NO302452B1 - Anvendelse av kondenserte pyridinderivater for fremstilling av farmasöytisk preparat - Google Patents

Anvendelse av kondenserte pyridinderivater for fremstilling av farmasöytisk preparat Download PDF

Info

Publication number
NO302452B1
NO302452B1 NO923858A NO923858A NO302452B1 NO 302452 B1 NO302452 B1 NO 302452B1 NO 923858 A NO923858 A NO 923858A NO 923858 A NO923858 A NO 923858A NO 302452 B1 NO302452 B1 NO 302452B1
Authority
NO
Norway
Prior art keywords
alkyl
compound
hydrogen
cells
formula
Prior art date
Application number
NO923858A
Other languages
English (en)
Norwegian (no)
Other versions
NO923858D0 (no
NO923858L (no
Inventor
Yasushi Saito
Masaki Kitahara
Mitsuaki Sakashita
Kyomi Toyoda
Toshie Shibazaki
Original Assignee
Nissan Chemical Ind Ltd
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Ind Ltd, Kowa Co filed Critical Nissan Chemical Ind Ltd
Publication of NO923858D0 publication Critical patent/NO923858D0/no
Publication of NO923858L publication Critical patent/NO923858L/no
Publication of NO302452B1 publication Critical patent/NO302452B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO923858A 1991-10-04 1992-10-02 Anvendelse av kondenserte pyridinderivater for fremstilling av farmasöytisk preparat NO302452B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP03257870A JP3130342B2 (ja) 1991-10-04 1991-10-04 動脈硬化性血管内膜肥厚抑制薬

Publications (3)

Publication Number Publication Date
NO923858D0 NO923858D0 (no) 1992-10-02
NO923858L NO923858L (no) 1993-04-05
NO302452B1 true NO302452B1 (no) 1998-03-09

Family

ID=17312323

Family Applications (1)

Application Number Title Priority Date Filing Date
NO923858A NO302452B1 (no) 1991-10-04 1992-10-02 Anvendelse av kondenserte pyridinderivater for fremstilling av farmasöytisk preparat

Country Status (18)

Country Link
US (1) US6162798A (fr)
EP (1) EP0535548B1 (fr)
JP (1) JP3130342B2 (fr)
KR (1) KR100264543B1 (fr)
AT (1) ATE209035T1 (fr)
AU (1) AU652669B2 (fr)
CA (1) CA2079706C (fr)
CZ (1) CZ281786B6 (fr)
DE (1) DE69232217T2 (fr)
DK (1) DK0535548T3 (fr)
HU (1) HU214624B (fr)
MX (1) MX9205659A (fr)
NO (1) NO302452B1 (fr)
NZ (1) NZ244555A (fr)
RU (1) RU2114620C1 (fr)
SK (1) SK279277B6 (fr)
TW (1) TW238300B (fr)
UA (1) UA39095C2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011898A1 (fr) * 1992-05-12 1995-05-04 Nissan Chemical Industries Ltd. Intermediaire condense de synthese du mevalonolactone de type pyridine et procede de fabrication de cet intermediaire
WO1997025986A1 (fr) * 1996-01-17 1997-07-24 Taiho Pharmaceutical Co., Ltd. Inhibiteurs d'epaississement de l'intima
JP4281248B2 (ja) * 1998-07-23 2009-06-17 日産化学工業株式会社 キノリン誘導体の製造法及び中間体
KR100655671B1 (ko) * 1999-01-14 2006-12-08 닛산 가가쿠 고교 가부시키 가이샤 퀴놀린카르브알데히드의 제조 방법
JP4496586B2 (ja) * 2000-01-24 2010-07-07 日産化学工業株式会社 キノリルアクリロニトリルの製造法及びその中間体
ATE366239T1 (de) * 2000-01-24 2007-07-15 Nissan Chemical Ind Ltd Verfahren zur herstellung von quinolylpropenal
JP4496584B2 (ja) * 2000-01-24 2010-07-07 日産化学工業株式会社 キノリルプロペナールの製造法
JP4496585B2 (ja) * 2000-01-24 2010-07-07 日産化学工業株式会社 キノリルプロペナールの製造方法
WO2001060800A1 (fr) 2000-02-21 2001-08-23 Kuraray Co., Ltd. Procedes de preparation de derives de quinoline et de leurs intermediaires
JP4867071B2 (ja) * 2000-02-21 2012-02-01 日産化学工業株式会社 キノリン誘導体の製造方法
WO2001098301A1 (fr) * 2000-06-20 2001-12-27 Japan Tobacco Inc. Composes de pyrazolopyridine et utilisation de ces derniers en tant que medicaments
TWI309644B (fr) * 2001-02-14 2009-05-11 Nissan Chemical Ind Ltd
MXPA03009095A (es) * 2001-04-05 2004-02-12 Nissan Chemical Ind Ltd Metodo para preparar 7-quinolinil-3,5-dihidroxihept-6-enoato.
US6835838B2 (en) * 2002-01-28 2004-12-28 Novartis Ag Process for the manufacture of organic compounds
CA2478317A1 (fr) * 2002-03-04 2003-09-18 Medimmune, Inc. Procedes permettant de prevenir ou de traiter des troubles par administration d'un antagoniste de l'integrine .alpha.v.beta.3 associe a un inhibiteur de la reductase hmg-coa ou unbisphosphonate
CN100378077C (zh) * 2002-11-06 2008-04-02 日产化学工业株式会社 喹啉甲醛类的制造方法
EP1568693A4 (fr) * 2002-11-06 2007-09-05 Nissan Chemical Ind Ltd Procede de production de quinolinecarbaldehyde
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
AU2004298486A1 (en) 2003-12-12 2005-06-30 Wyeth Quinolines useful in treating cardiovascular disease
DE602005011286D1 (en) * 2004-07-05 2009-01-08 Astellas Pharma Inc Pyrazolopyridinderivate
CN100445267C (zh) * 2005-10-21 2008-12-24 上海医药工业研究院 4-(4-氟-苯基)-3-羟甲基-2-环丙基-喹啉的制备方法
EP2867236B1 (fr) 2012-06-29 2017-06-14 Pfizer Inc Nouvelles 7h-pyrrolo[2,3-d]pyrimidines substituées par un groupe amino en position 4, utilisées comme inhibiteurs de lrrk2
CN103204807B (zh) * 2013-04-08 2015-12-23 黄河三角洲京博化工研究院有限公司 一种2-环丙基-4-（4-氟-苯基）-3-喹啉甲醛的合成方法
ES2671377T3 (es) * 2013-12-13 2018-06-06 Daiichi Sankyo Company, Limited Derivados de 5-hidroxi-4-(trifluorometil)pirazolopiridina
EP3083618B1 (fr) 2013-12-17 2018-02-21 Pfizer Inc Nouvelles 1h-pyrrolo[2,3- b]pyridines 3,4-disubstituées et 7h-pyrrolo[2,3-c]pyridazines 4,5-disubstituées en tant qu'inhibiteurs de la lrrk2
CN104031034B (zh) * 2014-07-01 2017-01-04 上海信谊百路达药业有限公司 一种匹伐他汀钙原料药中间体的制备方法
RU2722149C1 (ru) 2015-09-14 2020-05-27 Пфайзер Инк. Новые производные имидазо[4,5-c] хинолинов и имидазо[4,5-c][1,5] нафтиридинов в качестве ингибиторов LRRK2

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2569746B2 (ja) * 1987-08-20 1997-01-08 日産化学工業株式会社 キノリン系メバロノラクトン類
CA1336714C (fr) * 1987-08-20 1995-08-15 Yoshihiro Fujikawa Mevalonolactone de type quinoleine utilisee comme inhibiteurs de la biosynthese du cholesterol
US4761419A (en) * 1987-12-07 1988-08-02 Warner-Lambert Company 6-(((substituted)quinolinyl)ethyl)-and ethenyl)tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
JP2890448B2 (ja) * 1988-04-26 1999-05-17 日産化学工業株式会社 ピラゾロピリジン系メバロノラクトン類
US5024999A (en) * 1988-04-26 1991-06-18 Nissan Chemical Industries Ltd. Pyrazolopyridine type mevalonolactones useful as pharmaeuticals
US5026698A (en) * 1988-11-02 1991-06-25 Nissan Chemical Industries, Ltd. Thienopyridine type mevalonolactones

Also Published As

Publication number Publication date
HUT62794A (en) 1993-06-28
HU214624B (hu) 1998-04-28
CZ302792A3 (en) 1993-10-13
AU652669B2 (en) 1994-09-01
NO923858D0 (no) 1992-10-02
JP3130342B2 (ja) 2001-01-31
EP0535548A1 (fr) 1993-04-07
NO923858L (no) 1993-04-05
EP0535548B1 (fr) 2001-11-21
CZ281786B6 (cs) 1997-01-15
TW238300B (fr) 1995-01-11
CA2079706C (fr) 2004-03-30
UA39095C2 (uk) 2001-06-15
SK279277B6 (sk) 1998-09-09
US6162798A (en) 2000-12-19
AU2601292A (en) 1993-04-08
DE69232217D1 (de) 2002-01-03
JPH06329540A (ja) 1994-11-29
SK302792A3 (en) 1995-11-08
CA2079706A1 (fr) 1993-04-15
KR930007449A (ko) 1993-05-20
ATE209035T1 (de) 2001-12-15
RU2114620C1 (ru) 1998-07-10
DE69232217T2 (de) 2002-05-23
NZ244555A (en) 2000-06-23
DK0535548T3 (da) 2002-05-13
MX9205659A (es) 1993-04-01
KR100264543B1 (ko) 2001-10-24

Similar Documents

Publication Publication Date Title
NO302452B1 (no) Anvendelse av kondenserte pyridinderivater for fremstilling av farmasöytisk preparat
CA2802308C (fr) Derives d'acide napht-2-ylacetique dans le traitement du sida
CA3221259A1 (fr) N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides utilises en tant que modulateurs de canaux sodiques
CA3221939A1 (fr) Analogues de n-(hydroxyalkyl(hetero)aryl)tetrahydrofurane carboxamide en tant que modulateurs de canaux sodiques
RU2142275C1 (ru) Тиенопиримидиновые производные и фармацевтическая композиция
NO174050B (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzopyranforbindelser
JPH06192248A (ja) 新規のベンゾピラン化合物、その製造法、およびそれらを含む製薬組成物
US6124306A (en) Thioalkyl alpha substituted pyrimidine compounds
EP1142881A1 (fr) Inhibiteurs de poly(adp-ribose) polymerase consistant en des derives de pyrimidine
NO173444B (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive 4-(4'-fluorfenyl-)-tienopyridin-derivater
JPH09221473A (ja) ３−ヒドロキシ−４−アミノメチルピリジン誘導体およびそれらを含有するメイラード反応阻害剤
JP2025517407A (ja) 線維性疾患治療用アゾロ化合物
KR100624238B1 (ko) 알파-아릴메톡시아크릴레이트 유도체를 함유하는 대사성골 질환의 예방 및 치료용 약학 조성물
JP2003525227A (ja) ４−ピリジル−および２，４−ピリミジニル−置換ピロール誘導体および薬学におけるそれらの利用法
JP2620298B2 (ja) １，３‐ジオキサンアルカノイツク酸誘導体、その製法、これを含有する心臓及び血管の疾病の治療剤及び中間体
JPH10287678A5 (fr)
NO173501B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrazolopyridinforbindelser
EP1101765A2 (fr) Nouveaux composés analogues de la camptothécine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
JP4354016B2 (ja) 新規プリン誘導体およびこれを含む医薬組成物
JP2002500658A (ja) ２−アミノ−７−（１−置換−２−ヒドロキシエチル）−３，５−ジヒドロピロロ［３，２−ｄ］ピリミジン−４−オン
CA2313302C (fr) Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR19990007796A (ko) 혈관 신생 억제제
JPH07242642A (ja) 抗高コレステロール血症テトラゾール化合物のアミノ酸塩および製造法
JP2000290280A (ja) フェニルアゾール化合物、製造法及び抗高脂血症薬
RU1838313C (ru) Способ получени спиросоединени азолона или его N-оксидного производного или его основной соли с фармакологически применимым катионом

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees