NO312290B1 - Farmasöytisk preparat inneholdende 4-oksobutansyrer, samt forbindelser som omfattes av disse - Google Patents

Farmasöytisk preparat inneholdende 4-oksobutansyrer, samt forbindelser som omfattes av disse Download PDF

Info

Publication number: NO312290B1
Authority: NO; Norway
Prior art keywords: oxobutanoic acid; benzyl; phenyl; acid; formula
Prior art date: 1996-08-16

Application number

NO19990707A

Other languages

English (en)

Norwegian (no)

Other versions

NO990707D0 (no

NO990707L (no

Inventor

Gerard Moinet

Liliane Doare

Micheline Kergoat

Philippe Maizeray

Didier Mesangeau

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-16

Filing date

1999-02-15

Publication date

2002-04-22

1999-02-15 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1999-02-15 Publication of NO990707D0 publication Critical patent/NO990707D0/no

1999-02-15 Publication of NO990707L publication Critical patent/NO990707L/no

2002-04-22 Publication of NO312290B1 publication Critical patent/NO312290B1/no

Links

150000001875 compounds Chemical class 0.000 title claims description 32
239000000825 pharmaceutical preparation Substances 0.000 title claims description 6
UIUJIQZEACWQSV-UHFFFAOYSA-N succinic semialdehyde Chemical class OC(=O)CCC=O UIUJIQZEACWQSV-UHFFFAOYSA-N 0.000 title description 2
238000002360 preparation method Methods 0.000 claims description 17
239000002253 acid Substances 0.000 claims description 16
150000003839 salts Chemical class 0.000 claims description 14
-1 methylenedioxy group Chemical group 0.000 claims description 10
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
125000001424 substituent group Chemical group 0.000 claims description 8
229910052736 halogen Inorganic materials 0.000 claims description 6
150000002367 halogens Chemical class 0.000 claims description 6
239000012453 solvate Substances 0.000 claims description 6
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 5
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 5
150000007513 acids Chemical class 0.000 claims description 5
125000001624 naphthyl group Chemical group 0.000 claims description 5
125000004432 carbon atom Chemical group C* 0.000 claims description 4
125000000753 cycloalkyl group Chemical group 0.000 claims description 4
125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 4
QPORTTBGWVROJY-UHFFFAOYSA-N 2-benzyl-4-oxo-4-phenylbutanoic acid Chemical compound C=1C=CC=CC=1CC(C(=O)O)CC(=O)C1=CC=CC=C1 QPORTTBGWVROJY-UHFFFAOYSA-N 0.000 claims description 2
125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims description 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 2
GVPCMJHFPQEBOL-UHFFFAOYSA-N 2-benzyl-4-(4-fluorophenyl)-4-oxobutanoic acid;2-benzyl-4-(4-methoxyphenyl)-4-oxobutanoic acid;2-(cyclohexylmethyl)-4-(4-methoxyphenyl)-4-oxobutanoic acid Chemical compound C=1C=CC=CC=1CC(C(=O)O)CC(=O)C1=CC=C(F)C=C1.C1=CC(OC)=CC=C1C(=O)CC(C(O)=O)CC1CCCCC1.C1=CC(OC)=CC=C1C(=O)CC(C(O)=O)CC1=CC=CC=C1 GVPCMJHFPQEBOL-UHFFFAOYSA-N 0.000 claims 1
OBDXDWVDQXGGOD-UHFFFAOYSA-N 4-(1,3-benzodioxol-5-yl)-2-benzyl-4-oxobutanoic acid;2-benzyl-4-cyclohexyl-4-oxobutanoic acid;4-oxo-2-(oxolan-2-ylmethyl)-4-phenylbutanoic acid Chemical compound C=1C=CC=CC=1C(=O)CC(C(=O)O)CC1CCCO1.C=1C=CC=CC=1CC(C(=O)O)CC(=O)C1CCCCC1.C=1C=C2OCOC2=CC=1C(=O)CC(C(=O)O)CC1=CC=CC=C1 OBDXDWVDQXGGOD-UHFFFAOYSA-N 0.000 claims 1
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HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
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239000000644 isotonic solution Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
239000004137 magnesium phosphate Substances 0.000 description 1
229960002261 magnesium phosphate Drugs 0.000 description 1
229910000157 magnesium phosphate Inorganic materials 0.000 description 1
235000010994 magnesium phosphates Nutrition 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
150000002690 malonic acid derivatives Chemical class 0.000 description 1
239000000463 material Substances 0.000 description 1
239000000155 melt Substances 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
235000019426 modified starch Nutrition 0.000 description 1
230000023187 negative regulation of glucagon secretion Effects 0.000 description 1
229940105631 nembutal Drugs 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
229960002275 pentobarbital sodium Drugs 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
231100000161 signs of toxicity Toxicity 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical class [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007940 sugar coated tablet Substances 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000003826 tablet Substances 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000820 toxicity test Toxicity 0.000 description 1
208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Endocrinology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

NO19990707A 1996-08-16 1999-02-15 Farmasöytisk preparat inneholdende 4-oksobutansyrer, samt forbindelser som omfattes av disse NO312290B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9610254A FR2752422B1 (fr)	1996-08-16	1996-08-16	Composition pharmaceutique contenant des acides 4-oxo-butanoiques
PCT/EP1997/004252 WO1998007681A1 (fr)	1996-08-16	1997-08-05	Compositions pharmaceutiques contenant des acides 4-oxo-butanoiques

Publications (3)

Publication Number	Publication Date
NO990707D0 NO990707D0 (no)	1999-02-15
NO990707L NO990707L (no)	1999-02-15
NO312290B1 true NO312290B1 (no)	2002-04-22

Family

ID=9495089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19990707A NO312290B1 (no)	1996-08-16	1999-02-15	Farmasöytisk preparat inneholdende 4-oksobutansyrer, samt forbindelser som omfattes av disse

Country Status (29)

Country	Link
US (1)	US6143787A (cs)
EP (1)	EP0925273B1 (cs)
JP (1)	JP3105545B2 (cs)
KR (1)	KR100488430B1 (cs)
CN (1)	CN1082370C (cs)
AR (1)	AR009251A1 (cs)
AT (1)	ATE208364T1 (cs)
AU (1)	AU725440B2 (cs)
BR (1)	BR9711315A (cs)
CA (1)	CA2263348C (cs)
CY (1)	CY2298B1 (cs)
CZ (1)	CZ294165B6 (cs)
DE (1)	DE69708130T2 (cs)
DK (1)	DK0925273T3 (cs)
ES (1)	ES2166098T3 (cs)
FR (1)	FR2752422B1 (cs)
HU (1)	HUP0004223A3 (cs)
ID (1)	ID17875A (cs)
NO (1)	NO312290B1 (cs)
PL (1)	PL187371B1 (cs)
PT (1)	PT925273E (cs)
RU (1)	RU2175966C2 (cs)
SI (1)	SI0925273T1 (cs)
SK (1)	SK283055B6 (cs)
TR (1)	TR199900329T2 (cs)
TW (1)	TW438764B (cs)
UA (1)	UA57031C2 (cs)
WO (1)	WO1998007681A1 (cs)
ZA (1)	ZA977327B (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH04318852A (ja) *	1991-04-18	1992-11-10	Fujitsu Ltd	レジスト・パターン形成方法
KR100965201B1 (ko)	2001-06-12	2010-06-24	웰스테트 테라퓨틱스 코포레이션	대사 질환의 치료용 화합물
FR2832633B1 (fr) *	2001-11-28	2004-09-24	Lipha	Composition pharmaceutique comprenant une association metformine et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete
FR2832925B1 (fr) *	2001-12-03	2006-07-14	Lipha	Utilisation de derives de l'acide 4-oxobutanoique dans le traitement de l'inflammation
FR2834214B1 (fr) *	2001-12-28	2004-09-24	Lipha	Composition pharmaceutique comprenant un inhibiteur d'alpha-glucosidase et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete
FR2834640B1 (fr) *	2002-01-11	2004-09-24	Lipha	Composition pharmaceutique comprenant une glitazone et un acide 4-oxobutanoique et son utilisation pour traiter le diabete
AU2003286728A1 (en) *	2002-11-01	2004-06-07	Wellstat Therapeutics Corporation	Compounds for the treatment of metabolic disorders
ATE468114T1 (de) *	2002-11-08	2010-06-15	High Point Pharmaceuticals Llc	Sichere chemische entkuppler zur behandlung von fettsucht
FR2849599B1 (fr) *	2003-01-07	2006-12-29	Merck Sante Sas	Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete
FR2849598B1 (fr) *	2003-01-07	2006-09-22	Merck Sante Sas	Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
KR101127390B1 (ko) *	2003-04-15	2012-03-23	웰스태트 테러퓨틱스 코포레이션	대사 질환의 치료용 화합물
ATE522209T1 (de)	2007-12-03	2011-09-15	Merck Patent Gmbh	Verwendung von 4-oxobutansäure-derivaten bei der behandlung von mit immunologischen leiden verbundenen erkrankungen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1190340B (it) *	1986-06-06	1988-02-16	Roussel Maestretti Spa	Derivati dell'acido 4-fenil 4-osso 2-butenoico,loro procedimento di preparazione e loro impiego come prodotti medicinali
US5250517A (en) *	1987-10-06	1993-10-05	Hoffmann-La Roche Inc.	Renin inhibiting compounds
DK523288A (da) *	1987-10-06	1989-04-07	Hoffmann La Roche	Aminosyrederivater
US5055466A (en) *	1987-11-23	1991-10-08	E. R. Squibb & Sons, Inc.	N-morpholino derivatives and their use as anti-hypertensive agents
CA1329680C (en) *	1987-11-23	1994-05-17	Harold Norris Weller, Iii	N-heterocyclic alcohol derivatives
FR2733750B1 (fr)	1995-05-03	1997-06-13	Synthelabo	Derives de l'acide gamma-oxo-alpha-(phenylmethyl)-5,6- dihydro-4h-thieno(3,4-c)pyrrole-5-butanoique, leur preparation et leur application en therapeutique

1996
- 1996-08-16 FR FR9610254A patent/FR2752422B1/fr not_active Expired - Fee Related
1997
- 1997-05-08 UA UA99031301A patent/UA57031C2/uk unknown
- 1997-08-05 SK SK180-99A patent/SK283055B6/sk not_active IP Right Cessation
- 1997-08-05 DK DK97936682T patent/DK0925273T3/da active
- 1997-08-05 PT PT97936682T patent/PT925273E/pt unknown
- 1997-08-05 US US09/230,849 patent/US6143787A/en not_active Expired - Fee Related
- 1997-08-05 ES ES97936682T patent/ES2166098T3/es not_active Expired - Lifetime
- 1997-08-05 JP JP10510330A patent/JP3105545B2/ja not_active Expired - Fee Related
- 1997-08-05 CA CA002263348A patent/CA2263348C/en not_active Expired - Fee Related
- 1997-08-05 EP EP97936682A patent/EP0925273B1/fr not_active Expired - Lifetime
- 1997-08-05 TR TR1999/00329T patent/TR199900329T2/xx unknown
- 1997-08-05 CN CN97197180A patent/CN1082370C/zh not_active Expired - Fee Related
- 1997-08-05 AU AU39422/97A patent/AU725440B2/en not_active Ceased
- 1997-08-05 WO PCT/EP1997/004252 patent/WO1998007681A1/fr not_active Ceased
- 1997-08-05 CZ CZ1999498A patent/CZ294165B6/cs not_active IP Right Cessation
- 1997-08-05 DE DE69708130T patent/DE69708130T2/de not_active Expired - Lifetime
- 1997-08-05 KR KR10-1999-7001122A patent/KR100488430B1/ko not_active Expired - Fee Related
- 1997-08-05 RU RU99105208/04A patent/RU2175966C2/ru not_active IP Right Cessation
- 1997-08-05 HU HU0004223A patent/HUP0004223A3/hu unknown
- 1997-08-05 BR BR9711315A patent/BR9711315A/pt not_active IP Right Cessation
- 1997-08-05 SI SI9730237T patent/SI0925273T1/xx unknown
- 1997-08-05 AT AT97936682T patent/ATE208364T1/de not_active IP Right Cessation
- 1997-08-14 ZA ZA9707327A patent/ZA977327B/xx unknown
- 1997-08-14 ID IDP972848A patent/ID17875A/id unknown
- 1997-08-15 AR ARP970103720A patent/AR009251A1/es active IP Right Grant
- 1997-10-23 TW TW086115700A patent/TW438764B/zh active
1999
- 1999-02-12 PL PL97331645A patent/PL187371B1/pl not_active IP Right Cessation
- 1999-02-15 NO NO19990707A patent/NO312290B1/no not_active IP Right Cessation
2002
- 2002-09-24 CY CY0200057A patent/CY2298B1/xx unknown

Also Published As

Publication number	Publication date
EP0925273B1 (fr)	2001-11-07
JP3105545B2 (ja)	2000-11-06
CZ294165B6 (cs)	2004-10-13
WO1998007681A1 (fr)	1998-02-26
FR2752422A1 (fr)	1998-02-20
ZA977327B (en)	1998-03-30
PL187371B1 (pl)	2004-06-30
ES2166098T3 (es)	2002-04-01
JP2000506543A (ja)	2000-05-30
AR009251A1 (es)	2000-04-12
AU3942297A (en)	1998-03-06
CA2263348A1 (fr)	1998-02-26
NO990707D0 (no)	1999-02-15
CN1082370C (zh)	2002-04-10
EP0925273A1 (fr)	1999-06-30
HK1021728A1 (en)	2000-06-30
PT925273E (pt)	2002-04-29
RU2175966C2 (ru)	2001-11-20
SI0925273T1 (en)	2002-04-30
ATE208364T1 (de)	2001-11-15
UA57031C2 (uk)	2003-06-16
AU725440B2 (en)	2000-10-12
CA2263348C (en)	2008-05-13
TW438764B (en)	2001-06-07
TR199900329T2 (xx)	1999-04-21
US6143787A (en)	2000-11-07
SK283055B6 (sk)	2003-02-04
KR100488430B1 (ko)	2005-05-10
SK18099A3 (en)	2000-03-13
KR20000068106A (ko)	2000-11-25
CN1227538A (zh)	1999-09-01
NO990707L (no)	1999-02-15
DE69708130T2 (de)	2002-06-20
CZ49899A3 (cs)	1999-05-12
CY2298B1 (en)	2003-07-04
HUP0004223A3 (en)	2001-12-28
PL331645A1 (en)	1999-08-02
DK0925273T3 (da)	2002-02-18
FR2752422B1 (fr)	1998-11-06
ID17875A (id)	1998-02-05
HUP0004223A2 (hu)	2001-04-28
BR9711315A (pt)	1999-08-17
DE69708130D1 (de)	2001-12-13

Legal Events

Date	Code	Title	Description
2005-05-02	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
FI67369C (fi)	1985-03-11	Foerfarande foer framstaellning av nya terapeutiskt aktiva derivat av 3,4-dehydroprolin
US4346094A (en)	1982-08-24	3-Aryl-5-isothiazolecarboxylic acids and related compounds used to lower uric acid levels
US3383411A (en)	1968-05-14	4-alkanoylphenoxy-alkanoic acids
IE53226B1 (en)	1988-09-14	Enkephalinase enzyme inhibiting compounds
KR100488430B1 (ko)	2005-05-10	4-옥소부탄산을 함유하는 약제학적 조성물
SU976850A3 (ru)	1982-11-23	Способ получени производных 5-замещенных @ -пиронов
GB1561561A (en)	1980-02-27	Bis (i-phenoxyalkane carboxylic acids) and derivatives thereof process for their preparation and their use as medicaments
JP2004527547A (ja)	2004-09-09	抗凝血薬として用いるクマリン誘導体
US4134991A (en)	1979-01-16	Derivatives of 2-(3-phenyl-2-aminopropionyloxy)-acetic acid
IE49541B1 (en)	1985-10-30	4,5-dihydro-1-(3-mercapto-1-oxopropyl)-3-phenyl-1h-pyrazole-5-carboxylic acid and derivatives thereof
US4055595A (en)	1977-10-25	Substituted aryloxy-3,3,3-trifluoro-2-propionic acids, esters and salts thereof
US4659728A (en)	1987-04-21	Hydroxy substituted 4,5-diphenyl-2-oxazole propanoic acid
US4775691A (en)	1988-10-04	4H-benzo[4,5]cyclohepta[1,2-b]thiophene derivatives
US4237134A (en)	1980-12-02	Derivatives of thiazolidinecarboxylic acids and related acids
NO180085B (no)	1996-11-04	Acylsulfonamido- og sulfonamidopyridin-2-karboksylsyreestere og deres anvendelse som legemidler
US3598861A (en)	1971-08-10	2-(5'-phenyl-m-terphenyl - 4 - yloxy) lower aliphatic monocarbocyclic acids and esters thereof
US4599357A (en)	1986-07-08	1-mercaptoalkanoylindoline-2-carboxylic acids
US3598860A (en)	1971-08-10	2 - (4 -(3',4' - diphenylcyclopentyl)-phenoxy) lower aliphatic monocarbocyclic acids and esters thereof
US4018785A (en)	1977-04-19	Certain 2-iminothiazoline compounds
MXPA99001482A (en)	1999-09-01	Pharmaceutical composition containing 4-oxo-butynic acids
NO133142B (cs)	1975-12-08
US3598862A (en)	1971-08-10	2 - (4 - (3',5' - diphenylcyclohexyl) - phenoxy)lower aliphatic monocarbocylic acids and esters thereof
IE67059B1 (en)	1996-02-21	A process for the preparation of a 1,4-dihydropyridine derivative namely (-)-2-{[2-(aminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxy-carbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine and its salts
NO852616L (no)	1986-01-13	Fenylaminopropiofenon-derivater og fremgangsmaate til fremstilling derav.
PT88504B (pt)	1992-11-30	Processo para a preparacao de haloalquil-tiazoles