NO304578B1 - Pulverformulering med flytekontrollert avgivelse - Google Patents

Pulverformulering med flytekontrollert avgivelse Download PDF

Info

Publication number: NO304578B1
Authority: NO; Norway
Prior art keywords: salt; preparation according; preparation; weight; range
Prior art date: 1991-10-23

Application number

NO924104A

Other languages

English (en)

Norwegian (no)

Other versions

NO924104L (no

NO924104D0 (no

Inventor

Andrew Dennis

Peter Timmins

Kevin Lee

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-23

Filing date

1992-10-22

Publication date

1999-01-18

1992-10-22 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1992-10-22 Publication of NO924104D0 publication Critical patent/NO924104D0/no

1993-04-26 Publication of NO924104L publication Critical patent/NO924104L/no

1999-01-18 Publication of NO304578B1 publication Critical patent/NO304578B1/no

Links

239000000843 powder Substances 0.000 title claims abstract description 43
239000000203 mixture Substances 0.000 title claims abstract description 17
238000013270 controlled release Methods 0.000 title abstract description 6
238000009472 formulation Methods 0.000 title abstract description 4
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239000002775 capsule Substances 0.000 claims abstract description 39
229920000615 alginic acid Polymers 0.000 claims abstract description 17
235000010443 alginic acid Nutrition 0.000 claims abstract description 16
239000000783 alginic acid Substances 0.000 claims abstract description 14
229960001126 alginic acid Drugs 0.000 claims abstract description 14
150000004781 alginic acids Chemical class 0.000 claims abstract description 13
239000003349 gelling agent Substances 0.000 claims abstract description 13
-1 sodium alginate Chemical class 0.000 claims abstract description 10
230000001419 dependent effect Effects 0.000 claims abstract description 6
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IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 5
239000000661 sodium alginate Substances 0.000 claims abstract description 5
229940005550 sodium alginate Drugs 0.000 claims abstract description 5
238000002360 preparation method Methods 0.000 claims description 39
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 22
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AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims description 8
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
DOQPXTMNIUCOSY-UHFFFAOYSA-N [4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]-[2-(3,4-dimethoxyphenyl)ethyl]-methylazanium;chloride Chemical group [H+].[Cl-].C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 DOQPXTMNIUCOSY-UHFFFAOYSA-N 0.000 claims description 5
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KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 claims description 2
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ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 claims description 2
DERZBLKQOCDDDZ-JLHYYAGUSA-N cinnarizine Chemical compound C1CN(C(C=2C=CC=CC=2)C=2C=CC=CC=2)CCN1C\C=C\C1=CC=CC=C1 DERZBLKQOCDDDZ-JLHYYAGUSA-N 0.000 claims description 2
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ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 claims description 2
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QOIGKGMMAGJZNZ-UHFFFAOYSA-N gepirone Chemical compound O=C1CC(C)(C)CC(=O)N1CCCCN1CCN(C=2N=CC=CN=2)CC1 QOIGKGMMAGJZNZ-UHFFFAOYSA-N 0.000 claims description 2
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VWPOSFSPZNDTMJ-UCWKZMIHSA-N nadolol Chemical compound C1[C@@H](O)[C@@H](O)CC2=C1C=CC=C2OCC(O)CNC(C)(C)C VWPOSFSPZNDTMJ-UCWKZMIHSA-N 0.000 claims description 2
229960004255 nadolol Drugs 0.000 claims description 2
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DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims description 2
235000010408 potassium alginate Nutrition 0.000 claims description 2
239000000737 potassium alginate Substances 0.000 claims description 2
MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 2
KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims description 2
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

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Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Detergent Compositions (AREA)
Adjustment And Processing Of Grains (AREA)
Disintegrating Or Milling (AREA)
Slot Machines And Peripheral Devices (AREA)

NO924104A 1991-10-23 1992-10-22 Pulverformulering med flytekontrollert avgivelse NO304578B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/781,620 US5169638A (en)	1991-10-23	1991-10-23	Buoyant controlled release powder formulation

Publications (3)

Publication Number	Publication Date
NO924104D0 NO924104D0 (no)	1992-10-22
NO924104L NO924104L (no)	1993-04-26
NO304578B1 true NO304578B1 (no)	1999-01-18

Family

ID=25123359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO924104A NO304578B1 (no)	1991-10-23	1992-10-22	Pulverformulering med flytekontrollert avgivelse

Country Status (16)

Country	Link
US (1)	US5169638A (de)
EP (1)	EP0539059B1 (de)
JP (1)	JPH05194195A (de)
AT (1)	ATE161171T1 (de)
AU (1)	AU660193B2 (de)
CA (1)	CA2081070C (de)
DE (1)	DE69223588T2 (de)
DK (1)	DK0539059T3 (de)
ES (1)	ES2109986T3 (de)
FI (1)	FI108332B (de)
GR (1)	GR3026155T3 (de)
HU (1)	HU218273B (de)
MX (1)	MX9205920A (de)
NO (1)	NO304578B1 (de)
NZ (1)	NZ244517A (de)
ZA (1)	ZA927433B (de)

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1992
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- 1992-09-28 ZA ZA927433A patent/ZA927433B/xx unknown
- 1992-10-08 EP EP92309204A patent/EP0539059B1/de not_active Expired - Lifetime
- 1992-10-08 DK DK92309204.3T patent/DK0539059T3/da active
- 1992-10-08 DE DE69223588T patent/DE69223588T2/de not_active Expired - Fee Related
- 1992-10-08 AT AT92309204T patent/ATE161171T1/de not_active IP Right Cessation
- 1992-10-08 ES ES92309204T patent/ES2109986T3/es not_active Expired - Lifetime
- 1992-10-15 MX MX9205920A patent/MX9205920A/es not_active IP Right Cessation
- 1992-10-21 CA CA002081070A patent/CA2081070C/en not_active Expired - Fee Related
- 1992-10-21 AU AU27167/92A patent/AU660193B2/en not_active Ceased
- 1992-10-22 NO NO924104A patent/NO304578B1/no not_active IP Right Cessation
- 1992-10-22 HU HU9203342A patent/HU218273B/hu not_active IP Right Cessation
- 1992-10-23 JP JP4285845A patent/JPH05194195A/ja active Pending
- 1992-10-23 FI FI924831A patent/FI108332B/fi active
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Publication number	Publication date
JPH05194195A (ja)	1993-08-03
FI924831A0 (fi)	1992-10-23
ZA927433B (en)	1993-04-07
DE69223588D1 (de)	1998-01-29
HUT63325A (en)	1993-08-30
CA2081070C (en)	2002-12-24
GR3026155T3 (en)	1998-05-29
AU2716792A (en)	1993-04-29
ATE161171T1 (de)	1998-01-15
NZ244517A (en)	1994-10-26
US5169638A (en)	1992-12-08
DE69223588T2 (de)	1998-06-25
EP0539059B1 (de)	1997-12-17
FI924831L (fi)	1993-04-24
CA2081070A1 (en)	1993-04-24
MX9205920A (es)	1993-06-01
HU9203342D0 (en)	1992-12-28
FI108332B (fi)	2002-01-15
EP0539059A1 (de)	1993-04-28
HU218273B (en)	2000-07-28
AU660193B2 (en)	1995-06-15
NO924104L (no)	1993-04-26
NO924104D0 (no)	1992-10-22
DK0539059T3 (da)	1998-01-26
ES2109986T3 (es)	1998-02-01

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Date	Code	Title	Description
2010-05-31	MM1K	Lapsed by not paying the annual fees

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