NO303221B1 - Hydroksaminsyrederivater - Google Patents

Hydroksaminsyrederivater

Info

Publication number: NO303221B1
Authority: NO; Norway
Prior art keywords: acid derivatives; hydroxamic acid; substituted phenyl; hydrogen; phenyl
Prior art date: 1992-07-23

Application number

NO950226A

Other languages

English (en)

Norwegian (no)

Other versions

NO950226D0 (no

NO950226L (no

Inventor

Jonathan Philip Dickens

Michael John Crimmin

Raymond Paul Beckett

Original Assignee

British Biotech Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-23

Filing date

1995-01-20

Publication date

1998-06-15

1995-01-20 Application filed by British Biotech Pharm filed Critical British Biotech Pharm

1995-01-20 Publication of NO950226D0 publication Critical patent/NO950226D0/no

1995-01-20 Publication of NO950226L publication Critical patent/NO950226L/no

1998-06-15 Publication of NO303221B1 publication Critical patent/NO303221B1/no

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000003771 matrix metalloproteinase inhibitor Substances 0.000 abstract 1
229940121386 matrix metalloproteinase inhibitor Drugs 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229930195734 saturated hydrocarbon Natural products 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Oncology (AREA)
Diabetes (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Nutrition Science (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Adhesives Or Adhesive Processes (AREA)
Medicinal Preparation (AREA)

NO950226A 1992-07-23 1995-01-20 Hydroksaminsyrederivater NO303221B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929215665A GB9215665D0 (en)	1992-07-23	1992-07-23	Compounds
PCT/GB1993/001557 WO1994002447A1 (fr)	1992-07-23	1993-07-23	Derives d'acide hydroxamique en tant qu'inhibiteurs de metalloproteinase

Publications (3)

Publication Number	Publication Date
NO950226D0 NO950226D0 (no)	1995-01-20
NO950226L NO950226L (no)	1995-01-20
NO303221B1 true NO303221B1 (no)	1998-06-15

Family

ID=10719178

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO950226A NO303221B1 (no)	1992-07-23	1995-01-20	Hydroksaminsyrederivater

Country Status (26)

Country	Link
US (3)	US5643964A (fr)
EP (3)	EP0651739B1 (fr)
JP (3)	JP2768554B2 (fr)
KR (1)	KR100205710B1 (fr)
AT (3)	ATE198331T1 (fr)
AU (2)	AU661410B2 (fr)
CA (1)	CA2140626C (fr)
CY (1)	CY1944A (fr)
CZ (1)	CZ285896B6 (fr)
DE (5)	DE9321495U1 (fr)
DK (2)	DK0754688T3 (fr)
ES (1)	ES2153927T3 (fr)
FI (1)	FI114549B (fr)
GB (4)	GB9215665D0 (fr)
GR (2)	GR3023522T3 (fr)
HK (1)	HK149396A (fr)
HU (2)	HU220625B1 (fr)
NO (1)	NO303221B1 (fr)
NZ (1)	NZ254862A (fr)
PL (1)	PL174279B1 (fr)
PT (1)	PT754688E (fr)
RU (1)	RU2126791C1 (fr)
SK (1)	SK281240B6 (fr)
UA (1)	UA29450C2 (fr)
WO (2)	WO1994002446A1 (fr)
ZA (2)	ZA935351B (fr)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
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ES2075798B1 (es) *	1993-08-18	1996-03-01	British Bio Technology	Derivados de aminoacidos naturales como inhibidores de metaloproteinasas, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y el uso de dichos compuestos en medicina.
JPH09503201A (ja) *	1993-08-23	1997-03-31	イミュネックス・コーポレーション	Ｔｎｆ−アルファ分泌の阻害剤
US5594106A (en) *	1993-08-23	1997-01-14	Immunex Corporation	Inhibitors of TNF-α secretion
GB9401129D0 (en) *	1994-01-21	1994-03-16	British Bio Technology	Hydroxamic acid derivatives as metalloproteinase inhibitors
GB2299335B (en) *	1994-01-21	1997-12-17	British Biotech Pharm	Hydroxamic acid derivatives as metalloproteinase inhibitors
EP0905126B1 (fr) *	1994-01-22	2002-12-04	British Biotech Pharmaceuticals Limited	Inhibiteurs de métalloprotéinase
GB9404046D0 (en) *	1994-03-03	1994-04-20	Smithkline Beecham Corp	Novel compounds
GB9411088D0 (en) *	1994-06-03	1994-07-27	Hoffmann La Roche	Hydroxylamine derivatives
GB9416897D0 (en) *	1994-08-20	1994-10-12	British Biotech Pharm	Metalloproteinase inhibitors
GB9423914D0 (en) *	1994-11-26	1995-01-11	British Biotech Pharm	Polyether derivatives as metalloproteinase inhibitors
US5639746A (en) *	1994-12-29	1997-06-17	The Procter & Gamble Company	Hydroxamic acid-containing inhibitors of matrix metalloproteases
US5672598A (en) *	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids
AU5002196A (en) *	1995-03-28	1996-10-16	Novo Nordisk A/S	Immunosuppressive agents
US5691381A (en) *	1995-04-18	1997-11-25	The Dupont Merck Pharmaceutical Company	Hydroxamic and carbocyclic acids as metalloprotease inhibitors
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WO1996033968A1 (fr) *	1995-04-25	1996-10-31	Fuji Yakuhin Kogyo Kabushiki Kaisha	Inhibiteur des metalloproteinases, tres soluble dans l'eau
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US5917090A (en) *	1995-06-30	1999-06-29	British Biotech Pharmaceuticals Ltd.	Matrix metalloproteinase inhibitors
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GB2318353B (en) *	1995-07-20	1999-10-06	British Biotech Pharm	Metalloproteinase inhibitors
GB9514867D0 (en) *	1995-07-20	1995-09-20	British Biotech Pharm	Metalloproteinase inhibitors
US6281352B1 (en)	1995-11-14	2001-08-28	Dupont Pharmaceuticals Company	Macrocyclic compounds as metalloprotease inhibitors
GB9523637D0 (en) *	1995-11-18	1996-01-17	British Biotech Pharm	Synthesis of carboxylic acid derivatives
IL123431A (en) *	1995-11-22	2001-05-20	Darwin Discovery Ltd	Mercaptoalkyl peptidil compounds with imidazole transducer and their use as metallic protonase matrix (MMP) compounds and / or tumor cause factor (TNF)
ATE205184T1 (de)	1995-11-23	2001-09-15	British Biotech Pharm	Metalloproteinase inhibitoren
GB9609702D0 (en)	1996-05-09	1996-07-10	Royal Free Hosp School Med	Anticoagulant peptides
GB9609794D0 (en) *	1996-05-10	1996-07-17	Smithkline Beecham Plc	Novel compounds
BR9713182A (pt) *	1996-08-28	1999-11-03	Procter & Gamble	Amidas de ácido fosfìnico como inibidores de metalo protease de matriz
KR100339296B1 (ko) *	1996-08-28	2002-06-03	데이비드 엠 모이어	헤테로고리성 메탈로프로테아제 억제제
ATE226573T1 (de)	1996-08-28	2002-11-15	Procter & Gamble	Heterozyklische metalloproteaseinhibitoren
RU2203274C2 (ru) *	1996-08-28	2003-04-27	Дзе Проктер Энд Гэмбл Компани	Спироциклические ингибиторы металлопротеаз
DE69716934T2 (de) *	1996-08-28	2003-07-31	The Procter & Gamble Company, Cincinnati	1,3-diheterozyklische metalloprotease inhibitoren
IL128337A0 (en)	1996-09-10	2000-01-31	British Biotech Pharm	Cytostatic hydroxamic acid derivatives
US6462023B1 (en)	1996-09-10	2002-10-08	British Biotech Pharmaceuticals, Ltd.	Cytostatic agents
GB9708265D0 (en) *	1997-04-24	1997-06-18	Nycomed Imaging As	Contrast agents
US5952320A (en) *	1997-01-07	1999-09-14	Abbott Laboratories	Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
US5985911A (en) *	1997-01-07	1999-11-16	Abbott Laboratories	C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
AU6843498A (en) *	1997-03-28	1998-10-22	Zeneca Limited	Process for the preparation of n-(3-hydroxy-succinyl)-amino acid derivatives
US6251913B1 (en)	1997-03-28	2001-06-26	Zeneca Limited	Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor
US5883131A (en) *	1997-07-09	1999-03-16	Pfizer Inc.	Cyclic sulfone derivatives
CA2298617A1 (fr)	1997-07-31	1999-02-11	Yetunde Olabisi Taiwo	Inhibiteurs de metalloprotease acycliques
US6576664B1 (en) *	1997-08-18	2003-06-10	Bristol-Myers Squibb Pharma Company	Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
EP0897908A1 (fr) *	1997-08-19	1999-02-24	Roche Diagnostics GmbH	Acides 3-aryl-succinamido-hydroxamiques, procédé pour leur préparation et médicaments les contenant
ZA988967B (en) *	1997-10-03	2000-04-03	Du Pont Pharm Co	Lactam metalloprotease inhibitors.
US6403632B1 (en)	2000-03-01	2002-06-11	Bristol Myers Squibb Pharma Co	Lactam metalloprotease inhibitors
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1992
- 1992-07-23 GB GB929215665A patent/GB9215665D0/en active Pending
1993
- 1993-07-22 GB GB9500722A patent/GB2287023B/en not_active Expired - Fee Related
- 1993-07-22 GB GB9315222A patent/GB2268934B/en not_active Expired - Fee Related
- 1993-07-22 GB GB9315206A patent/GB2268933B/en not_active Expired - Fee Related
- 1993-07-23 AU AU47153/93A patent/AU661410B2/en not_active Ceased
- 1993-07-23 ZA ZA935351A patent/ZA935351B/xx unknown
- 1993-07-23 AT AT96115235T patent/ATE198331T1/de not_active IP Right Cessation
- 1993-07-23 DE DE9321495U patent/DE9321495U1/de not_active Expired - Lifetime
- 1993-07-23 US US08/374,601 patent/US5643964A/en not_active Expired - Fee Related
- 1993-07-23 ES ES96115235T patent/ES2153927T3/es not_active Expired - Lifetime
- 1993-07-23 NZ NZ254862A patent/NZ254862A/en not_active IP Right Cessation
- 1993-07-23 DK DK96115235T patent/DK0754688T3/da active
- 1993-07-23 PL PL93307171A patent/PL174279B1/pl not_active IP Right Cessation
- 1993-07-23 SK SK78-95A patent/SK281240B6/sk unknown
- 1993-07-23 PT PT96115235T patent/PT754688E/pt unknown
- 1993-07-23 AT AT93917900T patent/ATE162183T1/de active
- 1993-07-23 EP EP93917901A patent/EP0651739B1/fr not_active Expired - Lifetime
- 1993-07-23 DE DE69329804T patent/DE69329804T2/de not_active Expired - Fee Related
- 1993-07-23 AT AT93917901T patent/ATE151414T1/de not_active IP Right Cessation
- 1993-07-23 EP EP93917900A patent/EP0651738B1/fr not_active Expired - Lifetime
- 1993-07-23 WO PCT/GB1993/001556 patent/WO1994002446A1/fr not_active Ceased
- 1993-07-23 KR KR1019950700232A patent/KR100205710B1/ko not_active Expired - Fee Related
- 1993-07-23 AU AU47152/93A patent/AU4715293A/en not_active Abandoned
- 1993-07-23 WO PCT/GB1993/001557 patent/WO1994002447A1/fr not_active Ceased
- 1993-07-23 HU HU9500202A patent/HU220625B1/hu not_active IP Right Cessation
- 1993-07-23 JP JP6504307A patent/JP2768554B2/ja not_active Expired - Fee Related
- 1993-07-23 CA CA002140626A patent/CA2140626C/fr not_active Expired - Fee Related
- 1993-07-23 EP EP96115235A patent/EP0754688B1/fr not_active Expired - Lifetime
- 1993-07-23 RU RU95109920/04A patent/RU2126791C1/ru not_active IP Right Cessation
- 1993-07-23 DE DE4393452T patent/DE4393452T1/de not_active Ceased
- 1993-07-23 DE DE69316367T patent/DE69316367T2/de not_active Expired - Fee Related
- 1993-07-23 DK DK93917901.6T patent/DK0651739T3/da active
- 1993-07-23 DE DE69309686T patent/DE69309686T2/de not_active Expired - Fee Related
- 1993-07-23 US US08/374,602 patent/US5700838A/en not_active Expired - Fee Related
- 1993-07-23 CZ CZ95157A patent/CZ285896B6/cs not_active IP Right Cessation
- 1993-07-23 ZA ZA935352A patent/ZA935352B/xx unknown
- 1993-07-23 UA UA95018066A patent/UA29450C2/uk unknown
- 1993-07-23 JP JP6504306A patent/JPH07509459A/ja active Pending
1995
- 1995-01-20 FI FI950262A patent/FI114549B/fi not_active IP Right Cessation
- 1995-01-20 NO NO950226A patent/NO303221B1/no unknown
- 1995-06-12 HU HU95P/P00187P patent/HU211287A9/hu unknown
1996
- 1996-08-08 HK HK149396A patent/HK149396A/xx not_active IP Right Cessation
1997
- 1997-05-16 CY CY194497A patent/CY1944A/en unknown
- 1997-05-23 GR GR970401170T patent/GR3023522T3/el unknown
- 1997-10-23 US US08/956,338 patent/US5912360A/en not_active Expired - Lifetime
- 1997-12-22 JP JP9353810A patent/JP2971053B2/ja not_active Expired - Fee Related
2001
- 2001-03-05 GR GR20010400350T patent/GR3035510T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ285896B6 (cs)	1999-11-17
DK0754688T3 (da)	2001-03-05
GB2287023B (en)	1996-02-14
WO1994002447A1 (fr)	1994-02-03
GB9500722D0 (en)	1995-03-08
FI950262A0 (fi)	1995-01-20
EP0651738A1 (fr)	1995-05-10
GB2287023A (en)	1995-09-06
FI114549B (fi)	2004-11-15
NO950226D0 (no)	1995-01-20
HU220625B1 (hu)	2002-03-28
JP2768554B2 (ja)	1998-06-25
DE69329804D1 (de)	2001-02-01
EP0754688A2 (fr)	1997-01-22
DE69309686T2 (de)	1997-07-24
EP0651739A1 (fr)	1995-05-10
US5912360A (en)	1999-06-15
KR100205710B1 (ko)	1999-07-01
EP0754688A3 (fr)	1997-07-30
ATE162183T1 (de)	1998-01-15
SK281240B6 (sk)	2001-01-18
ATE151414T1 (de)	1997-04-15
CZ15795A3 (en)	1995-10-18
PL174279B1 (pl)	1998-07-31
UA29450C2 (uk)	2000-11-15
GB9315222D0 (en)	1993-09-08
GB2268934A (en)	1994-01-26
AU4715393A (en)	1994-02-14
ZA935352B (en)	1994-05-16
RU95109920A (ru)	1996-10-27
DE69316367D1 (de)	1998-02-19
CY1944A (en)	1997-05-16
GR3023522T3 (en)	1997-08-29
HUT70552A (en)	1995-10-30
HU211287A9 (en)	1995-11-28
SK7895A3 (en)	1995-07-11
NO950226L (no)	1995-01-20
US5643964A (en)	1997-07-01
DK0651739T3 (da)	1997-08-18
PT754688E (pt)	2001-04-30
GR3035510T3 (en)	2001-06-29
JPH07509459A (ja)	1995-10-19
DE69309686D1 (de)	1997-05-15
FI950262A7 (fi)	1995-01-20
WO1994002446A1 (fr)	1994-02-03
HK149396A (en)	1996-08-16
JPH07509460A (ja)	1995-10-19
EP0651739B1 (fr)	1997-04-09
ATE198331T1 (de)	2001-01-15
EP0651738B1 (fr)	1998-01-14
GB2268933B (en)	1996-04-10
JP2971053B2 (ja)	1999-11-02
NZ254862A (en)	1996-02-27
HU9500202D0 (en)	1995-03-28
GB9315206D0 (en)	1993-09-08
CA2140626A1 (fr)	1994-02-03
DE4393452T1 (de)	1995-06-01
DE69316367T2 (de)	1998-06-10
KR950702525A (ko)	1995-07-29
US5700838A (en)	1997-12-23
ZA935351B (en)	1994-02-14
GB2268934B (en)	1996-01-24
JPH10204081A (ja)	1998-08-04
ES2153927T3 (es)	2001-03-16
EP0754688B1 (fr)	2000-12-27
GB9215665D0 (en)	1992-09-09
CA2140626C (fr)	2002-09-03
DE9321495U1 (de)	1998-09-10
GB2268933A (en)	1994-01-26
PL307171A1 (en)	1995-05-15
AU661410B2 (en)	1995-07-20
RU2126791C1 (ru)	1999-02-27
AU4715293A (en)	1994-02-14
DE69329804T2 (de)	2001-05-31

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