-11-14 NO NO20005770A patent/NO328129B1/no not_active IP Right Cessation
- 2000-11-15 CU CU20000255A patent/CU23241B7/es not_active IP Right Cessation
- 2000-11-27 ZA ZA200006959A patent/ZA200006959B/en unknown
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2001
- 2001-07-31 IN IN419CA2001 patent/IN192220B/en unknown
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2008
- 2008-07-29 JP JP2008195115A patent/JP5607871B2/ja not_active Expired - Lifetime
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2014
- 2014-05-12 JP JP2014098831A patent/JP5872624B2/ja not_active Expired - Lifetime
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2015
- 2015-04-15 LT LTPA2015018C patent/LTC1076558I2/lt unknown
- 2015-04-17 HU HUS1500023C patent/HUS1500023I1/hu unknown
- 2015-04-24 LU LU92699C patent/LU92699I2/xx unknown
- 2015-04-28 BE BE2015C026C patent/BE2015C026I2/fr unknown
- 2015-05-06 FR FR15C0035C patent/FR15C0035I2/fr active Active
- 2015-05-29 CY CY2015020C patent/CY2015020I1/el unknown
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