NO307257B1 - Enantiomerisk rene imidazolylforbindelser, fremgangsmåte for fremstilling samt syreaddisjonssalter derav - Google Patents

Enantiomerisk rene imidazolylforbindelser, fremgangsmåte for fremstilling samt syreaddisjonssalter derav

Info

Publication number: NO307257B1
Authority: NO; Norway
Prior art keywords: addition salt; acid addition; acid; mixture; enantiomer
Prior art date: 1995-10-13

Application number

NO964282A

Other languages

English (en)

Norwegian (no)

Other versions

NO964282L (no

NO964282D0 (no

Inventor

Paulus Franciscus Corneli Meij

Jan-Maarten Verbeek

Original Assignee

Duphar Int Res

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

1996-10-09

Publication date

2000-03-06

1996-10-09 Application filed by Duphar Int Res filed Critical Duphar Int Res

1996-10-09 Publication of NO964282D0 publication Critical patent/NO964282D0/no

1997-04-14 Publication of NO964282L publication Critical patent/NO964282L/no

2000-03-06 Publication of NO307257B1 publication Critical patent/NO307257B1/no

Links

150000003839 salts Chemical class 0.000 title abstract 8
239000002253 acid Substances 0.000 title abstract 7
238000000034 method Methods 0.000 title abstract 3
125000002883 imidazolyl group Chemical group 0.000 title 1
239000000203 mixture Substances 0.000 abstract 6
150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
239000012452 mother liquor Substances 0.000 abstract 3
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 abstract 2
-1 imidazolyl compound Chemical class 0.000 abstract 2
238000000926 separation method Methods 0.000 abstract 2
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 abstract 1
ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Epoxy Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO964282A 1995-10-13 1996-10-09 Enantiomerisk rene imidazolylforbindelser, fremgangsmåte for fremstilling samt syreaddisjonssalter derav NO307257B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP95202765		1995-10-13

Publications (3)

Publication Number	Publication Date
NO964282D0 NO964282D0 (no)	1996-10-09
NO964282L NO964282L (no)	1997-04-14
NO307257B1 true NO307257B1 (no)	2000-03-06

Family

ID=8220714

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO964282A NO307257B1 (no)	1995-10-13	1996-10-09	Enantiomerisk rene imidazolylforbindelser, fremgangsmåte for fremstilling samt syreaddisjonssalter derav

Country Status (23)

Country	Link
US (1)	US5663343A (fr)
EP (1)	EP0768309B1 (fr)
JP (2)	JP4590038B2 (fr)
KR (1)	KR100459745B1 (fr)
CN (1)	CN1060774C (fr)
AT (1)	ATE224896T1 (fr)
AU (1)	AU702594B2 (fr)
CA (1)	CA2187484C (fr)
CZ (1)	CZ288042B6 (fr)
DE (1)	DE69623900T2 (fr)
DK (1)	DK0768309T3 (fr)
DZ (1)	DZ2104A1 (fr)
ES (1)	ES2183908T3 (fr)
HU (1)	HU226620B1 (fr)
IL (1)	IL119400A (fr)
NO (1)	NO307257B1 (fr)
NZ (1)	NZ299562A (fr)
PT (1)	PT768309E (fr)
RU (1)	RU2162085C2 (fr)
SK (1)	SK283471B6 (fr)
TW (1)	TW513423B (fr)
UA (1)	UA48947C2 (fr)
ZA (1)	ZA968525B (fr)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19813661A1 (de) *	1997-08-01	1999-02-04	Solvay Pharm Gmbh	Gegen Racemisierung stabilisierte pharmazeutische Zubereitungen von Cilansetron
US6372919B1 (en) *	2001-01-11	2002-04-16	Dov Pharmaceutical, Inc.	(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
RU2213562C2 (ru) *	2001-03-14	2003-10-10	Научно-исследовательский институт фармакологии РАМН	Лекарственная композиция
GB0216027D0 (en) *	2002-07-10	2002-08-21	Arachnova Therapeutics Ltd	New therapeutic use
US20040048874A1 (en) *	2001-05-22	2004-03-11	Bardsley Hazel Judith	New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
US7015333B2 (en) *	2002-11-18	2006-03-21	Solvay Pharmaceuticals B.V.	Process for preparation of imidazolyl compounds
EP1424337A1 (fr) *	2002-11-26	2004-06-02	Solvay Pharmaceuticals GmbH	Dérivés 4-hydroxy de 5,6,9,10-tetrahydro-10-((2-méthyl-1h-imidazol-1-yl)méthyl)-4h-pyrido-(3,2,1-jk)-carbazol-11(8h)-one
JP2006516977A (ja) *	2003-01-13	2006-07-13	ダイノゲンファーマシューティカルズ，インコーポレイテッド	悪心、嘔吐、レッチング、またはそれらの任意の組み合わせの治療方法
MXPA05007381A (es) *	2003-01-13	2006-02-10	Dynogen Pharmaceuticals Inc	Metodo para el tratamiento de transtornos funcionales del intestino.
JP2006522144A (ja) *	2003-04-04	2006-09-28	ダイノゲンファーマシューティカルズ，インコーポレイテッド	下部尿路障害の治療方法
WO2005047274A1 (fr) *	2003-11-12	2005-05-26	Dr. Reddy's Laboratories, Inc.	Preparation d'escitaloprame
US20070043100A1 (en)	2005-08-16	2007-02-22	Hagen Eric J	Novel polymorphs of azabicyclohexane
US20080045725A1 (en)	2006-04-28	2008-02-21	Murry Jerry A	Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane
US7662831B2 (en)	2006-07-27	2010-02-16	Wyeth Llc	Tetracyclic indoles as potassium channel modulators
US7601856B2 (en)	2006-07-27	2009-10-13	Wyeth	Benzofurans as potassium ion channel modulators
JP5156222B2 (ja) *	2006-11-28	2013-03-06	エムキュアファーマシューティカルズリミテッド	制吐作用化合物の新たな製造方法
GB0910373D0 (en) *	2009-06-16	2009-07-29	Filtrona Int Ltd	Tabacco smoke filter
US9806720B1 (en) *	2016-10-07	2017-10-31	Analog Devices Global	Compound semiconductor based inverter
AU2019270163A1 (en)	2018-05-18	2020-12-03	Kura Oncology, Inc.	Synthesis of tipifarnib

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL7413843A (nl) *	1974-10-23	1976-04-27	Stamicarbon	Optische scheiding van fenylglycine-amide.
US4463176A (en) *	1982-09-13	1984-07-31	Mead Johnson & Company	Process for resolution of optical isomers
US4849527A (en) *	1982-09-13	1989-07-18	Bristol-Myers Company	Process for resolution of optical isomers
SE460359B (sv) *	1984-01-25	1989-10-02	Glaxo Group Ltd	3-imidazolylmetyltetrahydrokarbazoloner, foerfarande foer framstaellning av dessa och en farmaceutisk komposition
DE3885357T2 (de) *	1987-06-29	1994-03-24	Duphar Int Res	Anellierte Indolderivate.
GB8812636D0 (en) *	1988-05-27	1988-06-29	Glaxo Group Ltd	Chemical compounds
EP0350129A1 (fr) *	1988-07-07	1990-01-10	Duphar International Research B.V	Indole cétones annelées avec un substituant imidazolylalkyle
DE4238553A1 (de) *	1992-11-14	1994-05-19	Kali Chemie Pharma Gmbh	Neue Imidazol-1-yl-Verbindungen enthaltende Arzneimittel
RU2041876C1 (ru) *	1993-12-29	1995-08-20	Научно-производственный центр "Фармзащита"	Способ получения 1,2,3,9- тетрагидро-9-метил-3- [(2-метил-1н- имидазол-1-ил) метил]-4н- карбазол-4-она или его солей, или их гидратов, и промежуточные продукты для их синтеза

1996
- 1996-09-26 AU AU65856/96A patent/AU702594B2/en not_active Ceased
- 1996-10-03 TW TW085112098A patent/TW513423B/zh not_active IP Right Cessation
- 1996-10-08 CZ CZ19962947A patent/CZ288042B6/cs not_active IP Right Cessation
- 1996-10-08 JP JP28461296A patent/JP4590038B2/ja not_active Expired - Fee Related
- 1996-10-08 SK SK1287-96A patent/SK283471B6/sk not_active IP Right Cessation
- 1996-10-09 NO NO964282A patent/NO307257B1/no not_active IP Right Cessation
- 1996-10-09 DZ DZ960148A patent/DZ2104A1/fr active
- 1996-10-09 HU HU9602778A patent/HU226620B1/hu not_active IP Right Cessation
- 1996-10-09 CA CA002187484A patent/CA2187484C/fr not_active Expired - Fee Related
- 1996-10-09 ZA ZA968525A patent/ZA968525B/xx unknown
- 1996-10-09 RU RU96120366/04A patent/RU2162085C2/ru not_active IP Right Cessation
- 1996-10-10 ES ES96202829T patent/ES2183908T3/es not_active Expired - Lifetime
- 1996-10-10 AT AT96202829T patent/ATE224896T1/de active
- 1996-10-10 KR KR1019960044972A patent/KR100459745B1/ko not_active Expired - Fee Related
- 1996-10-10 PT PT96202829T patent/PT768309E/pt unknown
- 1996-10-10 US US08/728,794 patent/US5663343A/en not_active Expired - Lifetime
- 1996-10-10 DE DE69623900T patent/DE69623900T2/de not_active Expired - Lifetime
- 1996-10-10 EP EP96202829A patent/EP0768309B1/fr not_active Expired - Lifetime
- 1996-10-10 UA UA96103876A patent/UA48947C2/uk unknown
- 1996-10-10 CN CN96122637A patent/CN1060774C/zh not_active Expired - Fee Related
- 1996-10-10 IL IL11940096A patent/IL119400A/xx not_active IP Right Cessation
- 1996-10-10 DK DK96202829T patent/DK0768309T3/da active
- 1996-10-11 NZ NZ299562A patent/NZ299562A/en not_active IP Right Cessation
2010
- 2010-04-15 JP JP2010094211A patent/JP2010159292A/ja active Pending

Also Published As

Publication number	Publication date
US5663343A (en)	1997-09-02
CZ294796A3 (en)	1997-05-14
CA2187484A1 (fr)	1997-04-14
DE69623900D1 (de)	2002-10-31
EP0768309A1 (fr)	1997-04-16
IL119400A (en)	2000-02-29
HUP9602778A3 (en)	1997-08-28
CN1160053A (zh)	1997-09-24
NO964282L (no)	1997-04-14
KR100459745B1 (ko)	2005-01-26
KR970021080A (ko)	1997-05-28
SK128796A3 (en)	1997-05-07
UA48947C2 (uk)	2002-09-16
PT768309E (pt)	2003-02-28
HK1000446A1 (en)	2003-01-10
AU6585696A (en)	1997-04-17
CZ288042B6 (cs)	2001-04-11
RU2162085C2 (ru)	2001-01-20
CN1060774C (zh)	2001-01-17
HU226620B1 (en)	2009-04-28
ES2183908T3 (es)	2003-04-01
NZ299562A (en)	1997-09-22
HUP9602778A2 (en)	1997-05-28
NO964282D0 (no)	1996-10-09
JP2010159292A (ja)	2010-07-22
SK283471B6 (sk)	2003-08-05
TW513423B (en)	2002-12-11
CA2187484C (fr)	2006-09-05
JPH09183779A (ja)	1997-07-15
EP0768309B1 (fr)	2002-09-25
DE69623900T2 (de)	2003-07-31
ATE224896T1 (de)	2002-10-15
JP4590038B2 (ja)	2010-12-01
AU702594B2 (en)	1999-02-25
ZA968525B (en)	1997-05-20
DK0768309T3 (da)	2002-12-09
HU9602778D0 (en)	1996-11-28
IL119400A0 (en)	1997-01-10
DZ2104A1 (fr)	2002-07-22

Legal Events

Date	Code	Title	Description
2012-06-04	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO307257B1 (no)	2000-03-06	Enantiomerisk rene imidazolylforbindelser, fremgangsmåte for fremstilling samt syreaddisjonssalter derav
US5281722A (en)	1994-01-25	Preparation and use of salts of the pure enantiomers of alpha-lipoic acid
CA2150355C (fr)	2008-03-11	Procede d'enrichissenment en un enantiomere donne d'acides phenylpriopioniques au moyen d'alpha-methylbenzylamine
RU96120366A (ru)	1998-12-27	Способ получения энантиомерно чистых соединений имидазолила, энантиомерно чистая кислая аддитивная соль имидазолила и в-пироглутаминовой кислоты
US20090093650A1 (en)	2009-04-09	Resolution of alpha-(phenoxy)phenylacetic acid derivatives with naphthyl-alkylamines
EP0623104B1 (fr)	1997-08-27	Resolution du profene
HU903768D0 (en)	1990-11-28	Process for producing new n-heteroaryl-purine-6-amine derivatives and pharmaceutical preparatives containing such compounds
JP2009108079A (ja)	2009-05-21	エナンチオマーに富むｎ−アシルアゼチジン−２−カルボン酸の製造方法
EP0220435B1 (fr)	1990-11-14	Procédé de préparation de semi-esters optiquement actifs
EP0508133A3 (en)	1993-03-03	Method of preparation of l-carnitine from d,l-carnitine nitrile salts
SK140898A3 (en)	1999-05-07	Improved process for the production of enantiomerically-pure azetidine-2-carboxylic acid
PL343556A1 (en)	2001-08-27	Method for producing enantiomer-free n-methyl-n- [(1s)-1-phenyl- 2-((3s)- 3-hydroxypyrrolidine- 1-yl)ethyl]- 2,2-diphenyl acetamide
Schjelderup et al.	1986	The absolute configuration of oxyphencyclimine, a parasympatholytic drug. Syntheses of both enantiomers
US4584313A (en)	1986-04-22	(Substituted-phenyl)-5-oxo-2-pyrrolidinepropanoic acids and esters thereof, and use for reversing electroconvulsive shock-induced amnesia
HU205594B (en)	1992-05-28	Process for producing optical isomeres of cyclopropane-carboxylic acids5
ATE198189T1 (de)	2001-01-15	Synthese von optisch aktivem aminoindanol
HU202803B (en)	1991-04-29	Process for separation of optical isomers of m-phenoxymandelic acid