NO329380B1 - Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom - Google Patents

Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom Download PDF

Info

Publication number: NO329380B1
Authority: NO; Norway
Prior art keywords: dihydro; benzo; compound according; oxazine; piperazin
Prior art date: 2002-05-13

Application number

NO20044665A

Other languages

English (en)

Norwegian (no)

Other versions

NO20044665L (no

Inventor

Jacob Berger

Robin Douglas Clark

Shu Hai Zhao

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-13

Filing date

2004-10-28

Publication date

2010-10-04

2004-10-28 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-03 Publication of NO20044665L publication Critical patent/NO20044665L/no

2010-10-04 Publication of NO329380B1 publication Critical patent/NO329380B1/no

Links

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230000000699 topical effect Effects 0.000 description 1
230000037317 transdermal delivery Effects 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 1
229960000281 trometamol Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
238000009736 wetting Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

NO20044665A 2002-05-13 2004-10-28 Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom NO329380B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US37800302P	2002-05-13	2002-05-13
PCT/EP2003/004671 WO2003095434A1 (en)	2002-05-13	2003-05-05	Benzoxazine derivatives as 5-ht6 modulators and uses thereof

Publications (2)

Publication Number	Publication Date
NO20044665L NO20044665L (no)	2004-12-03
NO329380B1 true NO329380B1 (no)	2010-10-04

Family

ID=29420358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20044665A NO329380B1 (no)	2002-05-13	2004-10-28	Benzoksazin-derivater, fremgangsmate for fremstilling av slike, farmasoytiske preparater omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom

Country Status (36)

Country	Link
US (4)	US6867204B2 (sr)
EP (1)	EP1506179B1 (sr)
JP (1)	JP4307377B2 (sr)
KR (1)	KR100636475B1 (sr)
CN (1)	CN100429206C (sr)
AR (1)	AR039988A1 (sr)
AT (1)	ATE316523T1 (sr)
AU (1)	AU2003233231B2 (sr)
BR (1)	BRPI0310032B8 (sr)
CA (1)	CA2485136C (sr)
DE (1)	DE60303376T2 (sr)
DK (1)	DK1506179T3 (sr)
EA (1)	EA009982B1 (sr)
EC (1)	ECSP045420A (sr)
EG (1)	EG25683A (sr)
ES (1)	ES2256744T3 (sr)
GT (1)	GT200300108A (sr)
HR (1)	HRP20041030B1 (sr)
IL (1)	IL164928A0 (sr)
JO (1)	JO2413B1 (sr)
MA (1)	MA27118A1 (sr)
MX (1)	MXPA04011254A (sr)
MY (1)	MY139612A (sr)
NO (1)	NO329380B1 (sr)
NZ (1)	NZ536230A (sr)
PA (1)	PA8573501A1 (sr)
PE (1)	PE20040757A1 (sr)
PL (1)	PL211057B1 (sr)
PT (1)	PT1506179E (sr)
RS (1)	RS51042B (sr)
TN (1)	TNSN04225A1 (sr)
TW (1)	TWI258479B (sr)
UA (1)	UA76877C2 (sr)
UY (1)	UY27803A1 (sr)
WO (1)	WO2003095434A1 (sr)
ZA (1)	ZA200408783B (sr)

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BRPI0308696B8 (pt)	2002-03-27	2021-05-25	Axovant Sciences Gmbh	composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos
HRP20041030B1 (hr) *	2002-05-13	2013-03-31	F. Hoffmann - La Roche Ag	Derivati benzoksazina kao regulatori 5-ht6 i njihova upotreba
MXPA05004758A (es) *	2002-11-08	2005-08-02	Hoffmann La Roche	Benzoxazinonas sustituidas y uso de las mismas.
PT1558582E (pt)	2003-07-22	2006-05-31	Arena Pharm Inc	Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo
ES2291984T3 (es) *	2003-12-09	2008-03-01	F. Hoffmann-La Roche Ag	Derivados de benzoxazina y su empleo.
BRPI0506909A (pt) *	2004-01-16	2007-05-29	Hoffmann La Roche	derivados de 1-benzil-5piperazin-1-il-3,4 diidro-1h-quinazolin-2-ona e os respectivos derivados de 1h-benzo (1,2,6) tiadiazina-2,2-dióxido e 1,4-diidro-benzo (d) (1,3)oxazin-2-ona como moduladores do receptor de 5-hidroxitriptamina (5-ht) para o tratamento de doenças do sistema nervoso central
KR100823805B1 (ko) *	2004-05-05	2008-04-21	에프. 호프만-라 로슈 아게	5-ｈｔ6 수용체, 5-ｈｔ2ａ 수용체 또는 둘다를 조절하기에유용한 아릴설포닐 벤조다이옥산
US7713954B2 (en) *	2004-09-30	2010-05-11	Roche Palo Alto Llc	Compositions and methods for treating cognitive disorders
US7378415B2 (en) *	2004-09-30	2008-05-27	Roche Palo Alto Llc	Benzoxazine and quinoxaline derivatives and uses thereof
CN102114244A (zh) *	2004-09-30	2011-07-06	弗·哈夫曼-拉罗切有限公司	治疗认知障碍的组合物和方法
AU2005291541B2 (en) *	2004-09-30	2011-03-10	F. Hoffmann-La Roche Ag	Benzoxazine and quinoxaline derivatives and uses
EP2508177A1 (en)	2007-12-12	2012-10-10	Glaxo Group Limited	Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline
WO2009123714A2 (en)	2008-04-02	2009-10-08	Arena Pharmaceuticals, Inc.	Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
WO2010062321A1 (en)	2008-10-28	2010-06-03	Arena Pharmaceuticals, Inc.	Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
AR078770A1 (es) *	2009-10-27	2011-11-30	Elara Pharmaceuticals Gmbh	Derivados de dihidrobenzo oxacinas y tiazinas, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades inflamatorias e hiperproliferativas.
KR101293384B1 (ko) *	2010-10-13	2013-08-05	주식회사 대웅제약	신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US9403800B2 (en) *	2012-01-24	2016-08-02	Chemregen, Inc.	Compounds for inhibition of cancer cell proliferation
US10087151B2 (en)	2014-01-09	2018-10-02	The J. David Gladstone Institutes, A Testimentary Trust Established Under The Will Of J. David Gladstone	Substituted benzoxazine and related compounds
WO2016201373A1 (en)	2015-06-12	2016-12-15	Axovant Sciences Ltd.	Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder
WO2017011767A2 (en)	2015-07-15	2017-01-19	Axovant Sciences Ltd.	Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease

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AU736256B2 (en)	1997-07-11	2001-07-26	Smithkline Beecham Plc	Novel compounds
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HRP20041030B1 (hr) *	2002-05-13	2013-03-31	F. Hoffmann - La Roche Ag	Derivati benzoksazina kao regulatori 5-ht6 i njihova upotreba

2003
- 2003-05-05 HR HRP20041030AA patent/HRP20041030B1/hr not_active IP Right Cessation
- 2003-05-05 UA UA20041210144A patent/UA76877C2/uk unknown
- 2003-05-05 KR KR1020047018299A patent/KR100636475B1/ko not_active Expired - Fee Related
- 2003-05-05 AU AU2003233231A patent/AU2003233231B2/en not_active Expired
- 2003-05-05 DE DE60303376T patent/DE60303376T2/de not_active Expired - Lifetime
- 2003-05-05 WO PCT/EP2003/004671 patent/WO2003095434A1/en not_active Ceased
- 2003-05-05 CA CA2485136A patent/CA2485136C/en not_active Expired - Lifetime
- 2003-05-05 EA EA200401455A patent/EA009982B1/ru not_active IP Right Cessation
- 2003-05-05 AT AT03727430T patent/ATE316523T1/de active
- 2003-05-05 DK DK03727430T patent/DK1506179T3/da active
- 2003-05-05 EP EP03727430A patent/EP1506179B1/en not_active Expired - Lifetime
- 2003-05-05 PT PT03727430T patent/PT1506179E/pt unknown
- 2003-05-05 NZ NZ536230A patent/NZ536230A/en not_active IP Right Cessation
- 2003-05-05 PL PL374019A patent/PL211057B1/pl unknown
- 2003-05-05 CN CNB038109972A patent/CN100429206C/zh not_active Expired - Lifetime
- 2003-05-05 MX MXPA04011254A patent/MXPA04011254A/es active IP Right Grant
- 2003-05-05 ES ES03727430T patent/ES2256744T3/es not_active Expired - Lifetime
- 2003-05-05 BR BRPI0310032A patent/BRPI0310032B8/pt not_active IP Right Cessation
- 2003-05-05 RS YUP-970/04A patent/RS51042B/sr unknown
- 2003-05-05 JP JP2004503451A patent/JP4307377B2/ja not_active Expired - Lifetime
- 2003-05-08 JO JO200352A patent/JO2413B1/en active
- 2003-05-08 TW TW092112575A patent/TWI258479B/zh not_active IP Right Cessation
- 2003-05-09 US US10/435,732 patent/US6867204B2/en not_active Expired - Lifetime
- 2003-05-09 GT GT200300108A patent/GT200300108A/es unknown
- 2003-05-09 PA PA20038573501A patent/PA8573501A1/es unknown
- 2003-05-09 PE PE2003000452A patent/PE20040757A1/es active IP Right Grant
- 2003-05-09 AR ARP030101624A patent/AR039988A1/es active IP Right Grant
- 2003-05-10 EG EG2003050432A patent/EG25683A/xx active
- 2003-05-12 MY MYPI20031765A patent/MY139612A/en unknown
- 2003-05-12 UY UY27803A patent/UY27803A1/es not_active IP Right Cessation
2004
- 2004-10-28 IL IL16492804A patent/IL164928A0/xx unknown
- 2004-10-28 NO NO20044665A patent/NO329380B1/no not_active IP Right Cessation
- 2004-10-29 ZA ZA2004/08783A patent/ZA200408783B/en unknown
- 2004-11-10 EC EC2004005420A patent/ECSP045420A/es unknown
- 2004-11-11 TN TNP2004000225A patent/TNSN04225A1/fr unknown
- 2004-11-12 MA MA27944A patent/MA27118A1/fr unknown
2005
- 2005-01-31 US US11/047,284 patent/US20050130962A1/en not_active Abandoned
2009
- 2009-09-04 US US12/584,373 patent/US8377931B2/en not_active Expired - Fee Related
2012
- 2012-12-13 US US13/713,484 patent/US20130123251A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2256744T3 (es)	2006-07-16
US6867204B2 (en)	2005-03-15
JP4307377B2 (ja)	2009-08-05
BRPI0310032B8 (pt)	2021-05-25
AR039988A1 (es)	2005-03-09
JP2005530774A (ja)	2005-10-13
GT200300108A (es)	2004-03-15
AU2003233231B2 (en)	2009-02-26
PL374019A1 (en)	2005-09-19
NZ536230A (en)	2007-05-31
EP1506179B1 (en)	2006-01-25
TW200400188A (en)	2004-01-01
HK1080846A1 (zh)	2006-05-04
PA8573501A1 (es)	2003-12-10
CN100429206C (zh)	2008-10-29
PT1506179E (pt)	2006-06-30
EA009982B1 (ru)	2008-04-28
EP1506179A1 (en)	2005-02-16
US20130123251A1 (en)	2013-05-16
MA27118A1 (fr)	2004-12-20
DK1506179T3 (da)	2006-06-06
KR100636475B1 (ko)	2006-10-18
US8377931B2 (en)	2013-02-19
JO2413B1 (en)	2007-11-11
PE20040757A1 (es)	2004-11-06
AU2003233231A1 (en)	2003-11-11
DE60303376T2 (de)	2006-11-16
MY139612A (en)	2009-10-30
NO20044665L (no)	2004-12-03
MXPA04011254A (es)	2005-01-25
US20030232825A1 (en)	2003-12-18
UY27803A1 (es)	2003-11-28
EG25683A (en)	2012-05-16
TWI258479B (en)	2006-07-21
HRP20041030A2 (en)	2005-06-30
IL164928A0 (en)	2005-12-18
WO2003095434A1 (en)	2003-11-20
CA2485136C (en)	2011-12-20
BR0310032A (pt)	2005-02-15
UA76877C2 (uk)	2006-09-15
TNSN04225A1 (fr)	2007-03-12
ECSP045420A (es)	2005-01-03
DE60303376D1 (de)	2006-04-13
RS51042B (sr)	2010-10-31
ATE316523T1 (de)	2006-02-15
EA200401455A1 (ru)	2005-06-30
KR20040106538A (ko)	2004-12-17
ZA200408783B (en)	2005-12-28
US20050130962A1 (en)	2005-06-16
RS97004A (sr)	2006-10-27
US20090325950A1 (en)	2009-12-31
BRPI0310032B1 (pt)	2019-01-08
CA2485136A1 (en)	2003-11-20
CN1653054A (zh)	2005-08-10
PL211057B1 (pl)	2012-04-30
HRP20041030B1 (hr)	2013-03-31

Legal Events

Date	Code	Title	Description
2023-07-10	MK1K	Patent expired

Publication	Publication Date	Title
US8377931B2 (en)	2013-02-19	Benzoxazine derivatives and uses thereof
KR100683361B1 (ko)	2007-02-15	치환된 벤즈옥사진온 및 그의 용도
JP4527730B2 (ja)	2010-08-18	ベンゾオキサジン誘導体及びその使用
ES2305742T3 (es)	2008-11-01	Derivados de quinolinon/benzoxazinona y uso de los mismos.
ES2348467T3 (es)	2010-12-07	Derivados y usos de la benzoxazina y la quinoxalina.
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