NO308741B1 - Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene - Google Patents

Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene

Info

Publication number
NO308741B1
NO308741B1 NO970892A NO970892A NO308741B1 NO 308741 B1 NO308741 B1 NO 308741B1 NO 970892 A NO970892 A NO 970892A NO 970892 A NO970892 A NO 970892A NO 308741 B1 NO308741 B1 NO 308741B1
Authority
NO
Norway
Prior art keywords
group
derivatives
ring
integer
alkylthio
Prior art date
Application number
NO970892A
Other languages
English (en)
Norwegian (no)
Other versions
NO970892D0 (no
NO970892L (no
Inventor
Koichi Kojima
Junichi Sakai
Yuichi Aizawa
Naozumi Samata
Masao Kozuka
Kenji Yoshimi
Isao Kaneko
Kazuro Koyama
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO970892D0 publication Critical patent/NO970892D0/no
Publication of NO970892L publication Critical patent/NO970892L/no
Publication of NO308741B1 publication Critical patent/NO308741B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NO970892A 1994-08-30 1997-02-27 Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene NO308741B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP20536394 1994-08-30
JP15057195 1995-06-16
PCT/JP1995/001714 WO1996006837A1 (en) 1994-08-30 1995-08-29 Isoxazoles

Publications (3)

Publication Number Publication Date
NO970892D0 NO970892D0 (no) 1997-02-27
NO970892L NO970892L (no) 1997-04-29
NO308741B1 true NO308741B1 (no) 2000-10-23

Family

ID=26480122

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970892A NO308741B1 (no) 1994-08-30 1997-02-27 Isoksazolderivater, mellomprodukter, farmasøytiske preparater og anvendelse av derivatene

Country Status (19)

Country Link
US (2) US5965591A (de)
EP (1) EP0779281B1 (de)
KR (1) KR970705549A (de)
CN (1) CN1098843C (de)
AT (1) ATE253057T1 (de)
AU (1) AU688102B2 (de)
CA (1) CA2198457A1 (de)
CZ (1) CZ290961B6 (de)
DE (1) DE69532039T2 (de)
DK (1) DK0779281T3 (de)
ES (1) ES2208690T3 (de)
FI (1) FI970864A7 (de)
HU (1) HU221138B1 (de)
MX (1) MX9701630A (de)
NO (1) NO308741B1 (de)
NZ (1) NZ291508A (de)
PT (1) PT779281E (de)
RU (1) RU2140414C1 (de)
WO (1) WO1996006837A1 (de)

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US6339099B1 (en) * 1997-06-20 2002-01-15 Dupont Pharmaceuticals Company Guanidine mimics as factor Xa inhibitors
WO2000027199A1 (en) * 1998-11-12 2000-05-18 Eli Lilly And Company Aminobenzisoxazole compounds and libraries thereof
US6497928B1 (en) 1999-05-14 2002-12-24 Canon Kabushiki Kaisha Liquid crystal device, mesomorphic functional material and liquid crystal apparatus
DE10000577A1 (de) 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
US6660736B2 (en) * 2002-03-27 2003-12-09 Hoffmann-La Roche Inc. Phthalimido derivatives and a process for their preparation
MY134480A (en) * 2002-09-20 2007-12-31 Hoffmann La Roche 4-pyrrolidino-phenyl-benzyl ether derivatives
CN102010382A (zh) * 2003-12-29 2011-04-13 塞普拉科公司 苯并[d]异噁唑-3-醇DAAO抑制剂
JP2007517056A (ja) * 2003-12-29 2007-06-28 セプラコア インコーポレーテッド ピロール及びピラゾールｄａａｏ阻害剤
US20070197610A1 (en) * 2004-03-16 2007-08-23 Janssen Pharmaceutica N.V. Benzisoxazoles
WO2006013049A2 (en) * 2004-08-02 2006-02-09 F.Hoffmann-La Roche Ag Benzyloxy derivatives as maob inhibitors
DE102005018389A1 (de) * 2005-04-20 2006-10-26 Sanofi-Aventis Deutschland Gmbh Azolderivate als Inhibitoren von Lipasen und Phospholipasen
EP2455075B1 (de) 2005-07-06 2018-06-20 Sunovion Pharmaceuticals Inc. Prozess zur Herstellung von Trans-4-(3,4-dichlorphenyl)-1,2,3,4-tetrahydro-1-napthalenamin
KR20080038369A (ko) * 2005-07-28 2008-05-06 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 프로드럭
US20070203111A1 (en) 2006-01-06 2007-08-30 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
NZ569608A (en) * 2006-01-06 2011-09-30 Sepracor Inc Tetralone-based monoamine reuptake inhibitors
RU2434002C2 (ru) * 2006-02-21 2011-11-20 Тояма Кемикал Ко., Лтд. Способ получения сложного эфира 3-[5-[4-(циклопентилокси)-2-гидроксибензоил]-2-[(3-оксо-2-замещенный-2, 3-дигидро-1, 2-бензизоксазол-6-ил)метокси]фенил]пропионовой кислоты и промежуточного продукта для данного способа
CN101421228B (zh) 2006-03-31 2014-05-21 塞普拉柯公司 手性酰胺和胺的制备
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
CA2674237C (en) 2006-12-28 2015-11-24 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
CA2676432A1 (en) * 2007-01-18 2008-07-24 Sepracor, Inc. Inhibitors of d-amino acid oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
CA2688493C (en) 2007-05-31 2016-04-19 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
WO2009104080A2 (en) 2008-02-20 2009-08-27 Targia Pharmaceuticals Cns pharmaceutical compositions and methods of use
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110034434A1 (en) * 2009-08-07 2011-02-10 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
WO2011100614A1 (en) 2010-02-11 2011-08-18 Vanderbilt University BENZISOXAZOLES AND AZABENZISOXAZOLES AS mgluR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
RU2014121984A (ru) 2011-10-31 2015-12-10 Ксенон Фармасьютикалз Инк. Бензолсульфонамидные соединения и их применение в качестве терапевтических средств
JP6014155B2 (ja) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
CN104718188B (zh) 2012-05-22 2018-08-21 基因泰克公司 N-取代的苯甲酰胺类及其在治疗疼痛中的用途
KR101663436B1 (ko) 2012-07-06 2016-10-06 제넨테크, 인크. N-치환된 벤즈아미드 및 이의 사용 방법
RU2015143906A (ru) 2013-03-14 2017-04-18 Дженентек, Инк. Замещенные триазолопиридины и способы их применения
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WO2015078374A1 (en) 2013-11-27 2015-06-04 Genentech, Inc. Substituted benzamides and methods of use thereof
JP2017525677A (ja) 2014-07-07 2017-09-07 ジェネンテック， インコーポレイテッド 治療用化合物及びその使用方法
HK1252567A1 (zh) 2015-05-22 2019-05-31 基因泰克公司 被取代的苯甲酰胺和其使用方法
JP2018526371A (ja) 2015-08-27 2018-09-13 ジェネンテック， インコーポレイテッド 治療化合物及びその使用方法
EP3380466A1 (de) 2015-11-25 2018-10-03 Genentech, Inc. Substituierte benzamide als natriumkanalblocker
EP3436432B1 (de) 2016-03-30 2021-01-27 Genentech, Inc. Substituierte benzamide und verfahren zur verwendung davon
CN105801510A (zh) * 2016-04-08 2016-07-27 李勇 一种治疗抑郁症的药物组合物
PE20190980A1 (es) 2016-10-17 2019-07-09 Genentech Inc Compuestos terapeuticos y metodos para utilizarlos
JP2020511511A (ja) 2017-03-24 2020-04-16 ジェネンテック， インコーポレイテッド ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体
AR114263A1 (es) 2018-02-26 2020-08-12 Genentech Inc Compuestos terapéuticos y métodos para utilizarlos
US10947251B2 (en) 2018-03-30 2021-03-16 Genentech, Inc. Therapeutic compounds and methods of use thereof
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
CN114349690B (zh) * 2022-02-15 2023-04-25 甘肃皓天医药科技有限责任公司 一种多拉韦林中间体合成方法

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Also Published As

Publication number Publication date
AU688102B2 (en) 1998-03-05
US6096771A (en) 2000-08-01
CN1098843C (zh) 2003-01-15
HU221138B1 (en) 2002-08-28
CN1162957A (zh) 1997-10-22
US5965591A (en) 1999-10-12
HUT77225A (hu) 1998-03-02
ATE253057T1 (de) 2003-11-15
DE69532039D1 (de) 2003-12-04
CZ59897A3 (en) 1997-07-16
NO970892D0 (no) 1997-02-27
WO1996006837A1 (en) 1996-03-07
DK0779281T3 (da) 2004-03-08
RU2140414C1 (ru) 1999-10-27
NZ291508A (en) 1999-07-29
EP0779281B1 (de) 2003-10-29
KR970705549A (ko) 1997-10-09
CZ290961B6 (cs) 2002-11-13
HK1018878A1 (en) 2000-01-07
FI970864A7 (fi) 1997-04-24
NO970892L (no) 1997-04-29
FI970864A0 (fi) 1997-02-28
AU3266095A (en) 1996-03-22
DE69532039T2 (de) 2004-07-08
CA2198457A1 (en) 1996-03-07
MX9701630A (es) 1997-06-28
EP0779281A4 (de) 2000-07-26
EP0779281A1 (de) 1997-06-18
PT779281E (pt) 2004-02-27
ES2208690T3 (es) 2004-06-16

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