NO2639780T3 - - Google Patents

Info

Publication number: NO2639780T3
Authority: NO; Norway

Application number

NO13001311A

Other languages

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-09-12

Filing date

2013-03-15

Publication date

2018-06-23

2013-03-15 Application filed filed Critical

2018-06-23 Publication of NO2639780T3 publication Critical patent/NO2639780T3/no

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO13001311A 2011-09-12 2013-03-15 NO2639780T3 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201161533606P	2011-09-12	2011-09-12

Publications (1)

Publication Number	Publication Date
NO2639780T3 true NO2639780T3 (fr)	2018-06-23

Family

ID=46964039

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO13001311A NO2639780T3 (fr)	2011-09-12	2013-03-15

Country Status (24)

Country	Link
US (3)	US9321760B2 (fr)
EP (1)	EP2755958B9 (fr)
JP (1)	JP6082011B2 (fr)
KR (1)	KR101992505B1 (fr)
CN (2)	CN106946796B (fr)
AU (2)	AU2012308681B2 (fr)
BR (1)	BR112014005468A2 (fr)
CA (1)	CA2844704C (fr)
DK (1)	DK2755958T3 (fr)
EA (1)	EA028057B1 (fr)
ES (1)	ES2646759T3 (fr)
HR (1)	HRP20171655T1 (fr)
HU (1)	HUE034979T2 (fr)
IL (2)	IL231381B (fr)
LT (1)	LT2755958T (fr)
MX (1)	MX347241B (fr)
NO (1)	NO2639780T3 (fr)
PL (1)	PL2755958T3 (fr)
PT (1)	PT2755958T (fr)
RS (1)	RS56486B1 (fr)
SG (1)	SG2014009260A (fr)
SI (1)	SI2755958T1 (fr)
WO (1)	WO2013040044A1 (fr)
ZA (1)	ZA201401007B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX354412B (es)	2011-06-10	2018-03-05	Merck Patent Gmbh	Composiciones y metodos para la produccion de compuestos de pirimidina con actividad inhibidora de tirosina cinasa de bruton.
US9321760B2 (en) *	2011-09-12	2016-04-26	Merck Patent Gmbh	Aminopyrimidine derivatives for use as modulators of kinase activity
US9580443B2 (en)	2012-11-16	2017-02-28	Merck Patent Gmbh	Heterocyclic derivatives as modulators of kinase activity
AR095202A1 (es) *	2013-03-11	2015-09-30	Merck Patent Gmbh	Heterociclos como moduladores de la actividad quinasa
JO3517B1 (ar)	2014-01-17	2020-07-05	Novartis Ag	ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
ES2699351T3 (es)	2014-01-17	2019-02-08	Novartis Ag	Derivados de 1-piridazin/triazin-3-il-piper(-azina)/idina/pirolidina y composiciones de las mismas para inhibir la actividad de SHP2
WO2015107494A1 (fr)	2014-01-17	2015-07-23	Novartis Ag	Dérivés de 1-(triazin-3-yl/pyridazin-3-yl)-piper(-azine)idine et compositions les contenant pour l'inhibition de l'activité de shp2
MX2016010268A (es) *	2014-02-11	2016-10-13	Merck Patent Gmbh	Pirimidinimidazolaminas como modulares de actividad de cinasa.
EP3942912B1 (fr)	2014-04-30	2023-11-22	LG Electronics Inc.	Robot pour tondre le gazon
MX2016015613A (es) *	2014-05-28	2017-04-13	Astrazeneca Ab	Procesos para la preparacion de azd5363 e intermedios novedosos utilizados en el mismo.
WO2016203405A1 (fr)	2015-06-19	2016-12-22	Novartis Ag	Composés et compositions pour inhiber l'activité de shp2
EP3310779B1 (fr)	2015-06-19	2019-05-08	Novartis AG	Composés et compositions pour l'inhibition de l'activité de shp2
US10287266B2 (en)	2015-06-19	2019-05-14	Novartis Ag	Compounds and compositions for inhibiting the activity of SHP2
US10829484B2 (en)	2015-07-28	2020-11-10	Plexxikon Inc.	Compounds and methods for kinase modulation, and indications therefor
ES2904615T3 (es) *	2016-03-16	2022-04-05	Plexxikon Inc	Compuestos y métodos para la modulación de quinasas e indicaciones al respecto
WO2017216706A1 (fr)	2016-06-14	2017-12-21	Novartis Ag	Composés et compositions pour l'inhibition de l'activité de shp2
CA3048340A1 (fr)	2017-01-10	2018-07-19	Novartis Ag	Combinaison pharmaceutique comprenant un inhibiteur d'alk et un inhibiteur de shp2
CN109467538A (zh)	2017-09-07	2019-03-15	和记黄埔医药（上海）有限公司	环烯烃取代的杂芳环类化合物及其用途
US11369608B2 (en)	2017-10-27	2022-06-28	University Of Virginia Patent Foundation	Compounds and methods for regulating, limiting, or inhibiting AVIL expression
EP3962485A4 (fr) *	2019-05-02	2022-12-28	University Of Virginia Patent Foundation	Analogues de (pipéridin-1-yl)aryle substitués pour la modulation de l'activité de l'avil
US11866421B2 (en)	2021-05-31	2024-01-09	Epigen Biosciences, Inc.	Pyrimidine and pyridine amine compounds and usage thereof in disease treatment
CN116903592B (zh) *	2023-07-13	2025-08-01	特科罗生物科技(成都)有限公司	一种嘧啶胺类nuak抑制剂及其制备方法和用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020137755A1 (en) *	2000-12-04	2002-09-26	Bilodeau Mark T.	Tyrosine kinase inhibitors
TW200306819A (en)	2002-01-25	2003-12-01	Vertex Pharma	Indazole compounds useful as protein kinase inhibitors
AU2004230841A1 (en)	2003-04-03	2004-10-28	Vertex Pharmaceuticals Incorporated	Compositions useful as inhibitors of protein kinases
EP1670771A4 (fr)	2003-09-30	2010-09-01	Irm Llc	Composes et compositions inhibant les proteines-kinases
WO2005039506A2 (fr)	2003-10-24	2005-05-06	Exelixis, Inc.	Modulateurs des p70s6 kinases et procede d'utilisation
PT1687305E (pt)	2003-11-21	2008-10-17	Novartis Ag	Derivados de 1h-imidazoquinolina como inibidores de proteína quinase
NZ590160A (en) *	2003-11-21	2012-07-27	Array Biopharma Inc	AKT protein kinase inhibitors
ATE447957T1 (de)	2003-12-09	2009-11-15	Us Gov Health & Human Serv	Verfahren zur unterdrückung einer immunantwort oder zur behandlung von proliferativen erkrankungen
WO2005117909A2 (fr)	2004-04-23	2005-12-15	Exelixis, Inc.	Modulateurs des proteines kinases et leurs methodes d'utilisation
JP5274842B2 (ja) *	2004-12-28	2013-08-28	エグゼリクシス，インコーポレイテッド	免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物
WO2006078992A2 (fr)	2005-01-19	2006-07-27	Neurogen Corporation	Analogues de piperazinyl-pyridine à substitution hétéroaryle
GB0501999D0 (en)	2005-02-01	2005-03-09	Sentinel Oncology Ltd	Pharmaceutical compounds
US8343953B2 (en)	2005-06-22	2013-01-01	Astex Therapeutics Limited	Pharmaceutical compounds
DK3421471T3 (da) *	2006-04-25	2021-06-14	Astex Therapeutics Ltd	Purin- og deazapurinderivater som farmaceutiske forbindelser
WO2008012635A2 (fr) *	2006-07-26	2008-01-31	Pfizer Products Inc.	Dérivés d'amines utiles en tant qu'agents anticancéreux
CA2669687C (fr) *	2006-11-15	2013-09-10	Forest Laboratories Holdings Limited	Derives de phtalazine
CA2672373C (fr) *	2006-12-19	2011-08-30	Pfizer Products Inc.	Derives de la nicotinamide en tant qu'inhibiteurs de h-pgds et leur utilisation dans le traitement de maladies liees aux prostaglandines d2
UA99284C2 (ru)	2007-05-11	2012-08-10	Елі Ліллі Енд Компані	ИНГИБИТОРЫ р70 S6-КИНАЗЫ
AR074072A1 (es)	2008-11-11	2010-12-22	Lilly Co Eli	Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme
SI2396307T1 (sl)	2009-02-11	2015-02-27	Merck Patent Gmbh	Novi amino azaheterockliäśni karboksamidi
EP2485589A4 (fr) *	2009-09-04	2013-02-06	Biogen Idec Inc	Inhibiteurs hétéroaryles de btk
AU2011282684B2 (en)	2010-07-29	2015-05-21	Merck Patent Gmbh	Cyclic amine azaheterocyclic carboxamides
UA110113C2 (xx)	2010-07-29	2015-11-25		Біциклічні азагетероциклічні карбоксаміди
LT2643313T (lt)	2010-11-24	2016-10-25	Merck Patent Gmbh	Chinazolino karboksamido azetidinai
US9321760B2 (en) *	2011-09-12	2016-04-26	Merck Patent Gmbh	Aminopyrimidine derivatives for use as modulators of kinase activity
PT2755965T (pt) *	2011-09-12	2017-11-02	Merck Patent Gmbh	Novas imidazol aminas como moduladores da atividade quinase
EP2920154B1 (fr) *	2012-11-16	2017-10-11	Merck Patent GmbH	Nouveaux dérivés imidazol-pipéridinyle en tant que modulateurs de l'activité kinase
MX2016010268A (es) *	2014-02-11	2016-10-13	Merck Patent Gmbh	Pirimidinimidazolaminas como modulares de actividad de cinasa.

2012
- 2012-09-12 US US14/236,405 patent/US9321760B2/en not_active Expired - Fee Related
- 2012-09-12 LT LTEP12766773.1T patent/LT2755958T/lt unknown
- 2012-09-12 BR BR112014005468A patent/BR112014005468A2/pt not_active IP Right Cessation
- 2012-09-12 CN CN201710022892.9A patent/CN106946796B/zh not_active Expired - Fee Related
- 2012-09-12 JP JP2014530756A patent/JP6082011B2/ja not_active Expired - Fee Related
- 2012-09-12 AU AU2012308681A patent/AU2012308681B2/en not_active Ceased
- 2012-09-12 CA CA2844704A patent/CA2844704C/fr not_active Expired - Fee Related
- 2012-09-12 EA EA201400338A patent/EA028057B1/ru not_active IP Right Cessation
- 2012-09-12 ES ES12766773.1T patent/ES2646759T3/es active Active
- 2012-09-12 CN CN201280054959.2A patent/CN103930407B/zh not_active Expired - Fee Related
- 2012-09-12 DK DK12766773.1T patent/DK2755958T3/en active
- 2012-09-12 PL PL12766773T patent/PL2755958T3/pl unknown
- 2012-09-12 SG SG2014009260A patent/SG2014009260A/en unknown
- 2012-09-12 KR KR1020147007739A patent/KR101992505B1/ko not_active Expired - Fee Related
- 2012-09-12 PT PT127667731T patent/PT2755958T/pt unknown
- 2012-09-12 WO PCT/US2012/054877 patent/WO2013040044A1/fr not_active Ceased
- 2012-09-12 SI SI201231118T patent/SI2755958T1/sl unknown
- 2012-09-12 MX MX2014002836A patent/MX347241B/es active IP Right Grant
- 2012-09-12 HR HRP20171655TT patent/HRP20171655T1/hr unknown
- 2012-09-12 EP EP12766773.1A patent/EP2755958B9/fr active Active
- 2012-09-12 HU HUE12766773A patent/HUE034979T2/en unknown
- 2012-09-12 RS RS20171130A patent/RS56486B1/sr unknown
2013
- 2013-03-15 NO NO13001311A patent/NO2639780T3/no unknown
2014
- 2014-02-10 ZA ZA2014/01007A patent/ZA201401007B/en unknown
- 2014-03-06 IL IL231381A patent/IL231381B/en active IP Right Grant
2016
- 2016-03-03 US US15/060,050 patent/US9662330B2/en not_active Expired - Fee Related
2017
- 2017-04-18 US US15/490,370 patent/US10080750B2/en active Active
- 2017-10-09 AU AU2017245469A patent/AU2017245469B2/en not_active Ceased
2019
- 2019-05-07 IL IL266510A patent/IL266510B/en active IP Right Grant

Also Published As

Publication number	Publication date
AU2012308681B2 (en)	2017-07-13
WO2013040044A1 (fr)	2013-03-21
ZA201401007B (en)	2018-07-25
LT2755958T (lt)	2017-11-10
IL266510B (en)	2021-01-31
HRP20171655T1 (hr)	2017-12-15
US10080750B2 (en)	2018-09-25
CA2844704C (fr)	2020-04-28
EP2755958B9 (fr)	2018-02-28
AU2012308681A1 (en)	2014-02-27
HK1198168A1 (en)	2015-03-13
KR20140062494A (ko)	2014-05-23
JP2014527082A (ja)	2014-10-09
EP2755958B1 (fr)	2017-08-09
BR112014005468A2 (pt)	2017-03-21
SG2014009260A (en)	2014-09-26
US9321760B2 (en)	2016-04-26
EP2755958A1 (fr)	2014-07-23
MX2014002836A (es)	2014-05-28
KR101992505B1 (ko)	2019-06-24
JP6082011B2 (ja)	2017-02-15
RS56486B1 (sr)	2018-01-31
SI2755958T1 (sl)	2017-12-29
ES2646759T3 (es)	2017-12-15
MX347241B (es)	2017-04-20
US9662330B2 (en)	2017-05-30
US20150126484A1 (en)	2015-05-07
US20160184308A1 (en)	2016-06-30
PL2755958T3 (pl)	2017-12-29
US20170217905A1 (en)	2017-08-03
CN106946796B (zh)	2020-05-08
EA201400338A1 (ru)	2014-12-30
CA2844704A1 (fr)	2013-03-21
HUE034979T2 (en)	2018-05-02
CN103930407B (zh)	2019-02-26
EA028057B1 (ru)	2017-10-31
IL231381B (en)	2019-05-30
IL231381A0 (en)	2014-04-30
CN103930407A (zh)	2014-07-16
IL266510A (en)	2019-07-31
CN106946796A (zh)	2017-07-14
DK2755958T3 (en)	2017-09-25
PT2755958T (pt)	2017-11-14
AU2017245469A1 (en)	2017-11-02
AU2017245469B2 (en)	2019-05-23

Publication	Publication Date	Title
BR112013031251A2 (fr)	2017-09-12
BR112013027245A2 (fr)	2017-01-03
BR112013026905A2 (fr)	2017-01-03
BR112013017670A2 (fr)	2017-08-15
BR112013027830A2 (fr)	2017-01-03
AP3853A (fr)	2016-09-30
BR112013027452A2 (fr)	2017-01-03
BR112013028733A2 (fr)	2017-08-29
BR112013027121A2 (fr)	2017-01-03
AP2016009466A0 (fr)	2016-09-30
BR112013031556A2 (fr)	2017-08-29
BR112013032368A2 (fr)	2017-01-03
NO2639780T3 (fr)	2018-06-23
BR112013032377A2 (fr)	2017-01-03
BR112013032380A2 (fr)	2017-01-03
BR112013027836A2 (fr)	2017-01-03
BR112013026895A2 (fr)	2017-01-03
BR112013018949A2 (fr)	2017-09-12
BR112013027761A2 (fr)	2017-01-03
BR112013021637A2 (fr)	2012-11-01
BR112013032392A2 (fr)	2017-01-03
BR112013030734A2 (fr)	2017-04-04
BR112013017878A2 (fr)	2017-08-15
BR112013027871A2 (fr)	2017-01-03
BR112013032394A2 (fr)	2017-01-03