NO302482B1 - Polyaspartamid-derivater, konjugater av disse samt anvendelse av derivatene og konjugatene - Google Patents
Polyaspartamid-derivater, konjugater av disse samt anvendelse av derivatene og konjugatene Download PDFInfo
- Publication number
- NO302482B1 NO302482B1 NO924921A NO924921A NO302482B1 NO 302482 B1 NO302482 B1 NO 302482B1 NO 924921 A NO924921 A NO 924921A NO 924921 A NO924921 A NO 924921A NO 302482 B1 NO302482 B1 NO 302482B1
- Authority
- NO
- Norway
- Prior art keywords
- acid
- residue
- aspartamide
- bile
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
- C08G73/14—Polyamide-imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/36—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino acids, polyamines and polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
- C08G73/1092—Polysuccinimides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Transceivers (AREA)
- Mobile Radio Communication Systems (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polyesters Or Polycarbonates (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4142147 | 1991-12-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO924921D0 NO924921D0 (no) | 1992-12-18 |
| NO924921L NO924921L (no) | 1993-06-21 |
| NO302482B1 true NO302482B1 (no) | 1998-03-09 |
Family
ID=6447596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO924921A NO302482B1 (no) | 1991-12-20 | 1992-12-18 | Polyaspartamid-derivater, konjugater av disse samt anvendelse av derivatene og konjugatene |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5714138A (da) |
| EP (1) | EP0548794B1 (da) |
| JP (1) | JPH0665372A (da) |
| AT (1) | ATE180968T1 (da) |
| CA (1) | CA2085782A1 (da) |
| DE (1) | DE59209709D1 (da) |
| DK (1) | DK0548794T3 (da) |
| ES (1) | ES2134787T3 (da) |
| FI (1) | FI925734A7 (da) |
| GR (1) | GR3030882T3 (da) |
| NO (1) | NO302482B1 (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE180968T1 (de) * | 1991-12-20 | 1999-06-15 | Hoechst Ag | Polyaspartamidderivate als adsorptionsmittel für gallensäuren, mit gallensäuren beladene polyaspartamidderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel |
| DE69413590D1 (de) * | 1993-04-23 | 1998-11-05 | Rhone Poulenc Chimie | Polyanhydroasparaginsäure und seine bioabbaubaren Hydrolyseprodukte |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6107494A (en) * | 1994-09-13 | 2000-08-22 | G.D. Searle And Company | Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US5994391A (en) * | 1994-09-13 | 1999-11-30 | G.D. Searle And Company | Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| JP2002533414A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するための回腸胆汁酸輸送阻害剤および胆汁酸隔離剤の組み合わせ |
| EP1340510A1 (en) | 1998-12-23 | 2003-09-03 | G.D. Searle LLC. | Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications |
| AU2157400A (en) | 1998-12-23 | 2000-07-31 | G.D. Searle & Co. | Combinations of cholesteryl ester transfer protein inhibitors and hmg coa reductase inhibitors for cardiovascular indications |
| JP2002533410A (ja) | 1998-12-23 | 2002-10-08 | ジー．ディー．サール エルエルシー | 心臓血管に適用するためのコレステリルエステル転送タンパク質阻害剤およびフィブリン酸誘導体の組み合わせ |
| CN1342090A (zh) | 1998-12-23 | 2002-03-27 | G·D·瑟尔有限公司 | 适用于心血管疾病的回肠胆汁酸转运抑制剂和贝酸衍生物的组合 |
| US6489366B1 (en) | 1998-12-23 | 2002-12-03 | G. D. Searle, Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| PL348508A1 (en) | 1998-12-23 | 2002-05-20 | Searle Llc | Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications |
| WO2001068637A2 (en) | 2000-03-10 | 2001-09-20 | Pharmacia Corporation | Method for the preparation of tetrahydrobenzothiepines |
| WO2003014193A1 (en) * | 2001-08-03 | 2003-02-20 | The Procter & Gamble Company | Polyaspartate derivatives for use in detergent compositions |
| MXPA04003524A (es) | 2001-11-02 | 2004-07-23 | Searle Llc | Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato. |
| BR0306643A (pt) | 2002-01-17 | 2004-10-19 | Pharmacia Corp | Novos compostos de hidroxi alquil/aril ou ceto tiepina como inibidores do transporte co-dependente de ácido biliar-sódio apical |
| FR2837710B1 (fr) * | 2002-03-26 | 2005-07-08 | Innovations Pharma Ag | Composition topique a base de resines echangeuses d'ions, notamment pour le traitement des erythemes |
| CN108264639B (zh) * | 2017-12-20 | 2020-08-07 | 湖北工业大学 | 一种温度pH双重响应性肉桂酸-聚天冬酰胺扼合物及其水相交联方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB747901A (en) * | 1953-07-01 | 1956-04-18 | Courtaulds Ltd | Improvements in and relating to the treatment of synthetic polypeptides |
| GB1024393A (en) * | 1963-03-30 | 1966-03-30 | Asahi Chemical Ind | Process for polymerizing n-carboxy-ª-amino acid anhydrides |
| FR1603159A (da) * | 1967-07-20 | 1971-03-22 | ||
| US3846380A (en) * | 1972-10-31 | 1974-11-05 | M Teranishi | Polyamino acid derivatives and compositions containing same |
| GB1506217A (en) * | 1975-08-26 | 1978-04-05 | Taiho Pharmaceutical Co Ltd | Oral antilipemic composition |
| US4363797A (en) * | 1977-09-14 | 1982-12-14 | Societe Anonyme Dite: L'oreal | Polyaspartic acid derivatives, their preparation and their use in cosmetic composition |
| FR2424293A1 (fr) * | 1978-04-27 | 1979-11-23 | Oreal | Nouveau procede de preparation de l'acide polydehydroaspartique |
| JPS6086124A (ja) * | 1983-10-17 | 1985-05-15 | Nitto Boseki Co Ltd | 規則性ポリアミノ酸樹脂の製造方法 |
| DE3626672A1 (de) * | 1986-08-07 | 1988-02-11 | Bayer Ag | Polyasparaginamidsaeure |
| DE3700128A1 (de) * | 1987-01-03 | 1988-07-14 | Hoechst Ag | Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe |
| US5516758A (en) * | 1989-03-23 | 1996-05-14 | Berlex Laboratories, Inc. | Polyamides bearing functionalized side chains useful as water soluble hypolipidemic agents |
| JP2909500B2 (ja) * | 1989-03-23 | 1999-06-23 | ベルレックス、ラボラトリーズ、レンコーポレイテッド | 水溶性抗高脂質血症剤として有用な官能化側鎖を有するポリアミド |
| DE4002736A1 (de) * | 1990-01-31 | 1991-08-01 | Hoechst Ag | Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe |
| US5190982A (en) * | 1990-04-26 | 1993-03-02 | Hoechst Aktiengesellschaft | Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents |
| CA2040996A1 (en) * | 1990-05-02 | 1991-11-03 | Robert L. Albright | Composition and method for controlling cholesterol |
| US5057597A (en) * | 1990-07-03 | 1991-10-15 | Koskan Larry P | Process for the manufacture of anhydro polyamino acids and polyamino acids |
| ATE180968T1 (de) * | 1991-12-20 | 1999-06-15 | Hoechst Ag | Polyaspartamidderivate als adsorptionsmittel für gallensäuren, mit gallensäuren beladene polyaspartamidderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel |
-
1992
- 1992-12-17 AT AT92121461T patent/ATE180968T1/de not_active IP Right Cessation
- 1992-12-17 DE DE59209709T patent/DE59209709D1/de not_active Expired - Fee Related
- 1992-12-17 FI FI925734A patent/FI925734A7/fi unknown
- 1992-12-17 DK DK92121461T patent/DK0548794T3/da active
- 1992-12-17 EP EP92121461A patent/EP0548794B1/de not_active Expired - Lifetime
- 1992-12-17 ES ES92121461T patent/ES2134787T3/es not_active Expired - Lifetime
- 1992-12-18 NO NO924921A patent/NO302482B1/no not_active IP Right Cessation
- 1992-12-18 JP JP4337736A patent/JPH0665372A/ja active Pending
- 1992-12-18 CA CA002085782A patent/CA2085782A1/en not_active Abandoned
-
1993
- 1993-12-10 US US08/164,767 patent/US5714138A/en not_active Expired - Fee Related
-
1997
- 1997-10-22 US US08/956,122 patent/US6036948A/en not_active Expired - Fee Related
-
1999
- 1999-07-30 GR GR990401963T patent/GR3030882T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0548794B1 (de) | 1999-06-09 |
| US5714138A (en) | 1998-02-03 |
| EP0548794A3 (en) | 1994-11-23 |
| DK0548794T3 (da) | 1999-12-06 |
| FI925734A0 (fi) | 1992-12-17 |
| NO924921L (no) | 1993-06-21 |
| EP0548794A2 (de) | 1993-06-30 |
| FI925734L (fi) | 1993-06-21 |
| NO924921D0 (no) | 1992-12-18 |
| ES2134787T3 (es) | 1999-10-16 |
| CA2085782A1 (en) | 1993-06-21 |
| FI925734A7 (fi) | 1993-06-21 |
| GR3030882T3 (en) | 1999-11-30 |
| US6036948A (en) | 2000-03-14 |
| ATE180968T1 (de) | 1999-06-15 |
| JPH0665372A (ja) | 1994-03-08 |
| DE59209709D1 (de) | 1999-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO302482B1 (no) | Polyaspartamid-derivater, konjugater av disse samt anvendelse av derivatene og konjugatene | |
| AU624215B2 (en) | Alkylated polyethylenimine derivatives, process for their preparation, their use as pharmaceuticals and pharmaceutical preparations | |
| CA2085831C (en) | Polymers and oligomers of bile acid derivatives, process for their preparation and their use as pharmaceuticals | |
| KR100314496B1 (ko) | 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도 | |
| Lee et al. | Modification of chitosan to improve its hypocholesterolemic capacity | |
| CA2263671A1 (en) | Polymer bile acid resorption inhibitors with simultaneous bile acid adsorbing effect | |
| JPH06157671A (ja) | 架橋、窒素含有ビニルコポリマー、その製造方法およびこれらの化合物の用途 | |
| Jiang et al. | Preparation and characterization of water-soluble chitosan derivative by Michael addition reaction | |
| Ventura et al. | Improvement of water solubility and dissolution rate of ursodeoxycholic acid and chenodeoxycholic acid by complexation with natural and modified β-cyclodextrins | |
| Serkova et al. | Evaluation of the effects of immunosuppressants on neuronal and glial cells in vitro by multinuclear magnetic resonance spectroscopy | |
| JPH069686A (ja) | 胆汁酸を濃縮するためのアルキル化ポリエチレンイミン誘導体の使用 | |
| JPH0616809A (ja) | アルキル化ポリエチレンイミン誘導体およびその製造方法 | |
| DE4136324A1 (de) | Dextranderivate als adsorptionsmittel fuer gallensaeuren, mit gallensaeuren beladene dextranderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel | |
| Chen et al. | A novel ursodeoxycholic acid–chitosan-folate conjugates for the delivery of calcitriol for cancer therapy | |
| CA1266550A (en) | Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids | |
| CZ293299A3 (cs) | Zesítěné vinylpolymery s adsorpčním účinkem na kyseliny žlučové, jejich monomery, způsob jejich výroby, léčiva tyto látky obsahující a jejich použití | |
| US5378456A (en) | Antitumor mitoxantrone polymeric compositions | |
| DE4136325A1 (de) | Cyclodextrinderivate als adsorptionsmittel fuer gallensaeure, mit gallensaeuren beladene cyclodextrinderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel | |
| US20090239822A1 (en) | Process for the preparation of esters of diacerein with hyaluronic acid and pharmaceutical compositions containing such esters | |
| WO1997030042A1 (en) | Polyester cyclic compounds, their complexes and bonded bodies | |
| CN113750255B (zh) | 环境响应型透明质酸-鬼臼毒素前药胶束及其制备方法和应用 | |
| DE4136322A1 (de) | Pektinderivate als adsorptionsmittel fuer gallensaeuren, mit gallensaeuren beladene pektinderivate und verfahren zu deren herstellung sowie deren anwendung als arzneimittel | |
| CN118440131A (zh) | 新型芳香十六元大环内酯的制备方法及作为细胞抑制剂的应用 | |
| Natalini et al. | Use of RP-HPLC on a dynamically coated artificial membrane to predict intestinal absorption of bile acids | |
| Hagey et al. | Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R, 25R)-3α, 7α, 24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α, 7α-dihydroxy-5β-cholestan-27-oic acid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN JUNE 2001 |