NO309574B1 - Legemiddel-beholder oppnådd fra termoplastisk stivelsessmelte og fremgangsmåte for fremstilling derav - Google Patents

Legemiddel-beholder oppnådd fra termoplastisk stivelsessmelte og fremgangsmåte for fremstilling derav Download PDF

Info

Publication number: NO309574B1
Authority: NO; Norway
Prior art keywords: starch; component; weight; cellulose; container according
Prior art date: 1990-08-30

Application number

NO921687A

Other languages

English (en)

Norwegian (no)

Other versions

NO921687D0 (no

NO921687L (no

Inventor

Ewart Thomas Cole

Markus Egli

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-30

Filing date

1992-04-29

Publication date

2001-02-19

1992-04-29 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1992-04-29 Publication of NO921687D0 publication Critical patent/NO921687D0/no

1992-04-29 Publication of NO921687L publication Critical patent/NO921687L/no

2001-02-19 Publication of NO309574B1 publication Critical patent/NO309574B1/no

Links

239000003814 drug Substances 0.000 title claims description 18
229940079593 drug Drugs 0.000 title claims description 15
238000000034 method Methods 0.000 title claims description 14
230000008569 process Effects 0.000 title description 6
229920008262 Thermoplastic starch Polymers 0.000 title description 2
239000004628 starch-based polymer Substances 0.000 title description 2
229920002472 Starch Polymers 0.000 claims abstract description 85
235000019698 starch Nutrition 0.000 claims abstract description 85
239000008107 starch Substances 0.000 claims abstract description 69
229920001169 thermoplastic Polymers 0.000 claims abstract description 43
239000004416 thermosoftening plastic Substances 0.000 claims abstract description 43
239000000155 melt Substances 0.000 claims abstract description 21
238000004090 dissolution Methods 0.000 claims abstract description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 34
229920000642 polymer Polymers 0.000 claims description 22
239000000203 mixture Substances 0.000 claims description 19
239000002775 capsule Substances 0.000 claims description 16
238000001746 injection moulding Methods 0.000 claims description 12
229920002678 cellulose Polymers 0.000 claims description 10
239000001913 cellulose Substances 0.000 claims description 10
235000010980 cellulose Nutrition 0.000 claims description 10
239000000835 fiber Substances 0.000 claims description 10
239000001267 polyvinylpyrrolidone Substances 0.000 claims description 10
229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 10
235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 10
150000003839 salts Chemical group 0.000 claims description 10
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238000002844 melting Methods 0.000 claims description 8
230000008018 melting Effects 0.000 claims description 8
239000004014 plasticizer Substances 0.000 claims description 8
230000009477 glass transition Effects 0.000 claims description 7
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 6
150000001875 compounds Chemical class 0.000 claims description 6
150000004676 glycans Chemical class 0.000 claims description 6
125000002768 hydroxyalkyl group Chemical group 0.000 claims description 6
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238000004519 manufacturing process Methods 0.000 claims description 6
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239000005017 polysaccharide Substances 0.000 claims description 6
229920000168 Microcrystalline cellulose Polymers 0.000 claims description 5
238000001125 extrusion Methods 0.000 claims description 5
239000000945 filler Substances 0.000 claims description 5
235000019813 microcrystalline cellulose Nutrition 0.000 claims description 5
239000008108 microcrystalline cellulose Substances 0.000 claims description 5
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239000003381 stabilizer Substances 0.000 claims description 5
238000006467 substitution reaction Methods 0.000 claims description 5
239000006185 dispersion Substances 0.000 claims description 4
229920001592 potato starch Polymers 0.000 claims description 4
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238000000071 blow moulding Methods 0.000 claims description 3
239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 3
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 3
239000012876 carrier material Substances 0.000 claims description 3
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 3
239000006082 mold release agent Substances 0.000 claims description 3
238000003856 thermoforming Methods 0.000 claims description 3
238000007666 vacuum forming Methods 0.000 claims description 3
JVIPLYCGEZUBIO-UHFFFAOYSA-N 2-(4-fluorophenyl)-1,3-dioxoisoindole-5-carboxylic acid Chemical compound O=C1C2=CC(C(=O)O)=CC=C2C(=O)N1C1=CC=C(F)C=C1 JVIPLYCGEZUBIO-UHFFFAOYSA-N 0.000 claims description 2
229920001425 Diethylaminoethyl cellulose Polymers 0.000 claims description 2
229920002873 Polyethylenimine Polymers 0.000 claims description 2
GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
150000001412 amines Chemical class 0.000 claims description 2
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239000003086 colorant Substances 0.000 claims description 2
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238000010309 melting process Methods 0.000 claims description 2
125000004964 sulfoalkyl group Chemical group 0.000 claims description 2
235000013311 vegetables Nutrition 0.000 claims description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
125000004181 carboxyalkyl group Chemical group 0.000 claims 1
239000000463 material Substances 0.000 abstract description 58
239000002609 medium Substances 0.000 abstract description 7
239000002612 dispersion medium Substances 0.000 abstract description 5
230000000694 effects Effects 0.000 abstract description 3
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235000019426 modified starch Nutrition 0.000 description 16
239000004368 Modified starch Substances 0.000 description 14
239000000843 powder Substances 0.000 description 9
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 7
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239000000654 additive Substances 0.000 description 5
239000002245 particle Substances 0.000 description 5
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GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
230000015556 catabolic process Effects 0.000 description 4
238000006731 degradation reaction Methods 0.000 description 4
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238000000465 moulding Methods 0.000 description 4
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 3
BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 3
229920002101 Chitin Polymers 0.000 description 3
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DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000004373 Pullulan Substances 0.000 description 3
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229960001138 acetylsalicylic acid Drugs 0.000 description 3
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239000007884 disintegrant Substances 0.000 description 3
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150000002500 ions Chemical class 0.000 description 3
239000000787 lecithin Substances 0.000 description 3
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238000010998 test method Methods 0.000 description 3
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150000003626 triacylglycerols Chemical class 0.000 description 3
KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 description 2
229920002261 Corn starch Polymers 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
244000061456 Solanum tuberosum Species 0.000 description 2
235000002595 Solanum tuberosum Nutrition 0.000 description 2
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
239000004411 aluminium Substances 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
238000001816 cooling Methods 0.000 description 2
239000008120 corn starch Substances 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
239000000975 dye Substances 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000007903 gelatin capsule Substances 0.000 description 2
125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
239000001023 inorganic pigment Substances 0.000 description 2
TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000011777 magnesium Substances 0.000 description 2
229910052749 magnesium Inorganic materials 0.000 description 2
239000000047 product Substances 0.000 description 2
238000007789 sealing Methods 0.000 description 2
239000010936 titanium Substances 0.000 description 2
229910052719 titanium Inorganic materials 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
235000019871 vegetable fat Nutrition 0.000 description 2
229920000945 Amylopectin Polymers 0.000 description 1
229920000856 Amylose Polymers 0.000 description 1
235000019737 Animal fat Nutrition 0.000 description 1
235000007319 Avena orientalis Nutrition 0.000 description 1
244000075850 Avena orientalis Species 0.000 description 1
241000208199 Buxus sempervirens Species 0.000 description 1
GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
239000004606 Fillers/Extenders Substances 0.000 description 1
229940123457 Free radical scavenger Drugs 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
UXDDRFCJKNROTO-UHFFFAOYSA-N Glycerol 1,2-diacetate Chemical compound CC(=O)OCC(CO)OC(C)=O UXDDRFCJKNROTO-UHFFFAOYSA-N 0.000 description 1
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
241001082241 Lythrum hyssopifolia Species 0.000 description 1
240000003183 Manihot esculenta Species 0.000 description 1
235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
240000007594 Oryza sativa Species 0.000 description 1
235000007164 Oryza sativa Nutrition 0.000 description 1
240000004713 Pisum sativum Species 0.000 description 1
235000010582 Pisum sativum Nutrition 0.000 description 1
229920003110 Primojel Polymers 0.000 description 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
241001062472 Stokellia anisodon Species 0.000 description 1
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
244000098338 Triticum aestivum Species 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
239000006096 absorbing agent Substances 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
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238000013019 agitation Methods 0.000 description 1
102000004139 alpha-Amylases Human genes 0.000 description 1
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238000004458 analytical method Methods 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
239000000987 azo dye Substances 0.000 description 1
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239000003139 biocide Substances 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000011362 coarse particle Substances 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
229960003368 croscarmellose sodium type a Drugs 0.000 description 1
238000004132 cross linking Methods 0.000 description 1
239000011243 crosslinked material Substances 0.000 description 1
239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000010586 diagram Methods 0.000 description 1
UXELAVSYWBWGQM-UHFFFAOYSA-L disodium;2,2-diethyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCC(CC)(C([O-])=O)C(C([O-])=O)S(O)(=O)=O UXELAVSYWBWGQM-UHFFFAOYSA-L 0.000 description 1
239000012738 dissolution medium Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000010514 hydrogenated cottonseed oil Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000002917 insecticide Substances 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229910052919 magnesium silicate Inorganic materials 0.000 description 1
235000019792 magnesium silicate Nutrition 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
235000009973 maize Nutrition 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000003605 opacifier Substances 0.000 description 1
239000012860 organic pigment Substances 0.000 description 1
238000006864 oxidative decomposition reaction Methods 0.000 description 1
239000008188 pellet Substances 0.000 description 1
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
238000001782 photodegradation Methods 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
229920000233 poly(alkylene oxides) Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
235000012015 potatoes Nutrition 0.000 description 1
238000003825 pressing Methods 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
239000002516 radical scavenger Substances 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
235000009566 rice Nutrition 0.000 description 1
150000003336 secondary aromatic amines Chemical class 0.000 description 1
239000010703 silicon Substances 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
229940071117 starch glycolate Drugs 0.000 description 1
239000007858 starting material Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000005979 thermal decomposition reaction Methods 0.000 description 1
239000012815 thermoplastic material Substances 0.000 description 1
239000011135 tin Substances 0.000 description 1
229910052718 tin Inorganic materials 0.000 description 1
ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 1
239000001069 triethyl citrate Substances 0.000 description 1
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
235000013769 triethyl citrate Nutrition 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical class [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L3/00—Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
- C08L3/02—Starch; Degradation products thereof, e.g. dextrin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Compositions Of Macromolecular Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Materials For Medical Uses (AREA)
Casting Or Compression Moulding Of Plastics Or The Like (AREA)
Manufacture Of Macromolecular Shaped Articles (AREA)
Adhesives Or Adhesive Processes (AREA)
Biological Depolymerization Polymers (AREA)
Extrusion Moulding Of Plastics Or The Like (AREA)
Blow-Moulding Or Thermoforming Of Plastics Or The Like (AREA)

NO921687A 1990-08-30 1992-04-29 Legemiddel-beholder oppnådd fra termoplastisk stivelsessmelte og fremgangsmåte for fremstilling derav NO309574B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US57546490A	1990-08-30	1990-08-30
PCT/US1991/005873 WO1992004408A1 (en)	1990-08-30	1991-08-19	Shaped articles as obtained from a thermoplastic starch melt

Publications (3)

Publication Number	Publication Date
NO921687D0 NO921687D0 (no)	1992-04-29
NO921687L NO921687L (no)	1992-04-29
NO309574B1 true NO309574B1 (no)	2001-02-19

Family

ID=24300434

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO921687A NO309574B1 (no)	1990-08-30	1992-04-29	Legemiddel-beholder oppnådd fra termoplastisk stivelsessmelte og fremgangsmåte for fremstilling derav

Country Status (16)

Country	Link
EP (1)	EP0500885B1 (es)
JP (1)	JP3201609B2 (es)
KR (1)	KR920702388A (es)
CN (1)	CN1059346A (es)
AT (1)	ATE149545T1 (es)
AU (1)	AU648109B2 (es)
CA (1)	CA2072116C (es)
DE (1)	DE69124983T2 (es)
DK (1)	DK0500885T3 (es)
ES (1)	ES2103003T3 (es)
GR (1)	GR3023469T3 (es)
IE (1)	IE912954A1 (es)
NO (1)	NO309574B1 (es)
NZ (1)	NZ239477A (es)
PT (1)	PT98770B (es)
WO (1)	WO1992004408A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG47625A1 (en) *	1991-11-14	1998-04-17	Bio Tech Biolog Naturverparkun	Biodegradable mould material
IT1256914B (it) *	1992-08-03	1995-12-27	Novamont Spa	Composizione polimerica biodegradabile.
US6277899B1 (en)	1992-08-03	2001-08-21	Novamont S.P.A.	Biodegradable polymeric composition
US5662731A (en) *	1992-08-11	1997-09-02	E. Khashoggi Industries	Compositions for manufacturing fiber-reinforced, starch-bound articles having a foamed cellular matrix
US5810961A (en) *	1993-11-19	1998-09-22	E. Khashoggi Industries, Llc	Methods for manufacturing molded sheets having a high starch content
US5352709A (en) *	1993-01-29	1994-10-04	International Technology Management Associates, Ltd.	Algal plastics
US5858350A (en)	1993-12-01	1999-01-12	Marine Polymer Technologies	Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system
DE19729305C2 (de) *	1997-07-09	2000-07-06	Aventis Res & Tech Gmbh & Co	Thermoplastische Mischung auf Basis von Stärke enthaltend mindestens eine kationische und mindestens eine anionische Stärke, Verfahren zu ihrer Herstellung sowie Verwendung
JP3672008B2 (ja) *	1999-01-20	2005-07-13	シオノギクオリカプス株式会社	硬質カプセル及びその製造方法
ATE291420T1 (de) *	1999-11-19	2005-04-15	Swiss Caps Rechte & Lizenzen	Verfahren zum herstellen eines stärke enthaltenden formkörpers, homogenisierte stärke enthaltende masse und vorrichtung zum herstellen einer weichkapsel
EP1438033B1 (de) *	2001-10-23	2008-06-11	InnoGEL AG	Hartkapseln auf basis von stärke-gel und verfahren zu deren herstellung
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1991
- 1991-08-19 DE DE69124983T patent/DE69124983T2/de not_active Expired - Lifetime
- 1991-08-19 AU AU85261/91A patent/AU648109B2/en not_active Expired
- 1991-08-19 EP EP91916235A patent/EP0500885B1/en not_active Expired - Lifetime
- 1991-08-19 JP JP51564691A patent/JP3201609B2/ja not_active Expired - Lifetime
- 1991-08-19 AT AT91916235T patent/ATE149545T1/de not_active IP Right Cessation
- 1991-08-19 CA CA002072116A patent/CA2072116C/en not_active Expired - Lifetime
- 1991-08-19 DK DK91916235.4T patent/DK0500885T3/da active
- 1991-08-19 ES ES91916235T patent/ES2103003T3/es not_active Expired - Lifetime
- 1991-08-19 KR KR1019920701004A patent/KR920702388A/ko not_active Withdrawn
- 1991-08-19 WO PCT/US1991/005873 patent/WO1992004408A1/en not_active Ceased
- 1991-08-20 CN CN91105908A patent/CN1059346A/zh active Pending
- 1991-08-20 NZ NZ239477A patent/NZ239477A/xx not_active IP Right Cessation
- 1991-08-20 IE IE295491A patent/IE912954A1/en not_active IP Right Cessation
- 1991-08-23 PT PT98770A patent/PT98770B/pt not_active IP Right Cessation
1992
- 1992-04-29 NO NO921687A patent/NO309574B1/no not_active IP Right Cessation
1997
- 1997-05-16 GR GR970401118T patent/GR3023469T3/el unknown

Also Published As

Publication number	Publication date
DE69124983T2 (de)	1997-10-16
GR3023469T3 (en)	1997-08-29
IE912954A1 (en)	1992-03-11
PT98770A (pt)	1992-08-31
CA2072116A1 (en)	1992-03-01
ES2103003T3 (es)	1997-08-16
JPH05502267A (ja)	1993-04-22
AU648109B2 (en)	1994-04-14
CN1059346A (zh)	1992-03-11
ATE149545T1 (de)	1997-03-15
WO1992004408A1 (en)	1992-03-19
EP0500885A1 (en)	1992-09-02
NO921687D0 (no)	1992-04-29
NO921687L (no)	1992-04-29
CA2072116C (en)	2003-09-23
EP0500885B1 (en)	1997-03-05
DK0500885T3 (da)	1997-08-25
KR920702388A (ko)	1992-09-03
JP3201609B2 (ja)	2001-08-27
PT98770B (pt)	1999-01-29
DE69124983D1 (de)	1997-04-10
NZ239477A (en)	1993-04-28
AU8526191A (en)	1992-03-30

Legal Events

Date	Code	Title	Description
2011-09-12	MK1K	Patent expired

Publication	Publication Date	Title
NO309574B1 (no)	2001-02-19	Legemiddel-beholder oppnådd fra termoplastisk stivelsessmelte og fremgangsmåte for fremstilling derav
RU2026321C1 (ru)	1995-01-09	Полимерная композиция для формования изделий из расплава
RU2056443C1 (ru)	1996-03-20	Композиция, способ переработки композиции и способ получения ее расплава
US3499962A (en)	1970-03-10	Encapsulation of water insoluble materials
US6143324A (en)	2000-11-07	Free-flowable directly compressible starch as binder, disintegrant and filler for compression tablets and hard gelatine capsules
CA1328711C (en)	1994-04-26	Shaped articles made from pre-processed starch
KR100286794B1 (ko)	2001-04-16	전분으로 구성되는 생분해성 조성물
US5571552A (en)	1996-11-05	Continuous coupled jet-cooking/spray-drying process and novel pregelatinized high amylose starches and gums prepared thereby
KR0178390B1 (ko)	1999-05-15	분해 전분을 함유하는 중합체 기초 혼합 조성물
NO304154B1 (no)	1998-11-02	Polymerblanding som inneholder strukturendret stivelse, samt anvendelse av polymerblandingen
JPH07711B2 (ja)	1995-01-11	澱粉をベ−スとする配合物
IE902429A1 (en)	1991-06-19	Polymer base blend compositions containing destructurized¹starch
JPH055065A (ja)	1993-01-14	親水性ポリマー及びそれとは異なる親水性物質を含有する新規組成物
CA2372025C (en)	2007-09-25	Method for producing a water-insoluble amorphous or partially amorphous controlled release matrix
CA2013134A1 (en)	1990-10-03	Destructurized starch and method of making same
HUT54399A (en)	1991-02-28	Polymere-based mixture composition containing destructurated starch
WO1997008244A1 (de)	1997-03-06	Formstabile verpackungen