NO319286B1 - Fremgangsmate ved biotransformasjon av kolkisinforbindelser til de tilsvarende 3-glykosyl-derivater - Google Patents

Fremgangsmate ved biotransformasjon av kolkisinforbindelser til de tilsvarende 3-glykosyl-derivater Download PDF

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Publication number
NO319286B1
NO319286B1 NO19991633A NO991633A NO319286B1 NO 319286 B1 NO319286 B1 NO 319286B1 NO 19991633 A NO19991633 A NO 19991633A NO 991633 A NO991633 A NO 991633A NO 319286 B1 NO319286 B1 NO 319286B1
Authority
NO
Norway
Prior art keywords
biotransformation
culture
colchicine
compounds
cultures
Prior art date
Application number
NO19991633A
Other languages
English (en)
Norwegian (no)
Other versions
NO991633D0 (no
NO991633L (no
Inventor
Ezio Bombardelli
Cesare Ponzone
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of NO991633D0 publication Critical patent/NO991633D0/no
Publication of NO991633L publication Critical patent/NO991633L/no
Publication of NO319286B1 publication Critical patent/NO319286B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/248—Colchicine radicals, e.g. colchicosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/11—Bacillus megaterium

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO19991633A 1996-10-07 1999-04-06 Fremgangsmate ved biotransformasjon av kolkisinforbindelser til de tilsvarende 3-glykosyl-derivater NO319286B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI002063A IT1285777B1 (it) 1996-10-07 1996-10-07 Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati
PCT/EP1997/005429 WO1998015642A1 (en) 1996-10-07 1997-10-02 A process for the biotransformation of colchicinoid compounds into the corresponding 3-glycosyl derivatives

Publications (3)

Publication Number Publication Date
NO991633D0 NO991633D0 (no) 1999-04-06
NO991633L NO991633L (no) 1999-04-06
NO319286B1 true NO319286B1 (no) 2005-07-11

Family

ID=11374985

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19991633A NO319286B1 (no) 1996-10-07 1999-04-06 Fremgangsmate ved biotransformasjon av kolkisinforbindelser til de tilsvarende 3-glykosyl-derivater

Country Status (20)

Country Link
US (1) US6150140A (cs)
EP (1) EP0931161B1 (cs)
JP (1) JP3428027B2 (cs)
KR (1) KR100311067B1 (cs)
CN (1) CN1094978C (cs)
AT (1) ATE213782T1 (cs)
AU (1) AU714810B2 (cs)
CA (1) CA2252725C (cs)
CZ (1) CZ295451B6 (cs)
DE (1) DE69710744T2 (cs)
DK (1) DK0931161T3 (cs)
ES (1) ES2171906T3 (cs)
HU (1) HU224896B1 (cs)
IT (1) IT1285777B1 (cs)
NO (1) NO319286B1 (cs)
PL (1) PL187106B1 (cs)
PT (1) PT931161E (cs)
RU (1) RU2196826C2 (cs)
SK (1) SK282344B6 (cs)
WO (1) WO1998015642A1 (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1295272B1 (it) * 1997-10-03 1999-05-04 Indena Spa Biotrasformazione di composti colchiconici nei corrispondenti 3- glicosilderivati
ITMI20031144A1 (it) * 2003-06-06 2004-12-07 Indena Spa Analoghi del colchicoside.
SG165175A1 (en) * 2004-05-12 2010-10-28 Indena Spa Biotransformation of colchicinoid compounds
WO2005108595A1 (en) 2004-05-12 2005-11-17 Indena S.P.A. Biotransformation of colchicinoid compounds
ES2356494T3 (es) 2008-05-28 2011-04-08 Indena S.P.A. Procedimiento para la glucosidación de colchicina y tiocolchicina.
EP2435403A4 (en) * 2009-05-27 2015-04-01 Takeda Pharmaceuticals Usa Inc THIOCOLCHICINE DERIVATIVES AND MANUFACTURING AND USE METHOD THEREFOR
US20110178180A1 (en) * 2010-01-18 2011-07-21 Kurt Nielsen Deuterium-enriched colchicine, thiocolchicine, and derivatives thereof; methods of preparation; and use thereof
KR20140014072A (ko) 2010-09-22 2014-02-05 엘리시안 라이프 사이언스이즈 프라이빗 리미티드 콜키시노이드 화합물의 미생물학적 생물전환 방법
EP3086794B1 (en) 2013-12-23 2020-01-08 Alkaloids Corporation Process for the conversion of colchicinoids to their 3-glycosylated derivatives via their respective 3-demethyl analogues
CN105861601B (zh) * 2016-04-29 2019-05-24 中国药科大学 一种生物转化制备二氢去氢双松柏醇葡萄糖单糖苷(hmzg)的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1344157A (fr) * 1959-05-22 1963-11-29 Roussel Uclaf Nouvelles colchicines et leur procédé d'obtention
JPS5233195B2 (cs) * 1971-09-30 1977-08-26
GB8701381D0 (en) * 1987-01-22 1987-02-25 Erba Farmitalia Antitumor agent
IE70073B1 (en) * 1990-12-14 1996-10-30 Ainsworth Tech Inc Communication system

Also Published As

Publication number Publication date
CZ118799A3 (cs) 1999-07-14
EP0931161B1 (en) 2002-02-27
ES2171906T3 (es) 2002-09-16
CA2252725A1 (en) 1998-04-16
KR100311067B1 (ko) 2001-12-17
EP0931161A1 (en) 1999-07-28
ATE213782T1 (de) 2002-03-15
CA2252725C (en) 2008-03-18
JP3428027B2 (ja) 2003-07-22
HUP9903806A3 (en) 2001-12-28
KR20000022478A (ko) 2000-04-25
AU4864897A (en) 1998-05-05
PT931161E (pt) 2002-07-31
PL331942A1 (en) 1999-08-16
NO991633D0 (no) 1999-04-06
CZ295451B6 (cs) 2005-08-17
DK0931161T3 (da) 2002-06-10
SK44599A3 (en) 2000-01-18
NO991633L (no) 1999-04-06
HK1019620A1 (en) 2000-02-18
ITMI962063A1 (it) 1998-04-07
CN1094978C (zh) 2002-11-27
WO1998015642A1 (en) 1998-04-16
IT1285777B1 (it) 1998-06-18
JP2000508179A (ja) 2000-07-04
CN1218514A (zh) 1999-06-02
DE69710744T2 (de) 2002-09-05
AU714810B2 (en) 2000-01-13
SK282344B6 (sk) 2002-01-07
HU224896B1 (en) 2006-04-28
PL187106B1 (pl) 2004-05-31
RU2196826C2 (ru) 2003-01-20
HUP9903806A2 (hu) 2000-03-28
DE69710744D1 (de) 2002-04-04
US6150140A (en) 2000-11-21

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