NO301765B1 - 1-(pyridol[3,4-b]-1,4-oksazinyl-4-yl)-1H-indoler, farmasöytisk sammensetning, samt anvendelse derav - Google Patents

1-(pyridol[3,4-b]-1,4-oksazinyl-4-yl)-1H-indoler, farmasöytisk sammensetning, samt anvendelse derav Download PDF

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Publication number
NO301765B1
NO301765B1 NO921490A NO921490A NO301765B1 NO 301765 B1 NO301765 B1 NO 301765B1 NO 921490 A NO921490 A NO 921490A NO 921490 A NO921490 A NO 921490A NO 301765 B1 NO301765 B1 NO 301765B1
Authority
NO
Norway
Prior art keywords
hydrogen
lower alkyl
indol
compound
loweralkyl
Prior art date
Application number
NO921490A
Other languages
English (en)
Norwegian (no)
Other versions
NO921490D0 (no
NO921490L (no
Inventor
Richard Charles Effland
Larry Davis
Gordon Edward Olsen
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of NO921490D0 publication Critical patent/NO921490D0/no
Publication of NO921490L publication Critical patent/NO921490L/no
Publication of NO301765B1 publication Critical patent/NO301765B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO921490A 1991-04-15 1992-04-14 1-(pyridol[3,4-b]-1,4-oksazinyl-4-yl)-1H-indoler, farmasöytisk sammensetning, samt anvendelse derav NO301765B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/684,758 US5214038A (en) 1991-04-15 1991-04-15 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof

Publications (3)

Publication Number Publication Date
NO921490D0 NO921490D0 (no) 1992-04-14
NO921490L NO921490L (no) 1992-10-16
NO301765B1 true NO301765B1 (no) 1997-12-08

Family

ID=24749434

Family Applications (1)

Application Number Title Priority Date Filing Date
NO921490A NO301765B1 (no) 1991-04-15 1992-04-14 1-(pyridol[3,4-b]-1,4-oksazinyl-4-yl)-1H-indoler, farmasöytisk sammensetning, samt anvendelse derav

Country Status (22)

Country Link
US (3) US5214038A (fr)
EP (1) EP0509400B1 (fr)
JP (1) JP2608359B2 (fr)
KR (1) KR100201509B1 (fr)
AT (1) ATE140006T1 (fr)
AU (1) AU643135B2 (fr)
CA (1) CA2065986C (fr)
CZ (1) CZ282054B6 (fr)
DE (1) DE69211892T2 (fr)
DK (1) DK0509400T3 (fr)
ES (1) ES2094840T3 (fr)
FI (1) FI97544C (fr)
GR (1) GR3020612T3 (fr)
HU (1) HUT62588A (fr)
IE (1) IE74907B1 (fr)
IL (1) IL101589A (fr)
NO (1) NO301765B1 (fr)
NZ (2) NZ242309A (fr)
PL (1) PL168671B1 (fr)
RU (1) RU2042680C1 (fr)
TW (1) TW211016B (fr)
ZA (1) ZA922721B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360811A (en) * 1990-03-13 1994-11-01 Hoechst-Roussel Pharmaceuticals Incorporated 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds as anti-inflammatory agents
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
GB9225859D0 (en) * 1992-12-11 1993-02-03 Smithkline Beecham Plc Novel treatment
US5356910A (en) * 1993-07-19 1994-10-18 Hoechst-Roussel Pharmaceuticals Inc. Use of N-(pyridinyl)-1H-indol-1-amines for the treatment of obsessive-compulsive disorder
GB9521680D0 (en) * 1995-10-23 1996-01-03 Orion Yhtymo Oy New use of imidazole derivatives
GB0119435D0 (en) * 2001-02-15 2001-10-03 Aventis Pharm Prod Inc Method of treating of demyelinating diseases or conditions
JP4292402B2 (ja) * 2001-09-07 2009-07-08 小野薬品工業株式会社 インドール誘導体化合物、それらの製造方法およびそれらを有効成分として含有する薬剤
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
CN105669540A (zh) 2009-01-28 2016-06-15 卡鲁斯治疗有限公司 Scriptaid电子等排体及其在治疗中的用途
IN2015DN03235A (fr) 2012-11-07 2015-10-02 Karus Therapeutics Ltd
ES2688815T3 (es) 2013-05-10 2018-11-07 Karus Therapeutics Limited Inhibidores de histona desacetilasa novedosos
GB201419228D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
GB201419264D0 (en) 2014-10-29 2014-12-10 Karus Therapeutics Ltd Compounds
AU2019322538B2 (en) 2018-08-13 2021-09-30 F. Hoffmann-La Roche Ag New heterocyclic compounds as monoacylglycerol lipase inhibitors
PL3883936T3 (pl) 2018-11-22 2023-11-20 F. Hoffmann-La Roche Ag Nowe związki heterocykliczne
MX2022002311A (es) 2019-09-12 2022-03-25 Hoffmann La Roche Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de monoacilglicerol lipasa (magl).

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029657A (en) * 1976-06-14 1977-06-14 The Dow Chemical Company 6,7-Dichloro-3,4-dihydro-2H-pyrazino(2,3-B)(1,4)oxazines
DE2726437A1 (de) * 1977-06-11 1978-12-21 Bayer Ag Hydrazonfarbstoffe
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
EP0287982B1 (fr) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(pyridinyl)-1H-indol-1-amines, leur procédé de préparation et leur utilisation comme médicaments
US4880822A (en) * 1987-04-24 1989-11-14 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyridinyl)-1H-indol-1-amines
US5039811A (en) * 1987-04-24 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-(pyridinyl)-1H-indol-1-amines
US4916135A (en) * 1989-05-08 1990-04-10 Hoechst Roussel Pharmaceuticals Inc. N-heteroaryl-4-quinolinamines
IL95251A (en) * 1989-08-02 1996-08-04 Hoechst Roussel Pharma 2,3-Dihydro-1- (pyridinylamino) - indoles, a method for their preparation and use as drugs
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4983608A (en) * 1989-09-05 1991-01-08 Hoechst-Roussell Pharmaceuticals, Inc. N-substituted-4-pyrimidinamines and pyrimidinediamines

Also Published As

Publication number Publication date
FI921641A7 (fi) 1992-10-16
EP0509400B1 (fr) 1996-07-03
AU643135B2 (en) 1993-11-04
CZ282054B6 (cs) 1997-05-14
DE69211892T2 (de) 1996-12-19
EP0509400A1 (fr) 1992-10-21
DE69211892D1 (de) 1996-08-08
FI921641A0 (fi) 1992-04-13
FI97544B (fi) 1996-09-30
IE74907B1 (en) 1997-08-13
NO921490D0 (no) 1992-04-14
KR920019796A (ko) 1992-11-20
RU2042680C1 (ru) 1995-08-27
NO921490L (no) 1992-10-16
FI97544C (fi) 1997-01-10
ES2094840T3 (es) 1997-02-01
AU1485292A (en) 1992-10-22
HU9201290D0 (en) 1992-07-28
HUT62588A (en) 1993-05-28
IE921190A1 (en) 1992-10-21
PL168671B1 (pl) 1996-03-29
CS113592A3 (en) 1992-11-18
NZ248131A (en) 1995-07-26
CA2065986C (fr) 2006-02-21
NZ242309A (en) 1995-07-26
US5519131A (en) 1996-05-21
JPH05112572A (ja) 1993-05-07
CA2065986A1 (fr) 1992-10-16
IL101589A0 (en) 1992-12-30
ZA922721B (en) 1992-11-25
ATE140006T1 (de) 1996-07-15
KR100201509B1 (ko) 1999-06-15
TW211016B (fr) 1993-08-11
US5276156A (en) 1994-01-04
PL294221A1 (en) 1993-08-09
US5214038A (en) 1993-05-25
JP2608359B2 (ja) 1997-05-07
GR3020612T3 (en) 1996-10-31
IL101589A (en) 1996-10-31
DK0509400T3 (da) 1996-10-28

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