NO313238B1 - N-substituerte piperidinyl bisykliske benzoatderivater - Google Patents

N-substituerte piperidinyl bisykliske benzoatderivater Download PDF

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Publication number
NO313238B1
NO313238B1 NO19971376A NO971376A NO313238B1 NO 313238 B1 NO313238 B1 NO 313238B1 NO 19971376 A NO19971376 A NO 19971376A NO 971376 A NO971376 A NO 971376A NO 313238 B1 NO313238 B1 NO 313238B1
Authority
NO
Norway
Prior art keywords
formula
chloro
hydrogen
dihydro
amino
Prior art date
Application number
NO19971376A
Other languages
English (en)
Norwegian (no)
Other versions
NO971376D0 (no
NO971376L (no
Inventor
Georges Henri Paul Van Daele
Jean-Paul Rene Marie A Bosmans
Frans Maria Alfons Van Keybus
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO971376D0 publication Critical patent/NO971376D0/no
Publication of NO971376L publication Critical patent/NO971376L/no
Publication of NO313238B1 publication Critical patent/NO313238B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO19971376A 1994-09-27 1997-03-24 N-substituerte piperidinyl bisykliske benzoatderivater NO313238B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94202792 1994-09-27
US45548695A 1995-05-31 1995-05-31
PCT/EP1995/003691 WO1996010027A1 (en) 1994-09-27 1995-09-19 N-substituted piperidinyl bicyclic benzoate derivatives

Publications (3)

Publication Number Publication Date
NO971376D0 NO971376D0 (no) 1997-03-24
NO971376L NO971376L (no) 1997-05-05
NO313238B1 true NO313238B1 (no) 2002-09-02

Family

ID=26136613

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19971376A NO313238B1 (no) 1994-09-27 1997-03-24 N-substituerte piperidinyl bisykliske benzoatderivater

Country Status (23)

Country Link
EP (1) EP0784620B1 (de)
JP (1) JP3953097B2 (de)
CN (1) CN1068880C (de)
AT (1) ATE187453T1 (de)
AU (1) AU699152B2 (de)
BR (1) BR9509036A (de)
CA (1) CA2200578C (de)
CZ (1) CZ289031B6 (de)
DE (1) DE69513846T2 (de)
DK (1) DK0784620T3 (de)
ES (1) ES2141383T3 (de)
FI (1) FI119640B (de)
GR (1) GR3032646T3 (de)
HU (1) HU218698B (de)
IL (1) IL115413A (de)
MY (1) MY113202A (de)
NO (1) NO313238B1 (de)
NZ (1) NZ293605A (de)
PL (1) PL182502B1 (de)
PT (1) PT784620E (de)
RU (1) RU2154064C2 (de)
WO (1) WO1996010027A1 (de)
ZA (1) ZA958081B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL345309A1 (en) * 1998-05-14 2001-12-03 Egyt Gyogyszervegyeszeti Gyar Benzofuran derivatives, pharmaceutical composition containing the same, and a process for the preparation of the active ingredient
ES2242940T3 (es) * 2002-01-16 2005-11-16 Janssen Pharmaceutica N.V. Prucaloprida n-oxido.
WO2005061483A2 (en) * 2003-12-23 2005-07-07 Bio-Medisinsk Innovasjon As Modulators of peripheral 5-ht receptors
WO2006012226A2 (en) 2004-06-24 2006-02-02 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
PT2404919E (pt) 2005-11-08 2013-10-22 Vertex Pharma Composto heterocíclico útil como um modulador de transportadores de cassete de ligação a atp
EP2164840A2 (de) 2007-05-09 2010-03-24 Vertex Pharmaceuticals Incorporated Modulatoren von cftr
CA2989620C (en) 2007-12-07 2022-05-03 Vertex Pharmaceuticals Incorporated Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
HUE049642T2 (hu) 2007-12-07 2020-09-28 Vertex Pharma 3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)-ciklopropánkarboxamido)-3-metilpiridin-2-il)-benzoesav szilárd formái
CA2716109C (en) 2008-02-28 2016-07-19 Vertex Pharmaceuticals Incorporated Heteroaryl derivatives as cftr modulators
TWI549950B (zh) * 2010-04-07 2016-09-21 維泰克斯製藥公司 ３－（６－（１－（２，２－二氟苯并［ｄ］［１，３］二氧雜環戊烯－５－基）環丙烷甲醯胺基）－３－甲基吡啶－２－基）苯甲酸之固體形式
ES2900353T3 (es) 2010-04-07 2022-03-16 Vertex Pharma Composiciones farmacéuticas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiriidin-2-il)benzoico y administración de las mismas
NZ727015A (en) 2012-01-25 2017-12-22 Vertex Pharma Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
CA2930199C (en) 2013-11-12 2022-10-25 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
HUE055423T2 (hu) 2014-11-18 2021-11-29 Vertex Pharma Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1593569A3 (ru) * 1982-07-30 1990-09-15 Janssen Pharmaceutica Nv Cпocoб пoлучehия пpoизboдhыx n-(3-гидpokcи-4-пипepидиhил)бehзamидa или иx kиcлotho-aддиtиbhыx coлeй
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
DE3810552A1 (de) * 1988-03-29 1989-10-19 Sandoz Ag Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
NZ243993A (en) * 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen

Also Published As

Publication number Publication date
MX9702363A (es) 1997-10-31
NO971376D0 (no) 1997-03-24
EP0784620B1 (de) 1999-12-08
JPH10506118A (ja) 1998-06-16
HU218698B (hu) 2000-11-28
GR3032646T3 (en) 2000-06-30
CA2200578C (en) 2006-11-07
EP0784620A1 (de) 1997-07-23
CN1166171A (zh) 1997-11-26
BR9509036A (pt) 1997-10-14
ES2141383T3 (es) 2000-03-16
DK0784620T3 (da) 2000-05-22
HUT77173A (hu) 1998-03-02
CZ91897A3 (en) 1997-12-17
ATE187453T1 (de) 1999-12-15
JP3953097B2 (ja) 2007-08-01
AU3608195A (en) 1996-04-19
FI971274A0 (fi) 1997-03-26
IL115413A (en) 2000-02-17
NZ293605A (en) 1998-07-28
WO1996010027A1 (en) 1996-04-04
DE69513846T2 (de) 2000-07-06
CZ289031B6 (cs) 2001-10-17
MY113202A (en) 2001-12-31
PT784620E (pt) 2000-05-31
PL319997A1 (en) 1997-09-01
CN1068880C (zh) 2001-07-25
FI119640B (fi) 2009-01-30
FI971274A7 (fi) 1997-03-26
NO971376L (no) 1997-05-05
CA2200578A1 (en) 1996-04-04
IL115413A0 (en) 1995-12-31
RU2154064C2 (ru) 2000-08-10
PL182502B1 (pl) 2002-01-31
DE69513846D1 (de) 2000-01-13
AU699152B2 (en) 1998-11-26
ZA958081B (en) 1997-03-26

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