SK283442B6 - Farmaceutický prípravok na orálne podanie - Google Patents

Farmaceutický prípravok na orálne podanie Download PDF

Info

Publication number: SK283442B6
Authority: SK; Slovakia
Prior art keywords: pharmaceutical preparation; cyclosporin; hlb value; gelucir; component
Prior art date: 1993-04-20

Application number

SK1298-95A

Other languages

English (en)

Slovak (sk)

Other versions

SK129895A3 (en

Inventor

Monika Petszulat

Klaus Neuer

Hatto Walch

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-20

Filing date

1994-04-20

Publication date

2003-07-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25925049&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK283442(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-04-08 Priority claimed from DE4412201A external-priority patent/DE4412201A1/de

1994-04-20 Application filed by Novartis Ag filed Critical Novartis Ag

1997-02-05 Publication of SK129895A3 publication Critical patent/SK129895A3/sk

2003-07-01 Publication of SK283442B6 publication Critical patent/SK283442B6/sk

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 5
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims abstract description 32
108010036949 Cyclosporine Proteins 0.000 claims abstract description 32
229960001265 ciclosporin Drugs 0.000 claims abstract description 31
239000000203 mixture Substances 0.000 claims abstract description 30
229930182912 cyclosporin Natural products 0.000 claims abstract description 28
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 10
239000013543 active substance Substances 0.000 claims abstract description 10
125000002947 alkylene group Chemical group 0.000 claims abstract description 8
239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 6
229920000570 polyether Polymers 0.000 claims abstract description 6
229920005862 polyol Polymers 0.000 claims abstract description 5
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 4
229920001515 polyalkylene glycol Polymers 0.000 claims abstract description 4
235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 4
239000008158 vegetable oil Substances 0.000 claims abstract description 4
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims abstract description 3
229930105110 Cyclosporin A Natural products 0.000 claims description 29
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
239000000825 pharmaceutical preparation Substances 0.000 claims description 12
125000005456 glyceride group Chemical group 0.000 claims description 9
229920006395 saturated elastomer Polymers 0.000 claims description 9
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
150000002148 esters Chemical class 0.000 claims description 6
-1 alkylene polyol Chemical class 0.000 claims description 4
239000004359 castor oil Substances 0.000 claims description 4
235000019438 castor oil Nutrition 0.000 claims description 4
235000011187 glycerol Nutrition 0.000 claims description 4
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 4
239000007903 gelatin capsule Substances 0.000 claims description 3
125000004432 carbon atom Chemical group C* 0.000 claims description 2
WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims 5
IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 5
235000021314 Palmitic acid Nutrition 0.000 claims 3
235000021355 Stearic acid Nutrition 0.000 claims 3
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical class CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 3
AOHAPDDBNAPPIN-UHFFFAOYSA-N 3-Methoxy-4,5-methylenedioxybenzoic acid Chemical compound COC1=CC(C(O)=O)=CC2=C1OCO2 AOHAPDDBNAPPIN-UHFFFAOYSA-N 0.000 claims 2
235000021360 Myristic acid Nutrition 0.000 claims 2
GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims 2
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims 2
239000002202 Polyethylene glycol Substances 0.000 claims 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
229930006000 Sucrose Natural products 0.000 claims 1
KGUHOFWIXKIURA-VQXBOQCVSA-N [(2r,3s,4s,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methyl dodecanoate Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)CCCCCCCCCCC)O[C@@H]1O[C@@]1(CO)[C@@H](O)[C@H](O)[C@@H](CO)O1 KGUHOFWIXKIURA-VQXBOQCVSA-N 0.000 claims 1
XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
229920001223 polyethylene glycol Polymers 0.000 claims 1
239000008117 stearic acid Substances 0.000 claims 1
239000005720 sucrose Substances 0.000 claims 1
229940032085 sucrose monolaurate Drugs 0.000 claims 1
150000003077 polyols Chemical class 0.000 abstract description 2
125000000217 alkyl group Chemical group 0.000 abstract 1
150000002009 diols Chemical class 0.000 abstract 1
229920000728 polyester Polymers 0.000 abstract 1
239000004480 active ingredient Substances 0.000 description 12
238000009472 formulation Methods 0.000 description 10
108010036941 Cyclosporins Proteins 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
239000004615 ingredient Substances 0.000 description 5
238000002360 preparation method Methods 0.000 description 4
239000000047 product Substances 0.000 description 4
241000282472 Canis lupus familiaris Species 0.000 description 3
239000008280 blood Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000002775 capsule Substances 0.000 description 3
230000004968 inflammatory condition Effects 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000000155 melt Substances 0.000 description 3
239000003921 oil Substances 0.000 description 3
235000019198 oils Nutrition 0.000 description 3
239000006186 oral dosage form Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
241001465754 Metazoa Species 0.000 description 2
239000000969 carrier Substances 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
239000008187 granular material Substances 0.000 description 2
229960003444 immunosuppressant agent Drugs 0.000 description 2
239000003018 immunosuppressive agent Substances 0.000 description 2
239000012669 liquid formulation Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000000034 method Methods 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
230000002035 prolonged effect Effects 0.000 description 2
208000023275 Autoimmune disease Diseases 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
230000002141 anti-parasite Effects 0.000 description 1
239000003096 antiparasitic agent Substances 0.000 description 1
229940125687 antiparasitic agent Drugs 0.000 description 1
230000002917 arthritic effect Effects 0.000 description 1
230000001363 autoimmune Effects 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
230000035622 drinking Effects 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
238000002875 fluorescence polarization Methods 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000005984 hydrogenation reaction Methods 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
208000027866 inflammatory disease Diseases 0.000 description 1
238000012153 long-term therapy Methods 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
201000004792 malaria Diseases 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000003589 nefrotoxic effect Effects 0.000 description 1
231100000381 nephrotoxic Toxicity 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
239000011253 protective coating Substances 0.000 description 1
206010039073 rheumatoid arthritis Diseases 0.000 description 1
239000000523 sample Substances 0.000 description 1
210000003752 saphenous vein Anatomy 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

SK1298-95A 1993-04-20 1994-04-20 Farmaceutický prípravok na orálne podanie SK283442B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4312728		1993-04-20
DE4412201A DE4412201A1 (de)	1993-04-20	1994-04-08	Neue pharmazeutische Zubereitungen zur oralen Verabreichung enthaltend Cyclosporin
PCT/EP1994/001228 WO1994023733A1 (de)	1993-04-20	1994-04-20	Neue pharmazeutische zubereitungen zur oralen verabreichung enthaltend cyclosporin

Publications (2)

Publication Number	Publication Date
SK129895A3 SK129895A3 (en)	1997-02-05
SK283442B6 true SK283442B6 (sk)	2003-07-01

Family

ID=25925049

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1298-95A SK283442B6 (sk)	1993-04-20	1994-04-20	Farmaceutický prípravok na orálne podanie

Country Status (13)

Country	Link
EP (1)	EP0697881B2 (cs)
JP (2)	JP3862273B2 (cs)
AT (1)	ATE218878T1 (cs)
CA (1)	CA2161143A1 (cs)
CZ (1)	CZ291237B6 (cs)
DK (1)	DK0697881T3 (cs)
ES (1)	ES2178653T3 (cs)
FI (1)	FI116120B (cs)
HU (1)	HUT72738A (cs)
NO (1)	NO321076B1 (cs)
PT (1)	PT697881E (cs)
SK (1)	SK283442B6 (cs)
WO (1)	WO1994023733A1 (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5962019A (en) *	1995-08-25	1999-10-05	Sangstat Medical Corporation	Oral cyclosporin formulations
US5766629A (en) *	1995-08-25	1998-06-16	Sangstat Medical Corporation	Oral cyclosporin formulations
US5834017A (en) *	1995-08-25	1998-11-10	Sangstat Medical Corporation	Oral cyclopsporin formulations
US5827822A (en) *	1996-03-25	1998-10-27	Sangstat Medical Corporation	Cyclosporin a formulations as nanoparticles
DE19545043A1 (de) *	1995-12-02	1997-06-05	Scherer Gmbh R P	Pharmazeutische Präparate zur oralen Anwendung und Verfahren zu ihrer Herstellung
PT988046E (pt) *	1997-01-30	2004-12-31	Novartis Ag	Composicoes farmaceuticas sem oleo contendo ciclosporina a
HU228855B1 (en) *	1997-03-12	2013-06-28	Abbott Lab	Hydrophilic binary systems for the administration of cyclosporine
US6008191A (en) *	1997-09-08	1999-12-28	Panacea Biotec Limited	Pharmaceutical compositions containing cyclosporin
US6346511B1 (en)	1997-09-08	2002-02-12	Panacea Biotec Limited	Pharmaceutical composition comprising cyclosporin
US6187747B1 (en)	1997-09-08	2001-02-13	Panacea Biotech Limited	Pharmaceutical composition comprising cyclosporin
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
US6284268B1 (en)	1997-12-10	2001-09-04	Cyclosporine Therapeutics Limited	Pharmaceutical compositions containing an omega-3 fatty acid oil
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
US6207179B1 (en)	2000-05-18	2001-03-27	Phoenix Scientific, Inc.	Parasiticidal formulation for animals and a method of making this formulation
HRP20070058B1 (hr)	2001-10-19	2014-05-23	Isotechnika Inc.	Sinteza ciklosporinskih analoga
US6979672B2 (en)	2002-12-20	2005-12-27	Polichem, S.A.	Cyclosporin-based pharmaceutical compositions
US7682433B2 (en)	2007-05-11	2010-03-23	Canon Kabushiki Kaisha	Ink set, ink jet recording method, ink cartridge, recording unit, and ink jet recording apparatus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH641356A5 (en) *	1979-02-27	1984-02-29	Sandoz Ag	Pharmaceutical compositions containing cyclosporin
GB8903804D0 (en) †	1989-02-20	1989-04-05	Sandoz Ltd	Improvements in or relating to organic compounds
DE3580717D1 (de) *	1984-08-02	1991-01-10	Sandoz Ag	Pharmazeutische anwendung von (nva)2-cyclosporine.
ES2033086T3 (es) †	1988-01-29	1993-03-01	Sankyo Company Limited	Un procedimiento para la preparacion de una composicion farmaceutica.
GB2222770B (en) †	1988-09-16	1992-07-29	Sandoz Ltd	Pharmaceutical compositions containing cyclosporins
BE1003009A5 (fr) †	1989-02-09	1991-10-22	Sandoz Sa	Nouvelles compositions pharmaceutiques a base de cyclosporines.

1994
- 1994-04-20 AT AT94915073T patent/ATE218878T1/de not_active IP Right Cessation
- 1994-04-20 WO PCT/EP1994/001228 patent/WO1994023733A1/de not_active Ceased
- 1994-04-20 SK SK1298-95A patent/SK283442B6/sk not_active IP Right Cessation
- 1994-04-20 JP JP52278294A patent/JP3862273B2/ja not_active Expired - Fee Related
- 1994-04-20 CA CA002161143A patent/CA2161143A1/en not_active Abandoned
- 1994-04-20 DK DK94915073T patent/DK0697881T3/da active
- 1994-04-20 CZ CZ19952729A patent/CZ291237B6/cs not_active IP Right Cessation
- 1994-04-20 PT PT94915073T patent/PT697881E/pt unknown
- 1994-04-20 EP EP94915073A patent/EP0697881B2/de not_active Expired - Lifetime
- 1994-04-20 HU HU9503019A patent/HUT72738A/hu unknown
- 1994-04-20 ES ES94915073T patent/ES2178653T3/es not_active Expired - Lifetime
1995
- 1995-10-18 NO NO19954152A patent/NO321076B1/no not_active IP Right Cessation
- 1995-10-19 FI FI954986A patent/FI116120B/fi active IP Right Grant
2006
- 2006-05-10 JP JP2006131593A patent/JP2006206615A/ja active Pending

Also Published As

Publication number	Publication date
NO321076B1 (no)	2006-03-13
JPH08508984A (ja)	1996-09-24
EP0697881B2 (de)	2009-05-06
HUT72738A (en)	1996-05-28
EP0697881B1 (de)	2002-06-12
FI954986L (fi)	1995-10-19
ES2178653T3 (es)	2003-01-01
FI954986A0 (fi)	1995-10-19
WO1994023733A1 (de)	1994-10-27
NO954152D0 (no)	1995-10-18
PT697881E (pt)	2002-10-31
SK129895A3 (en)	1997-02-05
CZ291237B6 (cs)	2003-01-15
FI116120B (fi)	2005-09-30
CZ272995A3 (en)	1996-02-14
JP3862273B2 (ja)	2006-12-27
NO954152L (no)	1995-10-18
CA2161143A1 (en)	1994-10-27
DK0697881T3 (da)	2002-10-07
HU9503019D0 (en)	1995-12-28
ATE218878T1 (de)	2002-06-15
JP2006206615A (ja)	2006-08-10
EP0697881A1 (de)	1996-02-28

Legal Events

Date	Code	Title	Description
2011-01-04	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20100420

Publication	Publication Date	Title
RU2257917C2 (ru)	2005-08-10	Самоэмульгирующиеся композиции для плохорастворимых в воде лекарственных препаратов
EP0710104B1 (de)	1998-11-04	Pharmazeutische präparate für schwerlösliche wirkstoffe
EP1039893B1 (en)	2011-02-02	Pharmaceutical compositions containing an omega-3 fatty acid oil
DE60019100T2 (de)	2006-03-23	Im wesentlichen ölfreie cyclosporin zusammensetzungen
KR100471680B1 (ko)	2007-04-25	사이클로스포린제제
SK285809B6 (sk)	2007-08-02	Mikroemulzný prekoncentrát cyklosporínu alebo makrolidu
SK129895A3 (en)	1997-02-05	Cyclosporine-containing pharmaceutical compositions for oral administration
SK13192000A3 (sk)	2001-02-12	Kompozícia vo forme mikroemulzného prekoncentrátu obsahujúca cyklosporín a jej použitie
US20040018992A1 (en)	2004-01-29	Pharmaceutical compositions for sparingly soluble therapeutic agents
GB2355656A (en)	2001-05-02	Preparation of gel emulsions of hydrophobic pharmaceuticals
US20020049158A1 (en)	2002-04-25	Oral drug composition containing a verapamil derivative as a drug-absorption promotor
SK283216B6 (sk)	2003-03-04	Prípravok obsahujúci cyklosporín a spôsob jeho prípravy
EP0657164A1 (en)	1995-06-14	Pharmaceutical compositions containing staurosphorine derivatives
US20020107183A1 (en)	2002-08-08	Pharmaceutical preparations comprising cyclosporin for oral administration
SK8702001A3 (en)	2002-01-07	Cyclosporin solution
US6979672B2 (en)	2005-12-27	Cyclosporin-based pharmaceutical compositions
KR0173349B1 (ko)	1999-02-01	사이클로스포린-함유 고체 분산체 조성물
SK123299A3 (en)	2000-02-14	Pharmaceutical compositions containing cyclosporin
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