NO314830B1 - Anvendelse av carvedilol ved fremstillilng av et medikament for anvendelseved behandling av kongestiv hjertefeil - Google Patents

Anvendelse av carvedilol ved fremstillilng av et medikament for anvendelseved behandling av kongestiv hjertefeil Download PDF

Info

Publication number: NO314830B1
Authority: NO; Norway
Prior art keywords: carvedilol; single unit; administered; pharmaceutical formulation; patients
Prior art date: 1995-02-08

Application number

NO19973667A

Other languages

English (en)

Norwegian (no)

Other versions

NO973667D0 (no

NO973667L (no

Inventor

Mary Ann Lukas-Laskey

Jr Robert Ruffolo

Neil H Shusterman

Gispert Sponer

Klaus Strein

Original Assignee

Boehringer Mannheim Pharm Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-08

Filing date

1997-08-08

Publication date

2003-06-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26012210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO314830(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1995-02-08 Priority claimed from DE1995103995 external-priority patent/DE19503995C2/de

1997-08-08 Application filed by Boehringer Mannheim Pharm Corp filed Critical Boehringer Mannheim Pharm Corp

1997-08-08 Publication of NO973667D0 publication Critical patent/NO973667D0/no

1997-08-08 Publication of NO973667L publication Critical patent/NO973667L/no

2003-06-02 Publication of NO314830B1 publication Critical patent/NO314830B1/no

Links

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235000019359 magnesium stearate Nutrition 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
229940071648 metered dose inhaler Drugs 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
229960002237 metoprolol Drugs 0.000 description 1
IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
230000002107 myocardial effect Effects 0.000 description 1
208000031225 myocardial ischemia Diseases 0.000 description 1
125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 description 1
125000001624 naphthyl group Chemical group 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
229940124309 non-selective beta-adrenoreceptor agonist Drugs 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
230000036513 peripheral conductance Effects 0.000 description 1
239000008024 pharmaceutical diluent Substances 0.000 description 1
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
125000004344 phenylpropyl group Chemical group 0.000 description 1
238000013310 pig model Methods 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000005086 pumping Methods 0.000 description 1
238000011552 rat model Methods 0.000 description 1
230000011514 reflex Effects 0.000 description 1
235000015598 salt intake Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
210000002820 sympathetic nervous system Anatomy 0.000 description 1
206010042772 syncope Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
230000002110 toxicologic effect Effects 0.000 description 1
231100000759 toxicological effect Toxicity 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
230000000304 vasodilatating effect Effects 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO19973667A 1995-02-08 1997-08-08 Anvendelse av carvedilol ved fremstillilng av et medikament for anvendelseved behandling av kongestiv hjertefeil NO314830B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE1995103995 DE19503995C2 (de)	1995-02-08	1995-02-08	Verwendung von Carvedilol zur Verminderung der Mortalität bei Patienten mit eingeschränkter myocardialer Funktion
US08/483,635 US5760069A (en)	1995-02-08	1995-06-07	Method of treatment for decreasing mortality resulting from congestive heart failure
PCT/EP1996/000498 WO1996024348A2 (en)	1995-02-08	1996-02-07	Use of carbazole compounds for the treatment of congestive heart failure

Publications (3)

Publication Number	Publication Date
NO973667D0 NO973667D0 (no)	1997-08-08
NO973667L NO973667L (no)	1997-08-08
NO314830B1 true NO314830B1 (no)	2003-06-02

Family

ID=26012210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19973667A NO314830B1 (no)	1995-02-08	1997-08-08	Anvendelse av carvedilol ved fremstillilng av et medikament for anvendelseved behandling av kongestiv hjertefeil

Country Status (26)

Country	Link
US (6)	US5760069A (cs)
EP (1)	EP0808162B1 (cs)
JP (1)	JP3546058B2 (cs)
KR (1)	KR100295940B1 (cs)
CN (1)	CN1093760C (cs)
AT (1)	ATE179891T1 (cs)
AU (1)	AU702106C (cs)
BR (1)	BR9607111A (cs)
CA (1)	CA2212548C (cs)
CZ (1)	CZ292002B6 (cs)
DE (1)	DE69602424T2 (cs)
DK (1)	DK0808162T3 (cs)
ES (1)	ES2134588T3 (cs)
FI (1)	FI973255A7 (cs)
GR (1)	GR3030966T3 (cs)
HU (1)	HUP9900773A3 (cs)
NO (1)	NO314830B1 (cs)
NZ (1)	NZ301692A (cs)
PL (1)	PL321737A1 (cs)
RO (1)	RO121629B1 (cs)
RU (1)	RU2197242C2 (cs)
SI (1)	SI0808162T1 (cs)
SK (1)	SK106897A3 (cs)
UA (1)	UA55382C2 (cs)
WO (1)	WO1996024348A2 (cs)
ZA (1)	ZA96994B (cs)

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EP1499310A4 (en) *	2002-04-30	2005-12-07	Sb Pharmco Inc	MONOCITRATE MONOHYDRATE OF CARVEDILOL
US6951880B2 (en) *	2002-05-16	2005-10-04	Genelabs Technologies, Inc.	Aryl and heteroaryl compounds as antibacterial and antifungal agents
JP2005533822A (ja) *	2002-06-27	2005-11-10	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	臭化水素酸カルベジロール
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US6632832B1 (en)	2002-09-10	2003-10-14	Dabur Research Foundation	Anti-cancer activity of carvedilol and its isomers
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US8367112B2 (en) *	2006-02-28	2013-02-05	Alkermes Pharma Ireland Limited	Nanoparticulate carverdilol formulations
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1995
- 1995-06-07 US US08/483,635 patent/US5760069A/en not_active Ceased
1996
- 1996-02-07 WO PCT/EP1996/000498 patent/WO1996024348A2/en not_active Ceased
- 1996-02-07 BR BR9607111A patent/BR9607111A/pt not_active Application Discontinuation
- 1996-02-07 RU RU97114836/14A patent/RU2197242C2/ru not_active IP Right Cessation
- 1996-02-07 ES ES96902984T patent/ES2134588T3/es not_active Expired - Lifetime
- 1996-02-07 HU HU9900773A patent/HUP9900773A3/hu unknown
- 1996-02-07 SK SK1068-97A patent/SK106897A3/sk unknown
- 1996-02-07 RO RO97-01454A patent/RO121629B1/ro unknown
- 1996-02-07 DE DE69602424T patent/DE69602424T2/de not_active Ceased
- 1996-02-07 NZ NZ301692A patent/NZ301692A/xx not_active IP Right Cessation
- 1996-02-07 SI SI9630081T patent/SI0808162T1/xx not_active IP Right Cessation
- 1996-02-07 CA CA002212548A patent/CA2212548C/en not_active Expired - Fee Related
- 1996-02-07 AT AT96902984T patent/ATE179891T1/de not_active IP Right Cessation
- 1996-02-07 CZ CZ19972463A patent/CZ292002B6/cs not_active IP Right Cessation
- 1996-02-07 PL PL96321737A patent/PL321737A1/xx unknown
- 1996-02-07 JP JP52398296A patent/JP3546058B2/ja not_active Expired - Lifetime
- 1996-02-07 US US08/875,603 patent/US5902821A/en not_active Ceased
- 1996-02-07 EP EP96902984A patent/EP0808162B1/en not_active Expired - Lifetime
- 1996-02-07 CN CN96192902A patent/CN1093760C/zh not_active Expired - Fee Related
- 1996-02-07 US US10/721,022 patent/USRE40707E1/en not_active Expired - Lifetime
- 1996-02-07 DK DK96902984T patent/DK0808162T3/da active
- 1996-02-07 KR KR1019970705480A patent/KR100295940B1/ko not_active Expired - Lifetime
- 1996-02-07 AU AU47181/96A patent/AU702106C/en not_active Revoked
- 1996-02-08 ZA ZA9600994A patent/ZA96994B/xx unknown
- 1996-07-02 UA UA97094498A patent/UA55382C2/uk unknown
1997
- 1997-08-07 FI FI973255A patent/FI973255A7/fi unknown
- 1997-08-08 NO NO19973667A patent/NO314830B1/no not_active IP Right Cessation
1999
- 1999-08-11 GR GR990402047T patent/GR3030966T3/el unknown
2001
- 2001-05-23 US US09/863,535 patent/US20010044455A1/en not_active Abandoned
2002
- 2002-12-19 US US10/324,856 patent/US20030105138A1/en not_active Abandoned
2003
- 2003-11-25 US US10/721,020 patent/USRE40000E1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5760069A (en)	1998-06-02
AU702106B2 (en)	1999-02-11
AU702106C (en)	2005-02-17
USRE40000E1 (en)	2008-01-08
SI0808162T1 (en)	1999-10-31
CZ246397A3 (cs)	1998-11-11
BR9607111A (pt)	1997-11-04
CZ292002B6 (cs)	2003-07-16
PL321737A1 (en)	1997-12-22
USRE40707E1 (en)	2009-05-05
NZ301692A (en)	2000-09-29
GR3030966T3 (en)	1999-11-30
US5902821A (en)	1999-05-11
WO1996024348A2 (en)	1996-08-15
MX9706042A (es)	1998-06-30
DK0808162T3 (da)	1999-11-15
AU4718196A (en)	1996-08-27
CN1093760C (zh)	2002-11-06
NO973667D0 (no)	1997-08-08
FI973255A0 (fi)	1997-08-07
ATE179891T1 (de)	1999-05-15
WO1996024348A3 (en)	1996-10-03
ES2134588T3 (es)	1999-10-01
HK1014861A1 (en)	1999-10-08
CN1185106A (zh)	1998-06-17
KR100295940B1 (ko)	2001-08-07
RU2197242C2 (ru)	2003-01-27
CA2212548C (en)	1999-08-24
SK106897A3 (en)	1999-03-12
EP0808162A2 (en)	1997-11-26
NO973667L (no)	1997-08-08
JPH10513463A (ja)	1998-12-22
FI973255A7 (fi)	1997-08-07
HUP9900773A2 (hu)	1999-07-28
EP0808162B1 (en)	1999-05-12
DE69602424D1 (de)	1999-06-17
JP3546058B2 (ja)	2004-07-21
RO121629B1 (ro)	2008-01-30
CA2212548A1 (en)	1996-08-15
UA55382C2 (uk)	2003-04-15
HUP9900773A3 (en)	2000-04-28
US20030105138A1 (en)	2003-06-05
ZA96994B (en)	1997-10-27
KR19980702085A (ko)	1998-07-15
US20010044455A1 (en)	2001-11-22
DE69602424T2 (de)	1999-10-07

Legal Events

Date	Code	Title	Description
2010-09-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP0808162B1 (en)	1999-05-12	Use of carbazole compounds for the manufacture of a medicament for the treatment of congestive heart failure
Guay	2001	Adjunctive agents in the management of chronic pain
EP2579879B1 (en)	2016-03-23	Triazine derivatives for delaying the onset of type 1 diabetes
EP0741567B1 (en)	2002-10-16	Inhibition of smooth muscle migration and proliferation with hydroxy carbazole compounds
Frishman et al.	1984	Calcium entry blockers for the treatment of severe hypertension and hypertensive crisis
JP2012025756A (ja)	2012-02-09	選択的ｓ１ｐ１レセプターアゴニストの投与法
JPWO2008020651A1 (ja)	2010-01-07	Ｐ２ｘ４受容体アンタゴニスト
US20030092735A1 (en)	2003-05-15	Use of substance P antagonists for the treatment of chronic fatigue syndrome and/or fibromyalgia and use of NK-1 receptor antagonists for the treatment of chronic fatigue syndrome
AU2009200393B2 (en)	2013-11-07	Association of a sinus If current inhibitor and a beta blocker
MXPA97006042A (en)	1998-10-30	Use of carbazol compounds for the treatment of cardiac congest insufficiency
HK1014861B (en)	2003-05-30	Use of carbazole compounds in the manufacture of a medicament for the treatment of congestive heart failure
MXPA04008919A (es)	2004-11-26	Citalopram para el tratamiento de alta presion sanguinea.
EP4704826A1 (en)	2026-03-11	Compositions and methods for treating post-traumatic stress disorder
HUP0402593A2 (hu)	2005-04-28	Kariporidból és ramiprilből álló kombinációs készítmény és alkalmazása
JPH0827029A (ja)	1996-01-30	５ｈｔ１作動薬の新規医薬用途
JPWO2000010571A1 (ja)	2001-10-30	カルシウムチャネル拮抗薬