NO305554B1 - Nye bis-naftalimider og farmas°ytisk blanding for behandling av kreft - Google Patents

Nye bis-naftalimider og farmas°ytisk blanding for behandling av kreft

Info

Publication number
NO305554B1
NO305554B1 NO960632A NO960632A NO305554B1 NO 305554 B1 NO305554 B1 NO 305554B1 NO 960632 A NO960632 A NO 960632A NO 960632 A NO960632 A NO 960632A NO 305554 B1 NO305554 B1 NO 305554B1
Authority
NO
Norway
Prior art keywords
cancer
treatment
naphthalimides
pharmaceuticals
new bis
Prior art date
Application number
NO960632A
Other languages
English (en)
Norwegian (no)
Other versions
NO960632D0 (no
NO960632L (no
Inventor
Gerhard Keilhauer
Cynthia Romerdahl
Miguel Fernandez Brana
Xiao-Dong Qian
Peter Bousquet
Josu Maria Castellano Berlanga
Marina Moran Moset
Maria Jesus Perez De Vega
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of NO960632D0 publication Critical patent/NO960632D0/no
Publication of NO960632L publication Critical patent/NO960632L/no
Publication of NO305554B1 publication Critical patent/NO305554B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NO960632A 1993-08-18 1996-02-16 Nye bis-naftalimider og farmas°ytisk blanding for behandling av kreft NO305554B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10894993A 1993-08-18 1993-08-18
PCT/EP1994/002621 WO1995005365A1 (en) 1993-08-18 1994-08-08 New bis-naphthalimides for the treatment of cancer

Publications (3)

Publication Number Publication Date
NO960632D0 NO960632D0 (no) 1996-02-16
NO960632L NO960632L (no) 1996-02-16
NO305554B1 true NO305554B1 (no) 1999-06-21

Family

ID=22324990

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960632A NO305554B1 (no) 1993-08-18 1996-02-16 Nye bis-naftalimider og farmas°ytisk blanding for behandling av kreft

Country Status (28)

Country Link
US (3) US5616589A (de)
EP (1) EP0714387B1 (de)
JP (1) JPH09501662A (de)
KR (1) KR960703863A (de)
CN (1) CN1039414C (de)
AT (1) ATE166647T1 (de)
AU (1) AU677696B2 (de)
BR (2) BR9407257A (de)
CA (1) CA2169059A1 (de)
CZ (1) CZ34296A3 (de)
DE (1) DE69410614T2 (de)
DK (1) DK0714387T3 (de)
ES (1) ES2116612T3 (de)
FI (1) FI960658A7 (de)
HR (1) HRP940458B1 (de)
HU (1) HU219232B (de)
IL (1) IL110460A (de)
NO (1) NO305554B1 (de)
NZ (1) NZ271374A (de)
PH (1) PH31395A (de)
PL (1) PL313078A1 (de)
RU (1) RU2138484C1 (de)
SG (1) SG64906A1 (de)
SI (1) SI9420053A (de)
TW (1) TW408112B (de)
UA (1) UA42733C2 (de)
WO (1) WO1995005365A1 (de)
ZA (1) ZA946196B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
EP0930883B1 (de) * 1996-10-21 2006-01-11 Allelix Biopharmaceuticals Inc. Neurotrophin antagoniste zur behandlung von der epilepsie, alzheimer'schen krankheit und schmerzen
US6420344B1 (en) 1999-03-16 2002-07-16 The Regents Of The University Of California Glycosylated polyamines
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
US6492380B1 (en) * 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
US6468990B1 (en) * 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
DE60100855T2 (de) * 2000-03-07 2004-07-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 1,8-naphthalimid imidazo[4,5,1-de]acridone mit antitumorwirkung
ATE506079T1 (de) 2003-11-05 2011-05-15 Photobiomed Corp Verbindungsgewebe und vernetzungsproteine mit naphthalimid-verbindungen
WO2005105753A2 (en) * 2004-05-05 2005-11-10 Unibioscreen S.A. Naphthalimide derivatives, methods for their production and pharmaceutical compositions therefrom
US20070134243A1 (en) * 2004-12-01 2007-06-14 Gazzard Lewis J Antibody drug conjugates and methods
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
EP1817059A2 (de) 2004-12-01 2007-08-15 Genentech, Inc. Konjugate von 1,8-bis-naphthalimiden mit einem antikörper
BRPI0615930A2 (pt) 2005-09-15 2016-08-23 Painceptor Pharma Corp métodos de modular a interação de uma neurotrofina e um receptor de neurotrofina, de tratar dor em um indivíduo, de tratar distúrbio inflamatório em um indivíduo, de tratar um distúrbio neurológico em um indivíduo, e de tratar uma doença ou distúrbio associado aos sistemas geniturinário e/ou gastrointestinal de um indivíduo, e, composto
WO2009089537A2 (en) 2008-01-11 2009-07-16 Northwestern University Anti-cancer compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
CA2125142A1 (en) * 1991-12-11 1993-06-24 Jung-Hui Sun Highly water soluble bis-naphthalimides useful as anticancer agents
DE4232739A1 (de) * 1992-09-30 1994-03-31 Knoll Ag Neue asymmetrisch substituierte bis-Naphthalimide

Also Published As

Publication number Publication date
CZ34296A3 (en) 1996-08-14
ES2116612T3 (es) 1998-07-16
HRP940458B1 (en) 2000-02-29
US5981753A (en) 1999-11-09
BR9407257A (pt) 1996-09-24
ZA946196B (en) 1996-02-19
UA42733C2 (uk) 2001-11-15
KR960703863A (ko) 1996-08-31
BR1100143A (pt) 2000-03-14
FI960658L (fi) 1996-02-14
EP0714387A1 (de) 1996-06-05
AU7498494A (en) 1995-03-14
EP0714387B1 (de) 1998-05-27
FI960658A0 (fi) 1996-02-14
PL313078A1 (en) 1996-05-27
JPH09501662A (ja) 1997-02-18
US5616589A (en) 1997-04-01
ATE166647T1 (de) 1998-06-15
HU9600360D0 (en) 1996-04-29
AU677696B2 (en) 1997-05-01
NO960632D0 (no) 1996-02-16
US5789418A (en) 1998-08-04
SG64906A1 (en) 1999-05-25
PH31395A (en) 1998-10-29
DK0714387T3 (da) 1998-10-12
DE69410614D1 (de) 1998-07-02
DE69410614T2 (de) 1998-09-24
IL110460A0 (en) 1994-10-21
TW408112B (en) 2000-10-11
NZ271374A (en) 1997-05-26
IL110460A (en) 2001-01-11
WO1995005365A1 (en) 1995-02-23
CA2169059A1 (en) 1995-02-23
HRP940458A2 (en) 1997-06-30
HUT73529A (en) 1996-08-28
HU219232B (en) 2001-03-28
CN1039414C (zh) 1998-08-05
CN1132506A (zh) 1996-10-02
RU2138484C1 (ru) 1999-09-27
SI9420053A (en) 1996-08-31
NO960632L (no) 1996-02-16
FI960658A7 (fi) 1996-02-14

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Legal Events

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MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN FEBRUARY 2003