NO301015B1 - Dekapeptid med antiovulatorisk aktivitet - Google Patents

Dekapeptid med antiovulatorisk aktivitet Download PDF

Info

Publication number: NO301015B1
Authority: NO; Norway
Prior art keywords: piclys; niclys; ilys; decapeptide; decapeptide according
Prior art date: 1987-08-24

Application number

NO900888A

Other languages

English (en)

Norwegian (no)

Other versions

NO900888D0 (no

NO900888L (no

Inventor

Karl Folkers

Cyril Y Bowers

Anders Ljungquist

Pui-Fun Louisa Tang

Minoru Kobota

Dong-Mei Feng

Original Assignee

Univ Texas

Univ Tulane

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-24

Filing date

1990-02-23

Publication date

1997-09-01

1990-02-23 Application filed by Univ Texas, Univ Tulane filed Critical Univ Texas

1990-02-23 Publication of NO900888D0 publication Critical patent/NO900888D0/no

1990-04-23 Publication of NO900888L publication Critical patent/NO900888L/no

1994-06-10 Priority to NO942179A priority Critical patent/NO302577B1/no

1997-09-01 Publication of NO301015B1 publication Critical patent/NO301015B1/no

Links

230000002513 anti-ovulatory effect Effects 0.000 title claims abstract description 42
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QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims abstract description 19
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QRYFGTULTGLGHU-NBERXCRTSA-N iturelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CCCCNC(=O)C=1C=NC=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)CCCNC(=O)C1=CC=CN=C1 QRYFGTULTGLGHU-NBERXCRTSA-N 0.000 abstract 6
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Polyesters Or Polycarbonates (AREA)
Macromonomer-Based Addition Polymer (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO900888A 1987-08-24 1990-02-23 Dekapeptid med antiovulatorisk aktivitet NO301015B1 (no)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
NO942179A NO302577B1 (no)	1987-08-24	1994-06-10	Analogifremgangsmåte for fremstilling av terapeutisk aktive dekapeptider

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/088,431 US4935491A (en)	1987-08-24	1987-08-24	Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
PCT/US1988/002922 WO1989001944A1 (en)	1987-08-24	1988-08-24	Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine

Publications (3)

Publication Number	Publication Date
NO900888D0 NO900888D0 (no)	1990-02-23
NO900888L NO900888L (no)	1990-04-23
NO301015B1 true NO301015B1 (no)	1997-09-01

Family

ID=22211329

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO900888A NO301015B1 (no)	1987-08-24	1990-02-23	Dekapeptid med antiovulatorisk aktivitet

Country Status (14)

Country	Link
US (3)	US4935491A (de)
EP (1)	EP0377665B1 (de)
JP (1)	JP2621970B2 (de)
KR (1)	KR0135276B1 (de)
AT (1)	ATE124957T1 (de)
AU (1)	AU619221B2 (de)
DE (1)	DE3854159T2 (de)
DK (1)	DK173753B1 (de)
FI (1)	FI102074B1 (de)
HU (2)	HU213098B (de)
MX (1)	MX9203688A (de)
NO (1)	NO301015B1 (de)
OA (1)	OA09786A (de)
WO (1)	WO1989001944A1 (de)

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US5171835A (en) *	1988-10-21	1992-12-15	The Administrators Of The Tulane Educational Fund	LHRH antagonists
US5447912A (en) *	1989-09-18	1995-09-05	Senetek, Plc	Erection-inducing methods and compositions
US5169932A (en) *	1989-10-30	1992-12-08	The Salk Institute For Biological Studies	Gnrh analogs
US5296468A (en) *	1989-10-30	1994-03-22	The Salk Institute For Biological Studies	GnRH analogs
US5352796A (en) *	1989-10-30	1994-10-04	The Salk Institute For Biological Studies	Amino acids useful in making GnRH analogs
US5212288A (en) *	1990-02-20	1993-05-18	Syntex (U.S.A.) Inc.	Temporary minimal protection synthesis of serine-containing polypeptides
US5180711A (en) *	1990-06-14	1993-01-19	Applied Research Systems Ars Holding N.V.	Combined treatment with gnrh antagonist and gnrh to control gonadotropin levels in mammals
US5169935A (en) *	1990-06-20	1992-12-08	The Salk Institute For Biological Studies	Method of making peptides
US5744450A (en) *	1991-03-14	1998-04-28	The Salk Institute For Biological Studies	GnRH analogs
DE69214818T2 (de) *	1991-04-25	1997-02-27	Romano S.-Cergue Deghenghi	LHRH-Antagonisten
DE4117507A1 (de) *	1991-05-24	1992-11-26	Schering Ag	Verfahren zur herstellung von n(pfeil hoch)6(pfeil hoch)-substituierten lysin-derivaten
US5656727A (en) *	1992-09-15	1997-08-12	The Administrators Of The Tulane Educational Fund	Antagonists of LHRH
US5480969A (en) *	1992-09-15	1996-01-02	The Administrators Of The Tulane Educational Fund	Antagonists of LHRH
JPH08510260A (ja) *	1993-05-20	1996-10-29	バイオテック・オーストラリア・プロプライエタリー・リミテッド	Ｌｈｒｈ拮抗剤
US5843901A (en)	1995-06-07	1998-12-01	Advanced Research & Technology Institute	LHRH antagonist peptides
US6043218A (en)	1996-10-22	2000-03-28	Medical University Of South Carolina	Positively charged non-natural amino acids, methods of making thereof, and use thereof in peptides
US6566330B1 (en)	1996-10-22	2003-05-20	Medical University Of South Carolina Foundation Research Development	Positively charged non-natural amino acids, methods of making and using thereof in peptides
US5968895A (en)	1996-12-11	1999-10-19	Praecis Pharmaceuticals, Inc.	Pharmaceutical formulations for sustained drug delivery
US5821230A (en) *	1997-04-11	1998-10-13	Ferring Bv	GnRH antagonist decapeptides
US5925730A (en)	1997-04-11	1999-07-20	Ferring Bv	GnRH antagonists
EP0880969A1 (de) *	1997-05-28	1998-12-02	Applied Research Systems ARS Holdings N.V.	Im physiologischem Medium schwerlösliche pharmazeutische Peptidezusammensetzungen
EP0882736A1 (de) *	1997-06-02	1998-12-09	Laboratoire Theramex S.A.	Peptidanaloge des LH-RH, ihre Verwendungen und die sie enthaltenden pharmazeutischen Zusammensetzungen
US6217844B1 (en)	1998-04-27	2001-04-17	Praecis Pharmaceuticals, Inc.	Methods for detecting lesions in dense breast tissue using LHRH antagonists
US7953788B2 (en)	2001-09-29	2011-05-31	Siebel Systems, Inc.	System and method for queuing data for an application server
DE69939036D1 (de)	1998-04-28	2008-08-14	Serono Lab	PEG Konjugate von LHRH Analogen
US6455499B1 (en)	1999-02-23	2002-09-24	Indiana University Foundation	Methods for treating disorders associated with LHRH activity
US7109171B2 (en)	2000-02-28	2006-09-19	Praecis Pharmaceuticals Inc.	Methods for treating FSH related conditions with GnRH antagonists
US6598784B2 (en) *	2000-12-20	2003-07-29	Meadwestvaco Packaging Syatens, Llc	Beverage carton with strap type carrying handle
DK1345593T3 (da) *	2000-12-27	2007-12-10	Ares Trading Sa	Lipidmikropartikler ved kryogen mikronisering
JP2002201168A (ja) *	2000-12-28	2002-07-16	Kaken Pharmaceut Co Ltd	シクロヘキサン誘導体
WO2002056903A2 (en) *	2001-01-17	2002-07-25	Praecis Pharmaceuticals Inc.	Methods for treating hormone associated conditions using a combination of lhrh antagonists and specific estrogen receptor modulators
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US4801577A (en) *	1987-02-05	1989-01-31	Syntex (U.S.A.) Inc.	Nonapeptide and decapeptide analogs of LHRH useful as LHRH antagonists
US4851385A (en) *	1987-07-15	1989-07-25	Indiana University Foundation	LHRH antagonist analogs having low histamine-release activity
DE68928278T2 (de) *	1988-02-10	1998-03-12	Tap Pharmaceuticals Inc	Lhrh-analog
US5300492A (en) *	1988-02-10	1994-04-05	Tap Pharmaceuticals	LHRH analogs
US5140009A (en) *	1988-02-10	1992-08-18	Tap Pharmaceuticals, Inc.	Octapeptide LHRH antagonists
US5180711A (en) *	1990-06-14	1993-01-19	Applied Research Systems Ars Holding N.V.	Combined treatment with gnrh antagonist and gnrh to control gonadotropin levels in mammals
US5413990A (en) *	1993-08-06	1995-05-09	Tap Pharmaceuticals Inc.	N-terminus modified analogs of LHRH

1987
- 1987-08-24 US US07/088,431 patent/US4935491A/en not_active Expired - Lifetime
1988
- 1988-08-24 AU AU25294/88A patent/AU619221B2/en not_active Expired
- 1988-08-24 AT AT88908786T patent/ATE124957T1/de not_active IP Right Cessation
- 1988-08-24 KR KR1019890700699A patent/KR0135276B1/ko not_active Expired - Fee Related
- 1988-08-24 MX MX9203688A patent/MX9203688A/es unknown
- 1988-08-24 WO PCT/US1988/002922 patent/WO1989001944A1/en not_active Ceased
- 1988-08-24 EP EP88908786A patent/EP0377665B1/de not_active Expired - Lifetime
- 1988-08-24 JP JP63507982A patent/JP2621970B2/ja not_active Expired - Lifetime
- 1988-08-24 DE DE3854159T patent/DE3854159T2/de not_active Expired - Lifetime
- 1988-08-24 HU HU885868A patent/HU213098B/hu unknown
1989
- 1989-06-26 US US07/371,552 patent/US5470947A/en not_active Expired - Lifetime
1990
- 1990-02-23 NO NO900888A patent/NO301015B1/no not_active IP Right Cessation
- 1990-02-23 FI FI900947A patent/FI102074B1/fi not_active IP Right Cessation
- 1990-02-23 DK DK199000486A patent/DK173753B1/da not_active IP Right Cessation
- 1990-02-26 OA OA59743A patent/OA09786A/en unknown
1995
- 1995-06-06 US US08/466,333 patent/US5763404A/en not_active Expired - Lifetime
- 1995-06-29 HU HU95P/P00574P patent/HU211882A9/hu unknown

Also Published As

Publication number	Publication date
FI102074B (fi)	1998-10-15
HU211882A9 (en)	1995-12-28
EP0377665B1 (de)	1995-07-12
AU2529488A (en)	1989-03-31
WO1989001944A1 (en)	1989-03-09
HUT59940A (en)	1992-07-28
HU885868D0 (en)	1991-12-30
US5763404A (en)	1998-06-09
EP0377665A1 (de)	1990-07-18
DE3854159D1 (de)	1995-08-17
FI900947A0 (fi)	1990-02-23
DK48690D0 (da)	1990-02-23
DK48690A (da)	1990-04-19
AU619221B2 (en)	1992-01-23
NO900888D0 (no)	1990-02-23
JP2621970B2 (ja)	1997-06-18
OA09786A (en)	1994-04-15
US5470947A (en)	1995-11-28
KR890701117A (ko)	1989-12-19
NO900888L (no)	1990-04-23
FI102074B1 (fi)	1998-10-15
JPH03501969A (ja)	1991-05-09
US4935491A (en)	1990-06-19
MX9203688A (es)	1992-09-01
KR0135276B1 (ko)	1998-04-23
HU213098B (en)	1997-02-28
DE3854159T2 (de)	1996-02-15
ATE124957T1 (de)	1995-07-15
DK173753B1 (da)	2001-09-10

Legal Events

Date	Code	Title	Description
2008-09-08	MK1K	Patent expired

Publication	Publication Date	Title
NO301015B1 (no)	1997-09-01	Dekapeptid med antiovulatorisk aktivitet
DK173375B1 (da)	2000-09-11	LHRH-Antagonister, deres fremstilling og lægemidler der indeholder dem
FI92326C (fi)	1994-10-25	LHRH:n nonapeptidi- ja dekapeptidianalogeja, jotka ovat käyttökelpoisia LHRH:n antagonisteina
JP4249806B2 (ja)	2009-04-08	５位および６位で修飾されているＧｎＲＨ拮抗物質
FI60553B (fi)	1981-10-30	Foerfarande foer framstaellning av ovulationsframkallande nonapeptidamidderivat
NO834404L (no)	1983-12-12	Nonapeptid- og dekapeptid-analoger av lhrh med befruktningshindrende virkning
NO178306B (no)	1995-11-20	Analogifremgangsmåte ved fremstilling av bombesin-antagonistpeptid
JPH05505630A (ja)	1993-08-19	Ｌｈｒｈ拮抗薬
HUP0003592A2 (hu)	2001-02-28	LH-RH peptid analógok, alkalmazásuk, és ezeket tartalmazó gyógyászati készítmények
HU211603A9 (en)	1995-12-28	Nonapeptide bombesin antagonists
HU200785B (en)	1990-08-28	Process for producing antagonist decapeptide derivatives of gonadotropin releasing hormone
JP3801867B2 (ja)	2006-07-26	改善された溶解特性を有する新規のｌｈｒｈアンタゴニスト
EP0328090A2 (de)	1989-08-16	LHRH-Analoge
US4705778A (en)	1987-11-10	Orally active LHRH analogs
US4083967A (en)	1978-04-11	Nona- and decapeptides
FI79716B (fi)	1989-10-31	Daeggdjur-pgrf.
JPH02501224A (ja)	1990-04-26	ブラジキニン　アンタゴニスト　ペプチド
US6297354B1 (en)	2001-10-02	Pentapeptide LHRH antagonists
US5439884A (en)	1995-08-08	Method of controlling fertilization using bombesin or its agonist
CA1339659C (en)	1998-02-03	Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine
IE892496A1 (en)	1991-02-13	Ghrh analogs