NO329380B1 - Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom - Google Patents

Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom Download PDF

Info

Publication number: NO329380B1
Authority: NO; Norway
Prior art keywords: dihydro; benzo; compound according; oxazine; piperazin
Prior art date: 2002-05-13

Application number

NO20044665A

Other languages

English (en)

Norwegian (no)

Other versions

NO20044665L (no

Inventor

Jacob Berger

Robin Douglas Clark

Shu Hai Zhao

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-13

Filing date

2004-10-28

Publication date

2010-10-04

2004-10-28 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-03 Publication of NO20044665L publication Critical patent/NO20044665L/no

2010-10-04 Publication of NO329380B1 publication Critical patent/NO329380B1/no

Links

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230000000699 topical effect Effects 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

NO20044665A 2002-05-13 2004-10-28 Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom NO329380B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37800302P	2002-05-13	2002-05-13
PCT/EP2003/004671 WO2003095434A1 (en)	2002-05-13	2003-05-05	Benzoxazine derivatives as 5-ht6 modulators and uses thereof

Publications (2)

Publication Number	Publication Date
NO20044665L NO20044665L (no)	2004-12-03
NO329380B1 true NO329380B1 (no)	2010-10-04

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ID=29420358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20044665A NO329380B1 (no)	2002-05-13	2004-10-28	Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom

Country Status (36)

Country	Link
US (4)	US6867204B2 (pt)
EP (1)	EP1506179B1 (pt)
JP (1)	JP4307377B2 (pt)
KR (1)	KR100636475B1 (pt)
CN (1)	CN100429206C (pt)
AR (1)	AR039988A1 (pt)
AT (1)	ATE316523T1 (pt)
AU (1)	AU2003233231B2 (pt)
BR (1)	BRPI0310032B8 (pt)
CA (1)	CA2485136C (pt)
DE (1)	DE60303376T2 (pt)
DK (1)	DK1506179T3 (pt)
EA (1)	EA009982B1 (pt)
EC (1)	ECSP045420A (pt)
EG (1)	EG25683A (pt)
ES (1)	ES2256744T3 (pt)
GT (1)	GT200300108A (pt)
HR (1)	HRP20041030B1 (pt)
IL (1)	IL164928A0 (pt)
JO (1)	JO2413B1 (pt)
MA (1)	MA27118A1 (pt)
MX (1)	MXPA04011254A (pt)
MY (1)	MY139612A (pt)
NO (1)	NO329380B1 (pt)
NZ (1)	NZ536230A (pt)
PA (1)	PA8573501A1 (pt)
PE (1)	PE20040757A1 (pt)
PL (1)	PL211057B1 (pt)
PT (1)	PT1506179E (pt)
RS (1)	RS51042B (pt)
TN (1)	TNSN04225A1 (pt)
TW (1)	TWI258479B (pt)
UA (1)	UA76877C2 (pt)
UY (1)	UY27803A1 (pt)
WO (1)	WO2003095434A1 (pt)
ZA (1)	ZA200408783B (pt)

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UA76877C2 (uk) *	2002-05-13	2006-09-15	Ф.Хоффманн-Ля Рош Аг	Похідні бензоксазину як 5-нт6 модулятори і їх застосування
PT1562918E (pt)	2002-11-08	2008-03-12	Hoffmann La Roche	Benzoxazinonas substituídas e as suas utilizações
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AU2004299201B2 (en) *	2003-12-09	2009-12-03	F. Hoffmann-La Roche Ag	Benzoxazine derivatives and uses thereof
AU2005205016B2 (en) *	2004-01-16	2010-07-15	F. Hoffmann-La Roche Ag	1-benzyl-5-piperazin-1-yl-3,4 dihydro-1H-quinazolin-2-one derivatives and the respective 1H-benzo(1,2,6)thiadiazine-2,2-dioxide and 1,4-dihydro-benzo(D) (1,3)oxazin-2-one derivatives as modulators of the 5-hydroxytryptamine receptor (5-HT) for the treatment of diseases of the central nervous system
RU2372344C2 (ru) *	2004-05-05	2009-11-10	Ф. Хоффманн-Ля Рош Аг	Арилсульфонилбензодиоксаны, применяемые для модуляции 5-нт6 рецептора, 5-нт2a рецептора или и того, и другого
AU2005291541B2 (en) *	2004-09-30	2011-03-10	F. Hoffmann-La Roche Ag	Benzoxazine and quinoxaline derivatives and uses
US7378415B2 (en) *	2004-09-30	2008-05-27	Roche Palo Alto Llc	Benzoxazine and quinoxaline derivatives and uses thereof
US7713954B2 (en) *	2004-09-30	2010-05-11	Roche Palo Alto Llc	Compositions and methods for treating cognitive disorders
EP1799306B1 (en) *	2004-09-30	2011-02-23	F. Hoffmann-La Roche AG	Compositions and methods for treating cognitive disorders
EP2254564A1 (en)	2007-12-12	2010-12-01	Glaxo Group Limited	Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
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KR101293384B1 (ko) *	2010-10-13	2013-08-05	주식회사 대웅제약	신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) *	2012-01-24	2016-08-02	Chemregen, Inc.	Compounds for inhibition of cancer cell proliferation
JP6510539B2 (ja)	2014-01-09	2019-05-08	ザジェイ．デヴィッドグラッドストーンインスティテューツ，アテスタメンタリートラストエスタブリッシュドアンダーザウィルオブジェイ．デヴィッドグラッドストーン	置換ベンゾオキサジン及び関連化合物
JP2018516992A (ja)	2015-06-12	2018-06-28	アクソファントサイエンシーズゲーエムベーハーＡｘｏｖａｎｔＳｃｉｅｎｃｅｓＧｍｂｈ	レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体
CN108472285A (zh)	2015-07-15	2018-08-31	阿速万科学有限责任公司	用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物

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2003
- 2003-05-05 UA UA20041210144A patent/UA76877C2/uk unknown
- 2003-05-05 DE DE60303376T patent/DE60303376T2/de not_active Expired - Lifetime
- 2003-05-05 NZ NZ536230A patent/NZ536230A/en not_active IP Right Cessation
- 2003-05-05 KR KR1020047018299A patent/KR100636475B1/ko not_active Expired - Fee Related
- 2003-05-05 EP EP03727430A patent/EP1506179B1/en not_active Expired - Lifetime
- 2003-05-05 MX MXPA04011254A patent/MXPA04011254A/es active IP Right Grant
- 2003-05-05 CA CA2485136A patent/CA2485136C/en not_active Expired - Lifetime
- 2003-05-05 WO PCT/EP2003/004671 patent/WO2003095434A1/en not_active Ceased
- 2003-05-05 JP JP2004503451A patent/JP4307377B2/ja not_active Expired - Lifetime
- 2003-05-05 DK DK03727430T patent/DK1506179T3/da active
- 2003-05-05 AU AU2003233231A patent/AU2003233231B2/en not_active Expired
- 2003-05-05 ES ES03727430T patent/ES2256744T3/es not_active Expired - Lifetime
- 2003-05-05 BR BRPI0310032A patent/BRPI0310032B8/pt not_active IP Right Cessation
- 2003-05-05 EA EA200401455A patent/EA009982B1/ru not_active IP Right Cessation
- 2003-05-05 HR HRP20041030AA patent/HRP20041030B1/hr not_active IP Right Cessation
- 2003-05-05 RS YUP-970/04A patent/RS51042B/sr unknown
- 2003-05-05 AT AT03727430T patent/ATE316523T1/de active
- 2003-05-05 CN CNB038109972A patent/CN100429206C/zh not_active Expired - Lifetime
- 2003-05-05 PL PL374019A patent/PL211057B1/pl unknown
- 2003-05-05 PT PT03727430T patent/PT1506179E/pt unknown
- 2003-05-08 TW TW092112575A patent/TWI258479B/zh not_active IP Right Cessation
- 2003-05-08 JO JO200352A patent/JO2413B1/en active
- 2003-05-09 US US10/435,732 patent/US6867204B2/en not_active Expired - Lifetime
- 2003-05-09 PA PA20038573501A patent/PA8573501A1/es unknown
- 2003-05-09 AR ARP030101624A patent/AR039988A1/es active IP Right Grant
- 2003-05-09 PE PE2003000452A patent/PE20040757A1/es active IP Right Grant
- 2003-05-09 GT GT200300108A patent/GT200300108A/es unknown
- 2003-05-10 EG EG2003050432A patent/EG25683A/xx active
- 2003-05-12 UY UY27803A patent/UY27803A1/es not_active IP Right Cessation
- 2003-05-12 MY MYPI20031765A patent/MY139612A/en unknown
2004
- 2004-10-28 NO NO20044665A patent/NO329380B1/no not_active IP Right Cessation
- 2004-10-28 IL IL16492804A patent/IL164928A0/xx unknown
- 2004-10-29 ZA ZA2004/08783A patent/ZA200408783B/en unknown
- 2004-11-10 EC EC2004005420A patent/ECSP045420A/es unknown
- 2004-11-11 TN TNP2004000225A patent/TNSN04225A1/fr unknown
- 2004-11-12 MA MA27944A patent/MA27118A1/fr unknown
2005
- 2005-01-31 US US11/047,284 patent/US20050130962A1/en not_active Abandoned
2009
- 2009-09-04 US US12/584,373 patent/US8377931B2/en not_active Expired - Fee Related
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- 2012-12-13 US US13/713,484 patent/US20130123251A1/en not_active Abandoned

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Publication number	Publication date
US20050130962A1 (en)	2005-06-16
US20130123251A1 (en)	2013-05-16
MXPA04011254A (es)	2005-01-25
TWI258479B (en)	2006-07-21
US20030232825A1 (en)	2003-12-18
AU2003233231A1 (en)	2003-11-11
JP4307377B2 (ja)	2009-08-05
CN100429206C (zh)	2008-10-29
DE60303376D1 (de)	2006-04-13
MA27118A1 (fr)	2004-12-20
JP2005530774A (ja)	2005-10-13
CN1653054A (zh)	2005-08-10
HRP20041030A2 (en)	2005-06-30
IL164928A0 (en)	2005-12-18
KR100636475B1 (ko)	2006-10-18
ES2256744T3 (es)	2006-07-16
UA76877C2 (uk)	2006-09-15
DK1506179T3 (da)	2006-06-06
HK1080846A1 (zh)	2006-05-04
EP1506179A1 (en)	2005-02-16
NZ536230A (en)	2007-05-31
TNSN04225A1 (fr)	2007-03-12
PT1506179E (pt)	2006-06-30
UY27803A1 (es)	2003-11-28
GT200300108A (es)	2004-03-15
PL211057B1 (pl)	2012-04-30
AR039988A1 (es)	2005-03-09
CA2485136A1 (en)	2003-11-20
PE20040757A1 (es)	2004-11-06
US8377931B2 (en)	2013-02-19
JO2413B1 (en)	2007-11-11
BR0310032A (pt)	2005-02-15
TW200400188A (en)	2004-01-01
PA8573501A1 (es)	2003-12-10
US20090325950A1 (en)	2009-12-31
EA200401455A1 (ru)	2005-06-30
BRPI0310032B8 (pt)	2021-05-25
AU2003233231B2 (en)	2009-02-26
ZA200408783B (en)	2005-12-28
US6867204B2 (en)	2005-03-15
ECSP045420A (es)	2005-01-03
BRPI0310032B1 (pt)	2019-01-08
RS51042B (sr)	2010-10-31
KR20040106538A (ko)	2004-12-17
HRP20041030B1 (hr)	2013-03-31
RS97004A (sr)	2006-10-27
DE60303376T2 (de)	2006-11-16
PL374019A1 (en)	2005-09-19
WO2003095434A1 (en)	2003-11-20
MY139612A (en)	2009-10-30
NO20044665L (no)	2004-12-03
EG25683A (en)	2012-05-16
CA2485136C (en)	2011-12-20
ATE316523T1 (de)	2006-02-15
EP1506179B1 (en)	2006-01-25
EA009982B1 (ru)	2008-04-28

Legal Events

Date	Code	Title	Description
2023-07-10	MK1K	Patent expired

Publication	Publication Date	Title
US8377931B2 (en)	2013-02-19	Benzoxazine derivatives and uses thereof
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JP4527730B2 (ja)	2010-08-18	ベンゾオキサジン誘導体及びその使用
ES2305742T3 (es)	2008-11-01	Derivados de quinolinon/benzoxazinona y uso de los mismos.
ES2302174T3 (es)	2008-07-01	Derivados 1-bencil-5-piperacin-1-il-3,4-dihidro-1h-quinazolin-2-ona y derivados respectivos de 1h-benzo(1,2,6)tiadiacin-2,2-dioxido y 1,4-dihidro-benzo(d)(1,3)oxacin-2-ona como moduladores del receptor 5-hidroxitriptamina(5-ht) para tratamiento enfermed. sistema nervioso central.
ES2348467T3 (es)	2010-12-07	Derivados y usos de la benzoxazina y la quinoxalina.
HK1080846B (en)	2009-08-14	Benzoxazine derivatives as 5-ht6 modulators and uses thereof
HK1087114A1 (zh)	2006-10-06	取代的苯并恶嗪酮及其用途
HK1087114B (en)	2009-02-13	Substituted benzoxazinones and uses thereof
MXPA06005840A (en)	2006-10-17	Benzoxazine derivatives and uses thereof