NO332096B1 - Oral opplosning inneholdende galantamin og et sotstoff - Google Patents

Oral opplosning inneholdende galantamin og et sotstoff Download PDF

Info

Publication number: NO332096B1
Authority: NO; Norway
Prior art keywords: oral solution; galantamine; solution according; pharmaceutically acceptable; oral
Prior art date: 1999-10-26

Application number

NO20022003A

Other languages

English (en)

Norwegian (no)

Other versions

NO20022003D0 (no

NO20022003L (no

Inventor

Proost Eddy Andre Josee De

Tony Mathilde Jozef Kempen

Marc Karel Jozef Francois

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-26

Filing date

2002-04-26

Publication date

2012-06-18

2002-04-26 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2002-04-26 Publication of NO20022003D0 publication Critical patent/NO20022003D0/no

2002-06-18 Publication of NO20022003L publication Critical patent/NO20022003L/no

2012-06-18 Publication of NO332096B1 publication Critical patent/NO332096B1/no

Links

ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title claims abstract description 47
229960003980 galantamine Drugs 0.000 title claims abstract description 23
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title claims abstract description 23
229940100688 oral solution Drugs 0.000 title claims abstract description 20
239000000126 substance Substances 0.000 title description 6
239000004071 soot Substances 0.000 title 1
150000003839 salts Chemical class 0.000 claims abstract description 15
239000000243 solution Substances 0.000 claims description 21
239000000203 mixture Substances 0.000 claims description 17
235000003599 food sweetener Nutrition 0.000 claims description 12
239000003765 sweetening agent Substances 0.000 claims description 12
206010012289 Dementia Diseases 0.000 claims description 11
239000007788 liquid Substances 0.000 claims description 11
208000010877 cognitive disease Diseases 0.000 claims description 10
208000027061 mild cognitive impairment Diseases 0.000 claims description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
239000008213 purified water Substances 0.000 claims description 8
208000024827 Alzheimer disease Diseases 0.000 claims description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
229960002024 galantamine hydrobromide Drugs 0.000 claims description 7
QORVDGQLPPAFRS-XPSHAMGMSA-N galantamine hydrobromide Chemical group Br.O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 QORVDGQLPPAFRS-XPSHAMGMSA-N 0.000 claims description 7
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BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
239000012467 final product Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000010417 guar gum Nutrition 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
229960002154 guar gum Drugs 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
229920013821 hydroxy alkyl cellulose Polymers 0.000 description 1
125000002768 hydroxyalkyl group Chemical group 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
229950007325 lauralkonium chloride Drugs 0.000 description 1
239000008297 liquid dosage form Substances 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
244000005700 microbiome Species 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
229940089953 neohesperidin dihydrochalcone Drugs 0.000 description 1
235000010434 neohesperidine DC Nutrition 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000003921 oil Substances 0.000 description 1
150000002482 oligosaccharides Polymers 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
235000019629 palatability Nutrition 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
229940067107 phenylethyl alcohol Drugs 0.000 description 1
229920000233 poly(alkylene oxides) Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920005606 polypropylene copolymer Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
150000004804 polysaccharides Chemical class 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
235000007686 potassium Nutrition 0.000 description 1
229960003975 potassium Drugs 0.000 description 1
235000010241 potassium sorbate Nutrition 0.000 description 1
239000004302 potassium sorbate Substances 0.000 description 1
229940069338 potassium sorbate Drugs 0.000 description 1
239000001294 propane Substances 0.000 description 1
150000003242 quaternary ammonium salts Chemical class 0.000 description 1
229930188195 rebaudioside Natural products 0.000 description 1
239000012313 reversal agent Substances 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
229960003885 sodium benzoate Drugs 0.000 description 1
229940001607 sodium bisulfite Drugs 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
229940001482 sodium sulfite Drugs 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
229940001474 sodium thiosulfate Drugs 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
229940013618 stevioside Drugs 0.000 description 1
OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
235000019202 steviosides Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
235000019408 sucralose Nutrition 0.000 description 1
BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
239000000892 thaumatin Substances 0.000 description 1
235000010436 thaumatin Nutrition 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Addiction (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Saccharide Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

NO20022003A 1999-10-26 2002-04-26 Oral opplosning inneholdende galantamin og et sotstoff NO332096B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP99203512		1999-10-26
PCT/EP2000/010203 WO2001030318A1 (en)	1999-10-26	2000-10-16	Oral solution containing galanthamine and a sweetening agent

Publications (3)

Publication Number	Publication Date
NO20022003D0 NO20022003D0 (no)	2002-04-26
NO20022003L NO20022003L (no)	2002-06-18
NO332096B1 true NO332096B1 (no)	2012-06-18

Family

ID=8240778

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20022003A NO332096B1 (no)	1999-10-26	2002-04-26	Oral opplosning inneholdende galantamin og et sotstoff

Country Status (29)

Country	Link
EP (1)	EP1237539B1 (cs)
JP (1)	JP2003512415A (cs)
KR (1)	KR100502391B1 (cs)
CN (1)	CN1200691C (cs)
AR (1)	AR026243A1 (cs)
AT (1)	ATE306904T1 (cs)
AU (1)	AU780826C (cs)
BG (1)	BG65792B1 (cs)
BR (1)	BR0015025A (cs)
CA (1)	CA2388830C (cs)
CZ (1)	CZ301996B6 (cs)
DE (1)	DE60023341T2 (cs)
DK (1)	DK1237539T3 (cs)
EA (1)	EA005683B1 (cs)
EE (1)	EE05230B1 (cs)
ES (1)	ES2250211T3 (cs)
HR (1)	HRP20020332B1 (cs)
HU (1)	HUP0203484A3 (cs)
IL (2)	IL149310A0 (cs)
IS (1)	IS2628B (cs)
MX (1)	MXPA02004149A (cs)
NO (1)	NO332096B1 (cs)
PL (1)	PL201694B1 (cs)
SI (1)	SI1237539T1 (cs)
SK (1)	SK285643B6 (cs)
TW (1)	TW592725B (cs)
UA (1)	UA76095C2 (cs)
WO (1)	WO2001030318A1 (cs)
ZA (1)	ZA200203313B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030162770A1 (en) *	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
WO2005016327A2 (en) *	2003-08-13	2005-02-24	Janssen Pharmaceutica, N.V.	Treatment of sleep disorders with cholinesterase inhibitors
US20050191349A1 (en) *	2003-12-31	2005-09-01	Garth Boehm	Galantamine formulations
US8709521B2 (en) *	2007-05-22	2014-04-29	The Coca-Cola Company	Sweetener compositions having enhanced sweetness and improved temporal and/or flavor profiles
LT2667715T (lt) *	2011-01-27	2017-11-10	Neuren Pharmaceuticals Limited	Autizmo spektro susirgimų gydymas, naudojant glicil-l-2-metilprolil-l-glutamo rūgštį
US20140107130A1 (en) *	2012-10-11	2014-04-17	Antrim Pharmaceuticals, LLC	Oral Solution Formulations of Aripiprazole
JP6457582B2 (ja) *	2017-04-14	2019-01-23	エルメッドエーザイ株式会社	ガランタミン含有医薬組成物、並びに医薬組成物におけるガランタミンの苦味抑制方法、及びガランタミンの苦味抑制剤
CN117717558A (zh) *	2023-12-06	2024-03-19	艾威药业(珠海)有限公司	加兰他敏及其药学上可接受的盐在制备治疗眼部疾病的药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4010079A1 (de) *	1990-03-29	1991-10-02	Lohmann Therapie Syst Lts	Pharmazeutische formulierung zur behandlung des alkoholismus
US5272137A (en) *	1992-02-14	1993-12-21	Mcneil-Pfc, Inc.	Aqueous pharmaceutical suspension for pharmaceutical actives
US6323195B1 (en) *	1993-10-15	2001-11-27	Aventis Pharmaceuticals Inc.	Galanthamine derivatives as acetylcholinesterase inhibitors
JPH10273435A (ja) *	1997-01-29	1998-10-13	Fujisawa Pharmaceut Co Ltd	内服用液剤

2000
- 2000-10-16 WO PCT/EP2000/010203 patent/WO2001030318A1/en not_active Ceased
- 2000-10-16 JP JP2001532738A patent/JP2003512415A/ja active Pending
- 2000-10-16 BR BR0015025-8A patent/BR0015025A/pt not_active Application Discontinuation
- 2000-10-16 CN CNB008147388A patent/CN1200691C/zh not_active Expired - Lifetime
- 2000-10-16 UA UA2002054064A patent/UA76095C2/uk unknown
- 2000-10-16 EP EP00975872A patent/EP1237539B1/en not_active Expired - Lifetime
- 2000-10-16 DK DK00975872T patent/DK1237539T3/da active
- 2000-10-16 DE DE60023341T patent/DE60023341T2/de not_active Expired - Lifetime
- 2000-10-16 TW TW089121526A patent/TW592725B/zh not_active IP Right Cessation
- 2000-10-16 KR KR10-2002-7003258A patent/KR100502391B1/ko not_active Expired - Lifetime
- 2000-10-16 MX MXPA02004149A patent/MXPA02004149A/es active IP Right Grant
- 2000-10-16 AT AT00975872T patent/ATE306904T1/de active
- 2000-10-16 EE EEP200200213A patent/EE05230B1/xx unknown
- 2000-10-16 IL IL14931000A patent/IL149310A0/xx active IP Right Grant
- 2000-10-16 CZ CZ20021329A patent/CZ301996B6/cs not_active IP Right Cessation
- 2000-10-16 CA CA002388830A patent/CA2388830C/en not_active Expired - Lifetime
- 2000-10-16 EA EA200200486A patent/EA005683B1/ru not_active IP Right Cessation
- 2000-10-16 AU AU13849/01A patent/AU780826C/en not_active Expired
- 2000-10-16 HR HR20020332A patent/HRP20020332B1/xx not_active IP Right Cessation
- 2000-10-16 HU HU0203484A patent/HUP0203484A3/hu unknown
- 2000-10-16 PL PL362849A patent/PL201694B1/pl unknown
- 2000-10-16 SI SI200030782T patent/SI1237539T1/sl unknown
- 2000-10-16 SK SK530-2002A patent/SK285643B6/sk not_active IP Right Cessation
- 2000-10-16 ES ES00975872T patent/ES2250211T3/es not_active Expired - Lifetime
- 2000-10-25 AR ARP000105621A patent/AR026243A1/es not_active Application Discontinuation
2002
- 2002-02-28 IS IS6291A patent/IS2628B/is unknown
- 2002-03-20 BG BG106534A patent/BG65792B1/bg unknown
- 2002-04-24 IL IL149310A patent/IL149310A/en unknown
- 2002-04-25 ZA ZA200203313A patent/ZA200203313B/xx unknown
- 2002-04-26 NO NO20022003A patent/NO332096B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ301996B6 (cs)	2010-09-01
JP2003512415A (ja)	2003-04-02
KR100502391B1 (ko)	2005-07-19
NO20022003D0 (no)	2002-04-26
BR0015025A (pt)	2002-06-18
CA2388830C (en)	2006-09-19
AU780826C (en)	2006-02-16
CZ20021329A3 (cs)	2002-08-14
UA76095C2 (en)	2006-07-17
IS6291A (is)	2002-02-28
BG106534A (en)	2002-12-29
EP1237539B1 (en)	2005-10-19
HUP0203484A3 (en)	2004-12-28
SI1237539T1 (sl)	2006-04-30
CA2388830A1 (en)	2001-05-03
EP1237539A1 (en)	2002-09-11
CN1382037A (zh)	2002-11-27
EA200200486A1 (ru)	2002-10-31
DK1237539T3 (da)	2006-02-27
BG65792B1 (bg)	2009-12-31
ZA200203313B (en)	2003-11-26
IL149310A0 (en)	2002-11-10
EE200200213A (et)	2003-06-16
HRP20020332B1 (hr)	2011-02-28
ATE306904T1 (de)	2005-11-15
AU1384901A (en)	2001-05-08
EE05230B1 (et)	2009-12-15
KR20020026010A (ko)	2002-04-04
SK285643B6 (sk)	2007-05-03
HK1049619A1 (en)	2003-05-23
PL362849A1 (en)	2004-11-02
WO2001030318A1 (en)	2001-05-03
SK5302002A3 (en)	2002-10-08
AU780826B2 (en)	2005-04-21
IS2628B (is)	2010-05-15
TW592725B (en)	2004-06-21
DE60023341T2 (de)	2006-07-27
HUP0203484A2 (hu)	2003-02-28
HRP20020332A2 (en)	2004-02-29
IL149310A (en)	2006-12-10
PL201694B1 (pl)	2009-04-30
DE60023341D1 (de)	2006-03-02
NO20022003L (no)	2002-06-18
CN1200691C (zh)	2005-05-11
ES2250211T3 (es)	2006-04-16
MXPA02004149A (es)	2002-10-17
AR026243A1 (es)	2003-02-05
EA005683B1 (ru)	2005-04-28

Legal Events

Date	Code	Title	Description
2020-11-09	MK1K	Patent expired

Publication	Publication Date	Title
EP2273975B1 (en)	2014-04-09	Pharmaceutical solutions, process of preparation and therapeutic uses
EP2214637B1 (en)	2013-05-08	Stabilized pediatric suspension of carisbamate
EP3013323B1 (en)	2020-05-13	Complex granule formulation having improved stability comprising levocetirizine and montelukast
AU780826B2 (en)	2005-04-21	Oral solution containing galanthamine and a sweetening agent
EP1176982A1 (en)	2002-02-06	Prucalopride oral solution
EP3582765B1 (en)	2021-04-28	Midodrine hydrochloride oral solution and uses thereof
US20050063998A1 (en)	2005-03-24	Oral solution containing galantamine and a sweetening agent
HK1049619B (en)	2005-12-23	Oral solution containing galanthamine and a sweetening agent