NO328417B1 - Epotilonderivater samt deres syntese og anvendelse - Google Patents

Epotilonderivater samt deres syntese og anvendelse Download PDF

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Publication number
NO328417B1
NO328417B1 NO20006378A NO20006378A NO328417B1 NO 328417 B1 NO328417 B1 NO 328417B1 NO 20006378 A NO20006378 A NO 20006378A NO 20006378 A NO20006378 A NO 20006378A NO 328417 B1 NO328417 B1 NO 328417B1
Authority
NO
Norway
Prior art keywords
formula
compound
equiv
absent
mmol
Prior art date
Application number
NO20006378A
Other languages
English (en)
Norwegian (no)
Other versions
NO20006378L (no
NO20006378D0 (no
Inventor
Kyriacos Costa Nicolaou
Nigel Paul King
Maurice Raymond Verschoyle Finlay
Yun He
Dionisios Vourloumis
Frank Roschangar
Antony Bigot
Hans Vallberg
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20006378D0 publication Critical patent/NO20006378D0/no
Publication of NO20006378L publication Critical patent/NO20006378L/no
Publication of NO328417B1 publication Critical patent/NO328417B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Silicon Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20006378A 1998-06-22 2000-12-14 Epotilonderivater samt deres syntese og anvendelse NO328417B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/102,602 US6380394B1 (en) 1996-12-13 1998-06-22 Epothilone analogs
PCT/EP1999/004287 WO1999067252A2 (fr) 1998-06-22 1999-06-21 Derives de l'epothilone, leur synthese et leur utilisation

Publications (3)

Publication Number Publication Date
NO20006378D0 NO20006378D0 (no) 2000-12-14
NO20006378L NO20006378L (no) 2001-02-21
NO328417B1 true NO328417B1 (no) 2010-02-15

Family

ID=22290705

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20006378A NO328417B1 (no) 1998-06-22 2000-12-14 Epotilonderivater samt deres syntese og anvendelse

Country Status (27)

Country Link
US (3) US6380394B1 (fr)
EP (2) EP1741715A1 (fr)
JP (1) JP4681732B2 (fr)
KR (3) KR100864742B1 (fr)
CN (1) CN1192031C (fr)
AT (1) ATE343573T1 (fr)
AU (1) AU757854B2 (fr)
BR (1) BR9911420A (fr)
CA (1) CA2334342C (fr)
CY (1) CY1105863T1 (fr)
CZ (1) CZ301783B6 (fr)
DE (1) DE69933767T2 (fr)
DK (1) DK1089998T3 (fr)
ES (1) ES2273502T3 (fr)
HU (1) HUP0102711A3 (fr)
ID (1) ID28210A (fr)
IL (3) IL139784A0 (fr)
MX (1) MXPA00012443A (fr)
NO (1) NO328417B1 (fr)
NZ (1) NZ508622A (fr)
PL (1) PL197648B1 (fr)
PT (1) PT1089998E (fr)
RU (1) RU2227142C2 (fr)
SK (2) SK285647B6 (fr)
TR (1) TR200003844T2 (fr)
WO (1) WO1999067252A2 (fr)
ZA (1) ZA200007059B (fr)

Families Citing this family (95)

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US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
CA2273083C (fr) 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthese d'epothilones, intermediaires utilises dans leur synthese, analogues et utilisations de celles-ci
US6867305B2 (en) * 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6660758B1 (en) * 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
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IL155306A0 (en) * 2000-10-13 2003-11-23 Univ Mississippi Methods for producing epothilone derivatives and analogs and epothilone derivatives and analogs produced thereby
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CN1774253A (zh) 2001-02-20 2006-05-17 布里斯托尔-迈尔斯斯奎布公司 用环氧丙酯酮衍生物治疗顽固性肿瘤
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CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
JP2010511408A (ja) 2006-12-04 2010-04-15 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 癌をＣｐＧリッチＤＮＡおよびキュプレドキシンで治療するための組成物および方法
JP2010518123A (ja) 2007-02-08 2010-05-27 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 癌をキュプレドキシンで予防するための組成物および方法
US8435983B2 (en) * 2007-03-23 2013-05-07 The University Of Toledo Conformationally restrained epothilone analogues as anti-leukemic agents
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US9284350B2 (en) 2010-02-12 2016-03-15 Pharmascience Inc. IAP BIR domain binding compounds
US20110300150A1 (en) 2010-05-18 2011-12-08 Scott Eliasof Compositions and methods for treatment of autoimmune and other disease
JP5889337B2 (ja) 2011-01-20 2016-03-22 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ｍｒｉマーカー、送達および抜取りシステムならびにこれらの製造方法および使用方法
CN102863474A (zh) 2011-07-09 2013-01-09 陈小平 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用
CN102993239A (zh) 2011-09-19 2013-03-27 陈小平 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物
EP2793947B1 (fr) 2011-12-23 2021-02-03 Innate Pharma Conjugaison enzymatique de polypeptides
US10132799B2 (en) 2012-07-13 2018-11-20 Innate Pharma Screening of conjugated antibodies
EP3564259A3 (fr) 2012-11-09 2020-02-12 Innate Pharma Étiquettes de reconnaissance pour la conjugaison à médiation par la tgase
WO2014075391A1 (fr) 2012-11-17 2014-05-22 北京市丰硕维康技术开发有限责任公司 Composé du platine et de dérivé de l'acide malonique ayant un groupe partant contenant un groupe amino ou alkylamino
WO2014116594A1 (fr) * 2013-01-23 2014-07-31 The University Of Toledo Agents anticancéreux hautement sélectifs ciblant le cancer de poumon non à petites cellules et d'autres formes de cancer
US10611824B2 (en) 2013-03-15 2020-04-07 Innate Pharma Solid phase TGase-mediated conjugation of antibodies
EP3010547B1 (fr) 2013-06-20 2021-04-21 Innate Pharma Conjugaison enzymatique de polypeptides
CN105517577A (zh) 2013-06-21 2016-04-20 先天制药公司 多肽的酶促偶联
EP3371176A4 (fr) * 2015-10-16 2019-09-04 William Marsh Rice University Analogues d'épothilone, procédés de synthèse, procédés de traitement, et conjugués médicamenteux de ceux-ci
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Also Published As

Publication number Publication date
ID28210A (id) 2001-05-10
ATE343573T1 (de) 2006-11-15
CA2334342C (fr) 2012-07-17
HUP0102711A2 (hu) 2001-12-28
MXPA00012443A (es) 2004-12-03
ZA200007059B (en) 2002-01-30
SK19712000A3 (sk) 2001-09-11
SK287864B6 (sk) 2012-02-03
RU2227142C2 (ru) 2004-04-20
HK1038358A1 (en) 2002-03-15
EP1741715A1 (fr) 2007-01-10
ES2273502T3 (es) 2007-05-01
PL345327A1 (en) 2001-12-17
SK285647B6 (sk) 2007-05-03
CN1192031C (zh) 2005-03-09
IL139784A0 (en) 2002-02-10
DK1089998T3 (da) 2007-01-15
WO1999067252A3 (fr) 2000-03-16
KR100864742B1 (ko) 2008-10-22
DE69933767T2 (de) 2007-09-13
CA2334342A1 (fr) 1999-12-29
AU4774899A (en) 2000-01-10
TR200003844T2 (tr) 2001-04-20
CN1306531A (zh) 2001-08-01
NO20006378L (no) 2001-02-21
DE69933767D1 (de) 2006-12-07
US6380394B1 (en) 2002-04-30
EP1089998B1 (fr) 2006-10-25
NO20006378D0 (no) 2000-12-14
JP4681732B2 (ja) 2011-05-11
CY1105863T1 (el) 2011-02-02
US20030203938A1 (en) 2003-10-30
NZ508622A (en) 2003-07-25
CZ301783B6 (cs) 2010-06-23
EP1089998A2 (fr) 2001-04-11
US7579366B2 (en) 2009-08-25
PT1089998E (pt) 2007-01-31
KR20080045298A (ko) 2008-05-22
KR20010083060A (ko) 2001-08-31
BR9911420A (pt) 2001-03-20
IL139784A (en) 2010-05-17
HUP0102711A3 (en) 2002-09-30
PL197648B1 (pl) 2008-04-30
US6531497B1 (en) 2003-03-11
KR20090066332A (ko) 2009-06-23
IL182744A (en) 2010-05-17
AU757854B2 (en) 2003-03-06
IL182744A0 (en) 2007-07-24
JP2002518504A (ja) 2002-06-25
WO1999067252A2 (fr) 1999-12-29
CZ20004769A3 (cs) 2001-07-11

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