NO317302B1 - Forbedret fremgangsmate for fremstilling av farmasoytisk verdifulle norbenzomorfan-derivater - Google Patents

Forbedret fremgangsmate for fremstilling av farmasoytisk verdifulle norbenzomorfan-derivater Download PDF

Info

Publication number
NO317302B1
NO317302B1 NO20005818A NO20005818A NO317302B1 NO 317302 B1 NO317302 B1 NO 317302B1 NO 20005818 A NO20005818 A NO 20005818A NO 20005818 A NO20005818 A NO 20005818A NO 317302 B1 NO317302 B1 NO 317302B1
Authority
NO
Norway
Prior art keywords
acid
aluminum
reaction
piperidine
process according
Prior art date
Application number
NO20005818A
Other languages
English (en)
Norwegian (no)
Other versions
NO20005818D0 (no
NO20005818L (no
Inventor
Matthias Grauert
Juergen Schnaubelt
Hanfried Baltes
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20005818D0 publication Critical patent/NO20005818D0/no
Publication of NO20005818L publication Critical patent/NO20005818L/no
Publication of NO317302B1 publication Critical patent/NO317302B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NO20005818A 1998-05-20 2000-11-17 Forbedret fremgangsmate for fremstilling av farmasoytisk verdifulle norbenzomorfan-derivater NO317302B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19822822A DE19822822A1 (de) 1998-05-20 1998-05-20 Verbessertes Verfahren zur Herstellung von pharmazeutisch wertvollen Norbenzomorphanderivaten
PCT/EP1999/003142 WO1999059976A1 (fr) 1998-05-20 1999-05-07 Procede ameliore de production de derives de norbenzomorphane precieux sur le plan pharmaceutique

Publications (3)

Publication Number Publication Date
NO20005818D0 NO20005818D0 (no) 2000-11-17
NO20005818L NO20005818L (no) 2000-11-17
NO317302B1 true NO317302B1 (no) 2004-10-04

Family

ID=7868527

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005818A NO317302B1 (no) 1998-05-20 2000-11-17 Forbedret fremgangsmate for fremstilling av farmasoytisk verdifulle norbenzomorfan-derivater

Country Status (37)

Country Link
US (1) US6124459A (fr)
EP (1) EP1080076B1 (fr)
JP (1) JP4526185B2 (fr)
KR (1) KR20010043703A (fr)
CN (1) CN1113058C (fr)
AR (1) AR016040A1 (fr)
AT (1) ATE254605T1 (fr)
AU (1) AU753563B2 (fr)
BG (1) BG104964A (fr)
BR (1) BR9910603A (fr)
CA (1) CA2330669C (fr)
CO (1) CO5060460A1 (fr)
DE (2) DE19822822A1 (fr)
DK (1) DK1080076T3 (fr)
EA (1) EA003059B1 (fr)
EE (1) EE04305B1 (fr)
EG (1) EG21526A (fr)
ES (1) ES2211093T3 (fr)
HR (1) HRP20000793A2 (fr)
HU (1) HUP0102034A3 (fr)
ID (1) ID27014A (fr)
IL (1) IL138998A0 (fr)
MY (1) MY120806A (fr)
NO (1) NO317302B1 (fr)
NZ (1) NZ508845A (fr)
PE (1) PE20000558A1 (fr)
PL (1) PL343935A1 (fr)
PT (1) PT1080076E (fr)
SI (1) SI1080076T1 (fr)
SK (1) SK283996B6 (fr)
TR (1) TR200003360T2 (fr)
TW (1) TW455582B (fr)
UA (1) UA59448C2 (fr)
UY (1) UY25515A1 (fr)
WO (1) WO1999059976A1 (fr)
YU (1) YU71400A (fr)
ZA (1) ZA200005740B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405149B1 (en) * 1998-12-21 2008-07-29 Megica Corporation Post passivation method for semiconductor chip or wafer
WO2016044546A1 (fr) * 2014-09-17 2016-03-24 Purdue Pharma L.P. Analogues de benzomorphane et leur utilisation
CN107089948B (zh) * 2017-04-28 2020-07-17 云南大学 吗吩衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
US3932422A (en) * 1974-05-20 1976-01-13 Sterling Drug Inc. 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones
US4255579A (en) * 1974-05-20 1981-03-10 Sterling Drug Inc. 11-Substituted hexahydro-2,6-methano-3-benzazocines
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
SK283996B6 (sk) 2004-07-07
UY25515A1 (es) 1999-12-13
ZA200005740B (en) 2001-10-17
CN1301256A (zh) 2001-06-27
DK1080076T3 (da) 2004-03-22
EE200000674A (et) 2002-04-15
DE19822822A1 (de) 1999-11-25
YU71400A (sh) 2003-04-30
ATE254605T1 (de) 2003-12-15
NO20005818D0 (no) 2000-11-17
UA59448C2 (uk) 2003-09-15
ES2211093T3 (es) 2004-07-01
ID27014A (id) 2001-02-22
HK1035728A1 (en) 2001-12-07
AU4139999A (en) 1999-12-06
EP1080076B1 (fr) 2003-11-19
TW455582B (en) 2001-09-21
CO5060460A1 (es) 2001-07-30
CA2330669C (fr) 2008-07-15
CA2330669A1 (fr) 1999-11-25
AR016040A1 (es) 2001-05-30
NZ508845A (en) 2002-11-26
CN1113058C (zh) 2003-07-02
PE20000558A1 (es) 2000-06-28
HUP0102034A3 (en) 2002-02-28
MY120806A (en) 2005-11-30
BG104964A (bg) 2001-07-31
NO20005818L (no) 2000-11-17
JP4526185B2 (ja) 2010-08-18
US6124459A (en) 2000-09-26
PT1080076E (pt) 2004-04-30
DE59907804D1 (de) 2003-12-24
AU753563B2 (en) 2002-10-24
KR20010043703A (ko) 2001-05-25
HRP20000793A2 (en) 2001-10-31
SK17312000A3 (sk) 2001-06-11
BR9910603A (pt) 2001-01-16
EG21526A (en) 2001-11-28
EE04305B1 (et) 2004-06-15
JP2002515491A (ja) 2002-05-28
PL343935A1 (en) 2001-09-10
EP1080076A1 (fr) 2001-03-07
EA200001212A1 (ru) 2001-04-23
SI1080076T1 (sl) 2004-04-30
HUP0102034A2 (hu) 2001-12-28
EA003059B1 (ru) 2002-12-26
WO1999059976A1 (fr) 1999-11-25
IL138998A0 (en) 2001-11-25
TR200003360T2 (tr) 2001-06-21

Similar Documents

Publication Publication Date Title
CN101987843B (zh) 常山酮氢溴酸盐及其类似物的合成方法
WO2014026657A2 (fr) Procédé pour la préparation d'un dérivé d'acide 2-méthyl-2'-phénylpropionique utilisant de nouveaux intermédiaires
US10544101B2 (en) Process for the preparation of butorphanol tartrate
CN104837817B (zh) 制备3‑氨基‑哌啶化合物的合成路线
KR100399669B1 (ko) 약제학적으로유용한벤조모르판유도체제조시의중간체인노르벤조모르판,특히(-)-(1r,5s,2'r)-3'-하이드록시-2-(2-메톡시프로필)-5,9,9-트리메틸-6,7-벤조모르판을제조하는방법
Popp Reissert Compounds Derived From Diazaaromatic Systems
JP4526185B2 (ja) 薬学的に価値のあるノルベンゾモルファン誘導体の改良製法
Sommer et al. Application of (2-cyanoaryl) arylacetonitriles in cyclization and annulation reactions. Preparation of 3-arylindans, 4-aryl-3, 4-dihydronaphthalenes, 4-arylisoquinolines, 1-aminonaphthalenes, and heterocyclic analogues
EP3280701A1 (fr) Procédé de résolution chirale de l'intermédiaire clé de la synthèse d'aprémilast et son utilisation pour la préparation d'aprémilast pur
JP2022055368A (ja) ベンゾアゼピン誘導体の製造方法及びその中間体
KR101625128B1 (ko) 3,4-디메톡시바이사이클로[4.2.0]옥타-1,3,5-트리엔-7-카보니트릴의 합성 방법, 및 이바브라딘 및 이의 약제학적으로 허용되는 산과의 부가염의 합성에서의 적용
MXPA00010964A (en) Improved method for preparing pharmaceutically valuable norbenzomorphane derivatives
KR930010500B1 (ko) 코타르닌의 제조방법
CN100497315C (zh) 一种(r)-(-)-阿朴吗啡的制备方法
CZ20004323A3 (cs) Způsob výroby R- a S- norbenzomorfanů
JP4011819B2 (ja) インドール誘導体の製造法およびその中間体
US3118900A (en) Substituted derivatives of 3-aza-6, 7-benzo-8-oxa-5-phenylbicyclo[3.3.1]-nonane
Kaslow et al. SUBSTITUTED PHENYLQUINOLINES1
NO781896L (no) 4-fenyl-8-amino-tetrahydroisokinoliner, farmasoeytiske preparater som inneholder disse, fremgangsmaate til fremstilling av disse preparater og deres anvendelse som antidepresjonsmidler
BG60660B2 (bg) ПРОИЗВОДНИ НА ПИРАНО/3,4-b/ИНДОЛА,ФАРМАЦЕВТИЧНИ СЪСТАВИ И МЕТОДИ НА ПРИЛОЖЕНИЕ
US20040192919A1 (en) Process for production of highly pure donepezil hydrochloride
US20050192338A1 (en) Process for the preparation of Ropinirole
BR112021011854A2 (pt) Síntese de gama-carbolinas heterocíclicas fundidas substituídas
HK1035728B (en) Improved method for preparing pharmaceutically valuable norbenzomorphane derivatives
NO139518B (no) Anordning for utpressing av pastamasse fra tuber