NO321076B1 - Farmasoytisk preparat for oral administrasjon inneholdende cyklosporin - Google Patents

Farmasoytisk preparat for oral administrasjon inneholdende cyklosporin Download PDF

Info

Publication number: NO321076B1
Authority: NO; Norway
Prior art keywords: pharmaceutical preparation; preparation according; cyclosporine; peg; component
Prior art date: 1993-04-20

Application number

NO19954152A

Other languages

English (en)

Norwegian (no)

Other versions

NO954152D0 (no

NO954152L (no

Inventor

Hatto Walch

Monika Fleck

Klaus Neuer

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-20

Filing date

1995-10-18

Publication date

2006-03-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25925049&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO321076(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-04-08 Priority claimed from DE4412201A external-priority patent/DE4412201A1/de

1995-10-18 Application filed by Novartis Ag filed Critical Novartis Ag

1995-10-18 Publication of NO954152D0 publication Critical patent/NO954152D0/no

1995-10-18 Publication of NO954152L publication Critical patent/NO954152L/no

2006-03-13 Publication of NO321076B1 publication Critical patent/NO321076B1/no

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title claims abstract description 22
108010036949 Cyclosporine Proteins 0.000 title claims abstract description 22
229930182912 cyclosporin Natural products 0.000 title claims abstract description 22
229960001265 ciclosporin Drugs 0.000 title claims abstract description 20
239000000825 pharmaceutical preparation Substances 0.000 title claims description 18
229930105110 Cyclosporin A Natural products 0.000 title claims description 3
239000000203 mixture Substances 0.000 claims abstract description 20
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 8
229920005862 polyol Polymers 0.000 claims abstract description 5
235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 5
239000008158 vegetable oil Substances 0.000 claims abstract description 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 4
239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 4
125000002947 alkylene group Chemical group 0.000 claims abstract description 4
229920001515 polyalkylene glycol Polymers 0.000 claims abstract description 4
229920000570 polyether Polymers 0.000 claims abstract description 4
125000000217 alkyl group Chemical group 0.000 claims abstract description 3
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims abstract description 3
238000002360 preparation method Methods 0.000 claims description 26
239000004480 active ingredient Substances 0.000 claims description 12
-1 alkylene ester Chemical class 0.000 claims description 9
125000005456 glyceride group Chemical group 0.000 claims description 7
229920006395 saturated elastomer Polymers 0.000 claims description 7
239000000126 substance Substances 0.000 claims description 7
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
239000000654 additive Substances 0.000 claims description 6
229920001223 polyethylene glycol Polymers 0.000 claims description 6
229920002535 Polyethylene Glycol 1500 Polymers 0.000 claims description 5
239000008172 hydrogenated vegetable oil Substances 0.000 claims description 5
VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 claims description 5
239000004359 castor oil Substances 0.000 claims description 3
235000019438 castor oil Nutrition 0.000 claims description 3
235000014113 dietary fatty acids Nutrition 0.000 claims description 3
229930195729 fatty acid Natural products 0.000 claims description 3
239000000194 fatty acid Substances 0.000 claims description 3
239000007903 gelatin capsule Substances 0.000 claims description 3
235000011187 glycerol Nutrition 0.000 claims description 3
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
239000000314 lubricant Substances 0.000 claims description 3
239000003981 vehicle Substances 0.000 claims description 3
235000019482 Palm oil Nutrition 0.000 claims description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
229930006000 Sucrose Natural products 0.000 claims description 2
239000011230 binding agent Substances 0.000 claims description 2
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 2
150000004665 fatty acids Chemical class 0.000 claims description 2
239000002540 palm oil Substances 0.000 claims description 2
239000003755 preservative agent Substances 0.000 claims description 2
239000005720 sucrose Substances 0.000 claims description 2
239000002562 thickening agent Substances 0.000 claims description 2
239000000796 flavoring agent Substances 0.000 claims 1
239000003346 palm kernel oil Substances 0.000 claims 1
235000019865 palm kernel oil Nutrition 0.000 claims 1
239000003381 stabilizer Substances 0.000 claims 1
239000013543 active substance Substances 0.000 abstract description 10
150000003077 polyols Chemical class 0.000 abstract description 2
150000002009 diols Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920000728 polyester Polymers 0.000 abstract 1
108010036941 Cyclosporins Proteins 0.000 description 7
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
239000007788 liquid Substances 0.000 description 5
239000008280 blood Substances 0.000 description 4
210000004369 blood Anatomy 0.000 description 4
241000282472 Canis lupus familiaris Species 0.000 description 3
208000027866 inflammatory disease Diseases 0.000 description 3
238000000034 method Methods 0.000 description 3
239000003921 oil Substances 0.000 description 3
235000019198 oils Nutrition 0.000 description 3
239000007787 solid Substances 0.000 description 3
241001465754 Metazoa Species 0.000 description 2
239000002775 capsule Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
229960003444 immunosuppressant agent Drugs 0.000 description 2
239000003018 immunosuppressive agent Substances 0.000 description 2
239000000155 melt Substances 0.000 description 2
208000023275 Autoimmune disease Diseases 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
208000010362 Protozoan Infections Diseases 0.000 description 1
208000025747 Rheumatic disease Diseases 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000002141 anti-parasite Effects 0.000 description 1
239000003096 antiparasitic agent Substances 0.000 description 1
229940125687 antiparasitic agent Drugs 0.000 description 1
230000002917 arthritic effect Effects 0.000 description 1
230000001363 autoimmune Effects 0.000 description 1
239000000969 carrier Substances 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000035622 drinking Effects 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
239000002360 explosive Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
238000002875 fluorescence polarization Methods 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
230000001976 improved effect Effects 0.000 description 1
230000004968 inflammatory condition Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
238000012153 long-term therapy Methods 0.000 description 1
201000004792 malaria Diseases 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000003589 nefrotoxic effect Effects 0.000 description 1
231100000381 nephrotoxic Toxicity 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000004033 plastic Substances 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
239000011253 protective coating Substances 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
210000003752 saphenous vein Anatomy 0.000 description 1
238000012216 screening Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000005809 transesterification reaction Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

NO19954152A 1993-04-20 1995-10-18 Farmasoytisk preparat for oral administrasjon inneholdende cyklosporin NO321076B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4312728		1993-04-20
DE4412201A DE4412201A1 (de)	1993-04-20	1994-04-08	Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
PCT/EP1994/001228 WO1994023733A1 (de)	1993-04-20	1994-04-20	Neue pharmazeutische zubereitungen zur oralen verabreichung enthaltend cyclosporin

Publications (3)

Publication Number	Publication Date
NO954152D0 NO954152D0 (no)	1995-10-18
NO954152L NO954152L (no)	1995-10-18
NO321076B1 true NO321076B1 (no)	2006-03-13

Family

ID=25925049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19954152A NO321076B1 (no)	1993-04-20	1995-10-18	Farmasoytisk preparat for oral administrasjon inneholdende cyklosporin

Country Status (13)

Country	Link
EP (1)	EP0697881B2 (cs)
JP (2)	JP3862273B2 (cs)
AT (1)	ATE218878T1 (cs)
CA (1)	CA2161143A1 (cs)
CZ (1)	CZ291237B6 (cs)
DK (1)	DK0697881T3 (cs)
ES (1)	ES2178653T3 (cs)
FI (1)	FI116120B (cs)
HU (1)	HUT72738A (cs)
NO (1)	NO321076B1 (cs)
PT (1)	PT697881E (cs)
SK (1)	SK283442B6 (cs)
WO (1)	WO1994023733A1 (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
DE19545043A1 (de) *	1995-12-02	1997-06-05	Scherer Gmbh R P	Pharmazeutische Präparate zur oralen Anwendung und Verfahren zu ihrer Herstellung
PT988046E (pt) *	1997-01-30	2004-12-31	Novartis Ag	Composicoes farmaceuticas sem oleo contendo ciclosporina a
HU228855B1 (en) *	1997-03-12	2013-06-28	Abbott Lab	Hydrophilic binary systems for the administration of cyclosporine
US6008191A (en) *	1997-09-08	1999-12-28	Panacea Biotec Limited	Pharmaceutical compositions containing cyclosporin
US6346511B1 (en)	1997-09-08	2002-02-12	Panacea Biotec Limited	Pharmaceutical composition comprising cyclosporin
US6187747B1 (en)	1997-09-08	2001-02-13	Panacea Biotech Limited	Pharmaceutical composition comprising cyclosporin
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
US6284268B1 (en)	1997-12-10	2001-09-04	Cyclosporine Therapeutics Limited	Pharmaceutical compositions containing an omega-3 fatty acid oil
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
US6207179B1 (en)	2000-05-18	2001-03-27	Phoenix Scientific, Inc.	Parasiticidal formulation for animals and a method of making this formulation
HRP20070058B1 (hr)	2001-10-19	2014-05-23	Isotechnika Inc.	Sinteza ciklosporinskih analoga
US6979672B2 (en)	2002-12-20	2005-12-27	Polichem, S.A.	Cyclosporin-based pharmaceutical compositions
US7682433B2 (en)	2007-05-11	2010-03-23	Canon Kabushiki Kaisha	Ink set, ink jet recording method, ink cartridge, recording unit, and ink jet recording apparatus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH641356A5 (en) *	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin
GB8903804D0 (en) †	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
DE3580717D1 (de) *	1984-08-02	1991-01-10	Sandoz Ag	Pharmazeutische anwendung von (nva)2-cyclosporine.
ES2033086T3 (es) †	1988-01-29	1993-03-01	Sankyo Company Limited	Un procedimiento para la preparacion de una composicion farmaceutica.
GB2222770B (en) †	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
BE1003009A5 (fr) †	1989-02-09	1991-10-22	Sandoz Sa	Nouvelles compositions pharmaceutiques a base de cyclosporines.

1994
- 1994-04-20 AT AT94915073T patent/ATE218878T1/de not_active IP Right Cessation
- 1994-04-20 WO PCT/EP1994/001228 patent/WO1994023733A1/de not_active Ceased
- 1994-04-20 SK SK1298-95A patent/SK283442B6/sk not_active IP Right Cessation
- 1994-04-20 JP JP52278294A patent/JP3862273B2/ja not_active Expired - Fee Related
- 1994-04-20 CA CA002161143A patent/CA2161143A1/en not_active Abandoned
- 1994-04-20 DK DK94915073T patent/DK0697881T3/da active
- 1994-04-20 CZ CZ19952729A patent/CZ291237B6/cs not_active IP Right Cessation
- 1994-04-20 PT PT94915073T patent/PT697881E/pt unknown
- 1994-04-20 EP EP94915073A patent/EP0697881B2/de not_active Expired - Lifetime
- 1994-04-20 HU HU9503019A patent/HUT72738A/hu unknown
- 1994-04-20 ES ES94915073T patent/ES2178653T3/es not_active Expired - Lifetime
1995
- 1995-10-18 NO NO19954152A patent/NO321076B1/no not_active IP Right Cessation
- 1995-10-19 FI FI954986A patent/FI116120B/fi active IP Right Grant
2006
- 2006-05-10 JP JP2006131593A patent/JP2006206615A/ja active Pending

Also Published As

Publication number	Publication date
JPH08508984A (ja)	1996-09-24
EP0697881B2 (de)	2009-05-06
HUT72738A (en)	1996-05-28
EP0697881B1 (de)	2002-06-12
FI954986L (fi)	1995-10-19
ES2178653T3 (es)	2003-01-01
FI954986A0 (fi)	1995-10-19
WO1994023733A1 (de)	1994-10-27
NO954152D0 (no)	1995-10-18
PT697881E (pt)	2002-10-31
SK283442B6 (sk)	2003-07-01
SK129895A3 (en)	1997-02-05
CZ291237B6 (cs)	2003-01-15
FI116120B (fi)	2005-09-30
CZ272995A3 (en)	1996-02-14
JP3862273B2 (ja)	2006-12-27
NO954152L (no)	1995-10-18
CA2161143A1 (en)	1994-10-27
DK0697881T3 (da)	2002-10-07
HU9503019D0 (en)	1995-12-28
ATE218878T1 (de)	2002-06-15
JP2006206615A (ja)	2006-08-10
EP0697881A1 (de)	1996-02-28

Legal Events

Date	Code	Title	Description
2010-11-29	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
RU2211047C2 (ru)	2003-08-27	Желатиновые капсулы с твердым покрытием, включающие фармацевтические композиции, практически не содержащие масел
US6428821B2 (en)	2002-08-06	Oral micro-emulsion composition of silybin
KR100602725B1 (ko)	2006-07-20	물에서 불충분하게 용해되는 약제를 위한 자가-유화용조성물
JP2662183B2 (ja)	1997-10-08	サイクロスポリン軟質カプセル剤組成物
AU765935B2 (en)	2003-10-02	Substantially oil-free cyclosporin compositions
JP3862273B2 (ja)	2006-12-27	経口投与用シクロスポリン含有新規製剤
US20100240753A1 (en)	2010-09-23	Effective pharmaceutical carrier for poorly bioavailable drugs
HU225535B1 (en)	2007-02-28	Microemulsion pre-concentrate and microemulsion
JP2012006931A (ja)	2012-01-12	疎水性治療剤の改善された送達のための組成物および方法
WO1997034622A1 (en)	1997-09-25	Oral cyclosporin formulations
HU213394B (en)	1997-06-30	Process for producing pharmaceutical compositions containing cyclosporins as active components
HUT77283A (hu)	1998-03-30	Egyszerű összetételű, a hatóanyagot biológiailag jól hozzáférhetően tartalmazó, orális alkalmazásra szánt új ciklosporinkészítmény és eljárás az előállítására
RU2279894C2 (ru)	2006-07-20	Фармацевтические композиции для перорального и местного применения
US5834017A (en)	1998-11-10	Oral cyclopsporin formulations
WO2016104889A1 (en)	2016-06-30	Composition for a self-emulsifying drug delivery system comprising dutasteride
US20020107183A1 (en)	2002-08-08	Pharmaceutical preparations comprising cyclosporin for oral administration
GB2451811A (en)	2009-02-18	Delivery composition for solubilising water-insoluble pharmaceutical active ingredients
KR20000029746A (ko)	2000-05-25	사이클로스포린제제
AU762963B2 (en)	2003-07-10	Cyclosporin solution
HK1037140B (en)	2003-12-24	Cyclosporin solution