NO320893B1 - Heterocykliske derivater som inhiberer faktor Xa og anvendelse derav, samt farmasoytisk sammensetning. - Google Patents

Heterocykliske derivater som inhiberer faktor Xa og anvendelse derav, samt farmasoytisk sammensetning. Download PDF

Info

Publication number: NO320893B1
Authority: NO; Norway
Prior art keywords: ppm; pyridyl; ylsulfonyl; formula; piperazine
Prior art date: 1998-05-02

Application number

NO20005497A

Other languages

English (en)

Norwegian (no)

Other versions

NO20005497L (no

NO20005497D0 (no

Inventor

Peter William Rodney Caulkett

Stuart Eric Pearson

Rolf Peter Walker

Anthony Michael Slater

Roger James

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-02

Filing date

2000-11-01

Publication date

2006-02-06

1998-05-02 Priority claimed from GBGB9809351.1A external-priority patent/GB9809351D0/en

1999-02-16 Priority claimed from GBGB9903337.5A external-priority patent/GB9903337D0/en

2000-11-01 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2000-11-01 Publication of NO20005497D0 publication Critical patent/NO20005497D0/no

2000-12-21 Publication of NO20005497L publication Critical patent/NO20005497L/no

2006-02-06 Publication of NO320893B1 publication Critical patent/NO320893B1/no

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 5
108010074860 Factor Xa Proteins 0.000 title claims description 18
125000000623 heterocyclic group Chemical group 0.000 title abstract description 10
238000000034 method Methods 0.000 claims abstract description 37
150000003839 salts Chemical class 0.000 claims abstract description 18
230000002429 anti-coagulating effect Effects 0.000 claims abstract description 8
230000002785 anti-thrombosis Effects 0.000 claims abstract description 8
239000003814 drug Substances 0.000 claims abstract description 7
239000003146 anticoagulant agent Substances 0.000 claims abstract description 6
238000002360 preparation method Methods 0.000 claims abstract description 4
150000001875 compounds Chemical class 0.000 claims description 57
-1 cyano, amino, hydroxy Chemical group 0.000 claims description 29
150000002367 halogens Chemical class 0.000 claims description 10
125000000217 alkyl group Chemical group 0.000 claims description 9
229910052736 halogen Inorganic materials 0.000 claims description 8
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 6
229910052801 chlorine Inorganic materials 0.000 claims description 6
239000000460 chlorine Chemical group 0.000 claims description 6
125000002883 imidazolyl group Chemical group 0.000 claims description 5
125000002098 pyridazinyl group Chemical group 0.000 claims description 5
125000004076 pyridyl group Chemical group 0.000 claims description 5
125000000714 pyrimidinyl group Chemical group 0.000 claims description 5
FFELGYNQPHSTQI-UHFFFAOYSA-N [4-[(5-chloro-1-benzofuran-2-yl)sulfonyl]piperazin-1-yl]-(4-pyridin-4-ylphenyl)methanone Chemical compound C=1C2=CC(Cl)=CC=C2OC=1S(=O)(=O)N(CC1)CCN1C(=O)C(C=C1)=CC=C1C1=CC=NC=C1 FFELGYNQPHSTQI-UHFFFAOYSA-N 0.000 claims description 4
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
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125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
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239000013078 crystal Substances 0.000 description 6
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO20005497A 1998-05-02 2000-11-01 Heterocykliske derivater som inhiberer faktor Xa og anvendelse derav, samt farmasoytisk sammensetning. NO320893B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9809351.1A GB9809351D0 (en)	1998-05-02	1998-05-02	Heterocyclic derivatives
GBGB9903337.5A GB9903337D0 (en)	1999-02-16	1999-02-16	Heterocyclic derivatives
PCT/GB1999/001308 WO1999057113A1 (en)	1998-05-02	1999-04-27	Heterocyclic derivatives which inhibit factor xa

Publications (3)

Publication Number	Publication Date
NO20005497D0 NO20005497D0 (no)	2000-11-01
NO20005497L NO20005497L (no)	2000-12-21
NO320893B1 true NO320893B1 (no)	2006-02-06

Family

ID=26313572

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005497A NO320893B1 (no)	1998-05-02	2000-11-01	Heterocykliske derivater som inhiberer faktor Xa og anvendelse derav, samt farmasoytisk sammensetning.

Country Status (22)

Country	Link
US (2)	US6753331B1 (de)
EP (2)	EP1082321B1 (de)
JP (1)	JP2002513790A (de)
KR (1)	KR20010043246A (de)
CN (1)	CN1133634C (de)
AT (1)	ATE282610T1 (de)
AU (1)	AU754453B2 (de)
BR (1)	BR9910179A (de)
CA (1)	CA2331042A1 (de)
DE (1)	DE69921994T2 (de)
EE (1)	EE200000527A (de)
ES (1)	ES2232131T3 (de)
HU (1)	HUP0101712A3 (de)
IL (1)	IL139406A (de)
NO (1)	NO320893B1 (de)
NZ (1)	NZ507835A (de)
PL (1)	PL343706A1 (de)
PT (1)	PT1082321E (de)
SI (1)	SI1082321T1 (de)
SK (1)	SK16512000A3 (de)
TR (1)	TR200003200T2 (de)
WO (1)	WO1999057113A1 (de)

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IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
GB9902989D0 (en)	1999-02-11	1999-03-31	Zeneca Ltd	Heterocyclic derivatives
GB9914342D0 (en) *	1999-06-19	1999-08-18	Zeneca Ltd	Compound
GB9917344D0 (en) *	1999-07-24	1999-09-22	Zeneca Ltd	Novel salt
TWI290136B (en)	2000-04-05	2007-11-21	Daiichi Seiyaku Co	Ethylenediamine derivatives
GB0012448D0 (en)	2000-05-24	2000-07-12	Astrazeneca Ab	New process
MXPA03004112A (es) *	2000-11-09	2003-08-19	Astrazeneca Ab	Composicion farmaceutica oral que contiene un copolimero de bloque.
GB0104752D0 (en) *	2001-02-27	2001-04-18	Astrazeneca Ab	Pharmaceutical compositions
WO2003000657A1 (en)	2001-06-20	2003-01-03	Daiichi Pharmaceutical Co., Ltd.	Diamine derivatives
AU2003302238A1 (en)	2002-12-03	2004-06-23	Axys Pharmaceuticals, Inc.	2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
WO2004108671A1 (en) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
WO2005012293A1 (ja) *	2003-08-01	2005-02-10	Nippon Soda Co., Ltd.	フェニルアゾール化合物、製造法および抗酸化薬
SE0400014D0 (sv)	2004-01-08	2004-01-08	Astrazeneca Ab	Heterocyclic derivatives
WO2007008143A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
WO2007008144A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
US20080221063A1 (en) *	2005-07-08	2008-09-11	Astrazeneca Ab	Heterocyclic Sulfonamide Derivatives As Inhibitors Of Factor Xa
WO2007008145A1 (en) *	2005-07-08	2007-01-18	Astrazeneca Ab	Heterocyclic sulfonamide derivatives as inhibitors of factor xa
BR112020018094A2 (pt)	2018-03-08	2020-12-22	Incyte Corporation	Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors
RS66218B1 (sr)	2019-07-01	2024-12-31	Tonix Pharma Ltd	Anti-cd154 antitela i njihove upotrebe
WO2022150452A1 (en)	2021-01-06	2022-07-14	Seth Lederman	Methods of inducing immune tolerance with modified anti-cd154 antibodies
WO2025248134A1 (en)	2024-05-31	2025-12-04	Tonix Pharma Limited	Treatment methods comprising administration of modified cd154 antibodies

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115420A0 (en)	1994-09-26	1995-12-31	Zeneca Ltd	Aminoheterocyclic derivatives
WO1997023212A1 (en) *	1995-12-21	1997-07-03	The Du Pont Merck Pharmaceutical Company	ISOXAZOLINE, ISOTHIAZOLINE AND PYRAZOLINE FACTOR Xa INHIBITORS
GB9602166D0 (en) *	1996-02-02	1996-04-03	Zeneca Ltd	Aminoheterocyclic derivatives
GB9602294D0 (en) *	1996-02-05	1996-04-03	Zeneca Ltd	Heterocyclic compounds
UA56197C2 (uk) *	1996-11-08	2003-05-15	Зенека Лімітед	Гетероциклічні похідні
WO1998054164A1 (en) *	1997-05-30	1998-12-03	Takeda Chemical Industries, Ltd.	Sulfonamide derivatives, their production and use
GB9715894D0 (en) *	1997-07-29	1997-10-01	Zeneca Ltd	Heterocyclic derivatives
DE19743435A1 (de) *	1997-10-01	1999-04-08	Merck Patent Gmbh	Benzamidinderivate

1999
- 1999-04-27 DE DE69921994T patent/DE69921994T2/de not_active Expired - Lifetime
- 1999-04-27 US US09/674,559 patent/US6753331B1/en not_active Expired - Fee Related
- 1999-04-27 EP EP99918178A patent/EP1082321B1/de not_active Expired - Lifetime
- 1999-04-27 CA CA002331042A patent/CA2331042A1/en not_active Abandoned
- 1999-04-27 TR TR2000/03200T patent/TR200003200T2/xx unknown
- 1999-04-27 NZ NZ507835A patent/NZ507835A/xx unknown
- 1999-04-27 HU HU0101712A patent/HUP0101712A3/hu unknown
- 1999-04-27 PT PT99918178T patent/PT1082321E/pt unknown
- 1999-04-27 PL PL99343706A patent/PL343706A1/xx not_active Application Discontinuation
- 1999-04-27 WO PCT/GB1999/001308 patent/WO1999057113A1/en not_active Ceased
- 1999-04-27 SK SK1651-2000A patent/SK16512000A3/sk unknown
- 1999-04-27 AU AU36206/99A patent/AU754453B2/en not_active Ceased
- 1999-04-27 AT AT99918178T patent/ATE282610T1/de not_active IP Right Cessation
- 1999-04-27 EP EP04022155A patent/EP1528061A1/de not_active Withdrawn
- 1999-04-27 SI SI9930725T patent/SI1082321T1/xx unknown
- 1999-04-27 BR BR9910179-3A patent/BR9910179A/pt not_active Application Discontinuation
- 1999-04-27 ES ES99918178T patent/ES2232131T3/es not_active Expired - Lifetime
- 1999-04-27 KR KR1020007012193A patent/KR20010043246A/ko not_active Ceased
- 1999-04-27 JP JP2000547083A patent/JP2002513790A/ja active Pending
- 1999-04-27 CN CNB99808218XA patent/CN1133634C/zh not_active Expired - Fee Related
- 1999-04-27 EE EEP200000527A patent/EE200000527A/xx unknown
- 1999-04-27 IL IL13940699A patent/IL139406A/en not_active IP Right Cessation
2000
- 2000-11-01 NO NO20005497A patent/NO320893B1/no unknown
2004
- 2004-04-06 US US10/817,960 patent/US20040266759A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CN1308631A (zh)	2001-08-15
US6753331B1 (en)	2004-06-22
NO20005497L (no)	2000-12-21
WO1999057113A1 (en)	1999-11-11
DE69921994T2 (de)	2005-12-01
IL139406A (en)	2004-07-25
JP2002513790A (ja)	2002-05-14
CN1133634C (zh)	2004-01-07
TR200003200T2 (tr)	2001-02-21
EP1082321B1 (de)	2004-11-17
CA2331042A1 (en)	1999-11-11
DE69921994D1 (de)	2004-12-23
HUP0101712A2 (hu)	2001-11-28
EP1528061A1 (de)	2005-05-04
HUP0101712A3 (en)	2003-01-28
PT1082321E (pt)	2005-03-31
SK16512000A3 (sk)	2001-05-10
HK1034711A1 (en)	2001-11-02
AU3620699A (en)	1999-11-23
SI1082321T1 (en)	2005-06-30
NO20005497D0 (no)	2000-11-01
ATE282610T1 (de)	2004-12-15
BR9910179A (pt)	2001-01-09
KR20010043246A (ko)	2001-05-25
EP1082321A1 (de)	2001-03-14
PL343706A1 (en)	2001-08-27
ES2232131T3 (es)	2005-05-16
EE200000527A (et)	2002-02-15
NZ507835A (en)	2003-01-31
AU754453B2 (en)	2002-11-14
IL139406A0 (en)	2001-11-25
US20040266759A1 (en)	2004-12-30

Publication	Publication Date	Title
NO320893B1 (no)	2006-02-06	Heterocykliske derivater som inhiberer faktor Xa og anvendelse derav, samt farmasoytisk sammensetning.
NO312894B1 (no)	2002-07-15	Heterocykelderivater som inhiberer faktor Xa, farmasöytisk formulering og fremgangsmåte for fremstilling derav
NO317419B1 (no)	2004-10-25	Heterocykliske derivater som inhiberer faktor XA
DE69730490T2 (de)	2005-09-29	Aminoheterocyclische verbindungen als antithrombotisches oder antikoagulierendes mittel
EP2138482A1 (de)	2009-12-30	Bicyclische heterocyclische verbindung
EP1082303B1 (de)	2005-01-26	Heterozyklische verbindungen mit faktor xa hemmender wirkung
NO317096B1 (no)	2004-08-09	Nye forbindelser, farmasoytisk formulering inneholdende slike forbindelser, fremgangsmate for deres fremstilling, og anvendelse derav
EP1311501B1 (de)	2005-11-02	Antithrombosemittel
EP1150974B1 (de)	2002-09-04	Heterocyclische derivate als inhibitoren von faktor xa
HK1034711B (en)	2005-05-13	Heterocyclic derivatives which inhibit factor xa
CZ20004049A3 (cs)	2001-02-14	Heterocyklické deriváty inhibující faktor Xa