NO302072B1 - Azabicyklo-arylacetylen- og -arylenyn-oksimer som cholinerge midler og preparater inneholdende slike - Google Patents

Azabicyklo-arylacetylen- og -arylenyn-oksimer som cholinerge midler og preparater inneholdende slike

Info

Publication number
NO302072B1
NO302072B1 NO941365A NO941365A NO302072B1 NO 302072 B1 NO302072 B1 NO 302072B1 NO 941365 A NO941365 A NO 941365A NO 941365 A NO941365 A NO 941365A NO 302072 B1 NO302072 B1 NO 302072B1
Authority
NO
Norway
Prior art keywords
oxymers
azabicycloarylacetylene
arylenine
preparations containing
cholinergic agents
Prior art date
Application number
NO941365A
Other languages
English (en)
Norwegian (no)
Other versions
NO941365L (no
NO941365D0 (no
Inventor
David Jeffrey Lauffer
Walter Hamilton Moos
Michael Raymond Pavia
Haile Tecle
Anthony Jerome Thomas
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO941365L publication Critical patent/NO941365L/no
Publication of NO941365D0 publication Critical patent/NO941365D0/no
Publication of NO302072B1 publication Critical patent/NO302072B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
NO941365A 1991-10-16 1994-04-15 Azabicyklo-arylacetylen- og -arylenyn-oksimer som cholinerge midler og preparater inneholdende slike NO302072B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/778,412 US5306718A (en) 1990-03-06 1991-10-16 Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment
PCT/US1992/008642 WO1993008192A1 (en) 1991-10-16 1992-10-09 Azabicyclo arylacetylene and arylenyne oximes as cholinergic agents and methods of treatment

Publications (3)

Publication Number Publication Date
NO941365L NO941365L (no) 1994-04-15
NO941365D0 NO941365D0 (no) 1994-04-15
NO302072B1 true NO302072B1 (no) 1998-01-19

Family

ID=25113261

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941365A NO302072B1 (no) 1991-10-16 1994-04-15 Azabicyklo-arylacetylen- og -arylenyn-oksimer som cholinerge midler og preparater inneholdende slike

Country Status (17)

Country Link
US (2) US5306718A (pt)
EP (1) EP0608336B1 (pt)
JP (1) JP3367670B2 (pt)
KR (1) KR100241479B1 (pt)
AT (1) ATE166354T1 (pt)
AU (1) AU658685B2 (pt)
CA (1) CA2115443C (pt)
DE (1) DE69225601T2 (pt)
DK (1) DK0608336T3 (pt)
ES (1) ES2119823T3 (pt)
FI (1) FI106797B (pt)
NO (1) NO302072B1 (pt)
NZ (1) NZ244726A (pt)
PH (1) PH31431A (pt)
PT (1) PT100961B (pt)
WO (1) WO1993008192A1 (pt)
ZA (1) ZA927973B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5346911A (en) * 1990-03-06 1994-09-13 Warner-Lambert Company Azabicyclo and azacyclo oxime and amine cholinergic agents and methods of treatment
US5514812A (en) * 1994-06-10 1996-05-07 Warner-Lambert Company Preparation of stereochemically pure oximes with muscarinic activity
AUPM910994A0 (en) * 1994-10-28 1994-11-24 Commonwealth Scientific And Industrial Research Organisation Bisallyloxyimides
US5534522A (en) * 1995-06-07 1996-07-09 Warner-Lambert Company (R)-(Z)-1-azabicyclo [2.2.1] heptan-3-one,O-[3-(3-methoxyphenyl)-2-propynyl] oxime maleate as a pharmaceutical agent
US6168912B1 (en) 1996-01-23 2001-01-02 Martek Biosciences Corporation Method and kit for making a multidimensional combinatorial chemical library
NZ335784A (en) * 1997-01-27 2000-12-22 Warner Lambert Co Process for isolation of (z)-azabicyclo oxime ethers by reacting an O-substituted hydroxylamine with an azabicycloketone
US6924313B1 (en) 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6683113B2 (en) * 1999-09-23 2004-01-27 Pharmacia Corporation (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
KR100465277B1 (ko) * 2002-01-24 2005-01-13 한국과학기술연구원 신규한 옥심계 아자 두 고리 화합물 및 그 제조방법
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3381012A (en) * 1961-08-08 1968-04-30 Sterling Drug Inc Primary, secondary, and tertiary-(1-piperidyl)-lower-alkylamines
US3502692A (en) * 1962-06-13 1970-03-24 American Cyanamid Co Cyclic nitroxides and process for preparing same
DE2019536A1 (de) * 1970-04-23 1971-11-11 Basf Ag Oximcarbamate
DE2552176A1 (de) * 1975-11-21 1977-06-02 Hoechst Ag Neue piperidin-derivate, ihre herstellung und verwendung
US4341795A (en) * 1975-12-01 1982-07-27 Union Carbide Corporation Asymmetrical bis-carbamate compounds
US4710508A (en) * 1986-12-08 1987-12-01 Warner-Lambert Company O-substituted tetrahydropyridine oxime cholinergic agents
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US4937239A (en) * 1989-02-13 1990-06-26 Warner-Lambert Company Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
IL97266A0 (en) * 1990-03-06 1992-05-25 Warner Lambert Co Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI941699A0 (fi) 1994-04-13
US5306718A (en) 1994-04-26
FI941699L (fi) 1994-04-13
AU2783592A (en) 1993-05-21
DE69225601T2 (de) 1998-12-17
JPH07500337A (ja) 1995-01-12
NO941365L (no) 1994-04-15
AU658685B2 (en) 1995-04-27
CA2115443A1 (en) 1993-04-29
JP3367670B2 (ja) 2003-01-14
FI106797B (fi) 2001-04-12
PT100961A (pt) 1993-11-30
ATE166354T1 (de) 1998-06-15
WO1993008192A1 (en) 1993-04-29
US5482938A (en) 1996-01-09
ES2119823T3 (es) 1998-10-16
ZA927973B (en) 1994-04-15
PH31431A (en) 1998-11-03
NZ244726A (en) 1995-09-26
NO941365D0 (no) 1994-04-15
PT100961B (pt) 1999-07-30
CA2115443C (en) 2003-05-13
DK0608336T3 (da) 1999-01-18
EP0608336B1 (en) 1998-05-20
EP0608336A1 (en) 1994-08-03
DE69225601D1 (de) 1998-06-25
KR100241479B1 (ko) 2000-03-02

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